Stefan He Kaufmann

Summary

Affiliation: Max-Planck-Institute for Infection Biology
Country: Germany

Publications

  1. ncbi request reprint Immune response to Mycobacterium bovis bacille Calmette Guérin infection in major histocompatibility complex class I- and II-deficient knock-out mice: contribution of CD4 and CD8 T cells to acquired resistance
    C H Ladel
    Department of Immunology, University of Ulm, Germany
    Eur J Immunol 25:377-84. 1995
  2. pmc Proteomics reveals open reading frames in Mycobacterium tuberculosis H37Rv not predicted by genomics
    P R Jungblut
    Core Facility for Protein Analysis, Max Planck Institute for Infection Biology, Berlin, Germany
    Infect Immun 69:5905-7. 2001
  3. ncbi request reprint Secretion of different listeriolysin cognates by recombinant attenuated Salmonella typhimurium: superior efficacy of haemolytic over non-haemolytic constructs after oral vaccination
    J Hess
    Max Planck Institute for Infection Biology, Department of Immunology, D 10117, Berlin, Germany
    Microbes Infect 2:1799-806. 2000
  4. ncbi request reprint Critical role of CD28 in protective immunity against Salmonella typhimurium
    H W Mittrucker
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 163:6769-76. 1999
  5. ncbi request reprint Effect on parasite eradication of Pneumocystis carinii-specific antibodies produced in the presence or absence of CD4(+) alphabeta T lymphocytes
    R Hanano
    Department of Immunology, University Clinics Ulm, Ulm, Germany
    Eur J Immunol 29:2464-75. 1999
  6. ncbi request reprint Challenges and responses in human vaccine development
    Stefan H E Kaufmann
    Max Planck Institute for Infection Biology, Department of Immunology, Chariteplatz 1, Berlin D 10117, Germany Electronic address
    Curr Opin Immunol 28:18-26. 2014
  7. pmc Identification of T-cell antigens specific for latent mycobacterium tuberculosis infection
    Sebastian D Schuck
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    PLoS ONE 4:e5590. 2009
  8. ncbi request reprint Crosstalk between human DC subsets promotes antibacterial activity and CD8+ T-cell stimulation in response to bacille Calmette-Guérin
    Laura Lozza
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    Eur J Immunol 44:80-92. 2014
  9. pmc The tuberculosis vaccine candidate Bacillus Calmette-Guérin ΔureC::hly coexpressing human interleukin-7 or -18 enhances antigen-specific T cell responses in mice
    Martin Rao
    Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany
    PLoS ONE 8:e78966. 2013
  10. pmc MiR-133b targets antiapoptotic genes and enhances death receptor-induced apoptosis
    Juan P Patron
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    PLoS ONE 7:e35345. 2012

Detail Information

Publications153 found, 100 shown here

  1. ncbi request reprint Immune response to Mycobacterium bovis bacille Calmette Guérin infection in major histocompatibility complex class I- and II-deficient knock-out mice: contribution of CD4 and CD8 T cells to acquired resistance
    C H Ladel
    Department of Immunology, University of Ulm, Germany
    Eur J Immunol 25:377-84. 1995
    ..bovis BCG within distinct granulomatous lesions, but fail to eradicate their intracellular pathogens. It appears most likely that CD8 T cells are also required to achieve this goal...
  2. pmc Proteomics reveals open reading frames in Mycobacterium tuberculosis H37Rv not predicted by genomics
    P R Jungblut
    Core Facility for Protein Analysis, Max Planck Institute for Infection Biology, Berlin, Germany
    Infect Immun 69:5905-7. 2001
    ....
  3. ncbi request reprint Secretion of different listeriolysin cognates by recombinant attenuated Salmonella typhimurium: superior efficacy of haemolytic over non-haemolytic constructs after oral vaccination
    J Hess
    Max Planck Institute for Infection Biology, Department of Immunology, D 10117, Berlin, Germany
    Microbes Infect 2:1799-806. 2000
    ..Therefore, rSalmonella strains secreting biologically active Hly represent valuable delivery systems for heterologous rAg or DNA which should be exploited for future mucosal vaccination strategies...
  4. ncbi request reprint Critical role of CD28 in protective immunity against Salmonella typhimurium
    H W Mittrucker
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 163:6769-76. 1999
    ..Thus, CD28 cosignaling is crucial for immunity against S. typhimurium. To our knowledge, this is the first report describing an essential role for CD28 in protective immunity against an intracellular microbial pathogen...
  5. ncbi request reprint Effect on parasite eradication of Pneumocystis carinii-specific antibodies produced in the presence or absence of CD4(+) alphabeta T lymphocytes
    R Hanano
    Department of Immunology, University Clinics Ulm, Ulm, Germany
    Eur J Immunol 29:2464-75. 1999
    ..Furthermore, serum components other than Abappear to participate in resistance to fungal manifestation...
