Hannelore Ehrenreich

Summary

Affiliation: Max Planck Institute for Experimental Medicine
Country: Germany

Publications

  1. pmc Outpatient Long-term Intensive Therapy for Alcoholics (OLITA): a successful biopsychosocial approach to the treatment of alcoholism
    Henning Krampe
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Dialogues Clin Neurosci 9:399-412. 2007
  2. pmc A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia
    Sabrina Grube
    Divison of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    EMBO Mol Med 3:309-19. 2011
  3. pmc A single gene defect causing claustrophobia
    A El-Kordi
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Transl Psychiatry 3:e254. 2013
  4. pmc Polygenic determinants of white matter volume derived from GWAS lack reproducibility in a replicate sample
    S Papiol
    1 Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany 2 DFG Research Center for Nanoscale Microscopy and Molecular Physiology of the Brain CNMPB, Gottingen, Germany 3 Centro de Investigaciones Biomédicas en Red de Salud Mental CIBERSAM, Barcelona, Spain
    Transl Psychiatry 4:e362. 2014
  5. pmc Dissociation of accumulated genetic risk and disease severity in patients with schizophrenia
    S Papiol
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Transl Psychiatry 1:e45. 2011
  6. pmc Odor naming and interpretation performance in 881 schizophrenia subjects: association with clinical parameters
    Anne Kastner
    Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Hermann Rein Str, 3, 37075 Gottingen, Germany
    BMC Psychiatry 13:218. 2013
  7. doi request reprint [Phenotype-based genetic association studies (PGAS): a new approach to understanding the genotype contribution to schizophrenic phenotypes]
    H Ehrenreich
    Klinische Neurowissenschaften, Max Planck Institut für Experimentelle Medizin und DFG Forschungszentrum für Molekularphysiologie des Gehirns CMPB, Gottingen
    Fortschr Neurol Psychiatr 81:240-2. 2013
  8. pmc Circulating damage marker profiles support a neuroprotective effect of erythropoietin in ischemic stroke patients
    Hannelore Ehrenreich
    Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Mol Med 17:1306-10. 2011
  9. pmc Effects of erythropoietin on depressive symptoms and neurocognitive deficits in depression and bipolar disorder
    Kamilla W Miskowiak
    Clinic for Affective Disorders, Department of Psychiatry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Trials 11:97. 2010
  10. ncbi request reprint A novel role for an established player: anemia drug erythropoietin for the treatment of cerebral hypoxia/ischemia
    Hannelore Ehrenreich
    Max Planck Institute for Experimental Medicine, Hermann Rein Str 3, 37075 Gottingen, Germany
    Transfus Apher Sci 31:39-44. 2004

Detail Information

Publications100

  1. pmc Outpatient Long-term Intensive Therapy for Alcoholics (OLITA): a successful biopsychosocial approach to the treatment of alcoholism
    Henning Krampe
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Dialogues Clin Neurosci 9:399-412. 2007
    ..Thus, process-outcome research on OLITA can serve for the development of new therapeutic guidelines on adapting individual relapse prevention strategies...
  2. pmc A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia
    Sabrina Grube
    Divison of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    EMBO Mol Med 3:309-19. 2011
    ..Reduction of SK3 function may constitute a pharmacological target to improve cognition in schizophrenia and other conditions with cognitive impairment...
  3. pmc A single gene defect causing claustrophobia
    A El-Kordi
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Transl Psychiatry 3:e254. 2013
    ..This mutant mRNA is functional but cannot be silenced by neuronal miR124 derived itself from a stress-regulated transcript. We suggest that loosing dynamic regulation of neuronal GPM6A expression poses a genetic risk for claustrophobia...
  4. pmc Polygenic determinants of white matter volume derived from GWAS lack reproducibility in a replicate sample
    S Papiol
    1 Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany 2 DFG Research Center for Nanoscale Microscopy and Molecular Physiology of the Brain CNMPB, Gottingen, Germany 3 Centro de Investigaciones Biomédicas en Red de Salud Mental CIBERSAM, Barcelona, Spain
    Transl Psychiatry 4:e362. 2014
    ..Caution is indicated in interpreting studies building on polygenic risk scores without replication sample...
  5. pmc Dissociation of accumulated genetic risk and disease severity in patients with schizophrenia
    S Papiol
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Transl Psychiatry 1:e45. 2011
    ..We conclude that GWAS does not extract disease genes of general significance in schizophrenia, but may yield, on a hypothesis-free basis, candidate genes relevant for defining disease subgroups...
  6. pmc Odor naming and interpretation performance in 881 schizophrenia subjects: association with clinical parameters
    Anne Kastner
    Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Hermann Rein Str, 3, 37075 Gottingen, Germany
    BMC Psychiatry 13:218. 2013
    ..However, associations of central olfactory measures with clinical outcome parameters have not been simultaneously studied in large samples of schizophrenia patients...
