Rüdiger Hilker

Summary

Affiliation: Max-Planck-Institute for Neurological Research
Country: Germany

Publications

  1. ncbi request reprint Cerebral blood flow and glucose metabolism in multi-infarct-dementia related to primary antiphospholipid antibody syndrome
    R Hilker
    Klinik und Poliklinik für Neurologie der Universität zu Köln, Germany
    Lupus 9:311-6. 2000
  2. ncbi request reprint Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways
    R Hilker
    Department of Neurology, University of Cologne, Cologne, Germany
    Neurology 65:1716-22. 2005
  3. pmc Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulation
    R Hilker
    Department of Neurology, University Hospital, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    J Neurol Neurosurg Psychiatry 76:1217-21. 2005
  4. ncbi request reprint Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity
    Ruediger Hilker
    Department of Neurology, University of Cologne, Cologne, Germany
    Arch Neurol 62:378-82. 2005
  5. ncbi request reprint [18F]fluorodopa uptake in the upper brainstem measured with positron emission tomography correlates with decreased REM sleep duration in early Parkinson's disease
    Ruediger Hilker
    Department of Neurology, University Hospital, Cologne, Germany
    Clin Neurol Neurosurg 105:262-9. 2003
  6. ncbi request reprint Deep brain stimulation of the subthalamic nucleus does not increase the striatal dopamine concentration in parkinsonian humans
    Ruediger Hilker
    Department of Neurology, University Hospital, Cologne, Germany
    Mov Disord 18:41-8. 2003
  7. ncbi request reprint Functional brain imaging in combined motor and sleep disorders
    Ruediger Hilker
    Department of Neurology, Medical University of Cologne, Germany
    J Neurol Sci 248:223-6. 2006
  8. pmc Health related quality of life is improved by botulinum neurotoxin type A in long term treated patients with focal dystonia
    R Hilker
    Klinik und Poliklinik fur Neurologie, der Universität zu Köln, Joseph Stelzmann Strasse 9, D 50924 Köln Germany
    J Neurol Neurosurg Psychiatry 71:193-9. 2001
  9. ncbi request reprint The striatal dopaminergic deficit is dependent on the number of mutant alleles in a family with mutations in the parkin gene: evidence for enzymatic parkin function in humans
    Rüdiger Hilker
    Department of Neurology, Medical University of Cologne, Cologne, Germany
    Neurosci Lett 323:50-4. 2002
  10. doi request reprint Negative impact of borderline global cognitive scores on quality of life after subthalamic nucleus stimulation in Parkinson's disease
    Karsten Witt
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    J Neurol Sci 310:261-6. 2011

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Cerebral blood flow and glucose metabolism in multi-infarct-dementia related to primary antiphospholipid antibody syndrome
    R Hilker
    Klinik und Poliklinik für Neurologie der Universität zu Köln, Germany
    Lupus 9:311-6. 2000
    ..This case shows that pathological findings in PAPS are congruent to cerebral changes of metabolism and blood flow in systemic lupus erythematosus (SLE)...
  2. ncbi request reprint Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways
    R Hilker
    Department of Neurology, University of Cologne, Cologne, Germany
    Neurology 65:1716-22. 2005
    ..To assess neurochemical deficits in patients with Parkinson disease (PD) associated dementia (PDD) in vivo...
  3. pmc Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulation
    R Hilker
    Department of Neurology, University Hospital, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    J Neurol Neurosurg Psychiatry 76:1217-21. 2005
    ..Deep brain stimulation of the STN (STN DBS), in its role as a highly effective treatment of severe PD motor complications, has been thought to inhibit STN hyperactivity and therefore decrease progression of PD...
  4. ncbi request reprint Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity
    Ruediger Hilker
    Department of Neurology, University of Cologne, Cologne, Germany
    Arch Neurol 62:378-82. 2005
    ..The investigation of disease progression provides important information on the dynamics of cell death in Parkinson disease (PD)...
  5. ncbi request reprint [18F]fluorodopa uptake in the upper brainstem measured with positron emission tomography correlates with decreased REM sleep duration in early Parkinson's disease
    Ruediger Hilker
    Department of Neurology, University Hospital, Cologne, Germany
    Clin Neurol Neurosurg 105:262-9. 2003
    ..This finding emphasises the pathophysiological significance of a disturbed neurotransmitter equilibrium in the rostral brainstem for REM sleep alterations in PD...