  6. ncbi request reprint Challenges and responses in human vaccine development
    Stefan H E Kaufmann
    Max Planck Institute for Infection Biology, Department of Immunology, Chariteplatz 1, Berlin D 10117, Germany Electronic address
    Curr Opin Immunol 28:18-26. 2014
    ..Gene expression profiles and immune parameters in patients, vaccinees and healthy controls have formed the basis for biosignatures that will provide guidelines for future vaccine design. ..
  7. pmc Identification of T-cell antigens specific for latent mycobacterium tuberculosis infection
    Sebastian D Schuck
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    PLoS ONE 4:e5590. 2009
    ..T-cell responses against dormancy-, resuscitation-, and reactivation-associated antigens of Mycobacterium tuberculosis are candidate biomarkers of latent infection in humans...
  8. ncbi request reprint Crosstalk between human DC subsets promotes antibacterial activity and CD8+ T-cell stimulation in response to bacille Calmette-Guérin
    Laura Lozza
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    Eur J Immunol 44:80-92. 2014
    ..We conclude that mDC-pDC crosstalk should be exploited for rational design of next-generation TB vaccines. ..
  9. pmc The tuberculosis vaccine candidate Bacillus Calmette-Guérin ΔureC::hly coexpressing human interleukin-7 or -18 enhances antigen-specific T cell responses in mice
    Martin Rao
    Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany
    PLoS ONE 8:e78966. 2013
    ..We conclude that expression of hIL-7 or hIL-18 enhanced specific T cell responses but failed to improve protection over BCG ΔureC::hly in mice. ..
  10. pmc MiR-133b targets antiapoptotic genes and enhances death receptor-induced apoptosis
    Juan P Patron
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    PLoS ONE 7:e35345. 2012
    ..These data reveal the ability of a single miR to influence major apoptosis pathways, suggesting an essential role for this molecule during cellular transformation, tumorigenesis and tissue homeostasis...
  11. pmc The adaptor molecule CARD9 is essential for tuberculosis control
    Anca Dorhoi
    Max Planck Institute for Infection Biology, Department of Immunology, 10117 Berlin, Germany
    J Exp Med 207:777-92. 2010
    ..Our data provide evidence that deregulated innate responses trigger excessive lung inflammation and demonstrate a pivotal role of CARD9 signaling in autonomous innate host defense against tuberculosis...
  12. pmc Granulysin-expressing CD4+ T cells as candidate immune marker for tuberculosis during childhood and adolescence
    Henrik Mueller
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    PLoS ONE 6:e29367. 2011
    ..Granulysin produced by cytolytic T cells directly contributes to immune defense against tuberculosis (TB). We investigated granulysin as a candidate immune marker for childhood and adolescent TB...
  13. pmc Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients
    January Weiner
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    PLoS ONE 7:e40221. 2012
    ..Our results provide specific insights into the biology of TB and pave the way for the rational development of metabolic biomarkers for TB...
  14. ncbi request reprint Host-directed therapy of tuberculosis: what is in it for microRNA?
    Marco Iannaccone
    Max Planck Institute for Infection Biology, Department of Immunology, Chariteplatz 1, D 10117, Berlin, Germany 49 30 28460 500 49 30 28460 501
    Expert Opin Ther Targets 18:491-4. 2014
    ..In this editorial, we discuss most recent lines of evidence for regulation of the immune response in TB by miRs that could form the basis for diagnosis and host-directed therapy in adjunct to canonical intervention measures in TB. ..
  15. doi request reprint Inflammation in tuberculosis: interactions, imbalances and interventions
    Stefan H E Kaufmann
    Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany Electronic address
    Curr Opin Immunol 25:441-9. 2013
    ..With inflammation networks being uncovered in TB, the relevance of several pathways for novel interventions becomes clearer. ..
  16. doi request reprint Tuberculosis vaccines: time to think about the next generation
    Stefan H E Kaufmann
    Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany
    Semin Immunol 25:172-81. 2013
    ..Qualitatively superior vaccines should be capable of preventing or eliminating Mtb infection, in this way eliminating the risk of TB reactivation. The time is now ripe to exploit radically new strategies to achieve this goal. ..
  17. doi request reprint Recombinant live vaccine candidates against tuberculosis
    Stefan H E Kaufmann
    Max Planck Institute for Infection Biology, Department of Immunology, Chariteplatz 1, 10117 Berlin, Germany
    Curr Opin Biotechnol 23:900-7. 2012
    ....
  18. doi request reprint Tuberculosis vaccine development: strength lies in tenacity
    Stefan H E Kaufmann
    Max Planck Institute for Infection Biology, Chariteplatz 1, 10117 Berlin, Germany
    Trends Immunol 33:373-9. 2012
    ..Amalgamation of this information will foster the way towards more efficacious vaccination strategies that not only prevent disease, but prevent or abolish infection...
  19. pmc Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting
    Novel N Chegou
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa
    BMC Infect Dis 12:10. 2012
    ..tb infection states. In this study, we assessed the diagnostic potential of 118 different M.tb infection phase-dependent antigens in TB patients and household contacts (HHCs) in a high-burden setting...
