R Kemler

Summary

Affiliation: Max-Planck Institute of Immunobiology
Country: Germany

Publications

  1. pmc Beta-catenin is vital for the integrity of mouse embryonic stem cells
    Angelo Raggioli
    Max Planck Institute of Immunobiology and Epigenetics, Emeritus Laboratory, Freiburg, Germany
    PLoS ONE 9:e86691. 2014
  2. pmc Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation
    Ahmed M Kotb
    Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, D 79108 Freiburg, Germany
    Breast Cancer Res 13:R104. 2011
  3. ncbi request reprint Cadherins and catenins in development
    O Huber
    Max Planck Institute for Immunobiology, Department of Molecular Embryolog, y Stübeweg 51, D 79108 Freiburg, Germany
    Curr Opin Cell Biol 8:685-91. 1996
  4. ncbi request reprint Embryonic heart and skin defects in mice lacking plakoglobin
    C Bierkamp
    Department of Molecular Embryology, Max Planck Institute for Immunobiology, Stubeweg 51, Freiburg, D 79108, Germany
    Dev Biol 180:780-5. 1996
  5. ncbi request reprint Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast
    Rolf Kemler
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Development 131:5817-24. 2004
  6. ncbi request reprint Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice
    C Bierkamp
    Max Planck Institute of Immunobiology, Department of Molecular Embryology, Stubeweg 51, D 79108 Freiburg and Max Planck Institute of Developmental Biology, Spemannstrasse 35, D 72076 Tubingen, Germany
    Development 126:371-81. 1999
  7. ncbi request reprint E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation
    S Orsulic
    Max Planck Institut fur Immunbiologie, Stubeweg 51, D 79108 Freiburg, Germany
    J Cell Sci 112:1237-45. 1999
  8. ncbi request reprint Lack of beta-catenin affects mouse development at gastrulation
    H Haegel
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Development 121:3529-37. 1995
  9. ncbi request reprint Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro
    A Hecht
    Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    J Biol Chem 274:18017-25. 1999
  10. ncbi request reprint Casein kinase II phosphorylation of E-cadherin increases E-cadherin/beta-catenin interaction and strengthens cell-cell adhesion
    H Lickert
    Max Planck Institute of Immunobiology, Department of Molecular Embryology, Stubeweg 51, D 79108 Freiburg, Germany
    J Biol Chem 275:5090-5. 2000

Detail Information

Publications76

  1. pmc Beta-catenin is vital for the integrity of mouse embryonic stem cells
    Angelo Raggioli
    Max Planck Institute of Immunobiology and Epigenetics, Emeritus Laboratory, Freiburg, Germany
    PLoS ONE 9:e86691. 2014
    ..Our study demonstrates the importance of β-catenin in maintaining correct cellular functions and helps to understand its role in embryonic stem cells...
  2. pmc Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation
    Ahmed M Kotb
    Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, D 79108 Freiburg, Germany
    Breast Cancer Res 13:R104. 2011
    ..Although they share many structural and functional features, they are expressed in an almost mutually exclusive manner in vivo...
  3. ncbi request reprint Cadherins and catenins in development
    O Huber
    Max Planck Institute for Immunobiology, Department of Molecular Embryolog, y Stübeweg 51, D 79108 Freiburg, Germany
    Curr Opin Cell Biol 8:685-91. 1996
    ..Recent findings demonstrate the involvement of cadherins and catenins in signaling pathways. In a working hypothesis, signaling via beta-catenin regulates the epithelial-mesenchymal transition in vertebrate development...
  4. ncbi request reprint Embryonic heart and skin defects in mice lacking plakoglobin
    C Bierkamp
    Department of Molecular Embryology, Max Planck Institute for Immunobiology, Stubeweg 51, Freiburg, D 79108, Germany
    Dev Biol 180:780-5. 1996
    ..The skin phenotype in plakoglobin-deficient mice is reminiscent of the human blistering disease, epidermolytic hyperkeratosis...
