K Herholz

Summary

Affiliation: Max-Planck-Institute for Neurological Research
Country: Germany

Publications

  1. ncbi request reprint Monitoring the effect of chemotherapy in a mixed glioma by C-11-methionine PET
    K Herholz
    Neurologische Universitatsklinik, Max Planck Institut für neurologische Forschung, Gleueler Str 50, 50931 Koln, Germany
    J Neuroimaging 13:269-71. 2003
  2. ncbi request reprint Positron emission tomography in clinical neurology
    Karl Herholz
    Department of Neurology, University Cologne, Koln, Germany
    Mol Imaging Biol 6:239-69. 2004
  3. ncbi request reprint In vivo study of acetylcholine esterase in basal forebrain, amygdala, and cortex in mild to moderate Alzheimer disease
    K Herholz
    Department of Neurology, University Cologne, and Max Planck Institute for Neurological Research, Cologne, Germany
    Neuroimage 21:136-43. 2004
  4. ncbi request reprint PET measurement of cerebral acetylcholine esterase activity without blood sampling
    K Herholz
    Neurologische Universitatsklinik, Josef Stelzmann Strasse 9, 50931 Koln, Germany
    Eur J Nucl Med 28:472-7. 2001
  5. ncbi request reprint A survey of neuroimaging research in European neurological departments
    K Herholz
    Neurologische Universitätsklinik and Max Planck Institut für Neurologische Forschung, Gleueler Strasse, 50, 50931 Koln, Germany
    Eur J Neurol 8:111-7. 2001
  6. ncbi request reprint PET studies in dementia
    Karl Herholz
    Neurologische Universitatsklinik, Max Planck Institut für neurologische Forschung, Koln, Germany
    Ann Nucl Med 17:79-89. 2003
  7. ncbi request reprint Learning face-name associations and the effect of age and performance: a PET activation study
    K Herholz
    Max Planck Institut für neurologische Forschung and Neurologische Universitätsklinik, Gleuler Str 50, D 50931, Cologne, Germany
    Neuropsychologia 39:643-50. 2001
  8. ncbi request reprint Impairment of neocortical metabolism predicts progression in Alzheimer's disease
    K Herholz
    Max Planck Institut für neurologische Forschung, Koln, Germany
    Dement Geriatr Cogn Disord 10:494-504. 1999
  9. ncbi request reprint Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET
    K Herholz
    University Cologne, Neurological Clinic and Max Planck Institute for Neurological Research, 50931 Koln, Germany
    Neuroimage 17:302-16. 2002
  10. ncbi request reprint Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways
    R Hilker
    Department of Neurology, University of Cologne, Cologne, Germany
    Neurology 65:1716-22. 2005

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Monitoring the effect of chemotherapy in a mixed glioma by C-11-methionine PET
    K Herholz
    Neurologische Universitatsklinik, Max Planck Institut für neurologische Forschung, Gleueler Str 50, 50931 Koln, Germany
    J Neuroimaging 13:269-71. 2003
    ..4% per day, resulting in complete remission that persisted until the end of follow-up at 3 years. Thus, the authors conclude that C-11-MET PET may be useful for monitoring chemotherapy in gliomas and deserves further study...
  2. ncbi request reprint Positron emission tomography in clinical neurology
    Karl Herholz
    Department of Neurology, University Cologne, Koln, Germany
    Mol Imaging Biol 6:239-69. 2004
    ..Techniques for presurgical localization of eloquent cortex and monitoring of therapy are presented...
  3. ncbi request reprint In vivo study of acetylcholine esterase in basal forebrain, amygdala, and cortex in mild to moderate Alzheimer disease
    K Herholz
    Department of Neurology, University Cologne, and Max Planck Institute for Neurological Research, Cologne, Germany
    Neuroimage 21:136-43. 2004
    ..The results support the concept that neocortical and amygdaloid functional changes of the cholinergic system are an early and leading event in AD, rather than the consequence of neurodegeneration of basal nuclei...
  4. ncbi request reprint PET measurement of cerebral acetylcholine esterase activity without blood sampling
    K Herholz
    Neurologische Universitatsklinik, Josef Stelzmann Strasse 9, 50931 Koln, Germany
    Eur J Nucl Med 28:472-7. 2001
    ....