  6. ncbi request reprint Deep brain stimulation of the subthalamic nucleus does not increase the striatal dopamine concentration in parkinsonian humans
    Ruediger Hilker
    Department of Neurology, University Hospital, Cologne, Germany
    Mov Disord 18:41-8. 2003
    ..We conclude that the modulation of dopaminergic activity does not seem to play a crucial role for the stimulation's mechanisms of action in parkinsonian humans...
  7. ncbi request reprint Functional brain imaging in combined motor and sleep disorders
    Ruediger Hilker
    Department of Neurology, Medical University of Cologne, Germany
    J Neurol Sci 248:223-6. 2006
    ..PET and SPECT also suggested that sleep abnormalities in Parkinson's disease (PD), such as REM sleep diminution or increased PLMs, are indirect manifestations of the primary striatal dopamine deficiency...
  8. pmc Health related quality of life is improved by botulinum neurotoxin type A in long term treated patients with focal dystonia
    R Hilker
    Klinik und Poliklinik fur Neurologie, der Universität zu Köln, Joseph Stelzmann Strasse 9, D 50924 Köln Germany
    J Neurol Neurosurg Psychiatry 71:193-9. 2001
    ....
  9. ncbi request reprint The striatal dopaminergic deficit is dependent on the number of mutant alleles in a family with mutations in the parkin gene: evidence for enzymatic parkin function in humans
    Rüdiger Hilker
    Department of Neurology, Medical University of Cologne, Cologne, Germany
    Neurosci Lett 323:50-4. 2002
    ..Thus, parkinsonism in parkin gene carriers may be related to abnormal nigral protein accumulation in the presence of a suprathreshold enzyme dysfunction...
  10. doi request reprint Negative impact of borderline global cognitive scores on quality of life after subthalamic nucleus stimulation in Parkinson's disease
    Karsten Witt
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    J Neurol Sci 310:261-6. 2011
    ....
  11. doi request reprint Is improvement in the quality of life after subthalamic nucleus stimulation in Parkinson's disease predictable?
    Christine Daniels
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 26:2516-21. 2011
    ..Improvement in QoL after STN-DBS is also correlated with changes in motor functions and changes in depression and anxiety...
  12. doi request reprint Intraoperative microelectrode recording for the delineation of subthalamic nucleus topography in Parkinson's disease
    Carola Seifried
    Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Brain Stimul 5:378-87. 2012
    ..To implant electrodes for DBS close to the sensorimotor region is considered crucial for optimal motor benefit and for avoidance of potential cognitive and behavioral side effects...
  13. doi request reprint Resting state fMRI reveals increased subthalamic nucleus-motor cortex connectivity in Parkinson's disease
    Simon Baudrexel
    Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
    Neuroimage 55:1728-38. 2011
    ..Taken together our results underline the importance of the STN as a key node for the modulation of BG-cortical motor network activity in PD patients...
  14. ncbi request reprint Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease
    Katherine J Schweitzer
    Hertie Institute of Clinical Brain Research, University of Tubingen, Tubingen, and Department of Neurology, University Hospital, Cologne, Germany
    Mov Disord 21:94-8. 2006
    ..It may therefore be hypothesized that a differing influence of factors determining SN echogenicity early in life and impairing forces occurring later in life may account for different pathogenetic subgroups of idiopathic PD...
  15. doi request reprint Diffusion tensor imaging of white matter involvement in essential tremor
    Johannes C Klein
    Department of Neurology, Goethe University, Frankfurt am Main, Germany
    Hum Brain Mapp 32:896-904. 2011
    ..The underlying cause of the DTI changes observed remains to be elucidated...
  16. doi request reprint Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease
    Christine Daniels
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 25:1583-9. 2010
    ....
  17. doi request reprint Quantitative mapping of T1 and T2* discloses nigral and brainstem pathology in early Parkinson's disease
    Simon Baudrexel
    Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Schleusenweg 2 16, D 60528 Frankfurt am Main, Germany
    Neuroimage 51:512-20. 2010
    ....
  18. doi request reprint Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo
    J C Klein
    Department of Neurology, Goethe University, Frankfurt am Main, Germany
    Neurology 74:885-92. 2010
    ..Whether both are distinct disease entities is an ongoing controversy. Therefore, we directly compared patients with DLB and PDD with multitracer PET...