  5. ncbi request reprint Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast
    Rolf Kemler
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Development 131:5817-24. 2004
    ..As a consequence, cells of the embryonic ectoderm change their fate, resulting in a premature epithelial-mesenchymal transition...
  6. ncbi request reprint Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice
    C Bierkamp
    Max Planck Institute of Immunobiology, Department of Molecular Embryology, Stubeweg 51, D 79108 Freiburg and Max Planck Institute of Developmental Biology, Spemannstrasse 35, D 72076 Tubingen, Germany
    Development 126:371-81. 1999
    ..Our analysis underlines the central role of plakoglobin for desmosomal assembly and function during embryogenesis...
  7. ncbi request reprint E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation
    S Orsulic
    Max Planck Institut fur Immunbiologie, Stubeweg 51, D 79108 Freiburg, Germany
    J Cell Sci 112:1237-45. 1999
    ..The potent ability of E-cadherin to recruit beta-catenin to the cell membrane and prevent its nuclear localization and transactivation was also demonstrated using SW480 colon carcinoma cells...
  8. ncbi request reprint Lack of beta-catenin affects mouse development at gastrulation
    H Haegel
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Development 121:3529-37. 1995
    ..Our results demonstrate that, although beta-catenin is expressed rather ubiquitously, it is specifically required in the ectodermal cell layer...
  9. ncbi request reprint Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro
    A Hecht
    Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    J Biol Chem 274:18017-25. 1999
    ....
  10. ncbi request reprint Casein kinase II phosphorylation of E-cadherin increases E-cadherin/beta-catenin interaction and strengthens cell-cell adhesion
    H Lickert
    Max Planck Institute of Immunobiology, Department of Molecular Embryology, Stubeweg 51, D 79108 Freiburg, Germany
    J Biol Chem 275:5090-5. 2000
    ..Thus, phosphorylation of the E-cadherin cytoplasmic domain by CKII and GSK-3beta appears to modulate the affinity between beta-catenin and E-cadherin, ultimately modifying the strength of cell-cell adhesion...
  11. pmc Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity
    A Bauer
    Max Planck Institute of Immunobiology, Department of Molecular Embryology, Stubeweg 51, D 79108 Freiburg, Germany
    EMBO J 19:6121-30. 2000
    ..These results indicate that the opposite action of Pontin52 and Reptin52 on beta-catenin-mediated transactivation constitutes an additional mechanism for the control of the canonical Wingless/Wnt pathway...
  12. pmc The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates
    A Hecht
    Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    EMBO J 19:1839-50. 2000
    ..p300 could participate in alleviating promoter repression imposed by chromatin structure and in recruiting the basal transcription machinery to promoters of particular Wnt target genes...
  13. ncbi request reprint Cell-junctional and cytoskeletal organization in mouse blastocysts lacking E-cadherin
    M Ohsugi
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Dev Biol 185:261-71. 1997
    ....
  14. ncbi request reprint Modification of the E-cadherin-catenin complex in mitotic Madin-Darby canine kidney epithelial cells
    A Bauer
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
    J Biol Chem 273:28314-21. 1998
    ..Hence, the cadherin/catenin complex is a target for different posttranslational modifications during mitosis, which may also have a profound impact on cadherin-mediated cell-cell adhesion...
  15. pmc E-cadherin null mutant embryos fail to form a trophectoderm epithelium
    L Larue
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Proc Natl Acad Sci U S A 91:8263-7. 1994
    ..These results demonstrate the pivotal role of E-cadherin in one of the most basic morphogenetic events in the development of multicellular organisms, the biogenesis of an epithelium...
  16. ncbi request reprint A role for cadherins in tissue formation
    L Larue
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Development 122:3185-94. 1996
    ..These results provide the first evidence that specific cadherins directly stimulate differentiation into certain types of tissues...
  17. ncbi request reprint Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm
    Natalia G Kan
    Max Planck Institut fur Immunbiologie, Abteilung für Molekulare Embryologie, Stubeweg 51, D 79108 Freiburg, Germany
    Development 134:31-41. 2007
    ..Thus, N-cadherin can maintain epithelia in differentiating ES cells, but not during the formation of the trophectoderm. Our results point to a specific and unique function for E-cadherin during mouse preimplantation development...
