T Boehm

Summary

Affiliation: Max-Planck Institute of Immunobiology
Country: Germany

Publications

  1. pmc Major histocompatibility complex peptide ligands as olfactory cues in human body odour assessment
    Manfred Milinski
    Department of Evolutionary Ecology, Max Planck Institute of Evolutionary Biology, August Thienemann Strasse 2, 24306 Ploen, Germany
    Proc Biol Sci 280:20122889. 2013
  2. doi request reprint Same function, different origins: multipotent stromal precursors in lymphoid tissues
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany
    Cell Stem Cell 12:501-3. 2013
  3. doi request reprint Evolution of vertebrate immunity
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, D 79108 Freiburg, Germany
    Curr Biol 22:R722-32. 2012
  4. doi request reprint Caught in the act: reprogramming of adipocytes into lymph-node stroma
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany Electronic address
    Immunity 37:596-8. 2012
  5. pmc Self-renewal of thymocytes in the absence of competitive precursor replenishment
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, D 79108 Freiburg, Germany
    J Exp Med 209:1397-400. 2012
  6. doi request reprint Evolution of the immune system in the lower vertebrates
    Thomas Boehm
    Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany
    Annu Rev Genomics Hum Genet 13:127-49. 2012
  7. doi request reprint Evolution of lymphoid tissues
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, D 79108 Freiburg, Germany
    Trends Immunol 33:315-21. 2012
  8. pmc VLR-based adaptive immunity
    Thomas Boehm
    Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany
    Annu Rev Immunol 30:203-20. 2012
  9. ncbi request reprint The evolutionary history of lymphoid organs
    Thomas Boehm
    Max Planck Institute of Immunobiology, D 79279 Freiburg, Germany
    Nat Immunol 8:131-5. 2007
  10. ncbi request reprint Thymus development and function
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Curr Opin Immunol 20:178-84. 2008

Collaborators

Detail Information

Publications67

  1. pmc Major histocompatibility complex peptide ligands as olfactory cues in human body odour assessment
    Manfred Milinski
    Department of Evolutionary Ecology, Max Planck Institute of Evolutionary Biology, August Thienemann Strasse 2, 24306 Ploen, Germany
    Proc Biol Sci 280:20122889. 2013
    ..This may provide a basis for the sensory evaluation of potential partners during human mate choice...
  2. doi request reprint Same function, different origins: multipotent stromal precursors in lymphoid tissues
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany
    Cell Stem Cell 12:501-3. 2013
    ..Recently, in Immunity, Castagnaro et al. (2013) identified multipotent mesenchymal precursors that specifically give rise to stromal cell types in the spleen, but not other lymphoid tissue, and support injury-induced regeneration...
  3. doi request reprint Evolution of vertebrate immunity
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, D 79108 Freiburg, Germany
    Curr Biol 22:R722-32. 2012
    ..Moreover, informed by phylogenetic considerations and inspired by improved knowledge of functional networks, new avenues emerge for innovative therapeutic strategies...
  4. doi request reprint Caught in the act: reprogramming of adipocytes into lymph-node stroma
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany Electronic address
    Immunity 37:596-8. 2012
    ..In this issue of Immunity, Bénézech et al. demonstrate that adipocyte precursors give rise to lymph-node stromal organizer cells, illuminating an important step in lymphoid-tissue development...
  5. pmc Self-renewal of thymocytes in the absence of competitive precursor replenishment
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, D 79108 Freiburg, Germany
    J Exp Med 209:1397-400. 2012
    ..These new findings suggest that early thymocytes do indeed have substantial self-renewing potential...
  6. doi request reprint Evolution of the immune system in the lower vertebrates
    Thomas Boehm
    Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany
    Annu Rev Genomics Hum Genet 13:127-49. 2012
    ..The discovery of conserved features of adaptive immunity will guide attempts to generate synthetic immunological functionalities and thus provide new avenues for intervening with faulty immune functions in humans...