  5. ncbi request reprint A survey of neuroimaging research in European neurological departments
    K Herholz
    Neurologische Universitätsklinik and Max Planck Institut für Neurologische Forschung, Gleueler Strasse, 50, 50931 Koln, Germany
    Eur J Neurol 8:111-7. 2001
    ..There is little exchange of scientists amongst laboratories. It was felt that funding and co-operation needed improvement in order to maintain a high standard in neuroimaging research...
  6. ncbi request reprint PET studies in dementia
    Karl Herholz
    Neurologische Universitatsklinik, Max Planck Institut für neurologische Forschung, Koln, Germany
    Ann Nucl Med 17:79-89. 2003
    ..In LBD there is also impairment of dopamine synthesis, similar to Parkinson disease...
  7. ncbi request reprint Learning face-name associations and the effect of age and performance: a PET activation study
    K Herholz
    Max Planck Institut für neurologische Forschung and Neurologische Universitätsklinik, Gleuler Str 50, D 50931, Cologne, Germany
    Neuropsychologia 39:643-50. 2001
    ..Learning is further mediated by a predominantly left-hemispheric network including inferior temporal and orbitofrontal cortex...
  8. ncbi request reprint Impairment of neocortical metabolism predicts progression in Alzheimer's disease
    K Herholz
    Max Planck Institut für neurologische Forschung, Koln, Germany
    Dement Geriatr Cogn Disord 10:494-504. 1999
    ..In patients with mild cognitive deficits at entry, the risk of deterioration was up to 4.7 times higher if the metabolism was severely impaired than with mild or absent metabolic impairment. Copyrightz1999S.KargerAG, Basel..
  9. ncbi request reprint Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET
    K Herholz
    University Cologne, Neurological Clinic and Max Planck Institute for Neurological Research, 50931 Koln, Germany
    Neuroimage 17:302-16. 2002
    ..Ventromedial frontal cortex was also abnormal. In conclusion, automated analysis of multicenter FDG PET is feasible, provides insights into AD pathophysiology, and can be used potentially as a sensitive biomarker for early AD diagnosis...
  10. ncbi request reprint Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways
    R Hilker
    Department of Neurology, University of Cologne, Cologne, Germany
    Neurology 65:1716-22. 2005
    ..To assess neurochemical deficits in patients with Parkinson disease (PD) associated dementia (PDD) in vivo...
  11. ncbi request reprint Propentofylline enhances cerebral metabolic response to auditory memory stimulation in Alzheimer's disease
    R Mielke
    Max Planck Institut für Neurologische Forschung und Universitätsklinik für Neurologie, Koln, Germany
    J Neurol Sci 154:76-82. 1998
    ..02). The placebo group showed a significantly decline in the MMSE score (P = 0.02) while there was no change in the treatment group. This suggests a protective role for propentofylline in slowing the progression of AD...
  12. ncbi request reprint Activation PET as an instrument to determine therapeutic efficacy in Alzheimer's disease
    W D Heiss
    Max Planck Institut für neurologische Forschung and Neurologische Universitätsklinik, Koln, Germany
    Ann N Y Acad Sci 695:327-31. 1993
    ....
  13. ncbi request reprint Activation of basal ganglia loops in idiopathic Parkinson's disease: a PET study
    A Thiel
    Max Planck Institut für neurologische Forschung, Germany
    J Neural Transm 110:1289-301. 2003
    ..The connections between DLPFC and Thalamus via the left caudate remained intact. This impairment may be the neuroanatomical correlate for dysexecutive syndromes in IPS more related to misjudgement than cognitive impairment...
  14. ncbi request reprint Anosognosia in very mild Alzheimer's disease but not in mild cognitive impairment
    E Kalbe
    Department of Neurology, University Hospital, and Max Planck Institute for Neurological Research, Cologne, Germany
    Dement Geriatr Cogn Disord 19:349-56. 2005
    ..To study awareness of cognitive dysfunction in patients with very mild Alzheimer's disease (AD) and subjects with mild cognitive impairment (MCI)...
  15. ncbi request reprint Imaging in gene therapy of patients with glioma
    A H Jacobs
    Max Planck Institute for Neurological Research, Center of Molecular Medicine ZMMK, Department of Neurology, University of Cologne, Cologne, Germany
    J Neurooncol 65:291-305. 2003
    ....
  16. doi request reprint CSF total and phosphorylated tau protein, regional glucose metabolism and dementia severity in Alzheimer's disease
    C Haense
    Max Planck Institute for Neurological Research, Cologne, Germany
    Eur J Neurol 15:1155-62. 2008
    ....