  18. pmc beta-catenin is a target for the ubiquitin-proteasome pathway
    H Aberle
    Max Planck Institute for Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    EMBO J 16:3797-804. 1997
    ..We show that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of beta-catenin...
  19. ncbi request reprint Beta-catenin is a major tyrosine-phosphorylated protein during mouse oocyte maturation and preimplantation development
    M Ohsugi
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Dev Dyn 216:168-76. 1999
    ..Our results suggest that tyrosine phosphorylation of beta-catenin represents a molecular mechanism to keep the accumulating E-cadherin adhesion complex in a nonfunctional form. Dev Dyn 1999;216:168-176...
  20. ncbi request reprint The generation and in vivo differentiation of murine embryonal stem cells genetically null for either N-cadherin or N- and P-cadherin
    R Moore
    Department of Molecular Embryology, Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Int J Dev Biol 43:831-4. 1999
    ....
  21. ncbi request reprint Expression of Eph receptors and ephrins is differentially regulated by E-cadherin
    S Orsulic
    Max Planck Institut fur Immunbiologie, Stubeweg 51, D 79108 Freiburg, Germany
    J Cell Sci 113:1793-802. 2000
    ..Our results indicate that E-cadherin may be directly or indirectly required for the membrane localization of Eph receptors and their membrane-bound ligands...
  22. ncbi request reprint Nuclear localization of beta-catenin by interaction with transcription factor LEF-1
    O Huber
    Department of Molecular Embryology, Max Planck Institute for Immunobiology, Freiburg, Germany
    Mech Dev 59:3-10. 1996
    ..As shown for beta-catenin, ectopic expression of LEF-1 in Xenopus embryos caused duplication of the body axis, indicating a regulatory role for a LEF-1-like molecule in dorsal mesoderm formation...
  23. doi request reprint Beta-catenin-mediated signaling and cell adhesion in postgastrulation mouse embryos
    Andreas Hierholzer
    Max Planck Institute of Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    Dev Dyn 239:191-9. 2010
    ..We found that beta-catenin is required for the correct localization of N-cadherin at the membrane of neural ectodermal cells and that its absence causes a disintegration of the neural tube...
  24. ncbi request reprint Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm
    Heiko Lickert
    Department of Molecular Embryology, Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Dev Cell 3:171-81. 2002
    ..We provide evidence that ablation of beta-catenin in embryonic endoderm changes cell fate from endoderm to precardiac mesoderm, consistent with the existence of bipotential mesendodermal progenitors in mouse embryos...
  25. ncbi request reprint A specific domain in alpha-catenin mediates binding to beta-catenin or plakoglobin
    O Huber
    Max Planck Institute for Immunobiology, Freiburg, Germany
    J Cell Sci 110:1759-65. 1997
    ..The results described here, together with our previous work, give strong support for the idea that these proteins associate by hydrophobic interactions of two alpha-helices...
  26. pmc Curbing the nuclear activities of beta-catenin. Control over Wnt target gene expression
    A Hecht
    Max Planck Institute of Immunobiology, Freiburg, Germany
    EMBO Rep 1:24-8. 2000
    ..These mechanisms provide points of intersection with other signaling pathways, and contribute to the complexity and specificity of Wnt target gene regulation...
  27. ncbi request reprint Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion
    S Butz
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    FEBS Lett 355:195-200. 1994
    ..A similar distinct association with catenins is also found for other cadherins. Comparison of different cell lines revealed that the relative amounts of the two complexes vary depending on cell types...
  28. ncbi request reprint Wnt3a plays a major role in the segmentation clock controlling somitogenesis
    Alexander Aulehla
    Abteilung Entwicklungsbiologie, Max Planck Institut fur Immunbiologie, Stubeweg 51, D 79108, Freiburg, Germany
    Dev Cell 4:395-406. 2003
    ..We propose that the segmentation clock is established by Wnt/beta-catenin signaling via a negative-feedback mechanism and that Wnt3a controls the segmentation process in vertebrates...
