Research Topics
Species | K HerholzSummaryAffiliation: Max-Planck-Institute for Neurological Research Country: Germany Publications
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Detail Information
Publications
Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PETK Herholz
University Cologne, Neurological Clinic and Max Planck Institute for Neurological Research, 50931 Koln, Germany
Neuroimage 17:302-16. 2002..Ventromedial frontal cortex was also abnormal. In conclusion, automated analysis of multicenter FDG PET is feasible, provides insights into AD pathophysiology, and can be used potentially as a sensitive biomarker for early AD diagnosis...- In vivo study of acetylcholine esterase in basal forebrain, amygdala, and cortex in mild to moderate Alzheimer diseaseK Herholz
Department of Neurology, University Cologne, and Max Planck Institute for Neurological Research, Cologne, Germany
Neuroimage 21:136-43. 2004..The results support the concept that neocortical and amygdaloid functional changes of the cholinergic system are an early and leading event in AD, rather than the consequence of neurodegeneration of basal nuclei... - PET studies in dementiaKarl Herholz
Neurologische Universitatsklinik, Max Planck Institut für neurologische Forschung, Koln, Germany
Ann Nucl Med 17:79-89. 2003..In LBD there is also impairment of dopamine synthesis, similar to Parkinson disease... - Monitoring the effect of chemotherapy in a mixed glioma by C-11-methionine PETK Herholz
Neurologische Universitatsklinik, Max Planck Institut für neurologische Forschung, Gleueler Str 50, 50931 Koln, Germany
J Neuroimaging 13:269-71. 2003..4% per day, resulting in complete remission that persisted until the end of follow-up at 3 years. Thus, the authors conclude that C-11-MET PET may be useful for monitoring chemotherapy in gliomas and deserves further study... - PET measurement of cerebral acetylcholine esterase activity without blood samplingK Herholz
Neurologische Universitatsklinik, Josef Stelzmann Strasse 9, 50931 Koln, Germany
Eur J Nucl Med 28:472-7. 2001.... - A survey of neuroimaging research in European neurological departmentsK Herholz
Neurologische Universitätsklinik and Max Planck Institut für Neurologische Forschung, Gleueler Strasse, 50, 50931 Koln, Germany
Eur J Neurol 8:111-7. 2001..There is little exchange of scientists amongst laboratories. It was felt that funding and co-operation needed improvement in order to maintain a high standard in neuroimaging research... - Learning face-name associations and the effect of age and performance: a PET activation studyK Herholz
Max Planck Institut für neurologische Forschung and Neurologische Universitätsklinik, Gleuler Str 50, D 50931, Cologne, Germany
Neuropsychologia 39:643-50. 2001..Learning is further mediated by a predominantly left-hemispheric network including inferior temporal and orbitofrontal cortex... - Impairment of neocortical metabolism predicts progression in Alzheimer's diseaseK Herholz
Max Planck Institut für neurologische Forschung, Koln, Germany
Dement Geriatr Cogn Disord 10:494-504. 1999..In patients with mild cognitive deficits at entry, the risk of deterioration was up to 4.7 times higher if the metabolism was severely impaired than with mild or absent metabolic impairment. Copyrightz1999S.KargerAG, Basel.. - Positron emission tomography in clinical neurologyKarl Herholz
Department of Neurology, University Cologne, Koln, Germany
Mol Imaging Biol 6:239-69. 2004..Techniques for presurgical localization of eloquent cortex and monitoring of therapy are presented... - Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathwaysR Hilker
Department of Neurology, University of Cologne, Cologne, Germany
Neurology 65:1716-22. 2005..To assess neurochemical deficits in patients with Parkinson disease (PD) associated dementia (PDD) in vivo... - Propentofylline enhances cerebral metabolic response to auditory memory stimulation in Alzheimer's diseaseR Mielke
Max Planck Institut für Neurologische Forschung und Universitätsklinik für Neurologie, Koln, Germany
J Neurol Sci 154:76-82. 1998..02). The placebo group showed a significantly decline in the MMSE score (P = 0.02) while there was no change in the treatment group. This suggests a protective role for propentofylline in slowing the progression of AD... - Activation PET as an instrument to determine therapeutic efficacy in Alzheimer's diseaseW D Heiss
Max Planck Institut für neurologische Forschung and Neurologische Universitätsklinik, Koln, Germany
Ann N Y Acad Sci 695:327-31. 1993.... 
