Suzanne Eaton

Summary

Affiliation: Max Planck Institute of Molecular Cell Biology and Genetics
Country: Germany

Publications

  1. ncbi request reprint Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A
    Michael Hannus
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 129:3493-503. 2002
  2. doi request reprint Multiple roles for lipids in the Hedgehog signalling pathway
    Suzanne Eaton
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Nat Rev Mol Cell Biol 9:437-45. 2008
  3. doi request reprint Retromer retrieves wntless
    Suzanne Eaton
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden 01307, Germany
    Dev Cell 14:4-6. 2008
  4. ncbi request reprint Cell biology of planar polarity transmission in the Drosophila wing
    Suzanne Eaton
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden 01307, Germany
    Mech Dev 120:1257-64. 2003
  5. ncbi request reprint Release and trafficking of lipid-linked morphogens
    Suzanne Eaton
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Curr Opin Genet Dev 16:17-22. 2006
  6. ncbi request reprint Lipoprotein-heparan sulfate interactions in the Hh pathway
    Christina Eugster
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Dev Cell 13:57-71. 2007
  7. ncbi request reprint The endocytic pathway and formation of the Wingless morphogen gradient
    Eric Marois
    Max Planck Institute for Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    Development 133:307-17. 2006
  8. doi request reprint Patched regulates Smoothened trafficking using lipoprotein-derived lipids
    Helena Khaliullina
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 136:4111-21. 2009
  9. doi request reprint A novel function for the Rab5 effector Rabenosyn-5 in planar cell polarity
    Giovanna Mottola
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 137:2353-64. 2010
  10. ncbi request reprint Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway
    Anne Kathrin Classen
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01309 Dresden, Germany
    Dev Cell 9:805-17. 2005

