Lars Bertram

Summary

Affiliation: Max Planck Institute for Molecular Genetics
Country: Germany

Publications

  1. doi request reprint Towards unveiling the genetics of neurodegenerative diseases
    Christina M Lill
    Department of Vertebrate Genomics, Neuropsychiatric Genetics Group, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Semin Neurol 31:531-41. 2011
  2. pmc Role of common and rare APP DNA sequence variants in Alzheimer disease
    B V Hooli
    Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, MA, USA
    Neurology 78:1250-7. 2012
  3. doi request reprint The genetics of Alzheimer disease: back to the future
    Lars Bertram
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Neuron 68:270-81. 2010
  4. doi request reprint Alzheimer's genetics in the GWAS era: a continuing story of 'replications and refutations'
    Lars Bertram
    Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 63, Room 204 1, 14195 Berlin, Germany
    Curr Neurol Neurosci Rep 11:246-53. 2011
  5. doi request reprint The role of genetics for biomarker development in neurodegeneration
    Lars Bertram
    Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 63, Room 204 1, 14195 Berlin, Germany
    Prog Neurobiol 95:501-4. 2011
  6. doi request reprint Dopaminergic gene polymorphisms affect long-term forgetting in old age: further support for the magnification hypothesis
    Goran Papenberg
    Max Planck Institute for Human Development, Berlin, Germany
    J Cogn Neurosci 25:571-9. 2013
  7. pmc Obesity and the brain: a possible genetic link
    Lars Bertram
    Neuropsychiatric Genetics Group, Max Planck Institute for Molecular Genetics, Ihnestrasse 63, Room 204, 1, 14195 Berlin, Germany
    Alzheimers Res Ther 2:27. 2010
  8. ncbi request reprint Aging and KIBRA/WWC1 genotype affect spatial memory processes in a virtual navigation task
    Nicolas W Schuck
    Max Planck Institute for Human Development, Center for Lifespan Psychology, 14195 Berlin, Germany Department of Psychology, Humboldt Universitat zu Berlin, 10099 Berlin, Germany
    Hippocampus 23:919-30. 2013
  9. doi request reprint Developing the "next generation" of genetic association databases for complex diseases
    Christina M Lill
    Neurospsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Hum Mutat 33:1366-72. 2012
  10. doi request reprint The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels
    Brit Maren M Schjeide
    Department Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Arch Gen Psychiatry 68:207-13. 2011

