Affiliation: Max-Planck-Institute for Infection Biology
Deigendesch N, Zychlinsky A, Meissner F. Copper Regulates the Canonical NLRP3 Inflammasome. J Immunol. 2018;200:1607-1617 pubmed publisher
..Our results indicate that targeting the intracellular copper homeostasis has potential for the treatment of NLRP3-dependent diseases. ..
Sollberger G, Choidas A, Burn G, Habenberger P, di Lucrezia R, Kordes S, et al
. Gasdermin D plays a vital role in the generation of neutrophil extracellular traps. Sci Immunol. 2018;3: pubmed publisher
..In addition to the central role of GSDMD in pyroptosis, we propose that GSDMD also plays an essential function in NETosis. ..
Apel F, Zychlinsky A, Kenny E. The role of neutrophil extracellular traps in rheumatic diseases. Nat Rev Rheumatol. 2018;14:467-475 pubmed publisher
..Our goal is to clarify the field of NET research in rheumatic diseases in the hope of improving the therapeutic approaches utilized for these diseases. ..
Stephenson H, Herzig A, Zychlinsky A. Beyond the grave: When is cell death critical for immunity to infection?. Curr Opin Immunol. 2016;38:59-66 pubmed publisher
Virreira Winter S, Zychlinsky A. The bacterial pigment pyocyanin inhibits the NLRP3 inflammasome through intracellular reactive oxygen and nitrogen species. J Biol Chem. 2018;293:4893-4900 pubmed publisher
..We propose that cytosolic ROS/RNS inhibit the NLRP3 inflammasome and that PCN's anti-inflammatory activity may help P. aeruginosa evade immune recognition. ..
Sollberger G, Tilley D, Zychlinsky A. Neutrophil Extracellular Traps: The Biology of Chromatin Externalization. Dev Cell. 2018;44:542-553 pubmed publisher
..Here we review neutrophil development and heterogeneity with a focus on NETs, NET formation, and their relevance in host defense and disease. ..
Brotcke Zumsteg A, Goosmann C, Brinkmann V, Morona R, Zychlinsky A. IcsA is a Shigella flexneri adhesin regulated by the type III secretion system and required for pathogenesis. Cell Host Microbe. 2014;15:435-45 pubmed publisher
..IcsA-dependent adhesion contributes to virulence in a mouse model of shigellosis, underscoring the importance of this adhesin to S. flexneri pathogenesis. ..
Amulic B, Knackstedt S, Abu Abed U, Deigendesch N, Harbort C, Caffrey B, et al
. Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps. Dev Cell. 2017;43:449-462.e5 pubmed publisher
..CDK6, in neutrophils, is required for clearance of the fungal pathogen Candida albicans. Our data describe a function for CDK4/6 in immunity. ..