  20. pmc Antigen 85C inhibition restricts Mycobacterium tuberculosis growth through disruption of cord factor biosynthesis
    Thulasi Warrier
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    Antimicrob Agents Chemother 56:1735-43. 2012
    ..tuberculosis envelope. I3-AG85 inhibited the division of and reduced TDM synthesis in an M. tuberculosis strain deficient in Ag85C. Our results indicate that Ag85 proteins are promising targets for novel antimycobacterial drug design...
  21. pmc Biomarker discovery in heterogeneous tissue samples -taking the in-silico deconfounding approach
    Dirk Repsilber
    Department of Genetics and Biometry, Research Institute for Biology of Farm Animals, Wilhelm Stahl Allee 2, D 18196 Dummerstorf, Germany
    BMC Bioinformatics 11:27. 2010
    ..This would be of importance for the identification of candidate biomarkers in heterogeneous tissues...
  22. ncbi request reprint Exploiting immunology and molecular genetics for rational vaccine design against tuberculosis
    S H E Kaufmann
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    Int J Tuberc Lung Dis 10:1068-79. 2006
    ..The goal for the future would be to have these novel vaccine candidates tested in different combinations to facilitate the design of the most efficacious vaccination protocol...
  23. ncbi request reprint How can immunology contribute to the control of tuberculosis?
    S H Kaufmann
    Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany
    Nat Rev Immunol 1:20-30. 2001
    ..tuberculosis will be vital in the design of a future vaccine...
  24. ncbi request reprint Changing funding patterns in tuberculosis
    Stefan H E Kaufmann
    Max Planck Institute for Infection Biology, Department of Immunology, Chariteplatz 1, 10117 Berlin, Germany
    Nat Med 13:299-303. 2007
  25. ncbi request reprint The contribution of immunology to the rational design of novel antibacterial vaccines
    Stefan H E Kaufmann
    Max Planck Institute for Infection Biology, Department of Immunology, Chariteplatz 1, D 10117 Berlin, Germany
    Nat Rev Microbiol 5:491-504. 2007
    ....
  26. ncbi request reprint Immune response against Mycobacterium tuberculosis: implications for vaccine development
    S H Kaufmann
    Department of Immunology, Max Planck Institute for Infection Biology, Monbijoustr 2, D 10117, Berlin, Germany
    J Biotechnol 83:13-7. 2000
    ..Second, the whole bacterial vaccine approach relying on multiple antigens and built-in adjuvanticity. Time will tell which type of vaccine is best suited for eradication of tuberculosis...
  27. doi request reprint Future vaccination strategies against tuberculosis: thinking outside the box
    Stefan H E Kaufmann
    Department of Immunology, Max Planck Institute for Infection Biology, Chariteplatz 1, D 10117 Berlin, Germany
    Immunity 33:567-77. 2010
    ..Here, we review current and future strategies toward the rational design of novel vaccines against TB, as well as the progress made thus far, and the hurdles that need to be overcome in the near and distant future...
  28. ncbi request reprint Elie Metchnikoff's and Paul Ehrlich's impact on infection biology
    Stefan H E Kaufmann
    Max Planck Institute for Infection Biology, Department of Immunology, Chariteplatz 1, D 10117 Berlin, Germany
    Microbes Infect 10:1417-9. 2008
    ..Hence, they are not only the founders of immunology but also were the first to envisage infection biology as the result of an interplay between host and pathogen...
  29. ncbi request reprint Envisioning future strategies for vaccination against tuberculosis
    Stefan H E Kaufmann
    Stefan H E Kaufmann is at the Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Nat Rev Immunol 6:699-704. 2006
    ....
  30. pmc Protection against tuberculosis: cytokines, T cells, and macrophages
    S H E Kaufmann
    Max Planck Institute for Infection Biology, Germany
    Ann Rheum Dis 61:ii54-8. 2002
    ..In vivo granuloma formation, which is central to protection, is induced and sustained by cytokines. Mycobacteria are contained within granulomas and in this way are prevented from spreading all over the body...
  31. ncbi request reprint From bacteriology to immunology: the dualism of specificity
    Stefan H E Kaufmann
    Max Planck Institute for Infection Biology, Department of Immunology, 10117 Berlin, Germany
    Nat Immunol 6:1063-6. 2005
  32. ncbi request reprint Antigen presentation and recognition in bacterial infections
    Stefan He Kaufmann
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, D 10117 Berlin, Germany
    Curr Opin Immunol 17:79-87. 2005
    ..Although several such mechanisms have been described in viral systems, few have thus far been elucidated in bacterial infections...
  33. ncbi request reprint Introduction: microbiology and immunology: lessons learned from Salmonella
    S H Kaufmann
    Department of Immunology, Max Planck Institute for Infection Biology, Schumannstr 21 22, 10117 Berlin, Germany
    Microbes Infect 3:1177-81. 2001
    ..enterica infections. This multidisciplinary research will enhance our understanding of the basic mechanisms of bacterial infections and immunity; it also provides new approaches towards therapeutic and control measures...
