Research Topics
Genomes and Genes
| N BroseSummaryAffiliation: Max Planck Institute for Experimental Medicine Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusionJayeeta Basu
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 27:1200-10. 2007....- Altered complexin expression in psychiatric and neurological disorders: cause or consequence?Nils Brose
Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann Rein Strasse 3, D 37075 Goettingen, Germany
Mol Cells 25:7-19. 2008.... 
The cross-sectional GRAS sample: a comprehensive phenotypical data collection of schizophrenic patientsKatja Ribbe
Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
BMC Psychiatry 10:91. 2010..This approach is different from and complementary to the genome-wide association studies (GWAS) on schizophrenia...- Erythropoietin enhances hippocampal long-term potentiation and memoryBartosz Adamcio
Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
BMC Biol 6:37. 2008..We developed a mouse model of robust cognitive improvement by EPO to obtain the first clues of how EPO influences cognition, and how it may act on hippocampal neurons to modulate plasticity... - Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol estersNils Brose
Abteilung Molekulare Neurobiologie, Max Planck Institut fur experimentelle Medizin, D 37075 Gottingen, Germany
J Cell Sci 115:4399-411. 2002..The examples of RasGRP1 and Munc13-1 show that detailed genetic analyses of C(1)-domain-containing non-PKC diacylglycerol/phorbol-ester receptors in mammals are ideally suited to achieve this goal... 
For better or for worse: complexins regulate SNARE function and vesicle fusionNils Brose
Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Gottingen, Germany
Traffic 9:1403-13. 2008....- Regulation of transmitter release by Unc-13 and its homologuesN Brose
Max Planck Institut fur experimentelle Medizin, AG Molekulare Neurobiologie, Gottingen, D 37075, Germany
Curr Opin Neurobiol 10:303-11. 2000..Members of the Unc-13 protein family, which are highly conserved during evolution and act as novel targets of the diacylglycerol second-messenger pathway, have been identified to play an essential role in this process... - Synaptopathy: dysfunction of synaptic function?Nils Brose
Department of Molecular Neurobiology, Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, 37077 Göttingen Germany
Biochem Soc Trans 38:443-4. 2010..Thus, despite revealing a value of synaptopathy, further investigation will be required to reveal its balance in the cause and effect in each of the major brain diseases... - Flowers for synaptic endocytosisNils Brose
Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
Cell 138:836-7. 2009..Yao et al. (2009) now report that a synaptic vesicle membrane protein named Flower promotes endocytosis at neuromuscular junctions in the fruit fly Drosophila... - Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammalsNils Brose
Department of Molecular Neurobiology, Max Planck Institute for Experimental Medicine and Deutsche Forschungsgemeinschaft Center for Molecular Physiology of the Brain, Hermann Rein Str 3, D 37075 Gottingen, Germany
Curr Opin Neurobiol 14:328-40. 2004.... - Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle primingA Betz
Max Planck Institut, für experimentelle Medizin, Abteilung Neurogenetik, AG Molekulare Neurobiologie, Hermann Rein Str 3, D 37075, Gottingen, Germany
Neuron 30:183-96. 2001..The Munc13-1/RIM1 interaction may create a functional link between synaptic vesicle tethering and priming, or it may regulate the priming reaction itself, thereby determining the number of fusion-competent vesicles... - Complexin2 null mutation requires a 'second hit' for induction of phenotypic changes relevant to schizophreniaK Radyushkin
Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
Genes Brain Behav 9:592-602. 2010..These findings provide suggestive evidence for the 'second hit' hypothesis of schizophrenia and may offer new tools for the development of advanced treatment strategies... - The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in miceI Augustin
AG Molekulare Neurobiologie, Max Planck Institut fur experimentelle Medizin, D 37075 Gottingen, Germany
J Neurosci 21:10-7. 2001..This, in turn, would lead to increases in paired-pulse facilitation and could contribute to the observed deficit in motor learning... - Complexins regulate a late step in Ca2+-dependent neurotransmitter releaseK Reim
Max Planck Institut fur experimentelle Medizin, Abteilung Neurogenetik, AG Molekulare Neurobiologie, Hermann Rein Str 3, D 37075 Gottingen, Bundesrepublik, Deutschland
Cell 104:71-81. 2001.... - Munc13-1 is essential for fusion competence of glutamatergic synaptic vesiclesI Augustin
