Research Topics
Species | Hans Ulrich DodtSummaryAffiliation: Max Planck Institute of Psychiatry Country: Germany Publications
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Detail Information
Publications
Precisely localized LTD in the neocortex revealed by infrared-guided laser stimulationH Dodt
Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
Science 286:110-3. 1999..A similar depression of glutamate receptor responses was observed during LTD of synaptic transmission. A spatially highly specific postsynaptic mechanism can account for the LTD induced by glutamate release...- Infrared-guided laser stimulation of neurons in brain slicesHans Ulrich Dodt
Max Planck Institute of Psychiatry, Munich, Federal Republic of Germany
Sci STKE 2002:pl2. 2002..Because the laser stimulation can be performed much faster than can paired recording, it is also possible to search for synaptic connections between distant neurons that have a low probability of connectivity... - Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brainHans Ulrich Dodt
Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804 Munich, Germany
Nat Methods 4:331-6. 2007..Our method is ideally suited for high-throughput phenotype screening of transgenic mice and thus will benefit the investigation of disease models... - Neocortical long-term potentiation and long-term depression: site of expression investigated by infrared-guided laser stimulationMatthias Eder
Department of Clinical Neuropharmacology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
J Neurosci 22:7558-68. 2002..In conclusion, our findings provide strong evidence for a postsynaptic expression of neocortical LTD and favor a primarily presynaptic locus of neocortical LTP... - Distribution and properties of functional postsynaptic kainate receptors on neocortical layer V pyramidal neuronsMatthias Eder
Clinical Neuropharmacology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
J Neurosci 23:6660-70. 2003..Furthermore, it is feasible to assume that extrasynaptic KARs could be activated by a "spillover" of synaptically released glutamate, ambient glutamate in the CSF, or glutamate released from adjacent astrocytes... - Sensory deprivation changes the pattern of synaptic connectivity in rat barrel cortexAnja Schierloh
Max Planck Institute of Psychiatry, Munich, Germany
Neuroreport 14:1787-91. 2003..These results indicate that sensory input is a prerequisite to establish a synaptic projection pattern which is correlated to the columnar organisation of the anatomical barrel structure... - Shining light on neurons--elucidation of neuronal functions by photostimulationMatthias Eder
Clinical Neuropharmacology, Max Planck Institute of Psychiatry, Munich, Germany
Rev Neurosci 15:167-83. 2004..Here we give a personal review of some of the technical aspects of photostimulation and recent findings, which illustrate the advantages of this technique... - The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in miceShahnaz Christina Azad
Max Planck Institute of Psychiatry, Clinical Neuropharmacology, Kraepelinstrasse 2, 80804 München, Germany
Neurosci Lett 370:186-90. 2004..The observed effects on synaptic strength could underly the beneficial effects of flupirtine on different types of chronic pain... 
Formalin-induced fluorescence reveals cell shape and morphology in biological tissue samplesUlrich Leischner
Max Planck Institute of Psychiatry, Munich, Germany
PLoS ONE 5:e10391. 2010..This method, called FIF-Ultramicroscopy, allows for the three-dimensional observation of cellular structures in various tissue types without complicated staining techniques...- Effects of sensory deprivation on columnar organization of neuronal circuits in the rat barrel cortexAnja Schierloh
Max Planck Institute of Psychiatry, Kraepelinstr 2, D 80804 Munich
Eur J Neurosci 20:1118-24. 2004..These results indicate that deprivation of sensory input influences the pattern of intracortical connections... - Cannabinoid receptor type 1 located on presynaptic terminals of principal neurons in the forebrain controls glutamatergic synaptic transmissionMaria R Domenici
Department of Clinical Neuropharmacology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
J Neurosci 26:5794-9. 2006..The present data strongly indicate that excitatory synaptic transmission in forebrain areas is directly modulated by CB1 expressed on presynaptic axon terminals originating from glutamatergic neurons... - WIN 55,212-2 decreases the spatial spread of neocortical excitation in vitroKlaus Becker
Max Planck Institute of Psychiatry, Clinical Neuropharmacology, Kraepelinstrasse 2, 80804 Munich, Germany
Neuroreport 16:993-6. 2005..The decrease of neocortical network excitability in the present study is probably due to a decreased excitability of glutamatergic neurons... - Resolution of ultramicroscopy and field of view analysisUlrich Leischner
Max Planck Institute of Psychiatry, Munich, Germany
PLoS ONE 4:e5785. 2009..These findings are of practical importance for researchers working with Ultramicroscopy to decide on adequate sampling rates. They are also necessary to modify deconvolution techniques to gain further image improvements... - Activation of mGlu receptors induces LTD without affecting postsynaptic sensitivity of CA1 neurons in rat hippocampal slicesGerhard Rammes
Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
J Physiol 546:455-60. 2003..These data do not support the notion that DHPG-induced LTD requires a modification of AMPA receptors, such as their internalisation, but are compatible with a presynaptic mechanism of expression... - Nitrous oxide (N2O) pre- and postsynaptically attenuates NMDA receptor-mediated neurotransmission in the amygdalaAndreas Ranft
Klinische Neuropharmakologie, Max Planck Institut fur Psychiatrie, Munchen, Germany
Neuropharmacology 52:716-23. 2007..It is conceivable that these effects not only contribute to anaesthesia and anxiolysis, but also have bearings on learning and memory as well as excitotoxicity in the amygdala... - The endocannabinoid system controls key epileptogenic circuits in the hippocampusKrisztina Monory
Department of Physiological Chemistry, Johannes Gutenberg University, Duesbergweg 6, 55099 Mainz, Germany
Neuron 51:455-66. 2006..The direct endocannabinoid-mediated control of hippocampal glutamatergic neurotransmission may constitute a promising therapeutic target for the treatment of disorders associated with excessive excitatory neuronal activity... - Quality-based registration and reconstruction of optical tomography volumesWolfgang Wein
Chair for Computer Aided Medical Procedures CAMP Technische Universität München, Germany
Med Image Comput Comput Assist Interv 10:718-25. 2007..The methods are applied on acquisitions of a mouse brain and mouse embryo to create outstanding three-dimensional reconstructions... - The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neuronsKatrin Deininger
Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
Proc Natl Acad Sci U S A 105:12539-44. 2008..We find that the EphA4 receptor is required for synaptic plasticity in the amygdala, raising the possibility that an underlying mechanism of Rin1 function in amygdala is to down-regulate EphA4 signaling by promoting its endocytosis... - Isoflurane modulates glutamatergic and GABAergic neurotransmission in the amygdalaAndreas Ranft
Department of Anaesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, D 81675 Munich, Germany
Eur J Neurosci 20:1276-80. 2004..The present results may contribute to the understanding of how stress reactions and long-lasting neuroplastic processes are suppressed under general anaesthesia...