Research Topics
Genomes and Genes | T BoehmSummaryAffiliation: Max-Planck Institute of Immunobiology Country: Germany Publications
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Publications
Same function, different origins: multipotent stromal precursors in lymphoid tissuesThomas Boehm
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany Electronic address
Cell Stem Cell 12:501-3. 2013..Recently, in Immunity, Castagnaro et al. (2013) identified multipotent mesenchymal precursors that specifically give rise to stromal cell types in the spleen, but not other lymphoid tissue, and support injury-induced regeneration...- Evolution of vertebrate immunityThomas Boehm
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, D 79108 Freiburg, Germany
Curr Biol 22:R722-32. 2012..Moreover, informed by phylogenetic considerations and inspired by improved knowledge of functional networks, new avenues emerge for innovative therapeutic strategies... - Caught in the act: reprogramming of adipocytes into lymph-node stromaThomas Boehm
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany Electronic address
Immunity 37:596-8. 2012..In this issue of Immunity, Bénézech et al. demonstrate that adipocyte precursors give rise to lymph-node stromal organizer cells, illuminating an important step in lymphoid-tissue development... 
Self-renewal of thymocytes in the absence of competitive precursor replenishmentThomas Boehm
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, D 79108 Freiburg, Germany
J Exp Med 209:1397-400. 2012..These new findings suggest that early thymocytes do indeed have substantial self-renewing potential...- Evolution of the immune system in the lower vertebratesThomas Boehm
Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany
Annu Rev Genomics Hum Genet 13:127-49. 2012..The discovery of conserved features of adaptive immunity will guide attempts to generate synthetic immunological functionalities and thus provide new avenues for intervening with faulty immune functions in humans... - Evolution of lymphoid tissuesThomas Boehm
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, D 79108 Freiburg, Germany
Trends Immunol 33:315-21. 2012..Such information has guided recent attempts at reconstructing lymphopoietic functions in vivo and in the future might inspire the development of new strategies for medical interventions restoring and modulating immune functions... - VLR-based adaptive immunityThomas Boehm
Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany
Annu Rev Immunol 30:203-20. 2012..The discovery of VLRs in agnathans illuminates the origins of adaptive immunity in early vertebrates... - The adaptive phenotype of cortical thymic epithelial cellsThomas Boehm
Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg, Freiburg, Germany
Eur J Immunol 39:944-7. 2009..Nevertheless, it appears that Prss16 has later evolved as an essential contributor to the MHC class II peptide/ligand repertoire... 
The evolutionary history of lymphoid organsThomas Boehm
Max Planck Institute of Immunobiology, D 79279 Freiburg, Germany
Nat Immunol 8:131-5. 2007....- Quality control in self/nonself discriminationThomas Boehm
Department of Developmental Immunology, Max Planck Institute of Immunobiology, Freiburg, Germany
Cell 125:845-58. 2006..Recent advances in understanding self/nonself discrimination in eukaryotes shed new light on the emergence of the most sophisticated self/nonself discrimination system known, the antigen receptors employed in the adaptive immune system... - Thymus-homing precursors and the thymic microenvironmentThomas Boehm
Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg, 51 D 79108, Freiburg, Germany
Trends Immunol 27:477-84. 2006.... - Co-evolution of a primordial peptide-presentation system and cellular immunityThomas Boehm
Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
Nat Rev Immunol 6:79-84. 2006.... - MHC peptides and the sensory evaluation of genotypeThomas Boehm
Department of Developmental Immunology, Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
Trends Neurosci 29:100-7. 2006..These findings provide a molecular mechanism by which an individual can sense the composition and compatibility of vital immune system molecules of a conspecific, with direct consequences for social behavior... - Design principles of adaptive immune systemsThomas Boehm
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, D 79108 Freiburg, Germany
Nat Rev Immunol 11:307-17. 2011.... - Laser capture microdissection-based expression profiling identifies PD1-ligand as a target of the nude locus gene productC C Bleul
MPI für Immunbiologie, Freiburg, Germany
