Michael Reth

Summary

Affiliation: Max-Planck Institute of Immunobiology
Country: Germany

Publications

  1. ncbi request reprint Initiation and processing of signals from the B cell antigen receptor
    M Reth
    Department of Molecular Immunology, Biology III, University Freiburg, Germany
    Annu Rev Immunol 15:453-79. 1997
  2. ncbi request reprint An unsolved problem of the clonal selection theory and the model of an oligomeric B-cell antigen receptor
    M Reth
    Department of Molecular Immunology, Biology III, University of Freiburg and Max Planck Institute for Immunobiology, Germany
    Immunol Rev 176:10-8. 2000
  3. ncbi request reprint Oligomeric antigen receptors: a new view on signaling for the selection of lymphocytes
    M Reth
    Dept of Molecular Immunology, Biology III, University of Freiburg and Max Planck Institute for Immunobiology, Stubeweg 51, 79108 Freiburg, Germany
    Trends Immunol 22:356-60. 2001
  4. ncbi request reprint Hydrogen peroxide as second messenger in lymphocyte activation
    Michael Reth
    Max Planck Institute für Immunobiologie, Universitat Freiburg, Biologie III, Abteilung Molekulare Immunologie, Stuebeweg 51, Freiburg 79108, Germany
    Nat Immunol 3:1129-34. 2002
  5. ncbi request reprint Feedback regulation of lymphocyte signalling
    Michael Reth
    Department of Molecular Immunology, Institute for Biology III, Albert Ludwigs University of Freiburg and Max Planck Institut for Immunobiology, 79108 Freiburg, Germany
    Nat Rev Immunol 4:269-77. 2004
  6. ncbi request reprint Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia
    Hassan Jumaa
    Biologie III, University of Freiburg and Max Planck Institute for Immunobiology, D 79108 Freiburg, Germany
    Nature 423:452-6. 2003
  7. ncbi request reprint Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf
    Tilman Brummer
    Department of Molecular Immunology, Biology III, University of Freiburg and Max Planck Institute for Immunobiology, Stuebeweg 51, Freiburg 79108, Germany
    Oncogene 22:8823-34. 2003
  8. ncbi request reprint Two dimensional Blue Native-/SDS-PAGE analysis of SLP family adaptor protein complexes
    Mahima Swamy
    Department of Molecular Immunology, Biologie III, University of Freiburg and Max Planck Institut für Immunbiologie, Stubeweg 51, 79108 Freiburg, Germany
    Immunol Lett 104:131-7. 2006
  9. pmc Identification of a pre-BCR lacking surrogate light chain
    Yu Wen Su
    Institute for Biology III, Albert Ludwigs University of Freiburg, Max Planck Institute for Immunobiology, Freiburg, Germany
    J Exp Med 198:1699-706. 2003
  10. ncbi request reprint A leucine zipper in the N terminus confers membrane association to SLP-65
    Fabian Kohler
    Institute for Biology III, Albert Ludwigs University of Freiburg and Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Nat Immunol 6:204-10. 2005

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Initiation and processing of signals from the B cell antigen receptor
    M Reth
    Department of Molecular Immunology, Biology III, University Freiburg, Germany
    Annu Rev Immunol 15:453-79. 1997
    ..Using a functional definition of signaling elements, we discuss the current knowledge of signaling events from the BCR and suggest the existence of an as-yet-unknown BCR transducer complex...
  2. ncbi request reprint An unsolved problem of the clonal selection theory and the model of an oligomeric B-cell antigen receptor
    M Reth
    Department of Molecular Immunology, Biology III, University of Freiburg and Max Planck Institute for Immunobiology, Germany
    Immunol Rev 176:10-8. 2000
    ..Binding to self- or foreign antigen results in a distortion of the oligomeric complex that gives the signal for negative selection of immature and activation of mature B cells...
  3. ncbi request reprint Oligomeric antigen receptors: a new view on signaling for the selection of lymphocytes
    M Reth
    Dept of Molecular Immunology, Biology III, University of Freiburg and Max Planck Institute for Immunobiology, Stubeweg 51, 79108 Freiburg, Germany
    Trends Immunol 22:356-60. 2001
    ..It is suggested that the antigen receptors on B and T-cells form oligomeric complexes, inside of which, signals can be processed and amplified in a manner that might explain the different signaling outputs of these receptors...