  19. doi request reprint Frontal FDG-PET activity correlates with cognitive outcome after STN-DBS in Parkinson disease
    E Kalbe
    Department of Neurology, University of Cologne, Germany
    Neurology 72:42-9. 2009
    ..To investigate the underlying pathomechanisms, we correlated alterations of cognitive test performance and changes of neuronal energy metabolism in frontal basal ganglia projection areas under bilateral STN stimulation...
  20. ncbi request reprint Deep brain stimulation of the subthalamic nucleus versus levodopa challenge in Parkinson's disease: measuring the on- and off-conditions with FDG-PET
    R Hilker
    Department of Neurology, Medical University of Cologne, Federal Republic of Germany
    J Neural Transm 109:1257-64. 2002
    ..While levodopa also led to a reduction of lentiform hyperactivity, effective STN stimulation seemed to interfere with distinct cerebellar and limbic circuits...
  21. pmc Differentiating multiple system atrophy from Parkinson's disease: contribution of striatal and midbrain MRI volumetry and multi-tracer PET imaging
    M Ghaemi
    Neurology Department, University Hospital, Cologne, Germany
    J Neurol Neurosurg Psychiatry 73:517-23. 2002
    ....
  22. doi request reprint The value of putaminal diffusion imaging versus 18-fluorodeoxyglucose positron emission tomography for the differential diagnosis of the Parkinson variant of multiple system atrophy
    Simon Baudrexel
    Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany Brain Imaging Center, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
    Mov Disord 29:380-7. 2014
    ..The clinical use of DWI for the differential diagnosis of MSA-P is encouraged. © 2013 International Parkinson and Movement Disorder Society. ..
  23. ncbi request reprint Early electroencephalography in acute ischemic stroke: prediction of a malignant course?
    Lothar Burghaus
    Department of Neurology, University Hospital, Kerpener Str 62, 50924 Cologne, Germany
    Clin Neurol Neurosurg 109:45-9. 2007
    ..As interventional treatment strategies must be started before the deterioration occurs predictors of a malignant course are necessary...
  24. doi request reprint The relationship between TMS measures of functional properties and DTI measures of microstructure of the corticospinal tract
    Annemarie Hübers
    Department of Neurology, Goethe University Frankfurt, Frankfurt, Germany
    Brain Stimul 5:297-304. 2012
    ..In this study, we explored the relationship between such measurements and regional FA in a group of healthy volunteers...
  25. doi request reprint Parkinson's disease and dementia: a longitudinal study (DEMPARK)
    Monika Balzer-Geldsetzer
    Department of Neurology, Philipps University Marburg, Marburg, Germany
    Neuroepidemiology 37:168-76. 2011
    ..Parkinson's disease (PD) is a progressive neurodegenerative motor disorder. However, non-motor complications frequently alter the course of the disease. A particularly disabling non-motor symptom is dementia...
  26. ncbi request reprint The sensitivity of 18-fluorodopa positron emission tomography and magnetic resonance imaging in Parkinson's disease
    W D Heiss
    Neurology Department, University Hospital, Cologne, Germany
    Eur J Neurol 11:5-12. 2004
    ....
  27. ncbi request reprint PET-based molecular imaging in neuroscience
    A H Jacobs
    Laboratory for Gene Therapy and Molecular Imaging, Max Planck Institute for Neurological Research, Gleuelerstrasse 50, 50931, Cologne, Germany
    Eur J Nucl Med Mol Imaging 30:1051-65. 2003
    ..Here, the potential impact of molecular imaging by PET in applications in neuroscience research with a special focus on neurodegeneration and neuro-oncology is reviewed...
  28. ncbi request reprint Molecular and functional imaging technology for the development of efficient treatment strategies for gliomas
    A H Jacobs
    Max Planck Institute for Neurological Research, Center of Molecular Medicine ZMMK, University of Cologne, Cologne, Germany
    Technol Cancer Res Treat 1:187-204. 2002
    ..Here, we review the main principles of PET imaging and its key roles in neurooncology research...
  29. doi request reprint STN-DBS activates the target area in Parkinson disease: an FDG-PET study
    R Hilker
    Department of Neurology, Goethe University, Schleusenweg 2 16, D 60528 Frankfurt, Germany
    Neurology 71:708-13. 2008
    ..The immediate effects of deep brain stimulation (DBS) on subcortical neurons of its target region are controversial...