  17. ncbi request reprint Subthalamic nucleus stimulation restores glucose metabolism in associative and limbic cortices and in cerebellum: evidence from a FDG-PET study in advanced Parkinson's disease
    Ruediger Hilker
    Departments of Neurology and dagger Stereotaxy and Functional Neurosurgery, University Hospital, Cologne, Germany
    J Cereb Blood Flow Metab 24:7-16. 2004
    ..These data suggest an activating effect of DBS upon its target structures and confirm a central role of the STN in motor as well as associative, limbic, and cerebellar basal ganglia circuits...
  18. ncbi request reprint Role of in vivo imaging of the central nervous system for developing novel drugs
    M A Rueger
    Laboratory for Gene Therapy and Molecular Imaging Max Planck Institute, for Neurological Research Center, Centre for Molecular Medicine CMMC, Cologne, Germany
    Q J Nucl Med Mol Imaging 51:164-81. 2007
    ..Non-invasive imaging provides further insights into the molecular pathophysiology of human diseases and facilitates the design and implementation of improved therapies...
  19. ncbi request reprint PET-based molecular imaging in neuroscience
    A H Jacobs
    Laboratory for Gene Therapy and Molecular Imaging, Max Planck Institute for Neurological Research, Gleuelerstrasse 50, 50931, Cologne, Germany
    Eur J Nucl Med Mol Imaging 30:1051-65. 2003
    ..Here, the potential impact of molecular imaging by PET in applications in neuroscience research with a special focus on neurodegeneration and neuro-oncology is reviewed...
  20. ncbi request reprint Imaging of acetylcholine esterase activity in brainstem nuclei involved in regulation of sleep and wakefulness
    C Eggers
    Department of Neurology, University of Cologne, Cologne, Germany
    Eur J Neurol 14:690-3. 2007
    ..This approach may be helpful to investigate the interaction of various nuclei in the complex network regulating sleep and wakefulness in representative patient groups with documented sleep disturbance...
  21. doi request reprint Performance of FDG PET for detection of Alzheimer's disease in two independent multicentre samples (NEST-DD and ADNI)
    C Haense
    Max Planck Institute for Neurological Research, Cologne, Germany
    Dement Geriatr Cogn Disord 28:259-66. 2009
    ..We investigated the performance of FDG PET using an automated procedure for discrimination between Alzheimer's disease (AD) and controls, and studied the influence of demographic and technical factors...
  22. ncbi request reprint Impaired benzodiazepine receptor binding in peri-lesional cortex of patients with symptomatic epilepsies studied by [(11)C]-flumazenil PET
    Brigitte Szelies
    Neurologische Universitätsklinik and Max Planck Institut für Neurologische Forschung, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Eur J Neurol 9:137-42. 2002
    ....
  23. ncbi request reprint Measurement of blood-brain hexose transport with dynamic PET: comparison of [18F]2-fluoro-2-deoxyglucose and [11C]O-methylglucose
    K Herholz
    Max Planck Institut für neurologische Forschung, Abteilung für Allgemeine Neurologie, Koln, F R G
    J Cereb Blood Flow Metab 9:104-10. 1989
    ..It is concluded that dynamic FDG PET for measurement of cerebral glucose metabolism is also useful to measure alterations of hexose transport and local blood volume in pathological tissue...
  24. ncbi request reprint Disturbance and recovery of language function: correlates in PET activation studies
    W D Heiss
    Max Planck Institute for Neurological Research, University of Cologne, Gleueler Strasse 50, 50931, Cologne, Germany
    Neuroimage 20:S42-9. 2003
    ....
  25. pmc Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulation
    R Hilker
    Department of Neurology, University Hospital, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    J Neurol Neurosurg Psychiatry 76:1217-21. 2005
    ..Deep brain stimulation of the STN (STN DBS), in its role as a highly effective treatment of severe PD motor complications, has been thought to inhibit STN hyperactivity and therefore decrease progression of PD...
  26. ncbi request reprint Molecular and functional imaging technology for the development of efficient treatment strategies for gliomas
    A H Jacobs
    Max Planck Institute for Neurological Research, Center of Molecular Medicine ZMMK, University of Cologne, Cologne, Germany
    Technol Cancer Res Treat 1:187-204. 2002
    ..Here, we review the main principles of PET imaging and its key roles in neurooncology research...
  27. ncbi request reprint Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin gene
    R Hilker
    Department of Neurology, Medical University of Cologne, Germany
    Ann Neurol 49:367-76. 2001
    ..These data indicate a preclinical disease process in these subjects...
