Rudiger Klein

Summary

Affiliation: Max-Planck-Institute of Neurobiology
Country: Germany

Publications

  1. pmc Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth
    Guido Pante
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
    J Cell Biol 171:337-48. 2005
  2. pmc Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons
    Liviu Aron
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Martinsried, Germany
    PLoS Biol 8:e1000349. 2010
  3. doi Eph/ephrin signalling during development
    Rudiger Klein
    Max Planck Institute of Neurobiology, Department of Molecular Neurobiology, Am Klopferspitz 18, Munich Martinsried, Germany
    Development 139:4105-9. 2012
  4. doi Bidirectional modulation of synaptic functions by Eph/ephrin signaling
    Rudiger Klein
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Munich Martinsried, Germany
    Nat Neurosci 12:15-20. 2009
  5. ncbi Eph/ephrin signaling in morphogenesis, neural development and plasticity
    Rudiger Klein
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Munich Martinsried, Germany
    Curr Opin Cell Biol 16:580-9. 2004
  6. doi Topography in hippocampal mossy fiber plasticity
    Rudiger Klein
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
    Neuron 65:580-2. 2010
  7. ncbi Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb
    Edgar R Kramer
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    Neuron 50:35-47. 2006
  8. doi Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity
    George A Wilkinson
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Munich Martinsried, Germany
    Dev Dyn 237:2220-34. 2008
  9. pmc Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport
    Alessandro Filosa
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Martinsried, Germany
    Nat Neurosci 12:1285-92. 2009
  10. ncbi Tyrosine phosphorylation sites in ephrinB2 are required for hippocampal long-term potentiation but not long-term depression
    Farima Bouzioukh
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
    J Neurosci 27:11279-88. 2007