  4. ncbi request reprint Hydrogen peroxide as second messenger in lymphocyte activation
    Michael Reth
    Max Planck Institute für Immunobiologie, Universitat Freiburg, Biologie III, Abteilung Molekulare Immunologie, Stuebeweg 51, Freiburg 79108, Germany
    Nat Immunol 3:1129-34. 2002
    ..Thus, by controlling the activity of the negative regulatory phosphatases inside the cell, H2O2 can set and influence critical thresholds for lymphocyte activation...
  5. ncbi request reprint Feedback regulation of lymphocyte signalling
    Michael Reth
    Department of Molecular Immunology, Institute for Biology III, Albert Ludwigs University of Freiburg and Max Planck Institut for Immunobiology, 79108 Freiburg, Germany
    Nat Rev Immunol 4:269-77. 2004
  6. ncbi request reprint Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia
    Hassan Jumaa
    Biologie III, University of Freiburg and Max Planck Institute for Immunobiology, D 79108 Freiburg, Germany
    Nature 423:452-6. 2003
    ..Thus, the somatic loss of SLP-65 and the accompanying block in pre-B-cell differentiation might be one of the primary causes of childhood pre-B ALL...
  7. ncbi request reprint Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf
    Tilman Brummer
    Department of Molecular Immunology, Biology III, University of Freiburg and Max Planck Institute for Immunobiology, Stuebeweg 51, Freiburg 79108, Germany
    Oncogene 22:8823-34. 2003
    ..We discuss a model in which ERK-mediated phosphorylation of the SPKTP motif is involved in negative feedback regulation of B-Raf...
  8. ncbi request reprint Two dimensional Blue Native-/SDS-PAGE analysis of SLP family adaptor protein complexes
    Mahima Swamy
    Department of Molecular Immunology, Biologie III, University of Freiburg and Max Planck Institut für Immunbiologie, Stubeweg 51, 79108 Freiburg, Germany
    Immunol Lett 104:131-7. 2006
    ..Surprisingly, stimulation-induced alteration of SLP complexes could not be detected, suggesting that active signaling complexes form only transiently, and are of low abundance...
  9. pmc Identification of a pre-BCR lacking surrogate light chain
    Yu Wen Su
    Institute for Biology III, Albert Ludwigs University of Freiburg, Max Planck Institute for Immunobiology, Freiburg, Germany
    J Exp Med 198:1699-706. 2003
    ....
  10. ncbi request reprint A leucine zipper in the N terminus confers membrane association to SLP-65
    Fabian Kohler
    Institute for Biology III, Albert Ludwigs University of Freiburg and Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Nat Immunol 6:204-10. 2005
    ..Our data elucidate the mechanism of SLP-65 membrane recruitment and suggest that leucine zipper motifs are essential interaction domains of signaling proteins...
  11. ncbi request reprint B-cell signal transduction: tyrosine phosphorylation, kinase activity, and calcium mobilization
    Tilman Brummer
    Department of Molecular Immunology, Biology III, University of Freiburg and Max Planck Institute for Immunobiology, Freiburg, Germany
    Methods Mol Biol 271:189-212. 2004
    ..Furthermore, we emphasize the use of phospho-specific antibodies (Abs) and low-molecular-weight enzyme inhibitors in the process of mapping BCR-activated signaling pathways as well as determining activation states of signaling proteins...
  12. doi request reprint Oligomeric organization of the B-cell antigen receptor on resting cells
    Jianying Yang
    Centre for Biological Signalling Studies bioss, Albert Ludwigs Universitat Freiburg, Department of Molecular Immunology, Faculty of Biology, Albert Ludwigs Universität Freiburg and Max Planck Institute for Immunobiology, Stubeweg 51, 79108 Freiburg, Germany
    Nature 467:465-9. 2010
    ..We propose that oligomers are the autoinhibited form of the BCR and that it is the shift from closed BCR oligomers to clustered monomers that drives B-cell activation in a way that is independent of the structural input from the antigen...
  13. ncbi request reprint Identification of disulfide bonds in the Ig-alpha/Ig-beta component of the B cell antigen receptor using the Drosophila S2 cell reconstitution system
    Gabrielle M Siegers
    Max Planck Institut für Immunbiologie and University of Freiburg, Biologie III Stübeweg 51, 79108 Freiburg, Germany
    Int Immunol 18:1385-96. 2006
    ..Our data also suggest that the Ig-alpha/Ig-beta heterodimer can assemble into oligomers...
  14. ncbi request reprint Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors
    Susana Minguet
    Department of Molecular Immunology, Institute for Biology III, Albert Ludwigs University of Freiburg and Max Planck Institute for Immunobiology, 79108 Freiburg, Germany
    Eur J Immunol 35:31-41. 2005
    ..This suggests that adenosine-mediated signals represent an important step in the molecular decision process controlling inflammation versus anergic immune responses...