  7. doi request reprint Evolution of lymphoid tissues
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, D 79108 Freiburg, Germany
    Trends Immunol 33:315-21. 2012
    ..Such information has guided recent attempts at reconstructing lymphopoietic functions in vivo and in the future might inspire the development of new strategies for medical interventions restoring and modulating immune functions...
  8. pmc VLR-based adaptive immunity
    Thomas Boehm
    Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany
    Annu Rev Immunol 30:203-20. 2012
    ..The discovery of VLRs in agnathans illuminates the origins of adaptive immunity in early vertebrates...
  9. ncbi request reprint The evolutionary history of lymphoid organs
    Thomas Boehm
    Max Planck Institute of Immunobiology, D 79279 Freiburg, Germany
    Nat Immunol 8:131-5. 2007
    ....
  10. ncbi request reprint Thymus development and function
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Curr Opin Immunol 20:178-84. 2008
    ..This review also addresses new experimental approaches toward a better understanding of thymopoiesis and discusses the impact of new animal models...
  11. ncbi request reprint Thymus-homing precursors and the thymic microenvironment
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg, 51 D 79108, Freiburg, Germany
    Trends Immunol 27:477-84. 2006
    ....
  12. ncbi request reprint Co-evolution of a primordial peptide-presentation system and cellular immunity
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
    Nat Rev Immunol 6:79-84. 2006
    ....
  13. ncbi request reprint MHC peptides and the sensory evaluation of genotype
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Trends Neurosci 29:100-7. 2006
    ..These findings provide a molecular mechanism by which an individual can sense the composition and compatibility of vital immune system molecules of a conspecific, with direct consequences for social behavior...
  14. doi request reprint The adaptive phenotype of cortical thymic epithelial cells
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg, Freiburg, Germany
    Eur J Immunol 39:944-7. 2009
    ..Nevertheless, it appears that Prss16 has later evolved as an essential contributor to the MHC class II peptide/ligand repertoire...
  15. ncbi request reprint Quality control in self/nonself discrimination
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Cell 125:845-58. 2006
    ..Recent advances in understanding self/nonself discrimination in eukaryotes shed new light on the emergence of the most sophisticated self/nonself discrimination system known, the antigen receptors employed in the adaptive immune system...
  16. ncbi request reprint Laser capture microdissection-based expression profiling identifies PD1-ligand as a target of the nude locus gene product
    C C Bleul
    MPI für Immunbiologie, Freiburg, Germany
    Eur J Immunol 31:2497-503. 2001
    ..The presented results support our prediction that this systematic approach by gene expression profiling yields regulators of thymopoiesis...
  17. doi request reprint Design principles of adaptive immune systems
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, D 79108 Freiburg, Germany
    Nat Rev Immunol 11:307-17. 2011
    ....
  18. ncbi request reprint Gene structure, chromosomal localization, and expression pattern of Capn12, a new member of the calpain large subunit gene family
    T N Dear
    Max Planck Institute for Immunobiology, Stuebeweg 51, Freiburg, D 79108, Germany
    Genomics 68:152-60. 2000
    ..4 cM. Refined mapping of Capn5, also previously localized to chromosome 7, indicated that it was not closely linked to Capn12, mapping tightly linked to a marker positioned at 48.5 cM...
  19. ncbi request reprint Formation of regulator/target gene relationships during evolution
    T Schlake
    Max Planck Institut fur Immunbiologie, Stubeweg 51, 79108, Freiburg, Germany
    Gene 256:29-34. 2000
    ....
  20. ncbi request reprint Identification and characterization of two novel calpain large subunit genes
    T N Dear
    Department of Developmental Immunology, Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Gene 274:245-52. 2001
    ..The 13 human large subunit genes and the single small subunit gene are located in eight syntenic groups on chromosomes 1, 2, 3, 6, 11, 15, 19 and X...
  21. ncbi request reprint Genetically separable determinants of hair keratin gene expression
    M Schorpp
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Dev Dyn 218:537-43. 2000
    ..Our results indicate that the molecular consequences of mutations of the Whn gene can be different and demonstrate an unexpected complexity of transcriptional control mechanisms of hair keratin genes...