Collaborators

Detail Information

Publications40

  1. pmc Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth
    Guido Pante
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
    J Cell Biol 171:337-48. 2005
    ..Because Mig6 also is induced by HGF stimulation, our results suggest that Mig6 is part of a negative feedback loop that attenuates Met functions in different contexts and cell types...
  2. pmc Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons
    Liviu Aron
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Martinsried, Germany
    PLoS Biol 8:e1000349. 2010
    ..A better understanding of the molecular connections between trophic signaling, cellular stress and aging could uncover new targets for drug development in PD...
  3. doi Eph/ephrin signalling during development
    Rudiger Klein
    Max Planck Institute of Neurobiology, Department of Molecular Neurobiology, Am Klopferspitz 18, Munich Martinsried, Germany
    Development 139:4105-9. 2012
    ..This article provides an overview of the general structures and signalling mechanisms, and of typical developmental functions along with cell biological principles...
  4. doi Bidirectional modulation of synaptic functions by Eph/ephrin signaling
    Rudiger Klein
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Munich Martinsried, Germany
    Nat Neurosci 12:15-20. 2009
    ..In some cases, Eph receptors can simply act as ligands for ephrins without any requirement for Eph receptor signaling, suggesting that the system does not always function bidirectionally...
  5. ncbi Eph/ephrin signaling in morphogenesis, neural development and plasticity
    Rudiger Klein
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Munich Martinsried, Germany
    Curr Opin Cell Biol 16:580-9. 2004
    ..Mechanistically, Eph-ephrin repulsive behavior appears to require ligand-receptor internalization and signaling to Rho GTPases...
  6. doi Topography in hippocampal mossy fiber plasticity
    Rudiger Klein
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
    Neuron 65:580-2. 2010
    ..In this issue of Neuron, Galimberti et al. demonstrate that mossy fibers of the rodent hippocampus exhibit prominent structural plasticity according to a novel topographic rule, in a process requiring the EphA4 receptor tyrosine kinase...
  7. ncbi Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb
    Edgar R Kramer
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    Neuron 50:35-47. 2006
    ..This phenotype is enhanced in mutant mice lacking Ret and EphA4. Thus, Ret and EphA4 signals cooperate to enforce the precision of the same binary choice in motor-axon guidance...
  8. doi Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity
    George A Wilkinson
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Munich Martinsried, Germany
    Dev Dyn 237:2220-34. 2008
    ..Postnatal day 1 mutant lungs show extracellular matrix alterations without differences in proportions of major distal cell populations. We conclude that lung alveolar formation relies on endothelial ephrinB2 function...
  9. pmc Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport
    Alessandro Filosa
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Martinsried, Germany
    Nat Neurosci 12:1285-92. 2009
    ..These results suggest that EphA4/ephrin-A3 signaling is a critical mechanism for astrocytes to regulate synaptic function and plasticity...
  10. ncbi Tyrosine phosphorylation sites in ephrinB2 are required for hippocampal long-term potentiation but not long-term depression
    Farima Bouzioukh
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
    J Neurosci 27:11279-88. 2007
    ..Our results provide the first evidence for phosphotyrosine-dependent ephrinB reverse signaling in a neuronal network and for differential ephrinB2 reverse signaling in two forms of synaptic plasticity...
  11. pmc FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons
    Satoru Yamagishi
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz, Martinsried, Germany
    EMBO J 30:2920-33. 2011
    ..Hence, the shed FLRT2 and FLRT3 ECDs represent a novel family of chemorepellents for Unc5-positive neurons and FLRT2/Unc5D signalling modulates cortical neuron migration...
  12. pmc Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling
    Graziana Gatto
    Department of Molecules Signaling Development, Max Planck Institute of Neurobiology, D 82152, Martinsried, Germany
    J Neurosci 33:5399-410. 2013
    ..The regulation of Eph receptor-mediated developmental processes by protein tyrosine phosphatases has diverged between chick and mouse...
  13. ncbi EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion
    Manuel Zimmer
    Max Planck Institute of Neurobiology, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Nat Cell Biol 5:869-78. 2003
    ..Here, we show a mechanism for the termination of adhesion and the promotion of cell repulsion after intercellular (trans) interaction between two transmembrane proteins...
  14. ncbi Regulation of EphA 4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function
    Joaquim Egea
    Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    Neuron 47:515-28. 2005
    ..These results suggest that signaling of Eph RTKs follows a multistep process of induced kinase activity and higher-order clustering different from RTKs responding to soluble ligands...
  15. ncbi Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain
    Archana Mishra
    Department of Molecules Signaling Development and Synaptic Receptor Trafficking Group, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany, German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environment and Health, D 85764 Neuherberg, Germany, Department of Neurology, Friedrich Baur Institute, Ludwig Maximilians University, D 80336 Munich, Germany, Munich Cluster for Systems Neurology SyNergy, D 80336 Munich, Germany, and Department of Physiology II, University of Bonn, D 53115 Bonn, Germany
    J Neurosci 34:4187-99. 2014
    ..These results provide genetic evidence for a specific role of IgSF9 in inhibitory synapse development/maintenance, presumably by its CAM-like activity. ..
  16. pmc EphrinB3/EphA4-mediated guidance of ascending and descending spinal tracts
    Sónia Paixão
    Department Molecules Signals Development, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
    Neuron 80:1407-20. 2013
    ....
  17. doi Genetic evidence for a contribution of EphA:ephrinA reverse signaling to motor axon guidance
    Irina Dudanova
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
    J Neurosci 32:5209-15. 2012
    ..In summary, we provide evidence for a role of EphA:ephrinA attractive reverse signaling in motor axon guidance and in vivo evidence of in-parallel forward Eph and reverse ephrin signaling function in the same neuronal population...
  18. pmc Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system
    Edgar R Kramer
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Martinsried, Germany
    PLoS Biol 5:e39. 2007
    ....
  19. pmc The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons
    Katrin Deininger
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
    Proc Natl Acad Sci U S A 105:12539-44. 2008
    ..We find that the EphA4 receptor is required for synaptic plasticity in the amygdala, raising the possibility that an underlying mechanism of Rin1 function in amygdala is to down-regulate EphA4 signaling by promoting its endocytosis...
  20. pmc PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature
    Taija Makinen
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
    Genes Dev 19:397-410. 2005
    ..Our studies define ephrinB2 as an essential regulator of lymphatic development and indicate that interactions with PDZ domain effectors are required to mediate its functions...
  21. ncbi Hippocampal plasticity requires postsynaptic ephrinBs