  29. doi request reprint Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system
    Dirk Junghans
    Max Planck Institute of Immunobiology, Department of Molecular Embryology, 79011 Freiburg, Germany
    Eur J Neurosci 27:559-71. 2008
    ....
  30. ncbi request reprint E-cadherin intron 2 contains cis-regulatory elements essential for gene expression
    Marc P Stemmler
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 132:965-76. 2005
    ..Taken together, our findings reveal a complex mechanism of gene regulation, with a vital role for the large intron 2...
  31. pmc Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein
    A Bauer
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
    Proc Natl Acad Sci U S A 95:14787-92. 1998
    ..We provide evidence for an in vivo multiprotein complex composed of Pontin52, beta-catenin, and lymphocyte enhancer factor-1/T-cell factor. Our results suggest involvement of Pontin52 in the nuclear function of beta-catenin...
  32. ncbi request reprint Expression patterns of Wnt genes in mouse gut development
    H Lickert
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108, Freiburg, Germany
    Mech Dev 105:181-4. 2001
    ..5. Wnt11 is highly expressed at the gastro-esophageal junctions, while Wnt4 is found in the epithelium lining the pyloric region of the stomach but not in the epithelium of the prospective gland region...
  33. ncbi request reprint Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development
    V Brault
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 128:1253-64. 2001
    ..Our results demonstrate the pivotal role of beta-catenin in morphogenetic processes during brain and craniofacial development...
  34. ncbi request reprint Functional analysis of cis-regulatory elements controlling initiation and maintenance of early Cdx1 gene expression in the mouse
    Heiko Lickert
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Dev Dyn 225:216-20. 2002
    ..Our analysis demonstrates that the early Cdx1 expression is regulated through the caudalizing Wnt/beta-catenin and RA activities...
  35. ncbi request reprint From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion
    R Kemler
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Trends Genet 9:317-21. 1993
    ..Catenins are part of a higher order protein structure that is of crucial importance for the adhesive function of cadherins. A working model of the construction and regulation of this multiprotein interaction is proposed...
  36. ncbi request reprint Analysis of regulatory elements of E-cadherin with reporter gene constructs in transgenic mouse embryos
    Marc P Stemmler
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Dev Dyn 227:238-45. 2003
    ..Our analyses show that E-cadherin expression is governed by a complex interplay of multiple regulatory regions dispersed throughout large parts of the locus...
  37. ncbi request reprint Cadherins and tissue formation: integrating adhesion and signaling
    K Vleminckx
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Bioessays 21:211-20. 1999
    ..We discuss how cadherins, through their effects on cell proliferation, cell death, cell polarization, and differentiation, play a role in the formation of tissues and organs in the developing embryo...
  38. ncbi request reprint Protocadherins
    Marcus Frank
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Curr Opin Cell Biol 14:557-62. 2002
    ..In the postnatal brain, protocadherins are possibly involved in the modulation of synaptic transmission and the generation of specific synaptic connections...
  39. ncbi request reprint Differential expression of individual gamma-protocadherins during mouse brain development
    Marcus Frank
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Mol Cell Neurosci 29:603-16. 2005
    ..Thus, a defined set of Pcdhs-gamma may engage in neuronal adhesion and signaling on the cellular level...
  40. ncbi request reprint Beta-catenin-mediated cell-adhesion is vital for embryonic forebrain development
    Dirk Junghans
    Max Planck Institute of Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    Dev Dyn 233:528-39. 2005
    ..In summary, we demonstrate that beta-catenin mediates cell-cell adhesion in the early telencephalon and is vital for maintaining the structural integrity of the neuroepithelium...
  41. ncbi request reprint Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism
    Daniel M Messerschmidt
    Department of Molecular Embryology, Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Dev Biol 344:129-37. 2010
    ..Based on our findings we propose a non-cell autonomous requirement of Nanog for proper PE formation in addition to its essential role in EPI determination...
