Takashi Hiiragi

Summary

Affiliation: Max-Planck Institute of Immunobiology
Country: Germany

Publications

  1. ncbi request reprint First cleavage plane of the mouse egg is not predetermined but defined by the topology of the two apposing pronuclei
    Takashi Hiiragi
    Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Nature 430:360-4. 2004
  2. ncbi request reprint Mechanism of first cleavage specification in the mouse egg: is our body plan set at day 0?
    Takashi Hiiragi
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Cell Cycle 4:661-4. 2005
  3. ncbi request reprint Fatal flaws in the case for prepatterning in the mouse egg
    Takashi Hiiragi
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Reprod Biomed Online 12:150-2. 2006
  4. doi request reprint Dynamic rearrangement of surface proteins is essential for cytokinesis
    Tobias Bauer
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg D 79108, Germany
    Genesis 46:152-62. 2008
  5. ncbi request reprint [Unique principles in early mammalian development]
    Takashi Hiiragi
    Max Planck Institute for Molecular Biomedicine
    Tanpakushitsu Kakusan Koso 53:720-6. 2008
  6. ncbi request reprint Where do we stand now? Mouse early embryo patterning meeting in Freiburg, Germany (2005)
    Takashi Hiiragi
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Int J Dev Biol 50:581-6; discussion 586-7. 2006
  7. ncbi request reprint Embryology: does prepatterning occur in the mouse egg?
    Takashi Hiiragi
    Max Planck Institute of Immunobiology, 79108 Freiburg, Germany
    Nature 442:E3-4; discussion E4. 2006
  8. pmc Space asymmetry directs preferential sperm entry in the absence of polarity in the mouse oocyte
    Nami Motosugi
    Max Planck Institute of Immunobiology, Freiburg, Germany
    PLoS Biol 4:e135. 2006
  9. ncbi request reprint Stochastic patterning in the mouse pre-implantation embryo
    Jens Erik Dietrich
    Max Planck Institute of Immunobiology, Department of Developmental Biology, Freiburg i Br, Germany
    Development 134:4219-31. 2007
  10. pmc Polarity of the mouse embryo is established at blastocyst and is not prepatterned
    Nami Motosugi
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg D 79108, Germany
    Genes Dev 19:1081-92. 2005

Detail Information

Publications14

  1. ncbi request reprint First cleavage plane of the mouse egg is not predetermined but defined by the topology of the two apposing pronuclei
    Takashi Hiiragi
    Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Nature 430:360-4. 2004
    ..The microtubule networks that allow mixing of parental chromosomes before dividing into two may be involved in these processes...
  2. ncbi request reprint Mechanism of first cleavage specification in the mouse egg: is our body plan set at day 0?
    Takashi Hiiragi
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Cell Cycle 4:661-4. 2005
    ..In this review we will elucidate the discrepancy between the previous model and our model, and discuss the possible causes...
  3. ncbi request reprint Fatal flaws in the case for prepatterning in the mouse egg
    Takashi Hiiragi
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Reprod Biomed Online 12:150-2. 2006
    ..However, in order to resolve this controversy it is essential to read relevant reports carefully without bias and to provide data on which a particular claim is based...
  4. doi request reprint Dynamic rearrangement of surface proteins is essential for cytokinesis
    Tobias Bauer
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg D 79108, Germany
    Genesis 46:152-62. 2008
    ..We propose that dynamic rearrangement of the cell surface proteins is a common feature of cytokinesis, playing a key role in modifying the mechanical properties of the cell membrane during cortical ingression...
  5. ncbi request reprint [Unique principles in early mammalian development]
    Takashi Hiiragi
    Max Planck Institute for Molecular Biomedicine
    Tanpakushitsu Kakusan Koso 53:720-6. 2008
  6. ncbi request reprint Where do we stand now? Mouse early embryo patterning meeting in Freiburg, Germany (2005)
    Takashi Hiiragi
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Int J Dev Biol 50:581-6; discussion 586-7. 2006
    ..However, if the "prepatterning model" is correct, the latter will require critical reassessment...
  7. ncbi request reprint Embryology: does prepatterning occur in the mouse egg?
    Takashi Hiiragi
    Max Planck Institute of Immunobiology, 79108 Freiburg, Germany
    Nature 442:E3-4; discussion E4. 2006
    ..Here we investigate the origin of these different views and conclude that they arise from differences in the data themselves and in their interpretation...
  8. pmc Space asymmetry directs preferential sperm entry in the absence of polarity in the mouse oocyte
    Nami Motosugi
    Max Planck Institute of Immunobiology, Freiburg, Germany
    PLoS Biol 4:e135. 2006
    ..Based on these experiments, we propose a model in which the space asymmetry exerted by the first polar body and the zona pellucida directs sperm entry preferentially to the polar body half, with no need for oocyte polarity...
  9. ncbi request reprint Stochastic patterning in the mouse pre-implantation embryo
    Jens Erik Dietrich
    Max Planck Institute of Immunobiology, Department of Developmental Biology, Freiburg i Br, Germany
    Development 134:4219-31. 2007
    ..This may represent a feature unique to early mammalian development...
  10. pmc Polarity of the mouse embryo is established at blastocyst and is not prepatterned
    Nami Motosugi
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg D 79108, Germany
    Genes Dev 19:1081-92. 2005
    ..We propose that these mechanical cues, in conjunction with the epithelial seal in the outer cell layer, lead to specification of the embryonic-abembryonic axis, thus establishing first polarity in the mouse embryo...
  11. doi request reprint Hypomethylation of paternal DNA in the late mouse zygote is not essential for development
    Zbigniew Polanski
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Int J Dev Biol 52:295-8. 2008
    ....
  12. ncbi request reprint Reprogramming is essential in nuclear transfer
    Takashi Hiiragi
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Mol Reprod Dev 70:417-21. 2005
    ..All these results enable us to distinguish more clearly between the inherent problem of reprogramming and technical problems associated with materials, manipulation, and in vitro culture...
  13. doi request reprint Computer simulation of emerging asymmetry in the mouse blastocyst
    Hisao Honda
    Hyogo University, Kakogawa, Hyogo 675 0195, Japan
    Development 135:1407-14. 2008
    ..These results reveal a unique feature of early mammalian development: an asymmetry may emerge autonomously in an equivalent population with no need for a priori intrinsic differences...
  14. doi request reprint Stochastic processes during mouse blastocyst patterning
    Jens Erik Dietrich
    Max Planck Institute for Molecular Biomedicine, Mammalian Development Laboratory, Munster, Germany
    Cells Tissues Organs 188:46-51. 2008
    ..Here we discuss findings that suggest the involvement of stochastic processes and the influence of external cues in the patterning process during mouse preimplantation development...