  7. doi request reprint [Phenotype-based genetic association studies (PGAS): a new approach to understanding the genotype contribution to schizophrenic phenotypes]
    H Ehrenreich
    Klinische Neurowissenschaften, Max Planck Institut für Experimentelle Medizin und DFG Forschungszentrum für Molekularphysiologie des Gehirns CMPB, Gottingen
    Fortschr Neurol Psychiatr 81:240-2. 2013
    ..First PGAS proof-of-concept results on cognition or development-relevant genes are already available...
  8. pmc Circulating damage marker profiles support a neuroprotective effect of erythropoietin in ischemic stroke patients
    Hannelore Ehrenreich
    Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Mol Med 17:1306-10. 2011
    ..To conclude, serum biomarker profiles, as an outcome measure of brain damage, corroborate an advantageous effect of EPO in ischemic stroke. In particular, reduction in the neuronal damage marker UCH-L1 may reflect neuroprotection by EPO...
  9. pmc Effects of erythropoietin on depressive symptoms and neurocognitive deficits in depression and bipolar disorder
    Kamilla W Miskowiak
    Clinic for Affective Disorders, Department of Psychiatry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Trials 11:97. 2010
    ....
  10. ncbi request reprint A novel role for an established player: anemia drug erythropoietin for the treatment of cerebral hypoxia/ischemia
    Hannelore Ehrenreich
    Max Planck Institute for Experimental Medicine, Hermann Rein Str 3, 37075 Gottingen, Germany
    Transfus Apher Sci 31:39-44. 2004
    ..At the moment a multicenter study is being carried out in Germany...
  11. ncbi request reprint Erythropoietin: a candidate compound for neuroprotection in schizophrenia
    H Ehrenreich
    Max Planck Institute for Experimental Medicine and Department of Psychiatry, Georg August University, Goettingen, Germany
    Mol Psychiatry 9:42-54. 2004
    ....
  12. ncbi request reprint Does disulfiram have a role in alcoholism treatment today? Not to forget about disulfiram's psychological effects
    Hannelore Ehrenreich
    Max Planck Institute for Experimental Medicine, Hermann Rein Str 3, 37075 Gottingen, Germany
    Addiction 99:26-7; author reply 27-8. 2004
  13. ncbi request reprint Medicine. A boost for translational neuroscience
    Hannelore Ehrenreich
    Division of Clinical Neuroscience, Max Planck Institute for Experimental Medicine, 37075 Goettingen, Germany
    Science 305:184-5. 2004
  14. ncbi request reprint Erythropoietin: novel approaches to neuroprotection in human brain disease
    Hannelore Ehrenreich
    Clinical Neuroscience Laboratory, Max Planck Institute for Experimental Medicine, Gottingen, Germany
    Metab Brain Dis 19:195-206. 2004
    ....
  15. ncbi request reprint Recombinant human erythropoietin in the treatment of acute ischemic stroke
    Hannelore Ehrenreich
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Stroke 40:e647-56. 2009
    ..Accordingly, the double-blind, placebo-controlled, randomized German Multicenter EPO Stroke Trial (Phase II/III; ClinicalTrials.gov Identifier: NCT00604630) was designed to evaluate efficacy and safety of EPO in stroke...
  16. ncbi request reprint Improvement of cognitive functions in chronic schizophrenic patients by recombinant human erythropoietin
    H Ehrenreich
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Mol Psychiatry 12:206-20. 2007
    ..The fact that rhEPO is the first compound to exert a selective and lasting beneficial effect on cognition should encourage new treatment strategies for schizophrenia...
  17. pmc Erythropoietin therapy for acute stroke is both safe and beneficial
    Hannelore Ehrenreich
    Max Planck Institute for Experimental Medicine, Departments of Neurology and Psychiatry, Georg August University, Goettingen, Germany
    Mol Med 8:495-505. 2002
    ..EPO protects neurons from hypoxic/ ischemic injury. The objective of this trial is to study the safety and efficacy of recombinant human EPO (rhEPO) for treatment of ischemic stroke in man...
  18. pmc A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain
    Hannelore Ehrenreich
    Max Planck Institute of Experimental Medicine, Georg August University, 37075 Goettingen, Germany
    Proc Natl Acad Sci U S A 102:862-7. 2005
    ..This effect is not only inhibited by EPO but also by neurotrophins. We suggest that the proapoptotic function of TPO helps to select for neurons that have acquired target-derived neurotrophic support...
  19. ncbi request reprint Recombinant human erythropoietin in the treatment of human brain disease: focus on cognition
    Hannelore Ehrenreich
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    J Ren Nutr 18:146-53. 2008
    ..These promising results are just the beginning and will hopefully stimulate further work along these lines...
  20. pmc Common variants of the genes encoding erythropoietin and its receptor modulate cognitive performance in schizophrenia
    Anne Kastner
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Mol Med 18:1029-40. 2012
    ..Together, these findings reveal a role of endogenous EPO/EPOR for cognition, at least in schizophrenic patients...