  22. ncbi request reprint Expression domains in the skin of genes affected by the nude mutation and identified by gene expression profiling
    T Schlake
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108, Freiburg, Germany
    Mech Dev 109:419-22. 2001
    ..Our results identify metallothionein IV among these genes. This is the first report on metallothionein IV expression in the murine hair follicle; its expression domain almost completely overlaps that of Whn...
  23. ncbi request reprint CAPN11: A calpain with high mRNA levels in testis and located on chromosome 6
    T N Dear
    Max Planck Institute for Immunobiology, Stuebeweg 51, Freiburg, D 79108, Germany
    Genomics 59:243-7. 1999
    ..The discovery of this new calpain emphasizes the complexity of the calpain family, with members being distinguished on the basis of protease activity, calcium dependence, and tissue expression...
  24. ncbi request reprint Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development
    T N Dear
    Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108, Freiburg, Germany
    Mech Dev 89:201-9. 1999
    ..Capn11 mRNA is restricted exclusively to spermatocytes and only during the later stages of meiosis...
  25. ncbi request reprint Abnormal bone marrow stroma in mice deficient for nemo-like kinase, Nlk
    M Kortenjann
    Max Planck Institute for Immunobiology, Freiburg, Germany
    Eur J Immunol 31:3580-7. 2001
    ..Nlk deficient mice thus provide a novel model to study the genetic requirements for bone marrow stromal differentiation...
  26. ncbi request reprint Only one nemo-like kinase gene homologue in invertebrate and mammalian genomes
    M Kortenjann
    Max Planck Institut fur Immunbiologie, Stubeweg 51, 79108 Freiburg, Germany
    Gene 278:161-5. 2001
    ....
  27. ncbi request reprint Evolutionary conservation of gene structures of the Pax1/9 gene family
    C Hetzer-Egger
    Department of Developmental Immunology, Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108, Freiburg, Germany
    Biochim Biophys Acta 1492:517-21. 2000
    ..AmphiPax1 is expressed in adult amphioxus in the pharyngeal endoderm...
  28. ncbi request reprint Chemokines define distinct microenvironments in the developing thymus
    C C Bleul
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Eur J Immunol 30:3371-9. 2000
    ..The complexity of these chemokine-defined microenvironments increases as the thymic anlage develops to a mature thymus...
  29. ncbi request reprint A novel serine protease overexpressed in the hair follicles of nude mice
    N Meier
    Department of Developmental Immunology, Max Planck Institute for Immunobiology, Stuebeweg 51, Freiburg, D 79108, Germany
    Biochem Biophys Res Commun 258:374-8. 1999
    ..Thus, BSSP is the first serine protease known to be expressed in the sebaceous gland. In nude mouse skin, this gene is overexpressed...
  30. ncbi request reprint Spontaneous mutations in SELH/Bc mice due to insertions of early transposons: molecular characterization of null alleles at the nude and albino loci
    M Hofmann
    Department of Developmental Immunology, Max Planck Institute for Immunology, Freiburg, Germany
    Genomics 52:107-9. 1998
  31. ncbi request reprint Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: molecular analysis of the nude skin phenotype
    T Schlake
    Department of Developmental Immunology, Max Planck Institute for Immunobiology, Freiburg, Germany
    Dev Dyn 217:368-76. 2000
    ..Our results implicate Whn as a transcriptional regulator of hair keratin genes and reveal the nude phenotype as the first example of an inherited skin disorder that is caused by loss of expression rather than mutation of keratin genes...
  32. ncbi request reprint Morpholino oligonucleotide-triggered knockdown reveals a role for maternal E-cadherin during early mouse development
    Benoit Kanzler
    Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
    Mech Dev 120:1423-32. 2003
    ..Our study thus reveals a previously unanticipated role of maternal E-cadherin during early stages of mouse development...
  33. ncbi request reprint Major shifts in genomic activity accompany progression through different stages of the hair cycle
    Thomas Schlake
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Gene Expr Patterns 4:141-52. 2004
    ..Expression of insulin-like growth factor binding proteins and anti-angiogenic factors is associated with the regression phase of the hair cycle...