Eur J Immunol 31:2497-503. 2001..The presented results support our prediction that this systematic approach by gene expression profiling yields regulators of thymopoiesis... - Thymus development and functionThomas Boehm
Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
Curr Opin Immunol 20:178-84. 2008..This review also addresses new experimental approaches toward a better understanding of thymopoiesis and discusses the impact of new animal models... - Gene structure, chromosomal localization, and expression pattern of Capn12, a new member of the calpain large subunit gene familyT N Dear
Max Planck Institute for Immunobiology, Stuebeweg 51, Freiburg, D 79108, Germany
Genomics 68:152-60. 2000..4 cM. Refined mapping of Capn5, also previously localized to chromosome 7, indicated that it was not closely linked to Capn12, mapping tightly linked to a marker positioned at 48.5 cM... - Formation of regulator/target gene relationships during evolutionT Schlake
Max Planck Institut fur Immunbiologie, Stubeweg 51, 79108, Freiburg, Germany
Gene 256:29-34. 2000.... - Identification and characterization of two novel calpain large subunit genesT N Dear
Department of Developmental Immunology, Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
Gene 274:245-52. 2001..The 13 human large subunit genes and the single small subunit gene are located in eight syntenic groups on chromosomes 1, 2, 3, 6, 11, 15, 19 and X... - Expression domains in the skin of genes affected by the nude mutation and identified by gene expression profilingT Schlake
Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108, Freiburg, Germany
Mech Dev 109:419-22. 2001..Our results identify metallothionein IV among these genes. This is the first report on metallothionein IV expression in the murine hair follicle; its expression domain almost completely overlaps that of Whn... - Genetically separable determinants of hair keratin gene expressionM Schorpp
Department of Developmental Immunology, Max Planck Institute of Immunobiology, Freiburg, Germany
Dev Dyn 218:537-43. 2000..Our results indicate that the molecular consequences of mutations of the Whn gene can be different and demonstrate an unexpected complexity of transcriptional control mechanisms of hair keratin genes... - CAPN11: A calpain with high mRNA levels in testis and located on chromosome 6T N Dear
Max Planck Institute for Immunobiology, Stuebeweg 51, Freiburg, D 79108, Germany
Genomics 59:243-7. 1999..The discovery of this new calpain emphasizes the complexity of the calpain family, with members being distinguished on the basis of protease activity, calcium dependence, and tissue expression... - Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during developmentT N Dear
Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108, Freiburg, Germany
Mech Dev 89:201-9. 1999..Capn11 mRNA is restricted exclusively to spermatocytes and only during the later stages of meiosis... - Abnormal bone marrow stroma in mice deficient for nemo-like kinase, NlkM Kortenjann
Max Planck Institute for Immunobiology, Freiburg, Germany
Eur J Immunol 31:3580-7. 2001..Nlk deficient mice thus provide a novel model to study the genetic requirements for bone marrow stromal differentiation... - Only one nemo-like kinase gene homologue in invertebrate and mammalian genomesM Kortenjann
Max Planck Institut fur Immunbiologie, Stubeweg 51, 79108 Freiburg, Germany
Gene 278:161-5. 2001.... - Chemokines define distinct microenvironments in the developing thymusC C Bleul
Max Planck Institut fur Immunbiologie, Freiburg, Germany
Eur J Immunol 30:3371-9. 2000..The complexity of these chemokine-defined microenvironments increases as the thymic anlage develops to a mature thymus... - Evolutionary conservation of gene structures of the Pax1/9 gene familyC Hetzer-Egger
Department of Developmental Immunology, Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108, Freiburg, Germany
Biochim Biophys Acta 1492:517-21. 2000..AmphiPax1 is expressed in adult amphioxus in the pharyngeal endoderm... - A novel serine protease overexpressed in the hair follicles of nude miceN Meier
Department of Developmental Immunology, Max Planck Institute for Immunobiology, Stuebeweg 51, Freiburg, D 79108, Germany
Biochem Biophys Res Commun 258:374-8. 1999..Thus, BSSP is the first serine protease known to be expressed in the sebaceous gland. In nude mouse skin, this gene is overexpressed... - Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: molecular analysis of the nude skin phenotypeT Schlake
Department of Developmental Immunology, Max Planck Institute for Immunobiology, Freiburg, Germany