  21. pmc Expression of constitutively active erythropoietin receptor in pyramidal neurons of cortex and hippocampus boosts higher cognitive functions in mice
    Derya Sargin
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    BMC Biol 9:27. 2011
    ..However, the critical EPO targets in brain are unknown, and separation of direct and indirect effects has remained difficult, given the role of EPO in hematopoiesis and brain oxygen supply...
  22. ncbi request reprint Modification of cognitive performance in schizophrenia by complexin 2 gene polymorphisms
    Martin Begemann
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Arch Gen Psychiatry 67:879-88. 2010
    ..In particular, the specific contribution of risk or candidate gene variants to the complex schizophrenic phenotype is largely unknown...
  23. doi request reprint Hypoxia inducible factor stabilization leads to lasting improvement of hippocampal memory in healthy mice
    Bartosz Adamcio
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Hermann Rein Str 3, 37075 Gottingen, Germany
    Behav Brain Res 208:80-4. 2010
    ..FG-4497 application for 3 weeks leads to delayed but lasting enhancement of hippocampal memory, making HIF stabilization an attractive target for pharmacological manipulation of cognition...
  24. doi request reprint Neuroinflammation in white matter tracts of Cnp1 mutant mice amplified by a minor brain injury
    Georg L Wieser
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075, Gottingen, Germany
    Glia 61:869-80. 2013
    ..This interaction of genetic and environmental factors may be relevant for neuropsychiatric diseases associated with secondary neuroinflammation...
  25. pmc Practice effects in healthy adults: a longitudinal study on frequent repetitive cognitive testing
    Claudia Bartels
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    BMC Neurosci 11:118. 2010
    ....
  26. ncbi request reprint Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism
    Ahmed El-Kordi
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Behav Brain Res 251:41-9. 2013
    ....
  27. ncbi request reprint Development of an outcome prediction measure for alcoholism therapy by multimodal monitoring of treatment processes
    Henning Krampe
    Max Planck Institute of Experimental Medicine, Hermann Rein Strasse 3, 37075 Goettingen, Germany
    J Psychiatr Res 43:30-47. 2008
    ..001). The results suggest to validate the item combination described in the TOPPS in addiction therapy as a treatment guideline of individual relapse prevention strategies...
  28. pmc The cross-sectional GRAS sample: a comprehensive phenotypical data collection of schizophrenic patients
    Katja Ribbe
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    BMC Psychiatry 10:91. 2010
    ..This approach is different from and complementary to the genome-wide association studies (GWAS) on schizophrenia...
  29. ncbi request reprint Recovery of hippocampus-related functions in chronic alcoholics during monitored long-term abstinence
    Claudia Bartels
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine Hermann Rein Str 3, 37075 Gottingen, Germany
    Alcohol Alcohol 42:92-102. 2007
    ....
  30. ncbi request reprint Follow-up of 180 alcoholic patients for up to 7 years after outpatient treatment: impact of alcohol deterrents on outcome
    Henning Krampe
    Department of Psychiatry and Psychotherapy, Georg August University, and Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Alcohol Clin Exp Res 30:86-95. 2006
    ....
  31. doi request reprint Uncoupling of neurodegeneration and gliosis in a murine model of juvenile cortical lesion
    Derya Sargin
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Goettingen 37075, Germany
    Glia 57:693-702. 2009
    ..Although the detailed mechanisms remain to be defined, these profound EPO effects open new ways for prophylaxis and therapy of neuropsychiatric diseases, e.g. schizophrenia...
  32. ncbi request reprint Preserved vasopressin response to osmostimulation despite decreased basal vasopressin levels in long-term abstinent alcoholics
    Henriette Jahn
    Department of Psychiatry and Psychotherapy, Georg August University, and Max Planck Institute for Experimental Medicine, Hermann Rein Str 3, D 37075 Gottingen, Germany
    Alcohol Clin Exp Res 28:1925-30. 2004
    ..This study was therefore designed to examine whether long-term abstinent alcoholics have a compromised response of AVP to osmostimulation...
  33. doi request reprint Prediction of the risk of comorbid alcoholism in schizophrenia by interaction of common genetic variants in the corticotropin-releasing factor system
    Katja Ribbe
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Arch Gen Psychiatry 68:1247-56. 2011
    ..Prediction of persons at risk for AUD is crucial for future preventive and therapeutic strategies...
  34. doi request reprint Cognitive and sensorimotor gating impairments in transgenic mice overexpressing the schizophrenia susceptibility gene Tcf4 in the brain
    Magdalena M Brzózka
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Biol Psychiatry 68:33-40. 2010
    ..Tcf4 null mutant mice die perinatally, and haploinsufficiency of TCF4 in humans causes severe mental retardation...
  35. ncbi request reprint In vitro gender differences in neuronal survival on hypoxia and in 17beta-estradiol-mediated neuroprotection
    Andrea Heyer
    Max Planck Institute for Experimental Medicine, Gottingen, Germany
    J Cereb Blood Flow Metab 25:427-30. 2005
    ..Estrogens, acting via membrane receptors, had a higher neuroprotective power in male neurons, explained at least in part by the pronounced increase in estrogen receptor beta/alpha ratio during hypoxia in male cells only...