  34. ncbi request reprint Immune response to tuberculosis: experimental animal models
    Stefan H E Kaufmann
    Department of Immunology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Tuberculosis (Edinb) 83:107-11. 2003
  35. ncbi request reprint Annulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis
    Stefan H E Kaufmann
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Nat Med 11:S33-44. 2005
    ..tuberculosis, and 15 million with both. Last year, 5 million and 50 million were newly infected with HIV or M. tuberculosis, respectively, with 2 million new double infections. Better control measures are urgently needed...
  36. ncbi request reprint 100th anniversary of Robert Koch's Nobel Prize for the discovery of the tubercle bacillus
    Stefan H E Kaufmann
    Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Trends Microbiol 13:469-75. 2005
    ..Despite great efforts, however, Koch failed to conquer tuberculosis, which still causes enormous health problems worldwide 100 years after his Nobel award...
  37. ncbi request reprint Recent findings in immunology give tuberculosis vaccines a new boost
    Stefan H E Kaufmann
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Trends Immunol 26:660-7. 2005
    ..For clinical trials, biomarkers need to be defined with T cells alternating between lung and periphery as prime indicator cells...
  38. pmc A dangerous liaison between two major killers: Mycobacterium tuberculosis and HIV target dendritic cells through DC-SIGN
    Stefan H E Kaufmann
    Department of Immunology, Max Planck Institute for Infection Biology, D 10117 Berlin, Germany
    J Exp Med 197:1-5. 2003
  39. pmc New issues in tuberculosis
    S H E Kaufmann
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstr, 21 22, 10117 Berlin, Germany
    Ann Rheum Dis 63:ii50-ii56. 2004
    ..We have constructed a recombinant BCG vaccine which, compared with wild-type BCG, induces superior protection not only against laboratory strains but also against clinical isolates of M. tuberculosis...
  40. doi request reprint Rational design of novel antibacterial vaccines with an emphasis on tuberculosis
    Stefan H E Kaufmann
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    Scand J Infect Dis 40:595-600. 2008
    ..In particular, these include broad-acting vaccines composed of protein antigens shared by all members of a given pathogen group but absent in the human host and vaccines which operate via T-cells...
  41. doi request reprint [Novel vaccination concepts on the basis of modern insights into immunology]
    S H E Kaufmann
    Max Planck Institut für Infektionsbiologie, Chariteplatz 1, 10117, Berlin
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 52:1069-82. 2009
    ..Thus, hope remains that the remarkable increase in knowledge in the areas of immunology and infectious disease research will help to successfully control infectious diseases...
  42. ncbi request reprint Cell-mediated immunity: dealing a direct blow to pathogens
    S H Kaufmann
    Max Planck Institute for Infection Biology, Berlin, Germany
    Curr Biol 9:R97-9. 1999
    ..Recent data demonstrating direct killing of intracellular bacteria by granulysin, a protein released from the granules of cytotoxic T lymphocytes, emphasize the contribution of these lymphocytes to the control of tuberculosis...
  43. ncbi request reprint [Immunologic foundations of new vaccination strategies]
    S H Kaufmann
    Abteilung fur Immunologie, Universitat Ulm, Germany
    Naturwissenschaften 85:62-72. 1998
    ..Such vaccines will not only contribute to control of infectious agents, but also allow novel strategies towards therapy of tumors, autoimmune disease and allergy...
  44. ncbi request reprint Impact of intracellular location of and antigen display by intracellular bacteria: implications for vaccine development
    S H Kaufmann
    Max Planck Institute for Infection Biology, Berlin, Germany
    Immunol Lett 65:81-4. 1999
    ..Secreted antigen display was found to be superior to somatic antigen display. Hence, we consider antigen secretion a major prerequisite of an effective vaccine against intracellular bacteria...
  45. pmc Diagnosis of tuberculosis by trained African giant pouched rats and confounding impact of pathogens and microflora of the respiratory tract
    Georgies F Mgode
    Department of Immunology, Max Planck Institute for Infection Biology, Campus Charite Mitte, Berlin, Germany
    J Clin Microbiol 50:274-80. 2012
    ..7%), of which 28.6% were rat positive. These findings and the absence of M. tuberculosis-specific volatiles in nonmycobacterial species indicate that rats can be trained to specifically detect M. tuberculosis...
  46. pmc Recombinant BCG ΔureC hly+ induces superior protection over parental BCG by stimulating a balanced combination of type 1 and type 17 cytokine responses
    Christiane Desel
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin
    J Infect Dis 204:1573-84. 2011
    ..The recombinant ΔureC hly+ BCG (rBCG) is more efficient than parental BCG (pBCG) against pulmonary TB in preclinical studies and has proven safe and immunogenic in phase I clinical trials...
  47. doi request reprint Fact and fiction in tuberculosis vaccine research: 10 years later
    Stefan H E Kaufmann
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    Lancet Infect Dis 11:633-40. 2011
    ..The pipeline of new vaccine candidates from preclinical to clinical testing could be accelerated by development of biomarkers that can predict the clinical outcome of tuberculosis...