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A
    Michael Hannus
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 129:3493-503. 2002
    ..In zebrafish, two wdb homologs are required for convergent extension during gastrulation, supporting the conjecture that Drosophila planar cell polarization and vertebrate gastrulation movements are regulated by similar mechanisms...
  2. doi request reprint Multiple roles for lipids in the Hedgehog signalling pathway
    Suzanne Eaton
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Nat Rev Mol Cell Biol 9:437-45. 2008
    ..The combination of this field with Hh studies will rapidly give us a more sophisticated understanding of both the Hh signal-transduction pathway and the cell biology of sterol metabolism...
  3. doi request reprint Retromer retrieves wntless
    Suzanne Eaton
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden 01307, Germany
    Dev Cell 14:4-6. 2008
    ..Wntless is retrieved from endosomes to the Golgi by retromer, permitting Wntless reutilization in Wnt transport. In the absence of retromer, Wntless is degraded in lysosomes and Wnt secretion is impaired...
  4. ncbi request reprint Cell biology of planar polarity transmission in the Drosophila wing
    Suzanne Eaton
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden 01307, Germany
    Mech Dev 120:1257-64. 2003
    ..Interestingly, Widerborst is found on a planar web of microtubules with connections to apical junctions, suggesting that these microtubules may have an important function in polarizing the cortex...
  5. ncbi request reprint Release and trafficking of lipid-linked morphogens
    Suzanne Eaton
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Curr Opin Genet Dev 16:17-22. 2006
    ....
  6. ncbi request reprint Lipoprotein-heparan sulfate interactions in the Hh pathway
    Christina Eugster
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Dev Cell 13:57-71. 2007
    ..They further suggest that the complement of proteins present on lipoprotein particles can regulate the activity of morphogens...
  7. ncbi request reprint The endocytic pathway and formation of the Wingless morphogen gradient
    Eric Marois
    Max Planck Institute for Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    Development 133:307-17. 2006
    ..Thus, subcellular localization of Wingless along the apical-basal axis of receiving cells may be instrumental in shaping the Wingless gradient...
  8. doi request reprint Patched regulates Smoothened trafficking using lipoprotein-derived lipids
    Helena Khaliullina
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 136:4111-21. 2009
    ..We propose that Ptc normally regulates Smo degradation by changing the lipid composition of endosomes through which Smo passes, and that the presence of Hh on lipoproteins inhibits utilization of their lipids by Ptc...
  9. doi request reprint A novel function for the Rab5 effector Rabenosyn-5 in planar cell polarity
    Giovanna Mottola
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 137:2353-64. 2010
    ..Our results suggest that establishment of planar polarity requires the activity of Rbsn-5 in regulating both the endocytic trafficking of Fmi at the apical cell boundaries and hair morphology...
  10. ncbi request reprint Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway
    Anne Kathrin Classen
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01309 Dresden, Germany
    Dev Cell 9:805-17. 2005
    ..We propose that these proteins polarize trafficking of Cadherin-containing exocyst vesicles during junction remodeling. This may be a common mechanism for the action of planar cell polarity proteins in diverse systems...
  11. pmc Effects of diet and development on the Drosophila lipidome
    Maria Carvalho
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Mol Syst Biol 8:600. 2012
    ..This study provides a comprehensive, quantitative and expandable resource for further pharmacological and genetic studies of metabolic disorders and molecular mechanisms underlying dietary response...
  12. doi request reprint Establishment of global patterns of planar polarity during growth of the Drosophila wing epithelium
    Andreas Sagner
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    Curr Biol 22:1296-301. 2012
    ..Thus, PCP may be guided by morphogenesis rather than morphogen gradients...
  13. ncbi request reprint Lipoprotein particles are required for Hedgehog and Wingless signalling
    Daniela Panàkovà
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Nature 435:58-65. 2005
    ..Similarly, the range of Wingless signalling is narrowed. We propose a novel function for lipoprotein particles, in which they act as vehicles for the movement of lipid-linked morphogens and glycophosphatidylinositol-linked proteins...
  14. pmc Lipoproteins in Drosophila melanogaster--assembly, function, and influence on tissue lipid composition
    Wilhelm Palm
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    PLoS Genet 8:e1002828. 2012
    ..These studies define major routes of interorgan lipid transport in Drosophila and uncover surprising tissue-specific differences in lipoprotein lipid utilization...
  15. doi request reprint Megalin-dependent yellow endocytosis restricts melanization in the Drosophila cuticle
    Falko Riedel
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden 01307, Germany
    Development 138:149-58. 2011
    ....
  16. doi request reprint Cell flow and tissue polarity patterns
    Suzanne Eaton
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Curr Opin Genet Dev 21:747-52. 2011
    ..This principle allows for the versatile and robust generation of polarity patterns in tissues...
  17. doi request reprint Cell flow reorients the axis of planar polarity in the wing epithelium of Drosophila
    Benoit Aigouy
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany
    Cell 142:773-86. 2010
    ..Mutation of the atypical Cadherin Dachsous perturbs the global polarity pattern by altering epithelial dynamics. This mechanism utilizes the cellular movements that sculpt tissues to align planar polarity with tissue shape...
  18. doi request reprint Lipoprotein particles cross the blood-brain barrier in Drosophila
    Marko Brankatschk
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    J Neurosci 30:10441-7. 2010
    ..Furthermore, lipid-linkage may be an efficient method to transport therapeutic molecules across the BBB...
  19. pmc Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals
    Wilhelm Palm
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    PLoS Biol 11:e1001505. 2013
    ..The existence of Hh secretion forms with distinct signaling activities suggests a novel mechanism for generating a diversity of Hh responses...
  20. pmc Survival strategies of a sterol auxotroph
    Maria Carvalho
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 137:3675-85. 2010
    ..These changes allow survival, but not growth, when membrane sterol levels are low. This relationship between sterols and sphingolipids could be an ancient and conserved principle of membrane homeostasis...
  21. doi request reprint Imaging Drosophila pupal wing morphogenesis
    Anne Kathrin Classen
    Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA
    Methods Mol Biol 420:265-75. 2008
    ..We then provide a protocol to prepare pupae for whole mount live imaging of P wings. This procedure has allowed us to live-image glial cell migration and proliferation along wing sensory nerves...
  22. ncbi request reprint Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes
    Gishnu Das
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Development 131:4467-76. 2004
    ..These interactions suggest a positive feedback loop initiated by Fz that results in the apical maintenance of other PCP factors through Fmi...
  23. ncbi request reprint The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing
    Reza Farhadifar
    Max Planck Institute for the Physics of Complex Systems, Nothnitzer Strasse 38, 01187 Dresden, Germany
    Curr Biol 17:2095-104. 2007
    ..Packing geometry is determined by developmental mechanisms that likely control the biophysical properties of cells and their interactions...
  24. ncbi request reprint Lipoproteins and their receptors in embryonic development: more than cholesterol clearance
    Thomas E Willnow
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, D 13125 Berlin, Germany
    Development 134:3239-49. 2007
    ..Here, we discuss the emerging view of how lipoproteins and their receptors regulate embryogenesis...
  25. ncbi request reprint Embryo morphogenesis: getting down to cells and molecules
    Lila Solnica-Krezel
    Vanderbilt University, VU Station B 351634, Nashville, TN 37235 1634, USA
    Development 130:4229-33. 2003