Max Planck Institut fur experimentelle Medizin, AG Molekulare Neurobiologie, Gottingen, Bundesrepublik Deutschland
Nature 400:457-61. 1999.... - Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter releaseA Betz
Max Planck Institut fur experimentelle Medizin, Abt Molekulare Neurobiologie, Gottingen, Bundesrepublik Deutschland
Neuron 21:123-36. 1998..These observations establish Munc13-1 as a novel presynaptic target of the diacylglycerol second messenger pathway that acts in parallel with protein kinase C to regulate neurotransmitter secretion... - Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistinAlexandros Poulopoulos
Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Gottingen, Germany
Neuron 63:628-42. 2009..Deletion of neuroligin 2 in mice perturbs GABAergic and glycinergic synaptic transmission and leads to a loss of postsynaptic specializations specifically at perisomatic inhibitory synapses... - Differential control of vesicle priming and short-term plasticity by Munc13 isoformsChristian Rosenmund
Max Planck Institut fur biophysikalische Chemie, Abteilung Membranbiophysik, Am Fassberg 11, D 37077, Gottingen, Germany
Neuron 33:411-24. 2002..Thus, differential expression of Munc13 isoforms at individual synapses represents a general mechanism that controls short-term plasticity and contributes to the heterogeneity of synaptic information coding... - CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteinsWolf J Jockusch
Max Planck Institute of Experimental Medicine, Department of Molecular Neurobiology, Hermann Rein Str 3, D 37075 Gottingen, Germany
Cell 131:796-808. 2007..Our findings demonstrate that CAPS proteins generate and maintain a highly fusion competent synaptic vesicle pool that supports phasic Ca(2+) triggered release of transmitters... - An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal sizeS M Wojcik
Department of Molecular Neurobiology, Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
Proc Natl Acad Sci U S A 101:7158-63. 2004..These results show that the expression level of VGLUTs determines the amount of glutamate that is loaded into vesicles and released and thereby regulates the efficacy of neurotransmission... - Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle primingFrederique Varoqueaux
Max Planck Institute for Experimental Medicine, Department of Molecular Neurobiology, D 37075 Gottingen, Germany
Proc Natl Acad Sci U S A 99:9037-42. 2002.... - Differential expression of two novel Munc13 proteins in rat brainI Augustin
Max Planck Institut fur experimentelle Medizin, Abteilung Molekulare Neurobiologie, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
Biochem J 337:363-71. 1999..Munc13-2 and Munc13-3 are expressed in a complementary fashion and might act in concert with Munc13-1 to modulate neurotransmitter release... - Neuroligins determine synapse maturation and functionFrederique Varoqueaux
Department of Molecular Neurobiology and Center for the Molecular Physiology of the Brain, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
Neuron 51:741-54. 2006..Our data show that neuroligins are required for proper synapse maturation and brain function, but not for the initial formation of synaptic contacts... - SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle primingAndrea Burgalossi
Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
Neuron 68:473-87. 2010..Our analysis of α- and βSNAP deletion mutant neurons shows that the two NSF cofactors support synaptic vesicle priming by determining the availability of free SNARE components, particularly during phases of high synaptic activity... - Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapsesJ Y Song
Max Planck Institut fur experimentelle Medizin, Abteilung Molekulare Neurobiologie, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
Proc Natl Acad Sci U S A 96:1100-5. 1999..In addition, the neuroligin/beta-neurexin junction may be involved in the specification of excitatory synapses... - Neuroligin-3-deficient mice: model of a monogenic heritable form of autism with an olfactory deficitK Radyushkin
Division of Clinical Neuroscience, Max Planck Institute for Experimental Medicine, Gottingen, Germany
Genes Brain Behav 8:416-25. 2009..Our findings show that the NL-3 knockout mouse represents a useful animal model for understanding pathophysiological events in monogenic heritable ASD and for developing novel treatment strategies in this devastating human disorder... - Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2Yaisa S Andrews-Zwilling
Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
J Biol Chem 281:19720-31. 2006..We conclude that one function of the Munc13/RIM1alpha interaction is the active zone recruitment of Munc13-1 and ubMunc13-2... - Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite developmentHiroshi Kawabe
Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
Neuron 65:358-72. 2010..We conclude that a Nedd4-1/Rap2A/TNIK signaling pathway regulates neurite growth and arborization in mammalian neurons... - Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autismStephane Jamain
Abteilung Molekulare Neurobiologie and Division für Klinische Neurowissenschaften, Max Planck Institut fur experimentelle Medizin, 37075 Gottingen, Germany
Proc Natl Acad Sci U S A 105:1710-5. 2008.... - Structurally and functionally unique complexins at retinal ribbon synapsesKerstin Reim
Department of Molecular Neurobiology, Max Planck Institute for Experimental Medicine, D 37075 Gottingen, Germany
J Cell Biol 169:669-80. 2005..The novel CPXs III and IV may contribute to the unique release efficacy of retinal sensory neurons... - Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoformH Koch
Max Planck Institut fur experimentelle Medizin, AG Molekulare Neurobiologie, Hermann Rein Str 3, D 37075 Gottingen, Germany
Biochem J 349:247-53. 2000..The MHD profiles described in the present study are useful tools for the identification of Munc13-like proteins, that would otherwise have remained undetected... - Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4Kerstin Reim
Department of Molecular Neurobiology and Center for the Molecular Physiology of the Brain, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
J Cell Sci 122:1352-61. 2009.... - A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string proteinSönke Tobaben
Max Planck Institute for Experimental Medicine, Department of Molecular Neurobiology and Deutsche Forschungsgemeinschaft Center for Molecular Physiology of the Brain, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
J Biol Chem 278:38376-83. 2003..The modular structure of SGTs allows them to recruit client proteins to Hsc70 and to direct the resulting complex toward downstream proteins that take over the respective client proteins... - Neuroligin 2 is exclusively localized to inhibitory synapsesFrederique Varoqueaux
Max Planck Institute for Experimental Medicine, Department of Molecular Neurobiology, Gottingen, Germany
Eur J Cell Biol 83:449-56. 2004..Our findings identify neuroligin 2 as a new cell adhesion protein specific for inhibitory synapses and open new avenues for identifiying the constituents of this unique type of postsynaptic specialization... - The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroliginGuido Meyer
Max Planck Institute for Experimental Medicine, Department of Molecular Neurobiology, Deutsche Forschungsgemeinschaft Centre for Molecular Physiology of the Brain, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
Neuropharmacology 47:724-33. 2004..In summary, we can sketch a complex pattern of overlap in the binding specificities of synaptic cell surface proteins towards PDZ-domain proteins... - Regulation of membrane fusion in synaptic excitation-secretion coupling: speed and accuracy matterSonja M Wojcik
Max Planck Institut fur experimentelle Medizin, Abteilung Molekulare Neurobiologie, Hermann Rein Strasse 3, D 37075 Gottingen, Deutschland
Neuron 55:11-24. 2007.... - CAPS1 regulates catecholamine loading of large dense-core vesiclesDina Speidel
Max Planck Institut fur experimentelle Medizin, Abteilung Molekulare Neurobiologie, D 37075 Gottingen, Germany
Neuron 46:75-88. 2005..We conclude that CAPS1 is required for an essential step in the uptake or storage of catecholamines in LDCVs... - Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapseFrederique Varoqueaux
Department of Molecular Neurobiology, Max Planck Institute for Experimental Medicine, Hermann Rein Str 3, D 37075 Gottingen, Germany
Mol Cell Biol 25:5973-84. 2005..Thus, non-Munc13 priming proteins exist at this synapse or vesicle priming occurs in part spontaneously: i.e., without dedicated priming proteins in the release machinery... - A shared vesicular carrier allows synaptic corelease of GABA and glycineSonja M Wojcik
Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
Neuron 50:575-87. 2006..Since GABA and glycine compete for vesicular uptake, these data point to a close association of Viaat with GABA-synthesizing enzymes as a key factor in specifying GABAergic neuronal phenotypes... - Neuroscience. SPARring with spinesGuido Meyer
Department of Molecular Neuroscience, Max Planck Institute for Experimental Medicine, , Germany
Science 302:1341-4. 2003 - Synaptic cell adhesion proteins and synaptogenesis in the mammalian central nervous systemN Brose
Max Planck Institut fur experimentelle Medizin, AG Molekulare Neurobiologie, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
