Genomes and Genes
Aida M Andres
Affiliation: Max Planck Institute for Evolutionary Anthropology
- Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentationAida M Andres
Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
PLoS Genet 6:e1001157. 2010..Although the precise selective pressure that maintains polymorphism is unknown, the demonstrated differences between the ERAP2 splice forms provide important insights into the potential mechanism for the action of selection...
- Sequence diversity of Pan troglodytes subspecies and the impact of WFDC6 selective constraints in reproductive immunityZélia Ferreira
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD
Genome Biol Evol 5:2512-23. 2013..Overall, chimpanzees and humans do not display similar footprints of selection across the WFDC locus, possibly due to different selective pressures between the two species related to immune response and reproductive biology...
- Reproduction and immunity-driven natural selection in the human WFDC locusZélia Ferreira
National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
Mol Biol Evol 30:938-50. 2013..This study provides further evidence that the WFDC and SEMG loci have been under strong adaptive pressure within the short timescale of modern humans...