  15. doi request reprint The SH2-domain of SHIP1 interacts with the SHIP1 C-terminus: impact on SHIP1/Ig-α interaction
    Oindrilla Mukherjee
    RWTH Aachen University, Medical Faculty, Department of Biochemistry and Molecular Immunology, Institute of Biochemistry and Molecular Biology, 52074 Aachen, Germany
    Biochim Biophys Acta 1823:206-14. 2012
    ....
  16. doi request reprint SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway
    Sebastian Herzog
    Max Planck Institute for Immunobiology, 79108 Freiburg, Germany
    Nat Immunol 9:623-31. 2008
    ..Together, these data illuminate a molecular function of SLP-65 and identify a key role for Foxo proteins in the regulation of light chain recombination, receptor editing and B cell selection...
  17. doi request reprint Enhanced B-cell activation mediated by TLR4 and BCR crosstalk
    Susana Minguet
    Molecular Immunology, Institute of Biology III, University of Freiburg and Max Planck Institute for Immunobiology, Freiburg, Germany
    Eur J Immunol 38:2475-87. 2008
    ..In contrast, co-engagement of TLR4 and BCR by antigen-coupled LPS synergistically enhances activation of B cells, pointing out attractive targets for signalling crosstalk in B lymphocytes...
  18. ncbi request reprint A revised and complete map of the chicken c-mil/raf-1 locus
    Tilman Brummer
    Department of Molecular Immunology, Institute for Biology III, Albert Ludwigs University of Freiburg and Max Planck Institut for Immunobiology, Freiburg 79108, Germany
    Oncogene 23:3128-31. 2004
    ....
  19. ncbi request reprint B cell signaling and tumorigenesis
    Hassan Jumaa
    Institute for Biology III, Albert Ludwigs University of Freiburg and Max Planck Institute for Immunobiology, 79108 Freiburg, Germany
    Annu Rev Immunol 23:415-45. 2005
    ..We point out the concepts of auto-inhibition and subcellular localization as crucial aspects in the regulation of B cell signaling...
  20. ncbi request reprint B cell antigen receptor assembly and Syk activation in the S2 cell reconstitution system
    Thomas Wossning
    Department of Molecular Immunology, Biology III, University of Freiburg, Stubeweg 51, 79108 Freiburg, Germany
    Immunol Lett 92:67-73. 2004
    ..This indicates that the C-terminal SH2 domain of Syk is the dominant regulatory subunit of this kinase...
  21. ncbi request reprint Association of protein kinase C-delta with the B cell antigen receptor complex
    Catrin Pracht
    Department of Molecular Immunology, Biology III, University of Freiburg and Max Planck Institute for Immunobiology, 79108 Freiburg, Germany
    Cell Signal 19:715-22. 2007
    ..k.a. PKC-mu) in response to BCR engagement, suggesting the early, membrane-proximal activation of an attenuating kinase complex including PKC-delta and PKD...
  22. pmc Immunoglobulins drive terminal maturation of splenic dendritic cells
    Natalia Zietara
    Department of Molecular Immunology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany
    Proc Natl Acad Sci U S A 110:2282-7. 2013
    ..This unexpected dependency of splenic DCs on Ig to cross-present antigen provides insights into the interplay between cellular and humoral immunity and the immunomodulatory capacity of Ig...
  23. pmc Bacillus subtilis MreB orthologs self-organize into filamentous structures underneath the cell membrane in a heterologous cell system
    Felix Dempwolff
    Mikrobiologie, Fakultat fur Biologie, Universitat Freiburg, Freiburg, Germany
    PLoS ONE 6:e27035. 2011
    ..Thus, MreB paralogs form a self-organizing and dynamic filamentous scaffold underneath the membrane that is able to recruit other proteins to the cell surface...
  24. pmc A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum
    Wolfgang W A Schamel
    Department of Molecular Immunology, Biology III, University of Freiburg and Max Planck Institut für Immunobiologie, D 79108 Freiburg, Germany
    Proc Natl Acad Sci U S A 100:9861-6. 2003
    ..In conclusion, BAP29 and BAP31 might be the long sought after retention proteins and/or chaperones that act on transmembrane regions of various proteins...
  25. ncbi request reprint The role of SHIP in mast cell degranulation and IgE-induced mast cell survival
    Michael Huber
    Department of Molecular Immunology, Biology III, University of Freiburg and Max Planck Institute for Immunobiology, Freiburg, Germany
    Immunol Lett 82:17-21. 2002
    ..These studies demonstrate that mast cell sensitization by IgE is an active rather than a passive process...