  48. ncbi request reprint New vaccines for tuberculosis
    Stefan H E Kaufmann
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    Lancet 375:2110-9. 2010
    ..Long-term vaccination strategies need to target these more ambitious goals. Even though vaccine development will have a price, the return of investment will greatly exceed original costs...
  49. ncbi request reprint The need for a novel generation of vaccines
    S H Kaufmann
    Max Planck Institute for Infection Biology, Berlin, Germany
    Immunobiology 201:272-82. 1999
    ..These encompass recombinant vaccine carriers expressing, and naked DNA constructs encoding, heterologous antigens. Both vaccination strategies proved to be protective in the model of experimental listeriosis of mice...
  50. doi request reprint Novel tuberculosis vaccination strategies based on understanding the immune response
    S H E Kaufmann
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Intern Med 267:337-53. 2010
    ..Ultimately, vaccination strategies that achieve sterile eradication of, or prevent infection with, tubercle bacilli would be an ambitious highly promising goal...
  51. ncbi request reprint Phenotypically activated gammadelta T lymphocytes in the peripheral blood of patients with tuberculosis
    S I Behr-Perst
    Max Planck Institute for Infection Biology, Department of Immunology, 10117 Berlin, Germany
    J Infect Dis 180:141-9. 1999
    ..The activation phenotype of peripheral gammadelta T cells in patients with tuberculosis emphasizes the role of these T cells in controlling the inflammatory process during tuberculosis and perhaps other microbial infections...
  52. ncbi request reprint Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells
    M Emoto
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 162:5094-8. 1999
    ..These results demonstrate a crucial role for LFA-1 in the accumulation of CD4+NKT cells in the liver...
  53. ncbi request reprint CD40 signaling converts a minimally immunogenic antigen into a potent vaccine against the intracellular pathogen Listeria monocytogenes
    M S Rolph
    Deptartment of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 166:5115-21. 2001
    ..Thus, CD40 signaling can deliver potent adjuvant activity for vaccination against intracellular pathogens and is particularly effective for pathogens requiring both CD4(+) and CD8(+) T cells for effective control...
  54. ncbi request reprint Immunization with gp96 from Listeria monocytogenes-infected mice is due to N-formylated listerial peptides
    A M Sponaas
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 167:6480-6. 2001
    ..We assume a unique role of gp96 in Ag processing through the H2-M3 pathway...
  55. ncbi request reprint Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location
    J Hess
    Department of Immunology, University of Ulm, Germany
    J Immunol 156:3321-6. 1996
    ..typhimurium SL7207 Hlys and control strains did not differ in beta 2m-/- mutants. This finding argues against direct correlation of cytosolic location of S. typhimurium SL7207 Hlys with CD8+ T cell dependency of protection...
  56. ncbi request reprint Studies with MHC-deficient knock-out mice reveal impact of both MHC I- and MHC II-dependent T cell responses on Listeria monocytogenes infection
    C H Ladel
    Department of Immunology, University of Ulm, Germany
    J Immunol 153:3116-22. 1994
    ..monocytogenes and point to the necessity of a coordinated interaction between CD8 and CD4 alpha beta T cells (and probably gamma delta T cells) in anti-L. monocytogenes resistance...
  57. pmc gp96-peptide vaccination of mice against intracellular bacteria
    U Zugel
    Department of Immunology, University of Ulm, Germany
    Infect Immun 69:4164-7. 2001
    ..Immunization with gp96 may therefore represent a promising vaccination strategy against bacterial pathogens...
  58. ncbi request reprint Contribution of alpha/beta and gamma/delta T lymphocytes to immunity against Mycobacterium bovis bacillus Calmette Guérin: studies with T cell receptor-deficient mutant mice
    C H Ladel
    Department of Immunology, University of Ulm, Germany
    Eur J Immunol 25:838-46. 1995
    ..Our data formally prove the crucial role of alpha/beta T cells and reveal accessory functions of gamma/delta T cells in optimum immunity against M. bovis BCG...
  59. ncbi request reprint Intracellular bacteria as targets and carriers for vaccination
    H Mollenkopf
    Max-Planck-Institute for Infection Biology, Department of Immunology, Berlin, Germany
    Biol Chem 382:521-32. 2001
    ..An alternative strategy relies on the application of subunit immunizations, either as nucleic acid vaccines or protein antigens of the pathogen. Finally, we present a short summary of the vaccination strategies against tuberculosis...
  60. pmc Mycobacterium bovis Bacille Calmette-Guérin strains secreting listeriolysin of Listeria monocytogenes
    J Hess
    Max Planck Institute for Infection Biology, Monbijoustrasse 2, D 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 95:5299-304. 1998
    ..Because CD8 T cells play a major role in protection against tuberculosis such Hly secreting r-BCG constructs are antituberculosis vaccine candidates...