Collaborators

Detail Information

Publications19

  1. doi request reprint Towards unveiling the genetics of neurodegenerative diseases
    Christina M Lill
    Department of Vertebrate Genomics, Neuropsychiatric Genetics Group, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Semin Neurol 31:531-41. 2011
    ..Unveiling the identity of these and other genetic factors will not only improve our understanding of the underlying pathophysiology, but may also lead to new avenues for preventing and treating these devastating diseases...
  2. pmc Role of common and rare APP DNA sequence variants in Alzheimer disease
    B V Hooli
    Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, MA, USA
    Neurology 78:1250-7. 2012
    ..In this study we systematically assessed the role of both rare and common APP DNA variants in Alzheimer disease (AD) families...
  3. doi request reprint The genetics of Alzheimer disease: back to the future
    Lars Bertram
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Neuron 68:270-81. 2010
    ..It seems likely that much of this "missing heritability" may be accounted for by rare sequence variants, which, owing to recent advances in high-throughput sequencing technologies, can now be assessed in unprecedented detail...
  4. doi request reprint Alzheimer's genetics in the GWAS era: a continuing story of 'replications and refutations'
    Lars Bertram
    Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 63, Room 204 1, 14195 Berlin, Germany
    Curr Neurol Neurosci Rep 11:246-53. 2011
    ..The paper closes with a discussion of the persistent methodologic difficulties and challenges and an outlook on what we can expect to gain from the next 10 years of AD genetics research...
  5. doi request reprint The role of genetics for biomarker development in neurodegeneration
    Lars Bertram
    Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 63, Room 204 1, 14195 Berlin, Germany
    Prog Neurobiol 95:501-4. 2011
    ..We argue that future progress will largely depend on a widespread application of novel high-throughput technologies now becoming available in both fields...
  6. doi request reprint Dopaminergic gene polymorphisms affect long-term forgetting in old age: further support for the magnification hypothesis
    Goran Papenberg
    Max Planck Institute for Human Development, Berlin, Germany
    J Cogn Neurosci 25:571-9. 2013
    ..Independent replication studies in other populations are needed to confirm the observed association...
  7. pmc Obesity and the brain: a possible genetic link
    Lars Bertram
    Neuropsychiatric Genetics Group, Max Planck Institute for Molecular Genetics, Ihnestrasse 63, Room 204, 1, 14195 Berlin, Germany
    Alzheimers Res Ther 2:27. 2010
    ..Although potentially providing a novel genetic link between obesity and brain structure, the relevance of these findings for normal brain function and disease remains to be determined...
  8. ncbi request reprint Aging and KIBRA/WWC1 genotype affect spatial memory processes in a virtual navigation task
    Nicolas W Schuck
    Max Planck Institute for Human Development, Center for Lifespan Psychology, 14195 Berlin, Germany Department of Psychology, Humboldt Universitat zu Berlin, 10099 Berlin, Germany
    Hippocampus 23:919-30. 2013
    ..2013 Wiley Periodicals, Inc. ..
  9. doi request reprint Developing the "next generation" of genetic association databases for complex diseases
    Christina M Lill
    Neurospsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Hum Mutat 33:1366-72. 2012
    ..We believe that our database approach may serve as a viable model that can be readily applied to other fields and ultimately improve our understanding of the genetic forces driving common human conditions...
  10. doi request reprint The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels
    Brit Maren M Schjeide
    Department Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Arch Gen Psychiatry 68:207-13. 2011
    ..Despite their strong statistical support, all 3 signals emerged from heterogeneous case-control populations and lack replication in different settings...
  11. doi request reprint Keeping up with genetic discoveries in amyotrophic lateral sclerosis: the ALSoD and ALSGene databases
    Christina M Lill
    Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Amyotroph Lateral Scler 12:238-49. 2011
    ..This review briefly introduces the background and main features of both databases and provides an overview of the currently most compelling genetic findings in ALS derived from analyses using these resources...
  12. ncbi request reprint Cohort Profile: The Berlin Aging Study II (BASE-II)
    Lars Bertram
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany, German Socio Economic Panel Study SOEP, Deutsches Institut für Wirtschaftsforschung, Berlin, Germany, Charité Research Group on Geriatrics, Charite Universitatsmedizin, Berlin, Germany, Institute of Medical and Human Genetics, Charite Universitatsmedizin, Berlin, Germany, Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany, Department of Psychology, TU Dresden, Dresden, Germany, Center for Medical Research, University of Tubingen, Tubingen, Germany, Department of Economics, University of Hamburg, Hamburg, Germany and Berlin University of Technology TUB, Berlin, Germany
    Int J Epidemiol 43:703-12. 2014
    ..A major goal of BASE-II is to facilitate collaboration with other research groups by freely sharing relevant phenotypic and genotypic data with qualified outside investigators. ..
  13. ncbi request reprint Assessment of microRNA-related SNP effects in the 3' untranslated region of the IL22RA2 risk locus in multiple sclerosis
    Christina M Lill
    Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr 63 73, Berlin, Germany
    Neurogenetics 15:129-34. 2014
    ..While our study provides independent validation of the association between rs17066096 and MS risk, this signal does not appear to be caused by sequence variants affecting microRNA function...
  14. pmc MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis
    Christina M Lill
    Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Brain 136:1778-82. 2013
    ..Our study provides compelling evidence that these five loci are genuine multiple sclerosis susceptibility loci. These results may eventually lead to a better understanding of the underlying disease pathophysiology...
  15. pmc Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database
    Christina M Lill
    Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS Genet 8:e1002548. 2012
    ..Our study provides an exhaustive and up-to-date summary of the status of PD genetics research that can be readily scaled to include the results of future large-scale genetics projects, including next-generation sequencing studies...
  16. doi request reprint The genetics of Alzheimer's disease
    Lars Bertram
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Prog Mol Biol Transl Sci 107:79-100. 2012
    ..In addition to reviewing the potential pathogenic relevance of these genes, we provide an outlook into the future of AD genetics research based on recent advances in high-throughput sequencing technologies...
  17. doi request reprint Aging magnifies the effects of dopamine transporter and D2 receptor genes on backward serial memory
    Shu Chen Li
    Max Planck Institute for Human Development, Center for Lifespan Psychology, Berlin, Germany
    Neurobiol Aging 34:358.e1-10. 2013
    ..g., dopamine functions) could alter the relations between genotypes and behavioral phenotypes (e.g., episodic memory)...
  18. pmc Genome-wide association studies in Alzheimer's disease
    Lars Bertram
    Neuropsychiatric Genetics Group, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Hum Mol Genet 18:R137-45. 2009
    ..A particular emphasis will be laid on findings with independent data in favor of the original association...
  19. doi request reprint Alzheimer's disease genetics current status and future perspectives
    Lars Bertram
    Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin 14195, Germany
    Int Rev Neurobiol 84:167-84. 2009
    ....