  36. doi request reprint A phenotype-based genetic association study reveals the contribution of neuregulin1 gene variants to age of onset and positive symptom severity in schizophrenia
    Sergi Papiol
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Am J Med Genet B Neuropsychiatr Genet 156:340-5. 2011
    ..The GRAS Data Collection as a prerequisite for PGAS has enabled us to associate protective NRG1 genotypes with later onset and milder course of schizophrenia...
  37. pmc Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans
    Sonja M Wojcik
    Max Planck Institute of Experimental Medicine, Department of Molecular Neurobiology, Gottingen, Germany
    Mol Med 19:135-48. 2013
    ..Thus, Baiap3/BAIAP3 is gender specifically associated with anxiety and benzodiazepine use disorder, and the analysis of Baiap3/BAIAP3-related functions may help elucidate mechanisms underlying the development of both disorders...
  38. pmc Erythropoietin attenuates neurological and histological consequences of toxic demyelination in mice
    Nora Hagemeyer
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Mol Med 18:628-35. 2012
    ..These findings underscore the value of future therapeutic strategies for multiple sclerosis based on EPO or EPO variants...
  39. pmc Erythropoietin enhances hippocampal long-term potentiation and memory
    Bartosz Adamcio
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    BMC Biol 6:37. 2008
    ..We developed a mouse model of robust cognitive improvement by EPO to obtain the first clues of how EPO influences cognition, and how it may act on hippocampal neurons to modulate plasticity...
  40. ncbi request reprint Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis
    Hannelore Ehrenreich
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Georg August University, Gottingen, Germany
    Brain 130:2577-88. 2007
    ..There were no adverse events, no safety concerns and a surprisingly low need of blood-lettings. This first pilot study demonstrates the necessity and feasibility of controlled trials using high-dose rhEPO in chronic progressive MS...
  41. ncbi request reprint Cell type specific signalling by hematopoietic growth factors in neural cells
    Nadiya Byts
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Hermann Rein Str 3, Gottingen, D 37075, Germany
    Neurochem Res 31:1219-30. 2006
    ..This effect was accompanied by activation of ERK1/2 and inhibition of STAT3 activity. A balance between growth factors, their receptors and signalling proteins may play an important role in regulation of neural cell survival...
  42. ncbi request reprint Arginine challenge unravels persistent disturbances of urea cycle and gluconeogenesis in abstinent alcoholics
    Martin Hasselblatt
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Alcohol Alcohol 41:372-8. 2006
    ..Our previous findings of persistently decreased plasma and urinary urea concentrations in long-term abstinent alcoholics prompted us to further elucidate this unexplained phenomenon...
  43. pmc A myelin gene causative of a catatonia-depression syndrome upon aging
    Nora Hagemeyer
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    EMBO Mol Med 4:528-39. 2012
    ..Analogously, in man, diffusion tensor imaging points to axonal loss in the frontal corpus callosum. To conclude, subtle white matter abnormalities inducing neurodegenerative changes can cause/amplify psychiatric diseases...
  44. ncbi request reprint Substantial decrease of psychiatric comorbidity in chronic alcoholics upon integrated outpatient treatment - results of a prospective study
    Thilo Wagner
    Department of Psychiatry and Psychotherapy, Georg August University, and Max Planck Institute for Experimental Medicine, Gottingen, Germany
    J Psychiatr Res 38:619-35. 2004
    ..The presence of an Axis II rather than an Axis I disorder on admission strongly predicts drinking outcome over a four-year follow-up...
  45. pmc Episode-specific differential gene expression of peripheral blood mononuclear cells in rapid cycling supports novel treatment approaches
    Martin Begemann
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Mol Med 14:546-52. 2008
    ..This case suggests that rapid cycling is a systemic disease, resembling hibernation, with prostaglandins playing a mediator role...
  46. ncbi request reprint Reduced oxidative damage in ALS by high-dose enteral melatonin treatment
    Jochen H Weishaupt
    Department of Neurology, Georg August University, Gottingen, Germany
    J Pineal Res 41:313-23. 2006
    ..This combination of preclinical effectiveness and proven safety in humans suggests that high-dose melatonin is suitable for clinical trials aimed at neuroprotection through antioxidation in ALS...
  47. doi request reprint Erythropoietin as neuroprotective and neuroregenerative treatment strategy: comprehensive overview of 12 years of preclinical and clinical research
    Derya Sargin
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Hermann Rein Str 3, 37075 Gottingen, Germany
    Best Pract Res Clin Anaesthesiol 24:573-94. 2010
    ....
  48. doi request reprint Callosal dysfunction in amyotrophic lateral sclerosis correlates with diffusion tensor imaging of the central motor system
    Claudia Bartels
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Hermann Rein Str 3, 37075 Gottingen, Germany
    Neuromuscul Disord 18:398-407. 2008
    ..The Contralateral Co-Movement Test delivers simple means of symptom quantification, independent of ALS Functional Rating Scale, for future neuroprotective trials...
