Research Topics
Species | Rüdiger HilkerSummaryAffiliation: Max-Planck-Institute for Neurological Research Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Cerebral blood flow and glucose metabolism in multi-infarct-dementia related to primary antiphospholipid antibody syndromeR Hilker
Klinik und Poliklinik für Neurologie der Universität zu Köln, Germany
Lupus 9:311-6. 2000..This case shows that pathological findings in PAPS are congruent to cerebral changes of metabolism and blood flow in systemic lupus erythematosus (SLE)...- Functional brain imaging in combined motor and sleep disordersRuediger Hilker
Department of Neurology, Medical University of Cologne, Germany
J Neurol Sci 248:223-6. 2006..PET and SPECT also suggested that sleep abnormalities in Parkinson's disease (PD), such as REM sleep diminution or increased PLMs, are indirect manifestations of the primary striatal dopamine deficiency... 
Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulationR Hilker
Department of Neurology, University Hospital, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
J Neurol Neurosurg Psychiatry 76:1217-21. 2005..Deep brain stimulation of the STN (STN DBS), in its role as a highly effective treatment of severe PD motor complications, has been thought to inhibit STN hyperactivity and therefore decrease progression of PD...- Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activityRuediger Hilker
Department of Neurology, University of Cologne, Cologne, Germany
Arch Neurol 62:378-82. 2005..The investigation of disease progression provides important information on the dynamics of cell death in Parkinson disease (PD)... - [18F]fluorodopa uptake in the upper brainstem measured with positron emission tomography correlates with decreased REM sleep duration in early Parkinson's diseaseRuediger Hilker
Department of Neurology, University Hospital, Cologne, Germany
Clin Neurol Neurosurg 105:262-9. 2003..This finding emphasises the pathophysiological significance of a disturbed neurotransmitter equilibrium in the rostral brainstem for REM sleep alterations in PD... - Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathwaysR Hilker
Department of Neurology, University of Cologne, Cologne, Germany
Neurology 65:1716-22. 2005..To assess neurochemical deficits in patients with Parkinson disease (PD) associated dementia (PDD) in vivo... - Deep brain stimulation of the subthalamic nucleus does not increase the striatal dopamine concentration in parkinsonian humansRuediger Hilker
Department of Neurology, University Hospital, Cologne, Germany
Mov Disord 18:41-8. 2003..We conclude that the modulation of dopaminergic activity does not seem to play a crucial role for the stimulation's mechanisms of action in parkinsonian humans... - The striatal dopaminergic deficit is dependent on the number of mutant alleles in a family with mutations in the parkin gene: evidence for enzymatic parkin function in humansRüdiger Hilker
Department of Neurology, Medical University of Cologne, Cologne, Germany
Neurosci Lett 323:50-4. 2002..Thus, parkinsonism in parkin gene carriers may be related to abnormal nigral protein accumulation in the presence of a suprathreshold enzyme dysfunction... - Health related quality of life is improved by botulinum neurotoxin type A in long term treated patients with focal dystoniaR Hilker
Klinik und Poliklinik fur Neurologie, der Universität zu Köln, Joseph Stelzmann Strasse 9, D 50924 Köln Germany
J Neurol Neurosurg Psychiatry 71:193-9. 2001.... 
