Marcus Pickhardt

Summary

Affiliation: Max-Planck-Unit for Structural Molecular Biology
Country: Germany

Publications

  1. ncbi request reprint The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis
    Martin von Bergen
    Max Planck Unit for Structural Molecular Biology, Notkestrasse 85, D 22607 Hamburg, Germany
    Biochemistry 45:6446-57. 2006
  2. ncbi request reprint Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs
    Inna Khlistunova
    Max Planck Unit for Structural Molecular Biology, DESY, Hamburg, Germany
    J Biol Chem 281:1205-14. 2006
  3. ncbi request reprint Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells
    Marcus Pickhardt
    Max Planck Unit for Structural Molecular Biology, c o DESY, Notkestrasse 85, D 22607 Hamburg, Germany
    Biochemistry 46:10016-23. 2007
  4. ncbi request reprint Screening for inhibitors of tau polymerization
    Marcus Pickhardt
    Max Planck Unit for Structural Molecular Biology, Notkestrasse 85, 22607 Hamburg, Germany
    Curr Alzheimer Res 2:219-26. 2005
  5. ncbi request reprint Inhibition of tau aggregation in cell models of tauopathy
    Inna Khlistunova
    Max Planck Unit for Structural Molecular Biology, Notkestrasse 85, 22607 Hamburg, Germany
    Curr Alzheimer Res 4:544-6. 2007
  6. ncbi request reprint Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells
    Marcus Pickhardt
    Max Planck Unit for Structural Molecular Biology, Notkestrasse 85, 22607 Hamburg, Germany
    J Biol Chem 280:3628-35. 2005
  7. ncbi request reprint Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping
    Gregor Larbig
    Darmstadt Technical University, Clemens Schöpf Institute for Organic Chemistry and Biochemistry, Petersenstrasse 22, D 64287 Darmstadt, Germany
    Curr Alzheimer Res 4:315-23. 2007
  8. ncbi request reprint Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease?
    Rajeshwar Narlawar
    Clemens Schöpf Institute of Chemistry and Biochemistry, Darmstadt University of Technology, Petersenstrasse 22, 64287 Darmstadt, Germany
    ChemMedChem 3:165-72. 2008
  9. ncbi request reprint Rhodanine-based tau aggregation inhibitors in cell models of tauopathy
    Bruno Bulic
    Max Planck Institute for Molecular Physiology, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    Angew Chem Int Ed Engl 46:9215-9. 2007

Collaborators

Detail Information

Publications9

  1. ncbi request reprint The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis
    Martin von Bergen
    Max Planck Unit for Structural Molecular Biology, Notkestrasse 85, D 22607 Hamburg, Germany
    Biochemistry 45:6446-57. 2006
    ..These data describe the physical parameters of the PHFs and enabled us to build a model of the molecular arrangement within the filamentous structures...
  2. ncbi request reprint Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs
    Inna Khlistunova
    Max Planck Unit for Structural Molecular Biology, DESY, Hamburg, Germany
    J Biol Chem 281:1205-14. 2006
    ....
  3. ncbi request reprint Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells
    Marcus Pickhardt
    Max Planck Unit for Structural Molecular Biology, c o DESY, Notkestrasse 85, D 22607 Hamburg, Germany
    Biochemistry 46:10016-23. 2007
    ..By chemical variation of the core, we improved the inhibitory potency five-fold. The compounds showed a low toxicity as judged by an N2A cell model of tau aggregation and lend themselves for further development...
  4. ncbi request reprint Screening for inhibitors of tau polymerization
    Marcus Pickhardt
    Max Planck Unit for Structural Molecular Biology, Notkestrasse 85, 22607 Hamburg, Germany
    Curr Alzheimer Res 2:219-26. 2005
    ..By this approach it is possible to identify small molecule compounds which prevent or reverse the aggregation of tau and thereby might improve the viability of neurons in a therapeutic approach...
  5. ncbi request reprint Inhibition of tau aggregation in cell models of tauopathy
    Inna Khlistunova
    Max Planck Unit for Structural Molecular Biology, Notkestrasse 85, 22607 Hamburg, Germany
    Curr Alzheimer Res 4:544-6. 2007
    ..Thus the cell models are suitable for developing aggregation inhibitor drugs and testing their cellular roles...
  6. ncbi request reprint Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells
    Marcus Pickhardt
    Max Planck Unit for Structural Molecular Biology, Notkestrasse 85, 22607 Hamburg, Germany
    J Biol Chem 280:3628-35. 2005
    ..Thus, small molecule inhibitors could provide a basis for the development of tools for the treatment of tau pathology in AD and other tauopathies...
  7. ncbi request reprint Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping
    Gregor Larbig
    Darmstadt Technical University, Clemens Schöpf Institute for Organic Chemistry and Biochemistry, Petersenstrasse 22, D 64287 Darmstadt, Germany
    Curr Alzheimer Res 4:315-23. 2007
    ..The virtual screen provided 136 hits; 19 representative hits were selected and assayed, this resulted in two novel leads with an IC(50) < 13 microM. These two leads feature a novel scaffold for tau aggregation inhibitors...
  8. ncbi request reprint Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease?
    Rajeshwar Narlawar
    Clemens Schöpf Institute of Chemistry and Biochemistry, Darmstadt University of Technology, Petersenstrasse 22, 64287 Darmstadt, Germany
    ChemMedChem 3:165-72. 2008
    ..Additionally, several compounds are potent inhibitors of tau protein aggregation and depolymerized tau protein aggregates at low micromolar concentrations...
  9. ncbi request reprint Rhodanine-based tau aggregation inhibitors in cell models of tauopathy
    Bruno Bulic
    Max Planck Institute for Molecular Physiology, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    Angew Chem Int Ed Engl 46:9215-9. 2007