  26. ncbi request reprint Functional folding of a cytoplasmic single-chain variable fragment and its use as elutable protein purification tag
    Winfried Elis
    Department of Molecular Immunology, Biology III, University of Freiburg, Freiburg, Germany
    Immunol Lett 92:185-92. 2004
    ....
  27. ncbi request reprint Clustering models
    Wolfgang W A Schamel
    Department of Molecular Immunology, Max Planck Institute for Immunobiology and Faculty of Biology, University of Freiburg, Stuebeweg 51, 79108 Freiburg, Germany
    Adv Exp Med Biol 640:64-73. 2008
    ..In this review, we focus on the homodclustering induced by multivalent ligands, the heterodustering induced by simultaneous binding of the ligand to the MIRR and a coreceptor and the pseudodimer model...
  28. pmc The TCR binding site does move
    Wolfgang W A Schamel
    Max Planck Institut for Immunbiology and Faculty of Biology III, University of Freiburg, Stubeweg 51, 79108 Freiburg, Germany
    Proc Natl Acad Sci U S A 104:16398-9. 2007
  29. ncbi request reprint B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta
    Roberta Pelanda
    Biologie III, University of Freiburg and Max Planck Institute for Immunobiology, Freiburg, Germany
    J Immunol 169:865-72. 2002
    ..Finally, Ig-alpha and Ig-beta are not redundant in their putative function, as pro-B cells from Ig-alpha and Ig-beta double-deficient mice are similar to those from single-deficient animals in every aspect analyzed...
  30. ncbi request reprint The role of the Syk/Shp-1 kinase-phosphatase equilibrium in B cell development and signaling
    Ameera Alsadeq
    Department of Molecular Immunology, Max Planck Institut of Immunobiology and Epigenetics, Freiburg 79108, Germany Biology III, Faculty of Biology, Albert Ludwigs University Freiburg, Freiburg 79108, Germany Spemann Graduate School of Biology and Medicine, Albert Ludwigs University Freiburg, Freiburg 79108, Germany and BIOSS Centre for Biological Signalling Studies, Albert Ludwigs University Freiburg, Freiburg 79108, Germany
    J Immunol 193:268-76. 2014
    ..Together, our data show that a properly balanced kinase/phosphatase equilibrium is crucial for normal B cell development and function. ..
  31. ncbi request reprint The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion
    Alexandra Flemming
    Institute for Biology III, Albert Ludwigs University of Freiburg and Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Nat Immunol 4:38-43. 2003
    ..Our results indicate that SLP-65 regulates a developmental program that promotes differentiation and limits pre-B cell expansion, thereby acting as a tumor suppressor...
  32. doi request reprint The dissociation activation model of B cell antigen receptor triggering
    Jianying Yang
    Centre of Biological Signalling Studies BIOSS, University Freiburg, Freiburg, Germany
    FEBS Lett 584:4872-7. 2010
    ..We propose the dissociation activation model (DAM), which fits better with the existing body of experimental data...
  33. ncbi request reprint Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop
    Véronique Rolli
    Department of Molecular Immunology, Biology III, University of Freiburg and Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Mol Cell 10:1057-69. 2002
    ..The BCR-dependent Syk activation and signal amplification is efficiently counterbalanced by protein tyrosine phosphatases, the activity of which is regulated by H(2)O(2) and the redox equilibrium inside the cell...
  34. ncbi request reprint Activation of T cells via tumor antigen specific chimeric receptors: the role of the intracellular signaling domain
    Florian O Losch
    Department of Molecular Immunology, Biology III, University of Freiburg and Max Planck Institute for Immunobiology, Germany
    Int J Cancer 103:399-407. 2003
    ..Given their specificity and efficiency, T cells grafted with these type of receptors may represent potential candidates for cancer passive immunotherapy...
  35. ncbi request reprint Perspectives on the nature of BCR-mediated survival signals
    Susan Harless Smith
    Department of Molecular Immunology, Max Planck Institute for Immunobiology, Stubeweg 51, AG Reth, D 79108 Freiburg, Germany
    Mol Cell 14:696-7. 2004
    ..Further, these studies exclude transient INF(gamma)-induced activation as a prerequisite to apoptosis in receptor-less cells...
  36. pmc Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling
    Tilman Brummer
    Department of Molecular Immunology, Biology III, University of Freiburg and Max Planck Institute for Immunobiology, Stuebeweg 51, Germany
    EMBO J 21:5611-22. 2002
    ..Our study shows that BCR-mediated ERK activation involves a cooperation of both B-Raf and Raf-1, which are activated specifically in a temporally distinct manner...