Negative impact of borderline global cognitive scores on quality of life after subthalamic nucleus stimulation in Parkinson's diseaseKarsten Witt
Department of Neurology, Christian Albrechts University, Kiel, Germany
J Neurol Sci 310:261-6. 2011....- Is improvement in the quality of life after subthalamic nucleus stimulation in Parkinson's disease predictable?Christine Daniels
Department of Neurology, Christian Albrechts University, Kiel, Germany
Mov Disord 26:2516-21. 2011..Improvement in QoL after STN-DBS is also correlated with changes in motor functions and changes in depression and anxiety... - Intraoperative microelectrode recording for the delineation of subthalamic nucleus topography in Parkinson's diseaseCarola Seifried
Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Brain Stimul 5:378-87. 2012..To implant electrodes for DBS close to the sensorimotor region is considered crucial for optimal motor benefit and for avoidance of potential cognitive and behavioral side effects... - Resting state fMRI reveals increased subthalamic nucleus-motor cortex connectivity in Parkinson's diseaseSimon Baudrexel
Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
Neuroimage 55:1728-38. 2011..Taken together our results underline the importance of the STN as a key node for the modulation of BG-cortical motor network activity in PD patients... - Diffusion tensor imaging of white matter involvement in essential tremorJohannes C Klein
Department of Neurology, Goethe University, Frankfurt am Main, Germany
Hum Brain Mapp 32:896-904. 2011..The underlying cause of the DTI changes observed remains to be elucidated... - Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's diseaseChristine Daniels
Department of Neurology, Christian Albrechts University, Kiel, Germany
Mov Disord 25:1583-9. 2010.... - Quantitative mapping of T1 and T2* discloses nigral and brainstem pathology in early Parkinson's diseaseSimon Baudrexel
Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Schleusenweg 2 16, D 60528 Frankfurt am Main, Germany
Neuroimage 51:512-20. 2010.... - Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivoJ C Klein
Department of Neurology, Goethe University, Frankfurt am Main, Germany
Neurology 74:885-92. 2010..Whether both are distinct disease entities is an ongoing controversy. Therefore, we directly compared patients with DLB and PDD with multitracer PET... - Early electroencephalography in acute ischemic stroke: prediction of a malignant course?Lothar Burghaus
Department of Neurology, University Hospital, Kerpener Str 62, 50924 Cologne, Germany
Clin Neurol Neurosurg 109:45-9. 2007..As interventional treatment strategies must be started before the deterioration occurs predictors of a malignant course are necessary... - Deep brain stimulation of the subthalamic nucleus versus levodopa challenge in Parkinson's disease: measuring the on- and off-conditions with FDG-PETR Hilker
Department of Neurology, Medical University of Cologne, Federal Republic of Germany
J Neural Transm 109:1257-64. 2002..While levodopa also led to a reduction of lentiform hyperactivity, effective STN stimulation seemed to interfere with distinct cerebellar and limbic circuits... - Frontal FDG-PET activity correlates with cognitive outcome after STN-DBS in Parkinson diseaseE Kalbe
Department of Neurology, University of Cologne, Germany
Neurology 72:42-9. 2009..To investigate the underlying pathomechanisms, we correlated alterations of cognitive test performance and changes of neuronal energy metabolism in frontal basal ganglia projection areas under bilateral STN stimulation... - Differentiating multiple system atrophy from Parkinson's disease: contribution of striatal and midbrain MRI volumetry and multi-tracer PET imagingM Ghaemi
Neurology Department, University Hospital, Cologne, Germany
J Neurol Neurosurg Psychiatry 73:517-23. 2002..In contrast, MRI and PET imaging of the midbrain does not provide a further gain in diagnostic accuracy... - The relationship between TMS measures of functional properties and DTI measures of microstructure of the corticospinal tractAnnemarie Hübers
Department of Neurology, Goethe University Frankfurt, Frankfurt, Germany
Brain Stimul 5:297-304. 2012..In this study, we explored the relationship between such measurements and regional FA in a group of healthy volunteers... - Parkinson's disease and dementia: a longitudinal study (DEMPARK)Monika Balzer-Geldsetzer
Department of Neurology, Philipps University Marburg, Marburg, Germany