  49. ncbi request reprint Therapist rotation--a new element in the outpatient treatment of alcoholism
    Henning Krampe
    Department of Psychiatry, Georg August University, Max Planck Institute for Experimental Medicine, Gottingen, Germany
    Subst Use Misuse 39:135-78. 2004
    ..Finally, the implementation of therapist rotation into OLITA is described, including the theoretical background of the program itself and the treatment procedure. New areas of application for the therapist rotation are discussed...
  50. doi request reprint Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4
    Kerstin Reim
    Department of Molecular Neurobiology and Center for the Molecular Physiology of the Brain, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    J Cell Sci 122:1352-61. 2009
    ....
  51. doi request reprint Erythropoietin augments survival of glioma cells after radiation and temozolomide
    Imam Hassouna
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Int J Radiat Oncol Biol Phys 72:927-34. 2008
    ..For prophylactic neuroprotection, erythropoietin (EPO) is a promising candidate, provided that concerns regarding potential tumor promoting effects are alleviated...
  52. ncbi request reprint Endothelin B receptor deficiency augments neuronal damage upon exposure to hypoxia-ischemia in vivo
    ANNA LEENA SIREN
    Department of Neurology, Georg August University, and Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Brain Res 945:144-9. 2002
    ..n=5, P=0.0560). To conclude, absence of functional ETB receptors is associated with an increased susceptibility to HI in-vivo, which is not intrinsic to neurons. Antagonism of ETB receptors seems not to be desirable in ischemic stroke...
  53. ncbi request reprint Hippocampal cannabinoid-1 receptor upregulation upon endothelin-B receptor deficiency: a neuroprotective substitution effect?
    Christian Unzicker
    Division of Clinical Neuroscience, Max Planck Institute for Experimental Medicine, Gottingen, Germany
    Neurochem Res 30:1305-9. 2005
    ..We suggest that CB1-receptor upregulation in the ETB-mutant hippocampus reflects an attempt to compensate for the lack of ETB-receptors...
  54. ncbi request reprint Expression patterns of erythropoietin and its receptor in the developing spinal cord and dorsal root ganglia
    Wolfgang Knabe
    Department of Anatomy Embryology, Georg August University Gottingen, Kreuzbergring 36, 37075 Gottingen, Germany
    Anat Embryol (Berl) 210:209-19. 2005
    ....
  55. ncbi request reprint Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin
    ANNA LEENA SIREN
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Brain 129:480-9. 2006
    ..This demonstrates that a localized brain lesion is a primary cause of delayed global neurodegeneration that can be efficiently counteracted by neuroprotection...
  56. pmc Mild expression differences of MECP2 influencing aggressive social behavior
    Martesa Tantra
    Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    EMBO Mol Med 6:662-84. 2014
    ..While the mouse data provides evidence of an interaction between genetic background and mild Mecp2 overexpression, the human data convey means by which genetic variation affects MECP2 expression and behavior...
  57. ncbi request reprint Effect of erythropoietin axotomy-induced apoptosis in rat retinal ganglion cells
    Jochen H Weishaupt
    Department of Neurology, University of Gottingen, Gottingen, Germany
    Invest Ophthalmol Vis Sci 45:1514-22. 2004
    ....
  58. pmc Erythropoietin improves operant conditioning and stability of cognitive performance in mice
    Ahmed El-Kordi
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    BMC Biol 7:37. 2009
    ..This procedure allows the study of the effects of erythropoietin on discrete processes of learning and attention in a sequential fashion...
  59. ncbi request reprint The approximate planimetric method: a simple, rapid and reliable method for estimation of lesion size in acute ischemic stroke
    Martin Hasselblatt
    Department of Neurology and Psychiatry, Georg August University, Gottingen, Germany
    Neuroradiology 45:164-5. 2003
    ..966, FLAIR: r = 0.979, p < 0.001). To conclude, the APM is simple, rapid and reliable for the estimation of lesion size in acute ischemic stroke. It can be recommended for broader application in clinical trials...
  60. ncbi request reprint Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism
    Anes Ju
    Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain CNMPB, Gottingen, Germany
    Behav Brain Res 270:159-64. 2014
    ..Together, these data support an early manifestation of communication deficits in Nlgn4(-/-) mice that appear more pronounced in immature females with their overall stronger USV as compared to males. ..
  61. ncbi request reprint Effect of endothelin-1 on astrocytic protein content
    Martin Hasselblatt
    Max Planck Institut fur experimentelle Medizin, Gottingen, Germany
    Glia 42:390-7. 2003
    ..This hypertrophic response involves uncoupling of the astrocytic gap junctional network and is not dependent on DNA synthesis...