Naturwissenschaften 86:516-24. 1999..The present short review discusses the possible role of these synaptic cell adhesion molecules in synaptogenesis... - A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and functionDina Speidel
Department of Molecular Neurobiology, Max Planck Institute for Experimental Medicine and Deutsche Forschungsgemeinschaft Center for Molecular Physiology of the Brain, D 37075 Gottingen, Germany
J Biol Chem 278:52802-9. 2003..The abundance of CAPS proteins in synaptic terminals indicates that they may also be important for neuronal functions that are not exclusively related to LDCV exocytosis... - Modification of cognitive performance in schizophrenia by complexin 2 gene polymorphismsMartin Begemann
Max Planck Institute of Experimental Medicine, Gottingen, Germany
Arch Gen Psychiatry 67:879-88. 2010..In particular, the specific contribution of risk or candidate gene variants to the complex schizophrenic phenotype is largely unknown... - EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerinHeike Wegmeyer
Department of Molecular Neurobiology and DFG Center for Molecular Physiology of the Brain, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
Neuron 55:756-67. 2007..Our results reveal an alpha-chimaerin-dependent signaling pathway downstream of EphA4, which is essential for axon guidance decisions and neuronal circuit formation in vivo... - Synaptic and vesicular co-localization of the glutamate transporters VGLUT1 and VGLUT2 in the mouse hippocampusEtienne Herzog
, Abteilung Molekulare Neurobiologie, , Germany
J Neurochem 99:1011-8. 2006..As the number of transporter molecules per vesicle affects quantal size, the developmental window where VGLUT1 and VGLUT2 are co-expressed may allow for greater plasticity in the control of quantal release... - Molecular dynamics of a presynaptic active zone protein studied in Munc13-1-enhanced yellow fluorescent protein knock-in mutant miceStefan Kalla
Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
J Neurosci 26:13054-66. 2006..They demonstrate the usefulness of the knock-in approach in general and of Munc13-1-EYFP knock-in mice in particular for imaging synaptic protein dynamics... - Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxinA Betz
Max Planck Institut fur experimentelle Medizin, Abteilung Molekulare Neurobiologie, Hermann Rein Strasse 3, D 37075 Gottingen, Federal Republic of Germany
J Biol Chem 272:2520-6. 1997..It is possible that the phenotype of unc-13 and unc-18 mutations is caused by the inability of the respective mutated gene products to bind to syntaxin... - Rat homologues of yeast sec7pI Telemenakis
Abteilung Molekulare Neurobiologie, Max Planck Institut fur experimentelle Medizin, Göttingen Germany
Eur J Cell Biol 74:143-9. 1997..On the protein level, msec7s are present in all rat tissues tested, with highest protein levels in brain and adrenal. In the adult rat brain, they are present in soluble and membrane-associated pools... - Synaptogenic proteins and synaptic organizers: "many hands make light work"Nils Brose
Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Gottingen, Germany
Neuron 61:650-2. 2009..A new study by Linhoff and colleagues in this issue of Neuron identifies adhesion proteins of the LRRTM family as novel synaptic organizers... - Structural insights into the calmodulin-Munc13 interaction obtained by cross-linking and mass spectrometryKalina Dimova
Proteomics Group, Max Planck Institute of Experimental Medicine, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
Biochemistry 48:5908-21. 2009.... - Calmodulin and Munc13 form a Ca2+ sensor/effector complex that controls short-term synaptic plasticityHarald J Junge
Department of Molecular Neurobiology, Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, D 37077 Gottingen, Germany
Cell 118:389-401. 2004.... - Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticityFernando Rodríguez-Castañeda
Department of NMR Based Structural Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
EMBO J 29:680-91. 2010..This Ca(2+)/CaM-binding mode of Munc13 likely constitutes a key molecular correlate of the characteristic Ca(2+)-dependent modulation of short-term synaptic plasticity... - Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cellsTina Pangrsic
InnerEarLab, Department of Otolaryngology and Center for Molecular Physiology of the Brain, University Medical Center Gottingen, Gottingen, Germany
Nat Neurosci 13:869-76. 2010..We conclude that replenishment does not match the release of vesicles at mutant active zones in vivo and a sufficient standing RRP therefore cannot be maintained. We propose that otoferlin is involved in replenishing synaptic vesicles... - Specificity emerges in the dissection of diacylglycerol- and protein kinase C-mediated signalling pathwaysNils Brose