CSF total and phosphorylated tau protein, regional glucose metabolism and dementia severity in Alzheimer's diseaseC Haense
Max Planck Institute for Neurological Research, Cologne, Germany
Eur J Neurol 15:1155-62. 2008....- Imaging in gene therapy of patients with gliomaA H Jacobs
Max Planck Institute for Neurological Research, Center of Molecular Medicine ZMMK, Department of Neurology, University of Cologne, Cologne, Germany
J Neurooncol 65:291-305. 2003.... - Subthalamic nucleus stimulation restores glucose metabolism in associative and limbic cortices and in cerebellum: evidence from a FDG-PET study in advanced Parkinson's diseaseRuediger Hilker
Departments of Neurology and dagger Stereotaxy and Functional Neurosurgery, University Hospital, Cologne, Germany
J Cereb Blood Flow Metab 24:7-16. 2004..These data suggest an activating effect of DBS upon its target structures and confirm a central role of the STN in motor as well as associative, limbic, and cerebellar basal ganglia circuits... - Role of in vivo imaging of the central nervous system for developing novel drugsM A Rueger
Laboratory for Gene Therapy and Molecular Imaging Max Planck Institute, for Neurological Research Center, Centre for Molecular Medicine CMMC, Cologne, Germany
Q J Nucl Med Mol Imaging 51:164-81. 2007..Non-invasive imaging provides further insights into the molecular pathophysiology of human diseases and facilitates the design and implementation of improved therapies... - PET-based molecular imaging in neuroscienceA H Jacobs
Laboratory for Gene Therapy and Molecular Imaging, Max Planck Institute for Neurological Research, Gleuelerstrasse 50, 50931, Cologne, Germany
Eur J Nucl Med Mol Imaging 30:1051-65. 2003..Here, the potential impact of molecular imaging by PET in applications in neuroscience research with a special focus on neurodegeneration and neuro-oncology is reviewed... - Imaging of acetylcholine esterase activity in brainstem nuclei involved in regulation of sleep and wakefulnessC Eggers
Department of Neurology, University of Cologne, Cologne, Germany
Eur J Neurol 14:690-3. 2007..This approach may be helpful to investigate the interaction of various nuclei in the complex network regulating sleep and wakefulness in representative patient groups with documented sleep disturbance... - Anosognosia in very mild Alzheimer's disease but not in mild cognitive impairmentE Kalbe
Department of Neurology, University Hospital, and Max Planck Institute for Neurological Research, Cologne, Germany
Dement Geriatr Cogn Disord 19:349-56. 2005..To study awareness of cognitive dysfunction in patients with very mild Alzheimer's disease (AD) and subjects with mild cognitive impairment (MCI)... - Performance of FDG PET for detection of Alzheimer's disease in two independent multicentre samples (NEST-DD and ADNI)C Haense
Max Planck Institute for Neurological Research, Cologne, Germany
Dement Geriatr Cogn Disord 28:259-66. 2009..We investigated the performance of FDG PET using an automated procedure for discrimination between Alzheimer's disease (AD) and controls, and studied the influence of demographic and technical factors... - Impaired benzodiazepine receptor binding in peri-lesional cortex of patients with symptomatic epilepsies studied by [(11)C]-flumazenil PETBrigitte Szelies
Neurologische Universitätsklinik and Max Planck Institut für Neurologische Forschung, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
Eur J Neurol 9:137-42. 2002.... 
Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulationR Hilker
Department of Neurology, University Hospital, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
J Neurol Neurosurg Psychiatry 76:1217-21. 2005..Deep brain stimulation of the STN (STN DBS), in its role as a highly effective treatment of severe PD motor complications, has been thought to inhibit STN hyperactivity and therefore decrease progression of PD...- Disturbance and recovery of language function: correlates in PET activation studiesW D Heiss
Max Planck Institute for Neurological Research, University of Cologne, Gleueler Strasse 50, 50931, Cologne, Germany
Neuroimage 20:S42-9. 2003.... - Measurement of blood-brain hexose transport with dynamic PET: comparison of [18F]2-fluoro-2-deoxyglucose and [11C]O-methylglucoseK Herholz
Max Planck Institut für neurologische Forschung, Abteilung für Allgemeine Neurologie, Koln, F R G
J Cereb Blood Flow Metab 9:104-10. 1989..It is concluded that dynamic FDG PET for measurement of cerebral glucose metabolism is also useful to measure alterations of hexose transport and local blood volume in pathological tissue... - Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin geneR Hilker
Department of Neurology, Medical University of Cologne, Germany
Ann Neurol 49:367-76. 2001..These data indicate a preclinical disease process in these subjects... - Molecular and functional imaging technology for the development of efficient treatment strategies for gliomasA H Jacobs
Max Planck Institute for Neurological Research, Center of Molecular Medicine ZMMK, University of Cologne, Cologne, Germany
Technol Cancer Res Treat 1:187-204. 2002..Here, we review the main principles of PET imaging and its key roles in neurooncology research... - Novel neuroimaging findings in a patient with cerebral Whipple's disease: a magnetic resonance imaging and positron emission tomography studyN Galldiks
Department of Neurology, Max Planck-Institute for Neurological Research, Cologne, Germany
J Neuroimaging 14:372-6. 2004.... - [Language activation in ischemic stroke and brain tumor: a PET study]W D Heiss
Max Planck Institut für neurologische Forschung, Klinik fur Neurologie, Universitat zu Koln
Zentralbl Neurochir 63:133-40. 2002.... - Brain receptor imagingWolf Dieter Heiss
Max Planck Institute for Neurological Research and Department of Neurology, University of Cologne, Cologne, Germany
J Nucl Med 47:302-12. 2006.... - The striatal dopaminergic deficit is dependent on the number of mutant alleles in a family with mutations in the parkin gene: evidence for enzymatic parkin function in humansRüdiger Hilker
Department of Neurology, Medical University of Cologne, Cologne, Germany
Neurosci Lett 323:50-4. 2002..Thus, parkinsonism in parkin gene carriers may be related to abnormal nigral protein accumulation in the presence of a suprathreshold enzyme dysfunction... - Cortical flattening applied to high-resolution 18F-FDG PETJohannes C Klein
Max Planck Institute for Neurological Research, Cologne, Germany
J Nucl Med 49:44-9. 2008..This type of registration has been demonstrated to provide better matching of congruent cortical structures than volume methods and, thus, offers a potentially more robust way of analyzing PET data... - Direct comparison of spatially normalized PET and SPECT scans in Alzheimer's diseaseKarl Herholz
Neurologische Universitatsklinik, Koln, Germany
J Nucl Med 43:21-6. 2002..We therefore used statistical parametric mapping to detect and compare abnormal brain areas objectively and quantitatively... - 18F-fluoro-L-thymidine and 11C-methylmethionine as markers of increased transport and proliferation in brain tumorsAndreas H Jacobs
Laboratory for Gene Therapy and Molecular Imaging, Max Planck Institute for Neurological Research, Cologne, Germany
J Nucl Med 46:1948-58. 2005..Additionally, the longer half-life might permit differentiation between transport and intracellular phosphorylation... - Prefrontal cortex dysfunction and depression in atypical parkinsonian syndromesBirgit Herting
Department of Neurology, Technische Universitat Dresden, Germany
Mov Disord 22:490-7. 2007..The findings of this pilot study support the hypothesis that depressive symptoms in MSA and PSP are associated with prefrontal dysfunction... - Essential language function of the right hemisphere in brain tumor patientsAlexander Thiel
Department of Neurology, University of Cologne, Cologne, Germany
Ann Neurol 57:128-31. 2005..Those patients with lowest dominance were also susceptible to right-sided TMS proving relevant language function of the right IFG... - Methyl-L-11C-methionine PET as a diagnostic marker for malignant progression in patients with gliomaRoland T Ullrich
Max Planck Institute for Neurological Research with Klaus Joachim Zülch Laboratories, Cologne, Germany
J Nucl Med 50:1962-8. 2009..Moreover, we analyzed the relationship between changes in (11)C-MET uptake on PET and changes in various molecular immunohistochemical markers during progression of gliomas... - From the left to the right: How the brain compensates progressive loss of language functionAlexander Thiel
Department of Neurology, University of Cologne, Germany