Dev Dyn 217:368-76. 2000..Our results implicate Whn as a transcriptional regulator of hair keratin genes and reveal the nude phenotype as the first example of an inherited skin disorder that is caused by loss of expression rather than mutation of keratin genes... - Spontaneous mutations in SELH/Bc mice due to insertions of early transposons: molecular characterization of null alleles at the nude and albino lociM Hofmann
Department of Developmental Immunology, Max-Planck-Institute for Immunology, Freiburg, Germany
Genomics 52:107-9. 1998 - Major shifts in genomic activity accompany progression through different stages of the hair cycleThomas Schlake
Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
Gene Expr Patterns 4:141-52. 2004..Expression of insulin-like growth factor binding proteins and anti-angiogenic factors is associated with the regression phase of the hair cycle... - Morpholino oligonucleotide-triggered knockdown reveals a role for maternal E-cadherin during early mouse developmentBenoit Kanzler
Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
Mech Dev 120:1423-32. 2003..Our study thus reveals a previously unanticipated role of maternal E-cadherin during early stages of mouse development... - Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaRThomas Boehm
Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
J Exp Med 198:757-69. 2003.... - Maintenance of thymic epithelial phenotype requires extrinsic signals in mouse and zebrafishCristian Soza-Ried
Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg, Freiburg, Germany
J Immunol 181:5272-7. 2008..These results indicate an evolutionarily conserved role of BMP signaling in the maintenance of Foxn1 expression... - Ltbetar signaling does not regulate Aire-dependent transcripts in medullary thymic epithelial cellsVera C Martins
Max Planck Institute for Immunobiology, Department for Developmental Immunology, Freiburg, Germany
J Immunol 181:400-7. 2008..We propose that the physiological medullary architecture ensures negative-selection by supporting lympho-epithelial interaction through a large epithelial cell surface distributed evenly across the medulla... - A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr miceA Poltorak
The Scripps Research Institute, La Jolla, CA 92037 Max Planck Institut für Immunbiologie, Freiburg, Germany
J Immunol 167:2106-11. 2001..Because the phosphorylation of STAT4 is a prerequisite for the IL-12-mediated induction of IFN-gamma, its absence in Cr mice is responsible for their defective IFN-gamma response to microorganisms... - Back to the beginning--the quest for thymic epithelial stem cellsJeremy B Swann
Department of Developmental Immunology, Max Planck Institute of Immunobiology, Freiburg, Germany
Eur J Immunol 37:2364-6. 2007..This finding demonstrates that much progress needs to be made before thymic epithelial stem cells can be harnessed for clinical benefit... - Evolution of genetic networks underlying the emergence of thymopoiesis in vertebratesBaubak Bajoghli
Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
Cell 138:186-97. 2009..Our results provide a framework elucidating the evolution of key features of the adaptive immune system in jawed vertebrates... - Everything in its placeJeremy B Swann
Max Planck Institute of Immunobiology, Department of Developmental Immunology, D 79108 Freiburg, Germany
Immunity 31:856-8. 2009..2009) define the thymic midcortex as a functionally inert zone between subcapsular and cortico-medullary regions, and Ehrlich et al. (2009) infer that structural features of the cortex and medulla regulate migration of thymocytes... - Thymopoiesis requires Pax9 function in thymic epithelial cellsClaudia Hetzer-Egger
Max Planck Institut fur Immunbiologie, Freiburg, Germany
Eur J Immunol 32:1175-81. 2002..Whereas expression of TCRbeta chain genes is readily detectable in the mutant thymus, no expression of the TCRgamma chain was detectable. Our results identify a new genetically defined control point of thymopoiesis... - A zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudimentMichael Schorpp
Department of Developmental Immunology, Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
Mech Dev 118:179-85. 2002..Our results provide the first specific marker for the epithelial compartment of the zebrafish thymus... - Genetic dissection of thymus development in mouse and zebrafishThomas Boehm
Department of Developmental Immunology, Max Planck Institute of Immunobiology, Freiburg, Germany
Immunol Rev 195:15-27. 2003..Strengths and weaknesses of mouse and zebrafish models are largely complementary such that genetic analysis of mouse and zebrafish mutants may lead to a better understanding of thymus development... - Aortic arch and pharyngeal phenotype in the absence of BMP-dependent neural crest in the mouseSabine Ohnemus
Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
Mech Dev 119:127-35. 2002.... - Capn5 is expressed in a subset of T cells and is dispensable for developmentTanna Franz
Department of Developmental Immunology, Max Planck Institute for Immunobiology, D 79108 Freiburg, Germany
Mol Cell Biol 24:1649-54. 2004..There was no evidence for the development of autoimmune disease in Capn5-null animals. However, a small proportion of homozygous null offspring from heterozygous matings were runted and most often did not survive to adulthood... - Capn7: a highly divergent vertebrate calpain with a novel C-terminal domainT Franz
Max-Planck Institute for Immunobiology, Stuebeweg 51, D-79108 Freiburg, Germany
Mamm Genome 10:318-21. 1999 - Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineageTatiana Corbeaux
Max Planck Institute of Immunobiology, Freiburg D 79108, Germany
Proc Natl Acad Sci U S A 107:16613-8. 2010..Our findings therefore support the notion that Foxn1 is the essential transcription factor regulating the differentiation of TECs and that its expression marks the major functional lineage of TECs in embryonic and adult thymic tissue... - Essential role of c-myb in definitive hematopoiesis is evolutionarily conservedCristian Soza-Ried
Department of Developmental Immunology, Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
Proc Natl Acad Sci U S A 107:17304-8. 2010..Our results, therefore, suggest that the key role of c-myb in definitive hematopoiesis is similar to that in mammals and must have become established early in vertebrate evolution... - BMP signaling is required for normal thymus developmentConrad C Bleul
Department of Developmental Immunology, Max Planck Institute of Immunobiology, Freiburg, Germany
J Immunol 175:5213-21. 2005..Our data demonstrate that BMP signaling is crucial for thymus development and that it is the thymic stroma rather than developing thymocytes that depends on BMP signals... - Formation of a functional thymus initiated by a postnatal epithelial progenitor cellConrad C Bleul
Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
Nature 441:992-6. 2006..Thus, single epithelial progenitor cells can give rise to a complete and functional thymic microenvironment, suggesting that cell-based therapies could be developed for thymus disorders... - Developing T lymphocytes are uniquely sensitive to a lack of topoisomerase III alphaMaren Mönnich
Department of Developmental Immunology, Max Planck Institute of Immunobiology, Freiburg, Germany
Eur J Immunol 40:2379-84. 2010..Deficiency in top3a activates a p53-dependent check-point but does not affect VDJ recombination. Our results suggest that TOP3A could be a candidate gene involved in human primary immunodeficiency syndromes... - B-1a B cells that link the innate and adaptive immune responses are lacking in the absence of the spleenHedda Wardemann
Department of Developmental Immunology, Max Planck Institute for Immunobiology, Freiburg 79108, Germany
J Exp Med 195:771-80. 2002..These findings reveal a hitherto unknown role of the spleen in generating and maintaining the B-1a B cell pool... - Conserved functions of Ikaros in vertebrate lymphocyte development: genetic evidence for distinct larval and adult phases of T cell development and two lineages of B cells in zebrafishMichael Schorpp
Department of Developmental Immunology, Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
J Immunol 177:2463-76. 2006..By contrast, B cells expressing the igz isotype do not develop, providing genetic evidence for two separate B cell lineages in zebrafish. Thus, Ikaros appears to play similar roles in fish and mammalian lymphopoiesis... - Mate choice decisions of stickleback females predictably modified by MHC peptide ligandsManfred Milinski
Department of Evolutionary Ecology, Max Planck Institute of Limnology, 24306 Plön, Germany
Proc Natl Acad Sci U S A 102:4414-8. 2005..Our results suggest that female sticklebacks use evolutionarily conserved structural features of MHC peptide ligands to evaluate MHC diversity of their prospective mating partners... - Evidence for a functional second thymus in miceGrzegorz Terszowski
Department of Immunology, University of Ulm, D 89081 Ulm, Germany
Science 312:284-7. 2006..The identification of a regular second thymus in the mouse may provide evolutionary links to thymus organogenesis in other vertebrates and suggests a need to reconsider the effect of thoracic thymectomy on de novo T cell production... - Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestrationThomas Boehm