  30. ncbi request reprint Prospects of molecular imaging in neurology
    A H Jacobs
    Max Planck Institute for Neurological Research, Center of Molecular Medicine ZMMK, Cologne, Germany
    J Cell Biochem Suppl 39:98-109. 2002
    ..Here, we review the three main imaging technologies, which have been developed for studying molecular processes in vivo, the disease models, which have been studied so far, and the potential future applications...
  31. ncbi request reprint Relative sparing of the parietal cortex in cerebellar ataxia documented by positron emission tomography
    J Rudolf
    Klinik und Poliklinik für Neurologie der Universität zu Köln, Joseph Stelzmann Str 9, D 50924, Koln, Germany
    Clin Neurol Neurosurg 102:210-214. 2000
    ..Most importantly, FDG-PET yields insight into the influence of cerebellar disease on supratentorial glucose metabolism and documents impairment of supratentorial neuronal function with relative sparing of the parietal cortex...
  32. ncbi request reprint Clinical spectrum of homozygous and heterozygous PINK1 mutations in a large German family with Parkinson disease: role of a single hit?
    Katja Hedrich
    Department of Neurology, University of Lubeck, Germany
    Arch Neurol 63:833-8. 2006
    ..Although homozygous mutations in the PTEN-induced putative kinase 1 (PINK1) gene have been unequivocally associated with early-onset Parkinson disease (PD), the role of single heterozygous PINK1 mutations is less clear...
  33. doi request reprint Diurnal variation of hypothalamic function and chronic subthalamic nucleus stimulation in Parkinson's disease
    Carola Seifried
    Department of Neurology, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
    Neuroendocrinology 97:283-90. 2013
    ..Considering anatomical and functional connections of the STN with the hypothalamic-pituitary (HP) system, we prospectively investigated whether chronic STN-DBS alters HP functioning in 11 PD patients...
  34. doi request reprint What is the best treatment for fluctuating Parkinson's disease: continuous drug delivery or deep brain stimulation of the subthalamic nucleus?
    Rüdiger Hilker
    Department of Neurology, Goethe University, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    J Neural Transm 118:907-14. 2011
    ..In this paper, we summarize relevant facts for this decision and provide some guidelines for a responsible counseling of eligible patients...
  35. doi request reprint Deficient homeostatic regulation of practice-dependent plasticity in writer's cramp
    Jun Suk Kang
    Department of Neurology, Goethe University Frankfurt, D 60528 Frankfurt am Main, Germany
    Cereb Cortex 21:1203-12. 2011
    ..Findings support the notion that deficient homeostatic metaplasticity of practice-dependent plasticity plays a significant role in the pathophysiology of writer's cramp...
  36. doi request reprint Reproducibility and diagnostic accuracy of substantia nigra sonography for the diagnosis of Parkinson's disease
    Simone van de Loo
    Department of Neurology, University Hospital, Goethe University, Frankfurt am Main, Germany
    J Neurol Neurosurg Psychiatry 81:1087-92. 2010
    ..Although this feature is well established, sufficient observer reliability and diagnostic accuracy are prerequisites for advancements of this method...
  37. doi request reprint 11C-flumazenil positron emission tomography demonstrates reduction of both global and local cerebral benzodiazepine receptor binding in a patient with Stiff Person Syndrome
    Norbert Galldiks
    Dept of Neurology, University of Cologne, Kerpener Str 62, 50924, Cologne, Germany
    J Neurol 255:1361-4. 2008
    ..These data provide first in vivo evidence for a reduced postsynaptic GABA-A receptor availability which may reflect the loss of GABAergic neuronal inhibition in SPS...
  38. doi request reprint Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit
    C Eggers
    Department of Neurology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Neurology 74:1798-805. 2010
    ..While homozygous mutations in the PINK1 gene cause recessively inherited early-onset Parkinson disease (PD), heterozygous mutations have been suggested as a susceptibility factor...
  39. ncbi request reprint Thirty days complication rate following surgery performed for deep-brain-stimulation
    Jurgen Voges
    Department of Neurology, Albertus Magnus University, Koln, Germany
    Mov Disord 22:1486-9. 2007
    ..4%). Surgical complications caused secondary AEs (e.g. pneumonia) preferentially in older patients and in patients treated for Parkinson's disease (PD). Complication rates did not differ among the five centers...