Brain Lang 98:57-65. 2006..It can thus be concluded that time is the factor which determines successful integration of the right hemisphere into the language network for compensation of lost left hemisphere language function... - Crossed cerebellar diaschisis in acute human stroke: a PET study of serial changes and response to supratentorial reperfusionJan Sobesky
Max Planck Institute for Neurological Research, University of Cologne, Cologne, Germany
J Cereb Blood Flow Metab 25:1685-91. 2005.... - Imaging in neurooncologyAndreas H Jacobs
Max Planck Institute for Neurological Research, Cologne, Germany
NeuroRx 2:333-47. 2005..In summary, imaging in patients with brain tumors plays a central role in the management of the disease and in the development of improved imaging-guided therapies... - Neuroimaging-guided rTMS of the left inferior frontal gyrus interferes with repetition primingAlexander Thiel
Department of Neurology, University of Cologne, Germany
Neuroimage 25:815-23. 2005.... - Methyl-[11C]- l-methionine uptake as measured by positron emission tomography correlates to microvessel density in patients with gliomaLutz W Kracht
, Cologne, Germany
Eur J Nucl Med Mol Imaging 30:868-73. 2003..11)C]MET-PET might be a useful tool to select potential responders to anti-angiogenic therapy and to monitor patients during such therapy... - Cerebral acetylcholine esterase activity in mild cognitive impairmentKarl Herholz
Department of Neurology, University of Cologne, Koln, Germany
Neuroreport 16:1431-4. 2005..These results suggest that low cortical acetylcholine esterase activity may be an indicator of impending dementia in patients with mild cognitive impairment... - Deep brain stimulation of the subthalamic nucleus does not increase the striatal dopamine concentration in parkinsonian humansRuediger Hilker
Department of Neurology, University Hospital, Cologne, Germany
Mov Disord 18:41-8. 2003..We conclude that the modulation of dopaminergic activity does not seem to play a crucial role for the stimulation's mechanisms of action in parkinsonian humans... - Metabolic rates in small brain nuclei determined by high-resolution PETWolf Dieter Heiss
Max Planck Institute for Neurological Research, 50931 Koln, Germany
J Nucl Med 45:1811-5. 2004..2 mm at sufficient efficiency and permitted the quantification of tracer concentrations in small volumes... - Delineation of brain tumor extent with [11C]L-methionine positron emission tomography: local comparison with stereotactic histopathologyLutz W Kracht
Max-Planck-Institute for Neurological Research, Cologne, Germany
Clin Cancer Res 10:7163-70. 2004..High [11C]MET uptake in infiltrating tumor of astrocytoma WHO grade 2 reflects high activity in this tumor compartment. Molecular imaging, with [11C]MET, will guide improved management of patients with brain tumors... - Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activityRuediger Hilker
Department of Neurology, University of Cologne, Cologne, Germany
Arch Neurol 62:378-82. 2005..The investigation of disease progression provides important information on the dynamics of cell death in Parkinson disease (PD)... - Efficient principal component analysis for multivariate 3D voxel-based mapping of brain functional imaging data sets as applied to FDG-PET and normal agingGerhard Zuendorf
Neurological Clinic and Max Planck Institute for Neurological Research, University Cologne, Gleueler Strasse 50, 50931 Cologne, Germany
Hum Brain Mapp 18:13-21. 2003..Thus, our method showed that the effect of aging on brain metabolism has at least two independent dimensions. This method should have widespread applications in multivariate analysis of brain functional images... - Use of 11C-methionine PET to monitor the effects of temozolomide chemotherapy in malignant gliomasNorbert Galldiks
Department of Neurology, University of Cologne, Cologne, Germany
Eur J Nucl Med Mol Imaging 33:516-24. 2006..A reduction in MET uptake during TMZ treatment predicts a favourable clinical outcome. Molecular imaging of amino acid uptake by MET-PET offers a new method of measurement of the biological activity of recurrent glioma... - [11C]-L-methionine positron emission tomography in the management of children and young adults with brain tumorsNorbert Galldiks
Department of Neurology, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
J Neurooncol 96:231-9. 2010..02). MET-PET might be a useful tool to differentiate tumorous from non-tumorous lesions in children and young adults when a decision for further therapy is difficult or impossible from routine structural imaging procedures alone... - Cortical acetylcholine esterase activity and ApoE4-genotype in Alzheimer diseaseCarsten Eggers
Department of Neurology, University of Cologne, Germany
Neurosci Lett 408:46-50. 2006..041, p<0.05) in the ApoE4 negative group only. These results indicate that cortical AChE activity is relatively well preserved in ApoE4 carriers, either by preservation of its cellular expression or as AChE activity in amyloid plaques... - Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementiasLisa Mosconi
Center for Brain Health, New York University School of Medicine, New York, New York 10016, USA
J Nucl Med 49:390-8. 2008.... - Evaluation of primary brain tumors using 11C-methionine PET with reference to a normal methionine uptake mapDavid J Coope