  62. ncbi request reprint Expression patterns of erythropoietin and its receptor in the developing midbrain
    W Knabe
    Department of Anatomy and Embryology, Georg August University, 37075 Gottingen, Germany
    Anat Embryol (Berl) 207:503-12. 2004
    ..Whether the observed expression patterns of EPO and EPOR may reflect EPO-mediated trophic and/or antiapoptotic effects on neurons is discussed...
  63. ncbi request reprint Seroprevalence of autoantibodies against brain antigens in health and disease
    Liane Dahm
    Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Ann Neurol 76:82-94. 2014
    ..To test whether similar results would be obtained for other brain antigen-directed AB previously connected with pathological conditions, we systematically screened serum samples of 4,236 individuals...
  64. doi request reprint The influence of personality factors on disease progression and health-related quality of life in people with ALS
    Henning Krampe
    Max Planck Institute of Experimental Medicine, Division of Clinical Neuroscience, Goettingen, Germany
    Amyotroph Lateral Scler 9:99-107. 2008
    ..These findings suggest that being less agreeable might serve as a protective factor with respect to QOL and disease progression in ALS...
  65. ncbi request reprint Mild overexpression of Mecp2 in mice causes a higher susceptibility toward seizures
    Chiranjeevi Bodda
    Institute of Human Genetics, Universitatsmedizin Gottingen, Gottingen, Germany
    Am J Pathol 183:195-210. 2013
    ..Based on our ex vivo and in vivo data, we conclude that epileptic seizures are manifested as the first symptom when MeCP2 is mildly overexpressed in mice...
  66. doi request reprint Chronic psychosocial stress in the absence of social support induces pathological pre-pulse inhibition in mice
    Bartosz Adamcio
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Hermann Rein Street 3, 37075 Gottingen, Germany
    Behav Brain Res 204:246-9. 2009
    ..Thus, social support in situations of severe psychosocial stress may prevent lasting impairment in basic information processing...
  67. ncbi request reprint Erythropoietin--a novel concept for neuroprotection
    A L Siren
    Max Planck Institute for Experimental Medicine, Goettingen, Germany
    Eur Arch Psychiatry Clin Neurosci 251:179-84. 2001
    ....
  68. ncbi request reprint Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain
    A L Siren
    Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    Acta Neuropathol 101:271-6. 2001
    ....
  69. ncbi request reprint Differential glial and vascular expression of endothelins and their receptors in rat brain after neurotrauma
    A L Siren
    Department of Psychiatry, Georg August University, and Max Planck Institute for Experimental Medicine, Goettingen, Germany
    Neurochem Res 25:957-69. 2000
    ..These changes seem to be posttranscriptional and cell type specific. They favor vasoconstriction increasing the risk of late vasospasm and ischemia...
  70. pmc Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism
    Stephane Jamain
    Abteilung Molekulare Neurobiologie and Division für Klinische Neurowissenschaften, Max Planck Institut fur experimentelle Medizin, 37075 Gottingen, Germany
    Proc Natl Acad Sci U S A 105:1710-5. 2008
    ....
  71. ncbi request reprint Persistent alterations of vasopressin and N-terminal proatrial natriuretic peptide plasma levels in long-term abstinent alcoholics
    Wolf K H Döring
    Departments of Psychiatry and Neurology, Georg August University, Gottingen, Germany
    Alcohol Clin Exp Res 27:849-61. 2003
    ..This cohort study was designed to monitor determinants of electrolyte and water balance over 280 days of abstinence in alcohol-dependent men compared with healthy controls...
  72. pmc The structure and usage of female and male mouse ultrasonic vocalizations reveal only minor differences
    Kurt Hammerschmidt
    Cognitive Ethology Laboratory, German Primate Center, Gottingen, Germany
    PLoS ONE 7:e41133. 2012
    ..anaesthetized intruders suggests that the latter are sufficient to elicit vocal activity. The subtle acoustic differences, however, indicate that the subject differentiates between intruder states...
  73. ncbi request reprint Role of the astrocytic ET(B) receptor in the regulation of extracellular endothelin-1 during hypoxia
    M Hasselblatt
    Department of Neurology, Georg-August-University, , Germany
    Glia 34:18-26. 2001
    ..This stimulation is (over)compensated for by increased ET-1 binding to functional ET(B) receptors. ET(B) deficiency, whether genetic or experimentally induced, impairs elimination of extracellular ET-1...
  74. ncbi request reprint Endothelin converting enzyme activity in primary rat astrocytes is modulated by endothelin B receptors
    H Ehrenreich
    Departments of Neurology, Georg August University, Gottingen, Germany
    Biochem Biophys Res Commun 261:149-55. 1999
    ..ECE-1 from sl/sl revealed a glycosylation pattern different from +/+ astrocytes. In conclusion, the ET(B) receptor may, via ECE-1 glycosylation, exert a negative feedback on ECE activity in the astrocytic endothelin system...