  28. ncbi request reprint Novel neuroimaging findings in a patient with cerebral Whipple's disease: a magnetic resonance imaging and positron emission tomography study
    N Galldiks
    Department of Neurology, Max Planck Institute for Neurological Research, Cologne, Germany
    J Neuroimaging 14:372-6. 2004
    ....
  29. ncbi request reprint [Language activation in ischemic stroke and brain tumor: a PET study]
    W D Heiss
    Max Planck Institut für neurologische Forschung, Klinik fur Neurologie, Universitat zu Koln
    Zentralbl Neurochir 63:133-40. 2002
    ....
  30. ncbi request reprint Brain receptor imaging
    Wolf Dieter Heiss
    Max Planck Institute for Neurological Research and Department of Neurology, University of Cologne, Cologne, Germany
    J Nucl Med 47:302-12. 2006
    ....
  31. ncbi request reprint Prefrontal cortex dysfunction and depression in atypical parkinsonian syndromes
    Birgit Herting
    Department of Neurology, Technische Universitat Dresden, Germany
    Mov Disord 22:490-7. 2007
    ..The findings of this pilot study support the hypothesis that depressive symptoms in MSA and PSP are associated with prefrontal dysfunction...
  32. ncbi request reprint Crossed cerebellar diaschisis in acute human stroke: a PET study of serial changes and response to supratentorial reperfusion
    Jan Sobesky
    Max Planck Institute for Neurological Research, University of Cologne, Cologne, Germany
    J Cereb Blood Flow Metab 25:1685-91. 2005
    ....
  33. ncbi request reprint Essential language function of the right hemisphere in brain tumor patients
    Alexander Thiel
    Department of Neurology, University of Cologne, Cologne, Germany
    Ann Neurol 57:128-31. 2005
    ..Those patients with lowest dominance were also susceptible to right-sided TMS proving relevant language function of the right IFG...
  34. ncbi request reprint Cerebral acetylcholine esterase activity in mild cognitive impairment
    Karl Herholz
    Department of Neurology, University of Cologne, Koln, Germany
    Neuroreport 16:1431-4. 2005
    ..These results suggest that low cortical acetylcholine esterase activity may be an indicator of impending dementia in patients with mild cognitive impairment...
  35. ncbi request reprint 18F-fluoro-L-thymidine and 11C-methylmethionine as markers of increased transport and proliferation in brain tumors
    Andreas H Jacobs
    Laboratory for Gene Therapy and Molecular Imaging, Max Planck Institute for Neurological Research, Cologne, Germany
    J Nucl Med 46:1948-58. 2005
    ..Additionally, the longer half-life might permit differentiation between transport and intracellular phosphorylation...
  36. ncbi request reprint Cortical flattening applied to high-resolution 18F-FDG PET
    Johannes C Klein
    Max Planck Institute for Neurological Research, Cologne, Germany
    J Nucl Med 49:44-9. 2008
    ..This type of registration has been demonstrated to provide better matching of congruent cortical structures than volume methods and, thus, offers a potentially more robust way of analyzing PET data...
  37. doi request reprint Methyl-L-11C-methionine PET as a diagnostic marker for malignant progression in patients with glioma
    Roland T Ullrich
    Max Planck Institute for Neurological Research with Klaus Joachim Zülch Laboratories, Cologne, Germany
    J Nucl Med 50:1962-8. 2009
    ..Moreover, we analyzed the relationship between changes in (11)C-MET uptake on PET and changes in various molecular immunohistochemical markers during progression of gliomas...
  38. ncbi request reprint From the left to the right: How the brain compensates progressive loss of language function
    Alexander Thiel
    Department of Neurology, University of Cologne, Germany
    Brain Lang 98:57-65. 2006
    ..It can thus be concluded that time is the factor which determines successful integration of the right hemisphere into the language network for compensation of lost left hemisphere language function...
  39. pmc Imaging in neurooncology
    Andreas H Jacobs
    Max Planck Institute for Neurological Research, Cologne, Germany
    NeuroRx 2:333-47. 2005
    ..In summary, imaging in patients with brain tumors plays a central role in the management of the disease and in the development of improved imaging-guided therapies...
  40. ncbi request reprint Neuroimaging-guided rTMS of the left inferior frontal gyrus interferes with repetition priming
    Alexander Thiel
    Department of Neurology, University of Cologne, Germany
    Neuroimage 25:815-23. 2005
    ....