Wolfson Molecular Imaging Centre, The University of Manchester, Manchester, United Kingdom
J Nucl Med 48:1971-80. 2007.... - Acetylcholine esterase activity in mild cognitive impairment and Alzheimer's diseaseKarl Herholz
Wolfson Molecular Imaging Centre, Clinical Neuroscience, University of Manchester, 27 Palatine Road, Manchester, UK
Eur J Nucl Med Mol Imaging 35:S25-9. 2008..Impairment of cholinergic neurotransmission is a well-established fact in Alzheimer's disease (AD), but there is controversy about its relevance at the early stages of the disease and in mild cognitive impairment (MCI)... - 18FDG PET in vascular dementia: differentiation from Alzheimer's disease using voxel-based multivariate analysisNacer Kerrouche
INSERM U320, University of Caen, Caen, France
J Cereb Blood Flow Metab 26:1213-21. 2006..By maximizing the separation between groups, this method extracted a metabolic pattern that efficiently differentiated VaD and AD... - Predominant ventromedial frontopolar metabolic impairment in frontotemporal dementiaEric Salmon
The Cyclotron Research Center, University of Liege, 4000 Liege, Belgium
Neuroimage 20:435-40. 2003.... - Age and ApoE genotype interaction in Alzheimer's disease: an FDG-PET studyLisa Mosconi
Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
Psychiatry Res 130:141-51. 2004..These results indicate that age-related regional rCMRglu decreases within the frontal and anterior cingulate areas may be more severe in AD patients carrying the ApoE4 allele... - Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depressionVjera A Holthoff
Department of Psychiatry and Psychotherapy, Dresden University of Technology, Germany
Biol Psychiatry 57:412-21. 2005..CONCLUSIONS: These findings support the notion that different functional circuits underlie apathy and depression in early AD... - Reduced glucose metabolism in temporo-parietal cortices of women with borderline personality disorderClaudia Lange
Department of Psychiatry and Psychotherapy, , von-Siebold-Str. 5, , Germany
Psychiatry Res 139:115-26. 2005..Decreased resting metabolic rate of these regions may reflect dissociative symptoms and possibly also identity disturbances and interpersonal difficulties of individuals with BPD... - Functional interactions of the entorhinal cortex: an 18F-FDG PET study on normal aging and Alzheimer's diseaseLisa Mosconi
Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Italy
J Nucl Med 45:382-92. 2004.... - Neural correlates of anosognosia for cognitive impairment in Alzheimer's diseaseEric Salmon
Cyclotron Research Centre, University of Liege, Liege, Belgium
Hum Brain Mapp 27:588-97. 2006.... - Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer diseaseDavide Anchisi
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, Milan, Italy
Arch Neurol 62:1728-33. 2005..CONCLUSION: These data provide evidence for clinical and functional heterogeneity among subjects with aMCI and suggest that 18FDG-PET findings combined with memory scores may be useful in predicting short-term conversion to AD... - Decomposition of metabolic brain clusters in the frontal variant of frontotemporal dementiaEric Salmon
Cyclotron Research Centre, University of Liege, B30 Sart Tilman, 4000 Liege, Belgium
Neuroimage 30:871-8. 2006..The study provides original data-driven arguments for metabolic involvement of separate brain clusters in the rostral limbic system, corresponding to pathological poles differentially affected in each FTD patient... - Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal dementiaFrederic Peters
Cyclotron Research Center, University of Liege, Liege, Belgium
Dement Geriatr Cogn Disord 21:373-9. 2006.... - Metabolic and molecular imaging in neuro-oncologyKarl Herholz
Wolfson Molecular Imaging Centre, University of Manchester, Oxford Road, Manchester, UK
Lancet Neurol 6:711-24. 2007..Functional and metabolic imaging can improve the planning and monitoring of radiation and chemotherapy and contribute to the development of new therapies... - Deficits of the cholinergic system in early ADKarl Herholz
University of Manchester, United Kingdom
Neuropsychologia 46:1642-7. 2008..The relation of these findings to neuronal function and post-mortem findings is being discussed... - Fast and robust registration of PET and MR images of human brainJiri Cizek
Max Planck Institute for Neurological Research, 50931 Cologne, Germany
Neuroimage 22:434-42. 2004..Registration progress is presented on the fly on a fusion of images and enables visual checking during a registration... - The nucleus accumbens: a target for deep brain stimulation in obsessive-compulsive- and anxiety-disordersVolker Sturm
Department of Stereotactic and Functional Neurosurgery, University of Cologne, 50924, Koln, Germany
J Chem Neuroanat 26:293-9. 2003.... - Cognitive dysfunction and emotional-behavioural changes in MS: the potential of positron emission tomographyKarl Herholz
University of Manchester, Wolfson Molecular Imaging Centre, 27 Palatine Road, Manchester M20 3LJ, UK
J Neurol Sci 245:9-13. 2006..Other tracers offer a broad spectrum of measuring local physiological functions and pathophysiological processes, but some of them are still limited to experimental animal research...