  75. ncbi request reprint Persistent disturbance of the hypothalamic-pituitary-gonadal axis in abstinent alcoholic men
    Martin Hasselblatt
    Department of Psychiatry, Georg August University, and Max Planck Institute for Experimental Medicine, Gottingen, Germany
    Alcohol Alcohol 38:239-42. 2003
    ..Testosterone synthesis in chronic alcoholics is affected by a variety of mechanisms. Little is known about the reversibility of these changes upon abstinence and available data on circulating hormone levels are incomplete and inconsistent...
  76. pmc Recombinant Human Erythropoietin: Novel Strategies for Neuroprotective/Neuro-regenerative Treatment of Multiple Sclerosis
    Claudia Bartels
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Ther Adv Neurol Disord 1:193-206. 2008
    ..An exploratory study on chronic progressive MS yielded lasting improvement in motor and cognitive performance upon high-dose long-term EPO treatment...
  77. pmc Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system
    Bastian G Brinkmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen 37075, Germany
    Neuron 59:581-95. 2008
    ..Thus, NRG1/ErbB signaling is markedly different between Schwann cells and oligodendrocytes that have evolved an NRG/ErbB-independent mechanism of myelination control...
  78. pmc Stromal endothelin B receptor-deficiency inhibits breast cancer growth and metastasis
    Claudia Binder
    Department of Hematology Oncology, Georg August University, D 37099 Goettingen, Germany
    Mol Cancer Ther 8:2452-60. 2009
    ..This shows that tumor growth and metastasis are critically dependent on ET(B)R function in cells of the microenvironment and suggests that successful ETR antagonist therapy should also target the stromal component of ET signaling..
  79. pmc Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
    A L Siren
    Max Planck Institute for Experimental Medicine, Georg August University, 37075 Goettingen, Germany
    Proc Natl Acad Sci U S A 98:4044-9. 2001
    ..The neurotrophic actions suggest there may be longer-latency effects as well. Evaluation of EPO, a compound established as clinically safe, as neuroprotective therapy in acute brain injury is further supported...
  80. doi request reprint Supervised disulfiram in the treatment of alcohol use disorder: a commentary
    Henning Krampe
    Alcohol Clin Exp Res 35:1732-6. 2011
    ..1111/j.1530-0277.2011.01523.x). The main focus of the commentary is on long-term effects, long-term use, and psychotherapeutic application of supervised disulfiram...
  81. ncbi request reprint Mechanisms of disease: inherited demyelinating neuropathies--from basic to clinical research
    Klaus Armin Nave
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Nat Clin Pract Neurol 3:453-64. 2007
    ..Transgenic animal models have become essential for dissecting CMT disease mechanisms and exploring novel therapies...
  82. ncbi request reprint Neuroprotective effects and intracellular signaling pathways of erythropoietin in a rat model of multiple sclerosis
    M B Sättler
    Neurologische Universitatsklinik, Robert Koch Str 40, 37075 Gottingen, Germany
    Cell Death Differ 11:S181-92. 2004
    ..We conclude that in MOG-EAE the PI3-K/Akt pathway has an important influence on RGC survival under systemic treatment with Epo...
  83. ncbi request reprint Endothelin b receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus
    H Ehrenreich
    Max Planck Institute for Experimental Medicine and Department of Neurology, Gottingen, Germany
    Neuroscience 95:993-1001. 2000
    ..In conclusion, endothelin B receptors appear to act as neuronal survival factors in the dentate gyrus in rodents and man, both during postnatal development and under pathological conditions...
  84. ncbi request reprint Effects of cerebrovascular challenges on plasma endothelin
    Wolfgang Jordan
    Psychiatrische Klinik, Department of Psychiatry and Psychotherapy, University of Gottingen, von Sieboldstr 5, 37075, Gottingen, Germany
    Neurosci Res 43:127-34. 2002
    ..No alterations in plasma ET-1 levels were found upon any of the cerebrovascular stimuli. We conclude that massive cerebrovascular challenges in healthy individuals do not lead to high circulating ET-1 levels...
  85. ncbi request reprint Endothelin-1 concentration in plasma is increased after jogging but decreased after cycling in healthy men
    P Lewczuk
    Departments of Neurology and Psychiatry, Georg August University, and Max Planck Institute for Experimental Medicine, Goettingen, Germany
    Clin Exp Med 2:166-70. 2003
    ..In contrast, similarly enhanced lung perfusion together with a relatively lower stimulation of endothelin-1 compared with jogging, may explain the net decrease in plasma after cycling...
  86. ncbi request reprint Complexin2 null mutation requires a 'second hit' for induction of phenotypic changes relevant to schizophrenia
    K Radyushkin
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Genes Brain Behav 9:592-602. 2010
    ..These findings provide suggestive evidence for the 'second hit' hypothesis of schizophrenia and may offer new tools for the development of advanced treatment strategies...
  87. ncbi request reprint The brain erythropoietin system and its potential for therapeutic exploitation in brain disease
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Munster, Germany
    J Neurosurg Anesthesiol 18:132-8. 2006
    ..The safety profile and effectiveness of EPO in a wide variety of neurologic disease models make EPO a candidate compound for a potential first-line therapeutic for neurologic emergencies...
