Thomas Schlake

Summary

Affiliation: Max-Planck Institute of Immunobiology
Country: Germany

Publications

  1. ncbi request reprint Major shifts in genomic activity accompany progression through different stages of the hair cycle
    Thomas Schlake
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Gene Expr Patterns 4:141-52. 2004
  2. ncbi request reprint FGF signals specifically regulate the structure of hair shaft medulla via IGF-binding protein 5
    Thomas Schlake
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Development 132:2981-90. 2005
  3. ncbi request reprint Segmental Igfbp5 expression is specifically associated with the bent structure of zigzag hairs
    Thomas Schlake
    Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Mech Dev 122:988-97. 2005
  4. ncbi request reprint Krox20, a novel candidate for the regulatory hierarchy that controls hair shaft bending
    Thomas Schlake
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Mech Dev 123:641-8. 2006
  5. ncbi request reprint Determination of hair structure and shape
    Thomas Schlake
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Semin Cell Dev Biol 18:267-73. 2007
  6. ncbi request reprint The nude gene and the skin
    T Schlake
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Exp Dermatol 10:293-304. 2001
  7. pmc Canonical WNT signalling controls hair follicle spacing
    Thomas Schlake
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Cell Adh Migr 1:149-51. 2007
  8. ncbi request reprint Expression domains in the skin of genes affected by the nude mutation and identified by gene expression profiling
    T Schlake
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108, Freiburg, Germany
    Mech Dev 109:419-22. 2001
  9. ncbi request reprint Localization of Shh expression by Wnt and Eda affects axial polarity and shape of hairs
    Brigitte Hammerschmidt
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Dev Biol 305:246-61. 2007
  10. ncbi request reprint Igf-I signalling controls the hair growth cycle and the differentiation of hair shafts
    Nicole Weger
    Max Planck Institute of Immunobiology, Freiburg, Germany
    J Invest Dermatol 125:873-82. 2005

Collaborators

  • Thomas Boehm
  • Nicole Weger
  • Brigitte Hammerschmidt
  • Stefanie Sick
  • Jens Timmer
  • Stefan Reinker

Detail Information

Publications12

  1. ncbi request reprint Major shifts in genomic activity accompany progression through different stages of the hair cycle
    Thomas Schlake
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Gene Expr Patterns 4:141-52. 2004
    ..Expression of insulin-like growth factor binding proteins and anti-angiogenic factors is associated with the regression phase of the hair cycle...
  2. ncbi request reprint FGF signals specifically regulate the structure of hair shaft medulla via IGF-binding protein 5
    Thomas Schlake
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Development 132:2981-90. 2005
    ..Thus, the results identify Igfbp5-mediated FGFR2-IIIb signals as a key regulator of the genetic program that controls the structure of the hair shaft medulla...
  3. ncbi request reprint Segmental Igfbp5 expression is specifically associated with the bent structure of zigzag hairs
    Thomas Schlake
    Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Mech Dev 122:988-97. 2005
    ..Both effects and the natural bending process are under negative control of IGF signalling. Thus, our data identify Igfbp5 as a central regulator of hair shaft differentiation and hair type determination...
  4. ncbi request reprint Krox20, a novel candidate for the regulatory hierarchy that controls hair shaft bending
    Thomas Schlake
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Mech Dev 123:641-8. 2006
    ..Our data suggest Krox20 as a nodal point of FGF and IGF signalling pathways controlling Igfbp5 expression which is associated with hair shaft differentiation and may generate the periodicity of the zigzag hair...
  5. ncbi request reprint Determination of hair structure and shape
    Thomas Schlake
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Semin Cell Dev Biol 18:267-73. 2007
    ..This review highlights our current knowledge of the control of hair structure and shape with emphasis on mouse hair follicle biology and discusses continuing problems...
  6. ncbi request reprint The nude gene and the skin
    T Schlake
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Exp Dermatol 10:293-304. 2001
    ..Furthermore, these studies give a hint as to when the nude gene has occurred first and how it has developed in molecular and functional terms since then...
  7. pmc Canonical WNT signalling controls hair follicle spacing
    Thomas Schlake
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Cell Adh Migr 1:149-51. 2007
    ..Furthermore, we suggest future experiments to challenge the RD model of spatial follicle arrangement...
  8. ncbi request reprint Expression domains in the skin of genes affected by the nude mutation and identified by gene expression profiling
    T Schlake
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108, Freiburg, Germany
    Mech Dev 109:419-22. 2001
    ..Our results identify metallothionein IV among these genes. This is the first report on metallothionein IV expression in the murine hair follicle; its expression domain almost completely overlaps that of Whn...
  9. ncbi request reprint Localization of Shh expression by Wnt and Eda affects axial polarity and shape of hairs
    Brigitte Hammerschmidt
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Dev Biol 305:246-61. 2007
    ..Moreover, the identified molecular hierarchy offers a model for the periodic patterning of zigzag hairs mechanistically similar to mesodermal segmentation...
  10. ncbi request reprint Igf-I signalling controls the hair growth cycle and the differentiation of hair shafts
    Nicole Weger
    Max Planck Institute of Immunobiology, Freiburg, Germany
    J Invest Dermatol 125:873-82. 2005
    ..Finally, Pdgfralpha was identified as the first molecular target that is affected in Igf-I transgenic mice. In summary, our data identify IGF-I signalling as an important mitogenic and morphogenetic regulator in hair follicle biology...
  11. ncbi request reprint WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism
    Stefanie Sick
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Science 314:1447-50. 2006
    ..These results confirm predictions of a WNT/DKK-specific mathematical model and provide in vivo corroboration of the reaction-diffusion mechanism for epidermal appendage formation...
  12. ncbi request reprint Igfbp3 modulates cell proliferation in the hair follicle
    Nicole Weger
    J Invest Dermatol 125:847-9. 2005