  34. ncbi request reprint Maintenance of thymic epithelial phenotype requires extrinsic signals in mouse and zebrafish
    Cristian Soza-Ried
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg, Freiburg, Germany
    J Immunol 181:5272-7. 2008
    ..These results indicate an evolutionarily conserved role of BMP signaling in the maintenance of Foxn1 expression...
  35. pmc Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR
    Thomas Boehm
    Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    J Exp Med 198:757-69. 2003
    ....
  36. ncbi request reprint Ltbetar signaling does not regulate Aire-dependent transcripts in medullary thymic epithelial cells
    Vera C Martins
    Max Planck Institute for Immunobiology, Department for Developmental Immunology, Freiburg, Germany
    J Immunol 181:400-7. 2008
    ..We propose that the physiological medullary architecture ensures negative-selection by supporting lympho-epithelial interaction through a large epithelial cell surface distributed evenly across the medulla...
  37. ncbi request reprint A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice
    A Poltorak
    The Scripps Research Institute, La Jolla, CA 92037 Max Planck Institut für Immunbiologie, Freiburg, Germany
    J Immunol 167:2106-11. 2001
    ..Because the phosphorylation of STAT4 is a prerequisite for the IL-12-mediated induction of IFN-gamma, its absence in Cr mice is responsible for their defective IFN-gamma response to microorganisms...
  38. ncbi request reprint Genetic dissection of thymus development in mouse and zebrafish
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Immunol Rev 195:15-27. 2003
    ..Strengths and weaknesses of mouse and zebrafish models are largely complementary such that genetic analysis of mouse and zebrafish mutants may lead to a better understanding of thymus development...
  39. doi request reprint Everything in its place
    Jeremy B Swann
    Max Planck Institute of Immunobiology, Department of Developmental Immunology, D 79108 Freiburg, Germany
    Immunity 31:856-8. 2009
    ..2009) define the thymic midcortex as a functionally inert zone between subcapsular and cortico-medullary regions, and Ehrlich et al. (2009) infer that structural features of the cortex and medulla regulate migration of thymocytes...
  40. doi request reprint Evolution of genetic networks underlying the emergence of thymopoiesis in vertebrates
    Baubak Bajoghli
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Cell 138:186-97. 2009
    ..Our results provide a framework elucidating the evolution of key features of the adaptive immune system in jawed vertebrates...
  41. ncbi request reprint Thymopoiesis requires Pax9 function in thymic epithelial cells
    Claudia Hetzer-Egger
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Eur J Immunol 32:1175-81. 2002
    ..Whereas expression of TCRbeta chain genes is readily detectable in the mutant thymus, no expression of the TCRgamma chain was detectable. Our results identify a new genetically defined control point of thymopoiesis...
  42. ncbi request reprint Back to the beginning--the quest for thymic epithelial stem cells
    Jeremy B Swann
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Eur J Immunol 37:2364-6. 2007
    ..This finding demonstrates that much progress needs to be made before thymic epithelial stem cells can be harnessed for clinical benefit...
  43. ncbi request reprint Aortic arch and pharyngeal phenotype in the absence of BMP-dependent neural crest in the mouse
    Sabine Ohnemus
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Mech Dev 119:127-35. 2002
    ....
  44. ncbi request reprint A zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudiment
    Michael Schorpp
    Department of Developmental Immunology, Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Mech Dev 118:179-85. 2002
    ..Our results provide the first specific marker for the epithelial compartment of the zebrafish thymus...
  45. pmc Capn5 is expressed in a subset of T cells and is dispensable for development
    Tanna Franz
    Department of Developmental Immunology, Max Planck Institute for Immunobiology, D 79108 Freiburg, Germany
    Mol Cell Biol 24:1649-54. 2004
    ..There was no evidence for the development of autoimmune disease in Capn5-null animals. However, a small proportion of homozygous null offspring from heterozygous matings were runted and most often did not survive to adulthood...