  42. ncbi request reprint Presenilin-dependent processing and nuclear function of gamma-protocadherins
    Ingrid G Haas
    Max Planck Institute of Immunobiology, Department of Molecular Embryology, Stuebeweg 51, Freiburg D 79108, Germany
    J Biol Chem 280:9313-9. 2005
    ..This is the first report providing experimental evidence for a cell surface receptor signaling function of protocadherins regulated by proteolytic events...
  43. doi request reprint Cdx1::Cre allele for gene analysis in the extraembryonic ectoderm and the three germ layers of mice at mid-gastrulation
    Andreas Hierholzer
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Genesis 47:204-9. 2009
    ..These results indicate that Cdx1::Cre mice are also a valuable tool to study gene function in tissues essential for placental development...
  44. ncbi request reprint E-cadherin is a survival factor for the lactating mouse mammary gland
    Oreda Boussadia
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Mech Dev 115:53-62. 2002
    ..These results demonstrate an essential role for E-cadherin in the function of differentiated alveolar epithelial cells. No tumors were detected in mutant glands lacking E-cadherin...
  45. ncbi request reprint Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability
    Stephan Bek
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    J Cell Sci 115:4743-53. 2002
    ..From these results we conclude that CKII regulates the function of beta-catenin in the cadherin adhesion complex as well as its cytoplasmic stability...
  46. ncbi request reprint Assembly of the cadherin-catenin complex in vitro with recombinant proteins
    H Aberle
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    J Cell Sci 107:3655-63. 1994
    ..The reconstitution in vitro of the cadherin-catenin complex should allow the study of the interaction with signalling molecules and with the actin-based cytoskeleton...
  47. doi request reprint Neural progenitors of the postnatal and adult mouse forebrain retain the ability to self-replicate, form neurospheres, and undergo multipotent differentiation in vivo
    Bettina Neumeister
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Stem Cells 27:714-23. 2009
    ....
  48. ncbi request reprint Mammalian cadherins and protocadherins: about cell death, synapses and processing
    Dirk Junghans
    Max Planck Institute of Immunobiology, Dept of Molecular Embryology, 79108 Freiburg, Germany
    Curr Opin Cell Biol 17:446-52. 2005
    ..In addition, the study of mice lacking the entire protocadherin-gamma cluster shed the first light on a possible novel function of members of this cadherin family in synapse formation and cell survival during development...
  49. ncbi request reprint Direct binding of Lef1 to sites in the boz promoter may mediate pre-midblastula-transition activation of boz expression
    Tinchung Leung
    Developmental Biology, Institute Biology 1, University of Freiburg, Freiburg, Germany
    Dev Dyn 228:424-32. 2003
    ..Thus, the early onset of boz expression may be crucial for organizer establishment in the presence of ubiquitous maternal activators of ventralizing genes...
  50. doi request reprint N-cadherin can structurally substitute for E-cadherin during intestinal development but leads to polyp formation
    Lenka Libusova
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 137:2297-305. 2010
    ..Our experimental model indicates that, in the absence of E-cad, the sole expression of N-cad in an epithelial environment is sufficient to induce neoplastic transformations...
  51. ncbi request reprint N-cadherin transsynaptically regulates short-term plasticity at glutamatergic synapses in embryonic stem cell-derived neurons
    Kay Jüngling
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat Bochum, 44780 Bochum, Germany
    J Neurosci 26:6968-78. 2006
    ..This indicates a retrograde control of short-term plasticity by N-cadherin. In summary, our results revealed an unexpected involvement of a synaptic adhesion molecule in the regulation of short-term plasticity at glutamatergic synapses...
  52. pmc E-cadherin inhibits cell surface localization of the pro-migratory 5T4 oncofetal antigen in mouse embryonic stem cells
    Helen L Spencer
    Centre for Molecular Medicine, Faculty of Medical and Human Sciences, The University of Manchester, Manchester M13 9PT, United Kingdom
    Mol Biol Cell 18:2838-51. 2007
    ..We conclude that E-cadherin protein stabilizes cortical actin cytoskeletal arrangement in ES cells, and this can prevent cell surface localization of the promigratory 5T4 antigen...