    Ilona C Grunwald
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
    Nat Neurosci 7:33-40. 2004
    ..This work raises the intriguing possibility that depending on the type of synapse, Eph/ephrins can be involved in activity-dependent plasticity in converse ways, with ephrinBs on the pre- or the postsynaptic side...
  22. pmc The protein dendrite arborization and synapse maturation 1 (Dasm-1) is dispensable for dendrite arborization
    Archana Mishra
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
    Mol Cell Biol 28:2782-91. 2008
    ..These findings indicate that the dendrite arborization phenotype was caused by off-target effects and that Dasm-1 is dispensable for hippocampal dendrite arborization...
  23. ncbi Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation
    Ingvar Ferby
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Klopferspitz 18, 82152 Martinsried, Germany
    Nat Med 12:568-73. 2006
    ..These results indicate that Mig6 is a specific negative regulator of Egfr signaling in skin morphogenesis and is a novel tumor suppressor of Egfr-dependent carcinogenesis...
  24. ncbi Release of full-length EphB2 receptors from hippocampal neurons to cocultured glial cells
    Jenny Lauterbach
    Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
    J Neurosci 26:11575-81. 2006
    ..e., when the neurons expressed EphB2, but not ephrinBs. These findings suggest that Eph/ephrin signaling is involved in the glial cell-mediated fine sculpting of neuronal structures...
  25. ncbi Axon guidance: opposing EPHects in the growth cone
    Rudiger Klein
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Munich Martinsried, Germany
    Cell 121:4-6. 2005
    ..2005) demonstrate that coexpressed ephrin-As and Ephs do not interact in cis but rather segregate into separate membrane domains, from which they signal opposing effects during motor axon guidance...
  26. pmc Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation
    Joaquim Egea
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    Genes Dev 22:3349-62. 2008
    ..We propose that this novel function cooperates with the signaling activities of the AVE to restrict EMT and mesoderm induction to the posterior epiblast...
  27. doi Neuron-astrocyte communication and synaptic plasticity
    Sónia Paixão
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
    Curr Opin Neurobiol 20:466-73. 2010
    ..Recent work has provided insights into the relative contributions of specific astrocytic cues and transporters to synaptic transmission, plasticity, and animal behavior...
  28. ncbi Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function
    Amparo Palmer
    Max Planck Institute of Neurobiology, Department of Molecular Neurobiology, D 82152 Martinsried, Germany
    Genes Dev 17:1429-50. 2003
  29. doi GDNF acts as a chemoattractant to support ephrinA-induced repulsion of limb motor axons
    Irina Dudanova
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Martinsried D 82152, Germany
    Curr Biol 20:2150-6. 2010
    ..GDNF also acts in a permissive manner by reducing ephrinA-induced collapse and keeping the axons in a growth-competent state. This is the first example of two opposing cues promoting the same trajectory choice at an intermediate target...
  30. pmc Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants
    Pontus Klein
    Molecules Signaling Development, Max Planck Institute of Neurobiology, Martinsried, Germany
    EMBO J 33:341-55. 2014
    ..These results provide a novel mechanism underlying Ret-mediated cell protection in a situation relevant for human PD...
  31. ncbi Altered expression patterns of EphrinB2 and EphB2 in human umbilical vessels and congenital venous malformations
    Stefanie Diehl
    Max Planck Institut fur Neurobiologie, Martinsried, Germany
    Pediatr Res 57:537-44. 2005
    ..Our study shows that the arterial markers ephrin B2 and EphB2 are expressed in a subset of veins, and it remains to be studied whether this is cause or consequence of an altered vascular identity...
  32. pmc EphA4-Mediated Ipsilateral Corticospinal Tract Misprojections Are Necessary for Bilateral Voluntary Movements But Not Bilateral Stereotypic Locomotion
    Najet Serradj
    Department of Physiology, Pharmacology and Neuroscience, City College of the City University of New York, New York, New York 10031 Department of Molecules Signaling Development, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany, Munich Cluster for Systems Neurology SyNergy, D 80336 Munich, Germany and Department of Neuroscience, Science for Life Laboratory, University of Uppsala, 75124 Uppsala, Sweden
    J Neurosci 34:5211-21. 2014
    ..Therefore, a specific change in CST connectivity is associated with and explains a change in voluntary movement. ..
  33. doi Repairing the parkinsonian brain with neurotrophic factors
    Liviu Aron
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
    Trends Neurosci 34:88-100. 2011
    ..Third, improved brain delivery of NTFs and new ways to stimulate NTF signaling are required to achieve clinical benefits. In this review, we discuss progress in these areas and highlight emerging concepts in NTF biology and therapy...
  34. ncbi Bidirectional Eph-ephrin signaling during axon guidance
    Joaquim Egea
    Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
    Trends Cell Biol 17:230-8. 2007
    ..Co-expression of Ephs and ephrins within the same cellular membrane can result in Eph-ephrin cis interaction or in lateral segregation into distinct domains from where they signal opposing effects on the axon...
  35. doi Integration of guidance cues: parallel signaling and crosstalk
    Irina Dudanova
    Department Molecules Signaling Development, Max Planck Institute of Neurobiology, Martinsried D 82152, Germany
    Trends Neurosci 36:295-304. 2013
    ..Some of the molecular mechanisms underlying these interactions are beginning to be unraveled...
  36. pmc The composition of EphB2 clusters determines the strength in the cellular repulsion response
    Andreas Schaupp
    Department of Molecules Signaling Development, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    J Cell Biol 204:409-22. 2014
    ..These results shed new light on the mechanism and regulation of EphB2 activation and provide a model on how Eph signaling translates into graded cellular responses. ..
  37. ncbi Met signaling is required for recruitment of motor neurons to PEA3-positive motor pools
    Françoise Helmbacher
    Max Planck Institute of Neurobiology, Am Klopferspitz 18a, 82152 Martinsried, Germany
    Neuron 39:767-77. 2003
    ..We propose the presence of a relay mechanism allowing cells induced by peripheral signals to recruit more anterior neurons to adopt the same motor pool-related phenotype...
  38. ncbi Axon guidance: receptor complexes and signaling mechanisms
    Ilona C Grunwald
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz 18a, 82152, Martinsried, Germany
    Curr Opin Neurobiol 12:250-9. 2002
    ..Novel effector molecules complete the picture and suggest additional signaling mechanisms...
  39. ncbi EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase
    Amparo Palmer
    Max Planck Institute of Neurobiology, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Mol Cell 9:725-37. 2002
    ..Our data suggest the presence of a switch mechanism that allows a shift from phosphotyrosine/SFK-dependent signaling to PDZ-dependent signaling...
  40. ncbi The axon's balancing act: cis- and trans-interactions between Ephs and ephrins
    Irina Dudanova
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Martinsried D 82152, Germany
    Neuron 71:1-3. 2011
    ..In this issue of Neuron, Kao and Kania demonstrate the importance of ephrin/Eph cis-interaction for correct pathway selection by spinal motor axons in vivo...