  46. ncbi request reprint Capn7: a highly divergent vertebrate calpain with a novel C-terminal domain
    T Franz
    Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Mamm Genome 10:318-21. 1999
  47. pmc Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage
    Tatiana Corbeaux
    Max Planck Institute of Immunobiology, Freiburg D 79108, Germany
    Proc Natl Acad Sci U S A 107:16613-8. 2010
    ..Our findings therefore support the notion that Foxn1 is the essential transcription factor regulating the differentiation of TECs and that its expression marks the major functional lineage of TECs in embryonic and adult thymic tissue...
  48. ncbi request reprint BMP signaling is required for normal thymus development
    Conrad C Bleul
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Freiburg, Germany
    J Immunol 175:5213-21. 2005
    ..Our data demonstrate that BMP signaling is crucial for thymus development and that it is the thymic stroma rather than developing thymocytes that depends on BMP signals...
  49. pmc Essential role of c-myb in definitive hematopoiesis is evolutionarily conserved
    Cristian Soza-Ried
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Proc Natl Acad Sci U S A 107:17304-8. 2010
    ..Our results, therefore, suggest that the key role of c-myb in definitive hematopoiesis is similar to that in mammals and must have become established early in vertebrate evolution...
  50. doi request reprint Developing T lymphocytes are uniquely sensitive to a lack of topoisomerase III alpha
    Maren Mönnich
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Eur J Immunol 40:2379-84. 2010
    ..Deficiency in top3a activates a p53-dependent check-point but does not affect VDJ recombination. Our results suggest that TOP3A could be a candidate gene involved in human primary immunodeficiency syndromes...
  51. ncbi request reprint Formation of a functional thymus initiated by a postnatal epithelial progenitor cell
    Conrad C Bleul
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Nature 441:992-6. 2006
    ..Thus, single epithelial progenitor cells can give rise to a complete and functional thymic microenvironment, suggesting that cell-based therapies could be developed for thymus disorders...
  52. pmc B-1a B cells that link the innate and adaptive immune responses are lacking in the absence of the spleen
    Hedda Wardemann
    Department of Developmental Immunology, Max Planck Institute for Immunobiology, Freiburg 79108, Germany
    J Exp Med 195:771-80. 2002
    ..These findings reveal a hitherto unknown role of the spleen in generating and maintaining the B-1a B cell pool...
  53. ncbi request reprint Conserved functions of Ikaros in vertebrate lymphocyte development: genetic evidence for distinct larval and adult phases of T cell development and two lineages of B cells in zebrafish
    Michael Schorpp
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    J Immunol 177:2463-76. 2006
    ..By contrast, B cells expressing the igz isotype do not develop, providing genetic evidence for two separate B cell lineages in zebrafish. Thus, Ikaros appears to play similar roles in fish and mammalian lymphopoiesis...
  54. ncbi request reprint MHC class I peptides as chemosensory signals in the vomeronasal organ
    Trese Leinders-Zufall
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Science 306:1033-7. 2004
    ..MHC peptides constitute a previously unknown family of chemosensory stimuli by which MHC genotypic diversity can influence social behavior...
  55. pmc Mate choice decisions of stickleback females predictably modified by MHC peptide ligands
    Manfred Milinski
    Department of Evolutionary Ecology, Max Planck Institute of Limnology, 24306 Plön, Germany
    Proc Natl Acad Sci U S A 102:4414-8. 2005
    ..Our results suggest that female sticklebacks use evolutionarily conserved structural features of MHC peptide ligands to evaluate MHC diversity of their prospective mating partners...
  56. pmc Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration
    Thomas Boehm
    Laboratory for Molecular Biology, Gene Center, University of Munich, Feodor Lynen Strasse 25, D 81377 Munich, Germany
    EMBO J 22:1014-24. 2003
    ..These findings outline a novel mechanism of signal chain abrogation through sequestration of a limiting component by specific protein-protein interactions...
  57. ncbi request reprint Evidence for a functional second thymus in mice
    Grzegorz Terszowski
    Department of Immunology, University of Ulm, D 89081 Ulm, Germany
    Science 312:284-7. 2006
    ..The identification of a regular second thymus in the mouse may provide evolutionary links to thymus organogenesis in other vertebrates and suggests a need to reconsider the effect of thoracic thymectomy on de novo T cell production...