  61. ncbi request reprint Contribution of MHC class I-dependent immune mechanisms induced by attenuated recombinant Salmonella typhimurium secreting superoxide dismutase to protection against murine listeriosis
    L Grode
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, 10117, Berlin, Germany
    Vaccine 19:3269-72. 2001
    ..monocytogenes. Our data suggest a role of TAP-dependent mechanisms in priming of protective immunity by rSalmonella micro-organisms secreting SOD...
  62. ncbi request reprint Development of live recombinant vaccine candidates against tuberculosis
    J Hess
    Max-Planck-Institute for Infection Biology, Department of Immunology, Berlin, Germany
    Scand J Infect Dis 33:723-4. 2001
    ..tuberculosis...
  63. ncbi request reprint Participation of leukocyte function-associated antigen-1 and NK cells in the homing of thymic CD8+NKT cells to the liver
    M Emoto
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    Eur J Immunol 30:3049-56. 2000
    ..These results not only indicate that thymus provides a source for CD8+NKT cells expressing TCRalpha/beta in the liver, but also suggest that LFA-1 expressed on NK cells is involved in the homing of thymic CD8+NKT cells to the liver...
  64. ncbi request reprint IL-4 neutralization or TNF-alpha treatment ameliorate disease by an intracellular pathogen in IFN-gamma receptor-deficient mice
    G Szalay
    Department of Immunology, University of Ulm, Germany
    J Immunol 157:4746-50. 1996
    ..In cases where the primary gene defect cannot be restored, precise identification of secondary effects will promote rational immunotherapy based on neutralization or reconstitution of secondary immune deviations...
  65. ncbi request reprint Control of thymus-independent intestinal intraepithelial lymphocytes by beta 2-microglobulin
    O Neuhaus
    Department of Immunology, University of Ulm, Germany
    Eur J Immunol 25:2332-9. 1995
    ..Regulation of self-reactive thymus-independent i-IEL through beta 2m/ MHC class I may contribute to control of autoreactive immune responses in the intestine...
  66. pmc Lethal tuberculosis in interleukin-6-deficient mutant mice
    C H Ladel
    Department of Immunology, University of Ulm, Germany
    Infect Immun 65:4843-9. 1997
    ..We assume that IL-6 contributes to host resistance by its proinflammatory activity and by its influence on cytokine secretion...
  67. pmc Limited mycobacterial infection of the liver as a consequence of its microanatomical structure causing restriction of mycobacterial growth to professional phagocytes
    P Seiler
    Max Planck Institute for Infection Biology, D-10117 Berlin, Germany
    Infect Immun 69:7922-6. 2001
    ..Unlike in organs more persistently seeded by M. tuberculosis, in the liver the bacteria do not infect cell types other than professional phagocytes...
  68. ncbi request reprint Identification of proteins from Mycobacterium tuberculosis missing in attenuated Mycobacterium bovis BCG strains
    J Mattow
    Max-Planck-Institute for Infection Biology, Berlin, Germany
    Electrophoresis 22:2936-46. 2001
    ..bovis BCG. The remaining 20 spots unique for M. tuberculosis were identified as proteins encoded by genes that are not known to be missing in M. bovis BCG...
  69. ncbi request reprint Abscess formation in Listeria monocytogenes-infected gamma delta T cell deficient mouse mutants involves alpha beta T cells
    S Thoma-Uszynski
    Department of Immunology, University of Ulm, Germany
    Microb Pathog 22:123-8. 1997
    ..We conclude that these inflammatory tissue reactions develop when alpha beta T cells of either CD4 or CD8 phenotype are released from control by gamma delta T cells...
  70. ncbi request reprint Role of CD28 for the generation and expansion of antigen-specific CD8(+) T lymphocytes during infection with Listeria monocytogenes
    H W Mittrucker
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 167:5620-7. 2001
    ..However, Ag-specific CD8(+) T cells generated in the absence of CD28 differentiated into normal effector and memory T cells...
  71. ncbi request reprint Development of novel tuberculosis vaccines
    J Hess
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    C R Acad Sci III 322:953-8. 1999
    ..A rational judgement on the efficacy of the different types of vaccine currently under development needs to await further evaluation...
  72. ncbi request reprint Cutting edge: role of B lymphocytes in protective immunity against Salmonella typhimurium infection
    H W Mittrucker
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 164:1648-52. 2000
    ..typhimurium involved both B cell-dependent and -independent effector mechanisms. Thus, B cell-mediated immunity plays a distinct role in control of S. typhimurium in susceptible mice...
  73. ncbi request reprint Autoimmune intestinal pathology induced by hsp60-specific CD8 T cells
    U Steinhoff
    Department of Immunology, Max Planck Institute of Infection Biology, Germany
    Immunity 11:349-58. 1999
    ..This report demonstrates that CD8 T cells with defined antigen specificity cause intestinal inflammation, emphasizing a link between infection and autoimmune disease...