  53. ncbi request reprint Conditional inactivation of the E-cadherin gene in thyroid follicular cells affects gland development but does not impair junction formation
    Gaetano Cali
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Richerche, 80131 Naples, Italy
    Endocrinology 148:2737-46. 2007
    ..Our results indicate that E-cadherin has a role in the development of the thyroid gland and in the expression of beta-catenin, but it is not essential for the maintenance of follicular cell adhesion...
  54. ncbi request reprint N-cadherin deficiency impairs pericyte recruitment, and not endothelial differentiation or sprouting, in embryonic stem cell-derived angiogenesis
    Emmanuelle Tillet
    Laboratoire de Développement et Vieillissement de l Endothélium, INSERM EMI 0219 CEA Joseph Fourier University, Grenoble, France
    Exp Cell Res 310:392-400. 2005
    ..We conclude that N-cadherin is necessary neither for vasculogenesis nor proliferation and migration of endothelial cells but is required for the subsequent maturation of endothelial sprouts by interacting with pericytes...
  55. ncbi request reprint Le(x) glycan mediates homotypic adhesion of embryonal cells independently from E-cadherin: a preliminary note
    Kazuko Handa
    Division of Biomembrane Research, Pacific Northwest Research Institute, Department of Pathobiology, University of Washington, Seattle, WA 98122, USA
    Biochem Biophys Res Commun 358:247-52. 2007
    ..Thus, ES or EC cells display autoaggregation and strong adhesion to Le(x)-coated plates in the absence of Ecad, further supporting the notion of Le(x) self-recognition (i.e., Le(x)-to-Le(x) interaction) in cell adhesion...
  56. pmc Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis
    Lizhu Lin
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:9313-8. 2007
    ..Our findings demonstrate that beta-catenin signaling regulates proliferation and survival of cardiac progenitors...
  57. ncbi request reprint Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos
    Heiko Lickert
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada
    Development 132:2599-609. 2005
    ..This functional genomic approach allows the rapid identification of functionally important components of embryonic development from large datasets of putative targets...
  58. pmc Lineage-specific requirements of beta-catenin in neural crest development
    Lisette Hari
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    J Cell Biol 159:867-80. 2002
    ..We propose that the requirement of beta-catenin for the specification of melanocytes and sensory neuronal lineages reflects roles of beta-catenin both in Wnt signaling and in mediating cell-cell interactions...
  59. pmc Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge
    Jeffery R Barrow
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 17:394-409. 2003
    ..Finally, we demonstrate that Wnt/beta-catenin signaling lies upstream of the Bmp signaling pathway in establishment of the AER and regulation of the dorsoventral polarity of the limb...
  60. ncbi request reprint Reptin and pontin antagonistically regulate heart growth in zebrafish embryos
    Wolfgang Rottbauer
    Cardiovascular Research Center, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
    Cell 111:661-72. 2002
    ..Pontin reduction phenocopies the cardiac hyperplasia of the lik mutation. Thus, the Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway...
  61. ncbi request reprint beta-Catenin is not required for proliferation and differentiation of epidermal mouse keratinocytes
    Horst Posthaus
    Institute of Animal Pathology, University of Bern, Länggassstr 122, 3012 Bern, Switzerland
    J Cell Sci 115:4587-95. 2002
    ..Taken together, our results demonstrate that epidermal proliferation and adhesion are independent of beta-catenin...
  62. pmc Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148
    Maria Grazia Lampugnani
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    J Cell Biol 161:793-804. 2003
    ..In sparse cells or in VE-cadherin-null cells, this phenomenon cannot occur and the receptor is fully activated by the growth factor...
  63. pmc The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility
    Anna Cattelino
    FIRC Institute of Molecular Oncology, 16 20139, Milan, Italy
    J Cell Biol 162:1111-22. 2003
    ..This may become more marked when the vessels are exposed to high or turbulent flow, such as at bifurcations or in the beating heart, leading to fluid leakage or hemorrhages...