  58. ncbi request reprint Image quality of the aortic and mitral valve with CT: relative versus absolute delay reconstruction
    Thomas Boehm
    Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland
    Acad Radiol 14:613-24. 2007
    ..The purpose of this study was to compare image quality and artifacts of 16-detector row CT imaging of the aortic and mitral valve when performing ECG-gated synchronization using relative and absolute reconstructions...
  59. pmc Susceptibility to anthrax lethal toxin is controlled by three linked quantitative trait loci
    Ryan D McAllister
    Department of Microbiology, University of Illinois, Urbana, IL, USA
    Am J Pathol 163:1735-41. 2003
    ..Additionally, to recapitulate dominant resistance to mortality as seen in (BALB/c x DBA/2) F(1) hybrids, DBA/2 alleles are required at all three QTL...
  60. ncbi request reprint Visualization of congenital thoracic vascular anomalies using multi-detector row computed tomography and two- and three-dimensional post-processing
    Thomas Schertler
    Department of Medical Radiology, Institute of Diagnostic Radiology, University Hospital Zurich, Switzerland
    Eur J Radiol 61:97-119. 2007
    ..We present cases of rare congenital anomalies of the thoracic vessels using MDCT with special respect to 2D- and 3D-post-processing...
  61. ncbi request reprint Image quality of volume rendering of the bronchial tree: Kymogram-gated versus retrospectively ECG-gated and non-gated multi-row detector CT
    Thomas Boehm
    Department of Radiology, Spitäler Chur AG, Loestrasse 170, CH 7000 Chur, Switzerland
    Acad Radiol 12:173-81. 2005
    ..To compare the image quality of three different heart-cycle-synchronized computed tomography (CT) reconstruction algorithms for volume-rendered (VR) 3D visualization of the bronchial tree...
  62. pmc Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease
    Heike Bommel
    Institute of Clinical Neurobiology, University of Wurzburg, 97080 Wurzburg, Germany
    J Cell Biol 159:563-9. 2002
    ..Thus, the pmn gene mutation provides the first genetic evidence that alterations in tubulin assembly lead to retrograde degeneration of motor axons, ultimately resulting in motoneuron cell death...
  63. ncbi request reprint Computerized modeling based on spiral CT data for noninvasive determination of aortic stent-graft length
    Albert Rott
    Institut für Diagnostische und Interventionelle Radiologie, Friedric Schiller Universität Jena, Germany
    J Endovasc Ther 9:520-8. 2002
    ..To preprocedurally determine the correct length of a nonbifurcated endovascular prosthesis for abdominal aortic aneurysm (AAA) repair using a computerized model...
  64. ncbi request reprint CT angiography of peripheral arterial bypass grafts: Accuracy and time-effectiveness of quantitative image analysis with an automated software tool
    Denise Keller
    Institute of Diagnostic Radiology, University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich
    Acad Radiol 13:610-20. 2006
    ....
  65. ncbi request reprint Dynamic cine mode imaging of the normal aortic valve using 16-channel multidetector row computed tomography
    Bernhard Baumert
    Institute of Diagnostic Radiology, University Hospital Zurich, Switzerland
    Invest Radiol 40:637-47. 2005
    ..We investigated the feasibility and image quality of dynamic cine-mode imaging of the normal aortic valve using multidetector row computed tomography (MDCT)...
  66. ncbi request reprint Essential role of the main olfactory system in social recognition of major histocompatibility complex peptide ligands
    Marc Spehr
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 26:1961-70. 2006
    ..These results suggest a general role for MHC peptides in chemical communication even in those vertebrates that lack a functional VNO...
  67. ncbi request reprint Computational fluid dynamics: hemodynamic changes in abdominal aortic aneurysm after stent-graft implantation
    Thomas Frauenfelder
    Institute of Diagnostic Radiology, University Hospital of Zurich, Zurich, Switzerland
    Cardiovasc Intervent Radiol 29:613-23. 2006
    ..CFD is a highly promising technique and improves our understanding of the local structural and fluid dynamic conditions for abdominal aortic stent placement...