  74. ncbi request reprint Rapid neutrophil response controls fast-replicating intracellular bacteria but not slow-replicating Mycobacterium tuberculosis
    P Seiler
    Max Planck Institut für Infektionsbiologie, D 10117 Berlin, Germany
    J Infect Dis 181:671-80. 2000
    ....
  75. ncbi request reprint Identification of acidic, low molecular mass proteins of Mycobacterium tuberculosis strain H37Rv by matrix-assisted laser desorption/ionization and electrospray ionization mass spectrometry
    J Mattow
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstr 21 22, D 10117 Berlin, Germany
    Proteomics 1:494-507. 2001
    ..Six additional spots were shown to comprise proteins encoded by open reading frames that have not been predicted for M. tuberculosis H37Rv by genomic investigations...
  76. ncbi request reprint Protection against murine tuberculosis by an attenuated recombinant Salmonella typhimurium vaccine strain that secretes the 30-kDa antigen of Mycobacterium bovis BCG
    J Hess
    Max Planck Institute for Infection Biology, Department of Immunology, Monbijoustr 2, D 10117, Berlin, Germany
    FEMS Immunol Med Microbiol 27:283-9. 2000
    ..These data suggest that the HlyB/HlyD/TolC-based antigen delivery system with attenuated r-S. typhimurium as carrier is capable of inducing an immune response against mycobacterial antigens...
  77. ncbi request reprint MHC class Ia-restricted T cells partially account for beta2-microglobulin-dependent resistance to Mycobacterium tuberculosis
    M S Rolph
    Dept of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    Eur J Immunol 31:1944-9. 2001
    ..Thus, antigen presentation via MHC class Ia is an important component in resistance to M. tuberculosis, but its absence only partially accounts for the increased susceptibility of beta 2-microglobulin-deficient mice...
  78. ncbi request reprint Substantial in vivo proliferation of CD4(+) and CD8(+) T lymphocytes during secondary Listeria monocytogenes infection
    H W Mittrucker
    Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany
    Eur J Immunol 30:1053-9. 2000
    ..Thus, our results reveal that in addition to the large CD8(+) T cell population an almost equally large population of Listeria-reactive CD4(+) T cells is generated in response to L. monocytogenes infection...
  79. ncbi request reprint Immune response to infection with Salmonella typhimurium in mice
    H W Mittrucker
    Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany
    J Leukoc Biol 67:457-63. 2000
    ..In summary, the response to S. typhimurium involves both T and B cell-mediated immunity, and mechanisms mediated by both lymphocyte populations are important for control of primary infection and protection against secondary infection...
  80. ncbi request reprint Intersection of group I CD1 molecules and mycobacteria in different intracellular compartments of dendritic cells
    U E Schaible
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 164:4843-52. 2000
    ....
  81. ncbi request reprint Immune responses to intracellular bacteria
    B Raupach
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, 10117, Berlin, Germany
    Curr Opin Immunol 13:417-28. 2001
    ....
  82. ncbi request reprint CD1 and CD1-restricted T cells in infections with intracellular bacteria
    U E Schaible
    Max Planck Institute for Infection Biology, Schumannstrbetae 21 22, D 10117, Berlin, Germany
    Trends Microbiol 8:419-25. 2000
    ..Here, we discuss the intracellular localization of CD1 molecules and mycobacterial lipids and the role of CD1-mediated T-cell responses in mycobacterial infections...
  83. ncbi request reprint Protective efficacy against tuberculosis of ESAT-6 secreted by a live Salmonella typhimurium vaccine carrier strain and expressed by naked DNA
    H J Mollenkopf
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstr 21 22, 10117 Berlin, Germany
    Vaccine 19:4028-35. 2001
    ..Vaccination with a single dose of r S. typhimurium secreting ESAT-6 reduced numbers of tubercle bacilli in the lungs throughout the course of infection. The combined prime-boost vaccination did not considerably enhance protection...
  84. ncbi request reprint CD1 molecules and CD1-dependent T cells in bacterial infections: a link from innate to acquired immunity?
    U E Schaible
    Max Planck Institute for Infection Biology, Berlin, Germany
    Semin Immunol 12:527-35. 2000
    ..Second, we provide an insight into differential intracellular meeting points for antigen processing between group I CD1 molecules, mycobacteria and mycobacterial glycolipid antigens...
  85. ncbi request reprint Comparative proteome analysis of Mycobacterium tuberculosis and Mycobacterium bovis BCG strains: towards functional genomics of microbial pathogens
    P R Jungblut
    Protein Analysis Unit, Max Planck Institute for Infection Biology, Berlin, Germany
    Mol Microbiol 33:1103-17. 1999
    ..It is to be hoped that the availability of the mycobacterial proteome will facilitate the design of novel measures for prevention and therapy of one of the great health threats, tuberculosis...
  86. ncbi request reprint IL-4 secretion by CD4+ NK1+ T cells induces monocyte chemoattractant protein-1 in early listeriosis
    I E Flesch
    Department of Immunology, University of Ulm, Germany
    J Immunol 159:7-10. 1997
    ..monocytogenes through MCP-1 induction...