  88. ncbi request reprint Erythropoietin in the cerebrospinal fluid in neurodegenerative diseases
    Johannes Brettschneider
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Neurosci Lett 404:347-51. 2006
    ..This may be due to a relative deficiency of endogenous CNS EPO in these conditions and/or to a more efficient extraction of free EPO molecules from brain intercellular fluid by increased numbers of EPOR...
  89. ncbi request reprint Melatonin as a candidate compound for neuroprotection in amyotrophic lateral sclerosis (ALS): high tolerability of daily oral melatonin administration in ALS patients
    Sonja Jacob
    J Pineal Res 33:186-7. 2002
  90. ncbi request reprint Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK signalling
    Anatoly Samoylenko
    University of Wurzburg, Section of Experimental Neurosurgery, Department of Neurosurgery, Josef Schneider St 11, 97080 Wurzburg, Germany
    Cell Signal 20:154-62. 2008
    ..Our data indicate that TPO via activation of its receptor-bound JAK2 delays the NGF-dependent acquisition of neuronal phenotype and decreases neuronal survival by suppressing NGF-induced ERK activity...
  91. ncbi request reprint Personality disorder and chronicity of addiction as independent outcome predictors in alcoholism treatment
    Henning Krampe
    Division of Clinical Neuroscience at the Max Planck Institute of Experimental Medicine in Goettingen, Germany
    Psychiatr Serv 57:708-12. 2006
    ..A prospective four-year study examined which components of addiction severity predicted time to relapse among 112 adults with chronic alcoholism who participated in a comprehensive outpatient treatment program...
  92. ncbi request reprint [Oral condition of abstaining alcoholics. A case-control study]
    Else Hornecker
    Abt Zahnerhaltung, Präventive Zahnheilkunde und Parodontologie, Zentrum Zahn, Mund und Kieferheilkunde, Georg August Universitat, Gottingen
    Schweiz Monatsschr Zahnmed 113:1281-8. 2003
    ..They also support the assumption that excessive consumption of alcohol may promote the progression of chronic periodontal disease...
  93. ncbi request reprint Pre-embedding immunogold labeling of TUNEL stain enables evaluation of DNA strand breaks and ultrastructural alterations in individual cells of neuronal tissue
    Martin Barth
    Department of Neurosurgery, Division of Neurosurgical Research, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Acta Neuropathol 104:621-36. 2002
    ..These results suggest that under pathological conditions apoptosis and necrosis are not mutually exclusive mechanisms but rather may occur concurrently along a continuum in which cell death occurs...
  94. ncbi request reprint Combined therapy with methylprednisolone and erythropoietin in a model of multiple sclerosis
    Ricarda Diem
    Neurologische Universitatsklinik, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Brain 128:375-85. 2005
    ..In contrast, isolated neuronal or axonal protection without clinical benefit was achieved under monotherapy with erythropoietin or methylprednisolone, respectively...
  95. ncbi request reprint Soccer, neurotrauma and amyotrophic lateral sclerosis: is there a connection?
    Ornella Piazza
    Max Planck Institute for Experimental Medicine Goettingen, Germany
    Curr Med Res Opin 20:505-8. 2004
    ..To further clarify this issue, extensive prospective epidemiological investigations on ALS following neurotrauma as well as carefully designed animal studies will have to be conducted...
  96. ncbi request reprint A pilot study on the oral conditions of severely alcohol addicted persons
    Else Hornecker
    Division of Periodontology in the Department of Operative Dentistry, Preventive Dentistry and Periodontology at the University of Goettingen, Germany
    J Contemp Dent Pract 4:51-9. 2003
    ..Our results indicate severe alcoholics have a high risk of periodontal break down and tooth loss. To what extent these findings were caused by general/oral neglect alone (in combination with nicotine abuse) is at present unknown...
  97. ncbi request reprint Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients
    Claudia D Spies
    Department of Anesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Campus Mitte, Schumannstrasse 20 21, 10098 Berlin, Germany
    Anesthesiology 100:1088-100. 2004
    ..The aim of this study was to evaluate perioperative T cell-mediated immune parameters as well as cytokine release from whole blood cells after lipopolysaccharide stimulation and its association with postoperative infections...
  98. ncbi request reprint ETB receptor deficiency causes salt-sensitive hypertension
    Berthold Hocher
    J Mol Med (Berl) 80:747-9; author reply 750-2. 2002
  99. ncbi request reprint Brain derived proteins as markers of acute stroke: their relation to pathophysiology, outcome prediction and neuroprotective drug monitoring
    Manfred Herrmann
    Center for Advanced Imaging and Department of Neuropsychology and Behavioral Neurobiology, Bremen University, Germany
    Restor Neurol Neurosci 21:177-90. 2003
    ..Neurone-specific enolase (NSE), protein S100B and glial fibrillary acidic protein (GFAP) are those proteins investigated most often as peripheral surrogate markers of brain damage after stroke in humans...