  40. ncbi request reprint Screening for cognitive deficits in Parkinson's disease with the Parkinson neuropsychometric dementia assessment (PANDA) instrument
    Elke Kalbe
    Department of Neurology, University Hospital, University of Cologne, Germany
    Parkinsonism Relat Disord 14:93-101. 2008
    ..The mood questionnaire also had high sensitivity and specificity. We conclude that the PANDA is an economical, easy-to-use and sensitive tool to detect neuropsychological dysfunctions in PD patients in clinical practice...
  41. ncbi request reprint Variability in infectivity of primary cell cultures of human brain tumors with HSV-1 amplicon vectors
    M A Rueger
    Department of Neurology, University of Cologne, Max Planck Institute for Neurological Research, Center for Molecular Medicine, European Molecular Imaging Laboratory, Cologne 50931, Germany
    Gene Ther 12:588-96. 2005
    ..Infectivity of primary tumor samples from respective patients should be tested to enable the development of efficient and safe herpes vector-based gene and virus therapy for clinical application...
  42. ncbi request reprint Deep brain stimulation of the subthalamic nucleus reversibly deteriorates stuttering in advanced Parkinson's disease
    L Burghaus
    Department of Neurology, University Hospital, Cologne, Germany
    J Neural Transm 113:625-31. 2006
    ..Clinical and imaging findings in this patient support the hypothesis that the basal ganglia circuitry plays an important role in the pathophysiology of stuttering...
  43. ncbi request reprint Morphometric fingerprint of asymptomatic Parkin and PINK1 mutation carriers in the basal ganglia
    F Binkofski
    Department of Neurology, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Neurology 69:842-50. 2007
    ..We hypothesized that subclinical nigrostriatal neurodegeneration caused by these mutations would induce morphologic changes in the dysfunctional striatal gray matter...
  44. ncbi request reprint 18F-fluoro-L-thymidine and 11C-methylmethionine as markers of increased transport and proliferation in brain tumors
    Andreas H Jacobs
    Laboratory for Gene Therapy and Molecular Imaging, Max Planck Institute for Neurological Research, Cologne, Germany
    J Nucl Med 46:1948-58. 2005
    ..Additionally, the longer half-life might permit differentiation between transport and intracellular phosphorylation...
  45. doi request reprint Rapid single-scan T2*-mapping using exponential excitation pulses and image-based correction for linear background gradients
    Simon Baudrexel
    Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
    Magn Reson Med 62:263-8. 2009
    ..In vivo T(2)* values acquired on healthy volunteers at 3T are in excellent agreement with results from the literature...
  46. ncbi request reprint Role of in vivo imaging of the central nervous system for developing novel drugs
    M A Rueger
    Laboratory for Gene Therapy and Molecular Imaging Max Planck Institute, for Neurological Research Center, Centre for Molecular Medicine CMMC, Cologne, Germany
    Q J Nucl Med Mol Imaging 51:164-81. 2007
    ..Non-invasive imaging provides further insights into the molecular pathophysiology of human diseases and facilitates the design and implementation of improved therapies...
  47. doi request reprint High resolution positron emission tomography demonstrates basal ganglia dysfunction in early Parkinson's disease
    C Eggers
    Department of Neurology, University of Cologne, Germany
    J Neurol Sci 276:27-30. 2009
    ..These first HRRT PET data in living parkinsonian humans extend previous brain imaging findings of abnormal network activity in the BG and confirm output nuclei and striatal overactivation also in early stage PD patients...
  48. ncbi request reprint Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin gene
    R Hilker
    Department of Neurology, Medical University of Cologne, Germany
    Ann Neurol 49:367-76. 2001
    ..These data indicate a preclinical disease process in these subjects...
  49. ncbi request reprint Acute demyelination: diagnostic difficulties and the need for brain biopsy
    M Maarouf
    Department of Stereotactic and Functional Neurosurgery, Cologne University, Cologne, Germany
    Acta Neurochir (Wien) 145:961-9; discussion 969. 2003
    ..The main differential diagnoses of these lesions include metastatic carcinoma, high-grade glioma and brain abscess. Acute demyelination seldom turns out to be the underlying pathology...