  87. ncbi request reprint Low-molecular-weight protein ligands from Onchocerca volvulus preferentially stimulate the human gammadelta T cell Vdelta1+ subset
    M E Munk
    Department of Immunology, University of Ulm, Germany
    J Infect Dis 174:1309-15. 1996
    ..It is concluded that somatic 5- to 30-kDa protein ligands from O. volvulus stimulate Vdelta1+ T cells and that Vdelta1+ T cells play a role in immunity to O. volvulus...
  88. ncbi request reprint Altered intestinal immune system but normal antibacterial resistance in the absence of P-selectin and ICAM-1
    U Steinhoff
    Department of Immunology, Max Planck Institute of Infection Biology, Berlin, Germany
    J Immunol 160:6112-20. 1998
    ..These findings demonstrate that P-selectin and ICAM-1 are critically involved in the shaping of lymphocyte populations of the gut but have only a minor influence on systemic and regional host defense against intracellular bacteria...
  89. pmc Soluble tumor necrosis factor alpha receptors in sera from leprosy patients
    M E Munk
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    Infect Immun 67:423-5. 1999
    ..This suggests that sTNF-R regulatory activities are partially impaired in patients with leprosy...
  90. ncbi request reprint Early IL-4 induction in bone marrow lymphoid precursor cells by mycobacterial lipoarabinomannan
    H L Collins
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 161:5546-54. 1998
    ..Thus, pathogenic mycobacteria and their glycolipids may influence hemopoiesis by rapidly inducing IL-4 secretion in the bone marrow...
  91. ncbi request reprint Hydrophobic interaction chromatography for the purification of cytolytic bacterial toxins
    B Schoel
    Department of Immunology, University of Ulm, Germany
    J Chromatogr A 667:131-9. 1994
    ..The results suggest the feasibility of using hydrophobic interaction chromatography, particularly with columns of weak hydrophobicity, for the purification of bacterial haemolysins in high yield...
  92. ncbi request reprint Pneumocystis carinii pneumonia in mutant mice deficient in both TCRalphabeta and TCRgammadelta cells: cytokine and antibody responses
    R Hanano
    Department of Immunology, University of Ulm, 89070 Ulm, Germany
    J Infect Dis 179:455-9. 1999
    ..Other IgG subclasses were strongly reduced and did not bind P. carinii. These results suggest that T cells are crucial for generation of antibodies against P. carinii relevant to resistance...
  93. ncbi request reprint Live antigen carriers as tools for improved anti-tuberculosis vaccines
    J Hess
    Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany
    FEMS Immunol Med Microbiol 23:165-73. 1999
    ..In addition, we report on our r-Salmonella typhimurium expression system combined with the HlyB/HlyD/ TolC export machinery for delivering the prominent mycobacterial antigen Ag85B for immune recognition...
  94. ncbi request reprint Effect of fetal calf serum on cytokine release by bone marrow-derived macrophages during infection with intracellular bacteria
    I E Flesch
    Department of Immunology, University Clinics Ulm, Germany
    Immunobiology 200:120-7. 1999
    ..Because the serum components responsible for BMM priming are undefined, BMM cultured under serum-free conditions provide an appropriate cell population for defining macrophage activating signals...
  95. ncbi request reprint Bacterial virulence, proinflammatory cytokines and host immunity: how to choose the appropriate Salmonella vaccine strain?
    B Raupach
    Department of Immunology, Max Planck Institut für Infektionsbiologie, Schumannstrasse 21 22, 10117 Berlin, Germany
    Microbes Infect 3:1261-9. 2001
    ..Consequently, Salmonella mutants defective in distinct virulence functions offer the potential to specifically modulate the immune response for defined medical applications...
  96. ncbi request reprint A dynamic two-dimensional polyacrylamide gel electrophoresis database: the mycobacterial proteome via Internet
    H J Mollenkopf
    Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany
    Electrophoresis 20:2172-80. 1999
    ..Furthermore, the database facilitates not only interactive use, but also worldwide active participation of other scientific groups with their own data, requiring only minimal computer hardware and knowledge of information technology...
  97. ncbi request reprint Prospects for better tuberculosis vaccines
    H L Collins
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    Lancet Infect Dis 1:21-8. 2001
    ..In this review we discuss the current state of vaccine research, including the identification of candidate antigens and the current methods used for their evaluation...
  98. ncbi request reprint [Immunology of tuberculosis]
    S H Kaufmann
    , , Berlin
    Pneumologie 49:643-8. 1995
    ..Therefore, at later time points, active tuberculosis may develop as a consequence of weakened immunity...
  99. pmc Protection against murine listeriosis by an attenuated recombinant Salmonella typhimurium vaccine strain that secretes the naturally somatic antigen superoxide dismutase
    J Hess
    Department of Immunology, University of Ulm, Germany
    Infect Immun 65:1286-92. 1997
    ..as the carrier is capable of potentiating the immune response against foreign proteins independent from their immunogenicity in and display by the natural host...