  37. ncbi request reprint Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation
    Yoshiteru Sasaki
    The CBR Institute for Biomedical Research, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Immunity 24:729-39. 2006
    ..Therefore, canonical NF-kappaB activity can substitute for BAFF-R signals in B cell development and pathogenesis...
  38. ncbi request reprint B cell defects in SLP65/BLNK-deficient mice can be partially corrected by the absence of CD22, an inhibitory coreceptor for BCR signaling
    Judith Gerlach
    Institute for Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany
    Eur J Immunol 33:3418-26. 2003
    ..Furthermore, these experiments suggest that B cell maturation in the spleen is directly dependent on the strength of BCR-derived Ca(2+) signals...
  39. pmc The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development
    Yogesh Kulathu
    Faculty of Biology, Max Planck Institute for Immunobiology, University of Freiburg, Freiburg, Germany
    EMBO J 27:1333-44. 2008
    ..We suggest that after activation and internalization of the BCR, Syk remains active as part of a membrane-bound Syk/SLP-65 complex controlling sustained signalling and calcium influx...
  40. pmc Functional analysis of histone methyltransferase g9a in B and T lymphocytes
    Lance R Thomas
    Department of Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232, USA
    J Immunol 181:485-93. 2008
    ..These findings indicate that the H3K9me2 epigenetic mark affects a highly restricted set of processes during lymphocyte development and activation...
  41. pmc Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells
    Rogier Kersseboom
    Department of Immunology, Erasmus MC Rotterdam, PO Box 1738, NL 3000 DR Rotterdam, Netherlands
    J Exp Med 198:91-8. 2003
    ....
  42. ncbi request reprint Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development
    Kaoru Saijo
    Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, NY 10021, USA
    Nat Immunol 4:274-9. 2003
    ..Our data show the existence of a functionally distinct SFK signaling module responsible for pre-BCR-mediated NF-kappaB activation and B cell development...
  43. ncbi request reprint Establishment of immortalized human hepatic stellate scavenger cells to develop bioartificial livers
    Takamasa Watanabe
    Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Transplantation 75:1873-80. 2003
    ..Because the limited lifespan of human HSC is a major hurdle to their use, the authors report here the amplification of human HSC populations in vitro by retroviral transfer of human telomerase reverse transcriptase (hTERT)...
  44. ncbi request reprint Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
    Karl Ludwig Laugwitz
    Institute of Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA
    Nature 433:647-53. 2005
    ..The discovery of native cardioblasts represents a genetically based system to identify steps in cardiac cell lineage formation and maturation in development and disease...
  45. ncbi request reprint Importance of TRF1 for functional telomere structure
    Tomohiko Iwano
    Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Kyoto, Japan
    J Biol Chem 279:1442-8. 2004
    ..These results strongly suggest that TRF1 interacts with other telomere-binding molecules and integrates into the functional telomere structure...
  46. pmc Yin Yang 1 is a critical regulator of B-cell development
    Huifei Liu
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 21:1179-89. 2007
    ..We provide evidence that YY1 binds the intronic Ei mu enhancer within the IgH locus, consistent with a direct role for YY1 in V(H)D(H)J(H) recombination. These findings identified YY1 as a critical regulator of early B-cell development...
  47. ncbi request reprint Activation of the CKI-CDK-Rb-E2F pathway in full genome hepatitis C virus-expressing cells
    Kyoko Tsukiyama-Kohara
    Department of Microbiology and Cell Biology and Cell Physiology, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    J Biol Chem 279:14531-41. 2004
    ..These results demonstrate that full genome HCV expression up-regulates the CDK-Rb-E2F pathway much more effectively than HCV proteins during passage...
  48. ncbi request reprint Reversible switching of immunoglobulin hypermutation machinery in a chicken B cell line
    Naoki Kanayama
    Department of Biotechnology, Okayama University, Tsushima naka 3 1 1, Okayama 700 8530, Japan
    Biochem Biophys Res Commun 327:70-5. 2005
    ..Starting from a single DT40-SW cell, Ig gene repertoire was efficiently diversified during culture only when AID expression was on...
  49. pmc Mutations of the Igbeta gene cause agammaglobulinemia in man
    Simona Ferrari
    Medical Genetics Unit, S Orsola Malpighi University Hospital, 40138 Bologna, Italy
    J Exp Med 204:2047-51. 2007
    ..These results indicate that mutations in Igbeta can cause agammaglobulinemia in man...