Neuroepidemiology 37:168-76. 2011..Parkinson's disease (PD) is a progressive neurodegenerative motor disorder. However, non-motor complications frequently alter the course of the disease. A particularly disabling non-motor symptom is dementia... - STN-DBS activates the target area in Parkinson disease: an FDG-PET studyR Hilker
Department of Neurology, Goethe University, Schleusenweg 2 16, D 60528 Frankfurt, Germany
Neurology 71:708-13. 2008..The immediate effects of deep brain stimulation (DBS) on subcortical neurons of its target region are controversial... - Relative sparing of the parietal cortex in cerebellar ataxia documented by positron emission tomographyJ Rudolf
Klinik und Poliklinik für Neurologie der Universität zu Köln, Joseph Stelzmann Str 9, D 50924, Koln, Germany
Clin Neurol Neurosurg 102:210-214. 2000..Most importantly, FDG-PET yields insight into the influence of cerebellar disease on supratentorial glucose metabolism and documents impairment of supratentorial neuronal function with relative sparing of the parietal cortex... - Prospects of molecular imaging in neurologyA H Jacobs
Max Planck Institute for Neurological Research, Center of Molecular Medicine ZMMK, Cologne, Germany
J Cell Biochem Suppl 39:98-109. 2002..Here, we review the three main imaging technologies, which have been developed for studying molecular processes in vivo, the disease models, which have been studied so far, and the potential future applications... - Molecular and functional imaging technology for the development of efficient treatment strategies for gliomasA H Jacobs
Max Planck Institute for Neurological Research, Center of Molecular Medicine ZMMK, University of Cologne, Cologne, Germany
Technol Cancer Res Treat 1:187-204. 2002..Here, we review the main principles of PET imaging and its key roles in neurooncology research... - PET-based molecular imaging in neuroscienceA H Jacobs
Laboratory for Gene Therapy and Molecular Imaging, Max Planck Institute for Neurological Research, Gleuelerstrasse 50, 50931, Cologne, Germany
Eur J Nucl Med Mol Imaging 30:1051-65. 2003..Here, the potential impact of molecular imaging by PET in applications in neuroscience research with a special focus on neurodegeneration and neuro-oncology is reviewed... - The sensitivity of 18-fluorodopa positron emission tomography and magnetic resonance imaging in Parkinson's diseaseW D Heiss
Neurology Department, University Hospital, Cologne, Germany
Eur J Neurol 11:5-12. 2004.... - What is the best treatment for fluctuating Parkinson's disease: continuous drug delivery or deep brain stimulation of the subthalamic nucleus?Rüdiger Hilker
Department of Neurology, Goethe University, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
J Neural Transm 118:907-14. 2011..In this paper, we summarize relevant facts for this decision and provide some guidelines for a responsible counseling of eligible patients... - Deficient homeostatic regulation of practice-dependent plasticity in writer's crampJun Suk Kang
Department of Neurology, Goethe University Frankfurt, D 60528 Frankfurt am Main, Germany
Cereb Cortex 21:1203-12. 2011..Findings support the notion that deficient homeostatic metaplasticity of practice-dependent plasticity plays a significant role in the pathophysiology of writer's cramp... - Reproducibility and diagnostic accuracy of substantia nigra sonography for the diagnosis of Parkinson's diseaseSimone van de Loo
Department of Neurology, University Hospital, Goethe University, Frankfurt am Main, Germany
J Neurol Neurosurg Psychiatry 81:1087-92. 2010..Although this feature is well established, sufficient observer reliability and diagnostic accuracy are prerequisites for advancements of this method... - 11C-flumazenil positron emission tomography demonstrates reduction of both global and local cerebral benzodiazepine receptor binding in a patient with Stiff Person SyndromeNorbert Galldiks
Dept of Neurology, University of Cologne, Kerpener Str 62, 50924, Cologne, Germany
J Neurol 255:1361-4. 2008..These data provide first in vivo evidence for a reduced postsynaptic GABA-A receptor availability which may reflect the loss of GABAergic neuronal inhibition in SPS... - Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficitC Eggers
Department of Neurology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
Neurology 74:1798-805. 2010..While homozygous mutations in the PINK1 gene cause recessively inherited early-onset Parkinson disease (PD), heterozygous mutations have been suggested as a susceptibility factor... - Clinical spectrum of homozygous and heterozygous PINK1 mutations in a large German family with Parkinson disease: role of a single hit?Katja Hedrich
Department of Neurology, University of Lubeck, Germany