  64. pmc E-cadherin controls adherens junctions in the epidermis and the renewal of hair follicles
    Peter Young
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    EMBO J 22:5723-33. 2003
    ..We conclude that E-cadherin is required for maintaining the adhesive properties of adherens junctions in keratinocytes and proper skin differentiation. Furthermore, continuous hair follicle cycling is dependent on E-cadherin...
  65. ncbi request reprint E-cadherin is required for the correct formation of autotypic adherens junctions of the outer mesaxon but not for the integrity of myelinated fibers of peripheral nerves
    Peter Young
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Mol Cell Neurosci 21:341-51. 2002
    ..We conclude that E-cadherin is required for the proper establishment and/or the maintenance of the outer mesaxon in myelinated PNS fibers but is dispensable for proper nerve function...
  66. ncbi request reprint Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells
    Hye Youn Lee
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Science 303:1020-3. 2004
    ..Moreover, Wnt1 is able to instruct early NCSCs (eNCSCs) to adopt a sensory neuronal fate in a beta-catenin-dependent manner. Thus, the role of Wnt/beta-catenin in stem cells is cell-type dependent...
  67. pmc Beta-catenin is dispensable for hematopoiesis and lymphopoiesis
    Monica Cobas
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
    J Exp Med 199:221-9. 2004
    ..In contrast to earlier reports, these data exclude an essential role for beta-catenin during hematopoiesis and lymphopoiesis...
  68. ncbi request reprint Maternal beta-catenin and E-cadherin in mouse development
    Wilhelmine N de Vries
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Development 131:4435-45. 2004
    ..This developmental deficit is alleviated by the simultaneous absence of maternal E-cadherin, suggesting that E-cadherin regulates nuclear beta-catenin availability during embryonic genome activation...
  69. pmc Genetic dissection of cadherin function during nephrogenesis
    Ulf Dahl
    Department of Medical Biochemistry, Goteborg University, S 405 30 Goteborg, Sweden
    Mol Cell Biol 22:1474-87. 2002
    ..Surprisingly, however, in none of the compound knockout strains was kidney development affected to a greater extent than within the individual cadherin knockout strains...
  70. pmc E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
    Judith A Tunggal
    Center for Molecular Medicine, University of Cologne CMMC, Cologne, Germany
    EMBO J 24:1146-56. 2005
    ..Surprisingly, our results indicate that E-cadherin is specifically required for tight junction, but not desmosome, formation and this appears to involve signalling rather than cell contact formation...
  71. ncbi request reprint Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development
    Chrissa Kioussi
    Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, CMM West, Room 345, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 111:673-85. 2002
    ....
  72. ncbi request reprint Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis
    Ute Koch
    Swiss Institute for Experimental Cancer Research ISREC, Ecole Polytechnique Federale de Lausanne EPFL, Epalinges, Switzerland
    Blood 111:160-4. 2008
    ..These results exclude an essential role for canonical Wnt signaling (as mediated by beta- and/or gamma-catenin) during hematopoiesis and lymphopoiesis...
  73. pmc beta-Catenin regulates excitatory postsynaptic strength at hippocampal synapses
    Takashi Okuda
    Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit, Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 104:13479-84. 2007
    ..Collectively, these findings suggest that the cadherin-beta-catenin complex is an integral component of synaptic strength regulation and plays a basic role in coupling synapse function and spine morphology...
  74. ncbi request reprint Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function
    Jana Kreslova
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Genesis 45:157-68. 2007
    ..These data suggest that, outside of the normal lens, beta-catenin functions as a coactivator of canonical Wnt signaling to suppress lens fate...
  75. ncbi request reprint Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination
    Lorin E Olson
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 125:593-605. 2006
    ....
  76. ncbi request reprint Long-range upstream and downstream enhancers control distinct subsets of the complex spatiotemporal Sox9 expression pattern
    Stefan Bagheri-Fam
    Institute of Human Genetics and Anthropology, University of Freiburg, Breisacherstr 33, D 79106 Freiburg, Germany
    Dev Biol 291:382-97. 2006
    ....