, Hermann-Rein-Strasse 3, , Germany
Proc Natl Acad Sci U S A 99:16522-3. 2002 - Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both Munc13 and protein kinase CXuelin Lou
Department of Membrane Biophysics, AG Synaptic Dynamics and Modulation, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
J Neurosci 28:8257-67. 2008..Thus, docked and readily releasable vesicles are a substrate for modulation via intracellular second-messenger pathways that act via Munc13 and PKC... - Synapse formation and clustering of neuroligin-2 in the absence of GABAA receptorsAnnarita Patrizi
Department of Anatomy, Pharmacology, and Forensic Medicine, and National Institute of Neuroscience Italy, C so Massimo d Azeglio, 52, I 10126 Turin, Italy
Proc Natl Acad Sci U S A 105:13151-6. 2008..However, GABAergic signaling appears to be crucial for activity-dependent regulation of synapse density during neuronal maturation... - Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCsJeong Seop Rhee
Abteilung Membranbiophysik, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, D 37077 Gottingen, Bundesrepublik Deutschland
Cell 108:121-33. 2002..Modulation of Munc13-1 activity by second messengers via the DAG/beta phorbol ester binding C(1) domain is essential for use-dependent alterations of synaptic efficacy and survival... - A similar impairment in CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouseHelen E Gibson
Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Eur J Neurosci 22:1701-12. 2005..This impairment in MF LTP could contribute to spatial learning deficits observed in R6/2 and Cplx2-/- mice... - Regulation of insulin exocytosis by Munc13-1Laura Sheu
Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
J Biol Chem 278:27556-63. 2003..In view of our findings, Munc13-1 is a potential drug target for therapeutic optimization of insulin secretion in diabetes... - Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosisJacqueline Vinatier
INSERM U513, Neurobiology and Psychiatry, Faculte de Medecine, Creteil, France
J Neurochem 97:1111-25. 2006..Overall, the discovery of endophilin as a partner for VGLUT1 in nerve terminals strongly suggests the existence of functional differences between VGLUT1 and -2 terminals in their abilities to replenish vesicle pools... - Differential control of the releasable vesicle pools by SNAP-25 splice variants and SNAP-23Jakob B Sørensen
Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
Cell 114:75-86. 2003..We conclude that three alternative SNARE components support exocytosis, but they differ in their ability to stabilize vesicles in the primed state... - Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous systemMingshan Xue
Departments of Neuroscience and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 105:7875-80. 2008..Our results demonstrate that at mammalian central nervous system synapses, Cplxs facilitate neurotransmitter release and do not simply act as inhibitory clamps of the synaptic vesicle fusion machinery... - CAPS facilitates filling of the rapidly releasable pool of large dense-core vesiclesYuanyuan Liu
Institut fur Physiologie, Universitat des Saarlandes, D 66421 Homburg Saar, Germany
J Neurosci 28:5594-601. 2008..We conclude that CAPS is required for the adequate refilling and/or maintenance of a rapidly releasable granule pool... - Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose toleranceEdwin P Kwan
Department of Physiology, University of Toronto, Medical Sciences Building Rm 7226, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
Diabetes 55:1421-9. 2006.... - Munc13-1 is required for the sustained release of insulin from pancreatic beta cellsLijun Kang
Joint Laboratory of Huazhong University of Science and Technology and Institute of Biophysics, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Cell Metab 3:463-8. 2006..Our data show that Munc13-1 plays an essential role in the development of the second phase of insulin secretion by priming insulin-containing LDCVs... - Identification of the minimal protein domain required for priming activity of Munc13-1David R Stevens
Physiologisches Institut, , Kirrberger Str. 8, D-66421 Homburg/Saar, Germany
Curr Biol 15:2243-8. 2005..Priming by Munc13-1 appears to require its interaction with Syntaxin 1 because point mutants that do not bind Syntaxin 1 do not prime chromaffin granules... - Characterization of the Munc13-calmodulin interaction by photoaffinity labelingKalina Dimova
Proteomics Group, Max-Planck-Institute of Experimental Medicine, Hermann-Rein-Strasse 3, , Germany
Biochim Biophys Acta 1763:1256-65. 2006.... - Profound ataxia in complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficitsDervila Glynn