Arch Neurol 63:833-8. 2006..Although homozygous mutations in the PTEN-induced putative kinase 1 (PINK1) gene have been unequivocally associated with early-onset Parkinson disease (PD), the role of single heterozygous PINK1 mutations is less clear... - 18F-fluoro-L-thymidine and 11C-methylmethionine as markers of increased transport and proliferation in brain tumorsAndreas H Jacobs
Laboratory for Gene Therapy and Molecular Imaging, Max Planck Institute for Neurological Research, Cologne, Germany
J Nucl Med 46:1948-58. 2005..Additionally, the longer half-life might permit differentiation between transport and intracellular phosphorylation... - Thirty days complication rate following surgery performed for deep-brain-stimulationJurgen Voges
Department of Neurology, Albertus Magnus University, Koln, Germany
Mov Disord 22:1486-9. 2007..4%). Surgical complications caused secondary AEs (e.g. pneumonia) preferentially in older patients and in patients treated for Parkinson's disease (PD). Complication rates did not differ among the five centers... - Screening for cognitive deficits in Parkinson's disease with the Parkinson neuropsychometric dementia assessment (PANDA) instrumentElke Kalbe
Department of Neurology, University Hospital, University of Cologne, Germany
Parkinsonism Relat Disord 14:93-101. 2008..The mood questionnaire also had high sensitivity and specificity. We conclude that the PANDA is an economical, easy-to-use and sensitive tool to detect neuropsychological dysfunctions in PD patients in clinical practice... - Morphometric fingerprint of asymptomatic Parkin and PINK1 mutation carriers in the basal gangliaF Binkofski
Department of Neurology, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany
Neurology 69:842-50. 2007..We hypothesized that subclinical nigrostriatal neurodegeneration caused by these mutations would induce morphologic changes in the dysfunctional striatal gray matter... - Variability in infectivity of primary cell cultures of human brain tumors with HSV-1 amplicon vectorsM A Rueger
Department of Neurology, University of Cologne, Max-Planck Institute for Neurological Research, Center for Molecular Medicine, European Molecular Imaging Laboratory, Cologne 50931, Germany
Gene Ther 12:588-96. 2005..Infectivity of primary tumor samples from respective patients should be tested to enable the development of efficient and safe herpes vector-based gene and virus therapy for clinical application... - Deep brain stimulation of the subthalamic nucleus reversibly deteriorates stuttering in advanced Parkinson's diseaseL Burghaus
Department of Neurology, University Hospital, Cologne, Germany
J Neural Transm 113:625-31. 2006..Clinical and imaging findings in this patient support the hypothesis that the basal ganglia circuitry plays an important role in the pathophysiology of stuttering... - Rapid single-scan T2*-mapping using exponential excitation pulses and image-based correction for linear background gradientsSimon Baudrexel
Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
Magn Reson Med 62:263-8. 2009..In vivo T(2)* values acquired on healthy volunteers at 3T are in excellent agreement with results from the literature... - Role of in vivo imaging of the central nervous system for developing novel drugsM A Rueger
Laboratory for Gene Therapy and Molecular Imaging Max Planck Institute, for Neurological Research Center, Centre for Molecular Medicine CMMC, Cologne, Germany
Q J Nucl Med Mol Imaging 51:164-81. 2007..Non-invasive imaging provides further insights into the molecular pathophysiology of human diseases and facilitates the design and implementation of improved therapies... - High resolution positron emission tomography demonstrates basal ganglia dysfunction in early Parkinson's diseaseC Eggers
Department of Neurology, University of Cologne, Germany
J Neurol Sci 276:27-30. 2009..These first HRRT PET data in living parkinsonian humans extend previous brain imaging findings of abnormal network activity in the BG and confirm output nuclei and striatal overactivation also in early stage PD patients... - Acute demyelination: diagnostic difficulties and the need for brain biopsyM Maarouf
Department of Stereotactic and Functional Neurosurgery, Cologne University, Cologne, Germany
Acta Neurochir (Wien) 145:961-9; discussion 969. 2003..The main differential diagnoses of these lesions include metastatic carcinoma, high-grade glioma and brain abscess. Acute demyelination seldom turns out to be the underlying pathology... - Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin geneR Hilker
Department of Neurology, Medical University of Cologne, Germany
Ann Neurol 49:367-76. 2001..These data indicate a preclinical disease process in these subjects...