Laboratory for Molecular Biology, Gene Center, University of Munich, Feodor Lynen Strasse 25, D 81377 Munich, Germany
EMBO J 22:1014-24. 2003..These findings outline a novel mechanism of signal chain abrogation through sequestration of a limiting component by specific protein-protein interactions... - MHC class I peptides as chemosensory signals in the vomeronasal organTrese Leinders-Zufall
Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Science 306:1033-7. 2004..MHC peptides constitute a previously unknown family of chemosensory stimuli by which MHC genotypic diversity can influence social behavior... - Susceptibility to anthrax lethal toxin is controlled by three linked quantitative trait lociRyan D McAllister
Department of Microbiology, University of Illinois, Urbana, IL, USA
Am J Pathol 163:1735-41. 2003..Additionally, to recapitulate dominant resistance to mortality as seen in (BALB/c x DBA/2) F(1) hybrids, DBA/2 alleles are required at all three QTL... - Visualization of congenital thoracic vascular anomalies using multi-detector row computed tomography and two- and three-dimensional post-processingThomas Schertler
Department of Medical Radiology, Institute of Diagnostic Radiology, University Hospital Zurich, Switzerland
Eur J Radiol 61:97-119. 2007..We present cases of rare congenital anomalies of the thoracic vessels using MDCT with special respect to 2D- and 3D-post-processing... - Image quality of volume rendering of the bronchial tree: Kymogram-gated versus retrospectively ECG-gated and non-gated multi-row detector CTThomas Boehm
Department of Radiology, Spitäler Chur AG, Loestrasse 170, CH 7000 Chur, Switzerland
Acad Radiol 12:173-81. 2005..To compare the image quality of three different heart-cycle-synchronized computed tomography (CT) reconstruction algorithms for volume-rendered (VR) 3D visualization of the bronchial tree... - Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron diseaseHeike Bommel
Institute of Clinical Neurobiology, University of Wurzburg, 97080 Wurzburg, Germany
J Cell Biol 159:563-9. 2002..Thus, the pmn gene mutation provides the first genetic evidence that alterations in tubulin assembly lead to retrograde degeneration of motor axons, ultimately resulting in motoneuron cell death... - Essential role of the main olfactory system in social recognition of major histocompatibility complex peptide ligandsMarc Spehr
Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Neurosci 26:1961-70. 2006..These results suggest a general role for MHC peptides in chemical communication even in those vertebrates that lack a functional VNO... - Computational fluid dynamics: hemodynamic changes in abdominal aortic aneurysm after stent-graft implantationThomas Frauenfelder
Institute of Diagnostic Radiology, University Hospital of Zurich, Zurich, Switzerland
Cardiovasc Intervent Radiol 29:613-23. 2006..CFD is a highly promising technique and improves our understanding of the local structural and fluid dynamic conditions for abdominal aortic stent placement... - Dynamic cine mode imaging of the normal aortic valve using 16-channel multidetector row computed tomographyBernhard Baumert
Institute of Diagnostic Radiology, University Hospital Zurich, Switzerland
Invest Radiol 40:637-47. 2005..Further studies regarding assessment of diseased valves are necessary... - Computerized modeling based on spiral CT data for noninvasive determination of aortic stent-graft lengthAlbert Rott
Institut für Diagnostische und Interventionelle Radiologie, Friedric Schiller Universität Jena, Germany
J Endovasc Ther 9:520-8. 2002..To preprocedurally determine the correct length of a nonbifurcated endovascular prosthesis for abdominal aortic aneurysm (AAA) repair using a computerized model... - CT angiography of peripheral arterial bypass grafts: Accuracy and time-effectiveness of quantitative image analysis with an automated software toolDenise Keller
Institute of Diagnostic Radiology, University Hospital Zurich, Raemistrasse 100, CH-8091 Zurich
Acad Radiol 13:610-20. 2006..It may assist in determining the significance of an abnormality and can yield objective morphometric data of vessel calibers... - Image quality of the aortic and mitral valve with CT: relative versus absolute delay reconstructionThomas Boehm
Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland
Acad Radiol 14:613-24. 2007..The purpose of this study was to compare image quality and artifacts of 16-detector row CT imaging of the aortic and mitral valve when performing ECG-gated synchronization using relative and absolute reconstructions...