Department of Pharmacology, University of Cambridge, UK
Hum Mol Genet 14:2369-85. 2005..These results support the idea that altered expression of complexins in disease states may contribute to the symptomatology of disorders in which they are dysregulated... - Depletion of Complexin II does not affect disease progression in a mouse model of Huntington's disease (HD); support for role for complexin II in behavioural pathology in a mouse model of HDDervila Glynn
Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, UK
Brain Res Bull 72:108-20. 2007..This indicates that loss of complexin II is part of the mechanism underlying the R6/2 phenotype. Whether it is causal or compensatory remains to be determined... - Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2Alexander A Chubykin
Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
Neuron 54:919-31. 2007..This hypothesis reconciles the overexpression and knockout phenotypes and suggests that neuroligins contribute to the use-dependent formation of neural circuits... - Distinct domains of complexin I differentially regulate neurotransmitter releaseMingshan Xue
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
Nat Struct Mol Biol 14:949-58. 2007.... - Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processingSteffen Rossner
Paul Flechsig Institut für Hirnforschung, Abteilung Neurochemie, Universitat Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
J Biol Chem 279:27841-4. 2004..We establish that, in addition to PKC, Munc13-1 significantly contributes to the regulation of secretory APP metabolism... - CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cellsDina Speidel
Department of Clinical Sciences Malmo, Lund University, UMAS, Malmo, Sweden
Cell Metab 7:57-67. 2008..We conclude that although CAPS proteins are not required for Ca(2+)-dependent exocytosis to proceed, they exert a modulatory effect on insulin granule priming, exocytosis, and stability... - Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25Gabor Nagy
Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
Neuron 41:417-29. 2004..Overexpression of the SNAP-25b isoform increased the size of both primed vesicle pools by a factor of two, and mutations in the conserved Thr-138 site had similar effects as in the a isoform... - Vesicle priming and recruitment by ubMunc13-2 are differentially regulated by calcium and calmodulinDragoslav Zikich
Neurobiology Department, Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
J Neurosci 28:1949-60. 2008..These different Ca2+ activation steps determine the kinetic properties of exocytosis and vesicle recruitment and can thus alter plasticity and efficacy of transmitter release... - Synaptic targeting of neuroligin is independent of neurexin and SAP90/PSD95 bindingThomas Dresbach
Institute for Anatomy and Cell Biology, Ruprecht Karls University Heidelberg, D 69120 Heidelberg, Germany
Mol Cell Neurosci 27:227-35. 2004.... - Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion proteinPetra Steinacker
Neurologische Klinik und Poliklinik, Georg August Universitat Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
Mol Cell Biol 25:1339-46. 2005..These results indicate that 14-3-3gamma is unlikely to play a causal role in CJD and related diseases... - Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cellsMaaike Neeft
Department of Cell Biology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
Mol Biol Cell 16:731-41. 2005..Mutations in either of the two genes prevent formation of this complex and abolish secretion... - Molecular mechanisms of active zone functionChristian Rosenmund
Max Planck Institut fur biophysikalische Chemie, Abteilung Membranbiophysik, Am Fassberg 11, 37077 Gottingen, Germany
Curr Opin Neurobiol 13:509-19. 2003..Particular emphasis is put on the molecular players that control spatial restriction, efficiency and timing of exocytosis in the mammalian nervous system... - The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localizationFatemeh Fouladkou
Hospital for Sick Children and Biochemistry Department, University of Toronto, MaRS TMDT, 101 College Street, Toronto, Ontario M5G 1L7, Canada
Proc Natl Acad Sci U S A 105:8585-90. 2008..Taken together, our results fail to support a role for Nedd4-1 as the E3 ligase regulating PTEN stability and subcellular localization... - Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretionWolfram Antonin
Department of Neurobiology, Max Planck Institute for Biophysical Chemistry 37077 Göttingen, Germany
Mol Cell Biol 22:1545-54. 2002..Furthermore, the rates of both protein synthesis and intracellular transport of secretory proteins were reduced. We conclude that syncollin plays a role in maturation and/or concentration of zymogens in zymogen granules...