  41. ncbi request reprint Methyl-[11C]- l-methionine uptake as measured by positron emission tomography correlates to microvessel density in patients with glioma
    Lutz W Kracht
    Max Planck Institut für neurologische Forschung, Cologne, Germany
    Eur J Nucl Med Mol Imaging 30:868-73. 2003
    ..11)C]MET-PET might be a useful tool to select potential responders to anti-angiogenic therapy and to monitor patients during such therapy...
  42. ncbi request reprint Deep brain stimulation of the subthalamic nucleus does not increase the striatal dopamine concentration in parkinsonian humans
    Ruediger Hilker
    Department of Neurology, University Hospital, Cologne, Germany
    Mov Disord 18:41-8. 2003
    ..We conclude that the modulation of dopaminergic activity does not seem to play a crucial role for the stimulation's mechanisms of action in parkinsonian humans...
  43. ncbi request reprint Metabolic rates in small brain nuclei determined by high-resolution PET
    Wolf Dieter Heiss
    Max Planck Institute for Neurological Research, 50931 Koln, Germany
    J Nucl Med 45:1811-5. 2004
    ..2 mm at sufficient efficiency and permitted the quantification of tracer concentrations in small volumes...
  44. ncbi request reprint Delineation of brain tumor extent with [11C]L-methionine positron emission tomography: local comparison with stereotactic histopathology
    Lutz W Kracht
    Max Planck Institute for Neurological Research, Cologne, Germany
    Clin Cancer Res 10:7163-70. 2004
    ..It remains unclear whether the increased [11C]MET uptake is limited to solid tumor tissue or even detects infiltrating tumor parts...
  45. ncbi request reprint Efficient principal component analysis for multivariate 3D voxel-based mapping of brain functional imaging data sets as applied to FDG-PET and normal aging
    Gerhard Zuendorf
    Neurological Clinic and Max Planck Institute for Neurological Research, University Cologne, Gleueler Strasse 50, 50931 Cologne, Germany
    Hum Brain Mapp 18:13-21. 2003
    ..Thus, our method showed that the effect of aging on brain metabolism has at least two independent dimensions. This method should have widespread applications in multivariate analysis of brain functional images...
  46. ncbi request reprint The striatal dopaminergic deficit is dependent on the number of mutant alleles in a family with mutations in the parkin gene: evidence for enzymatic parkin function in humans
    Rüdiger Hilker
    Department of Neurology, Medical University of Cologne, Cologne, Germany
    Neurosci Lett 323:50-4. 2002
    ..Thus, parkinsonism in parkin gene carriers may be related to abnormal nigral protein accumulation in the presence of a suprathreshold enzyme dysfunction...
  47. ncbi request reprint Direct comparison of spatially normalized PET and SPECT scans in Alzheimer's disease
    Karl Herholz
    Neurologische Universitatsklinik, Koln, Germany
    J Nucl Med 43:21-6. 2002
    ..We therefore used statistical parametric mapping to detect and compare abnormal brain areas objectively and quantitatively...
  48. ncbi request reprint Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity
    Ruediger Hilker
    Department of Neurology, University of Cologne, Cologne, Germany
    Arch Neurol 62:378-82. 2005
    ..The investigation of disease progression provides important information on the dynamics of cell death in Parkinson disease (PD)...
  49. ncbi request reprint Use of 11C-methionine PET to monitor the effects of temozolomide chemotherapy in malignant gliomas
    Norbert Galldiks
    Department of Neurology, University of Cologne, Cologne, Germany
    Eur J Nucl Med Mol Imaging 33:516-24. 2006
    ..The purpose of this study was to monitor the metabolic effects of temozolomide (TMZ) chemotherapy in malignant gliomas by means of repeated positron emission tomography (PET) with [(11)C]methionine (MET)...
  50. pmc [11C]-L-methionine positron emission tomography in the management of children and young adults with brain tumors
    Norbert Galldiks
    Department of Neurology, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    J Neurooncol 96:231-9. 2010
    ..02). MET-PET might be a useful tool to differentiate tumorous from non-tumorous lesions in children and young adults when a decision for further therapy is difficult or impossible from routine structural imaging procedures alone...
  51. ncbi request reprint Cortical acetylcholine esterase activity and ApoE4-genotype in Alzheimer disease
    Carsten Eggers
    Department of Neurology, University of Cologne, Germany
    Neurosci Lett 408:46-50. 2006
    ..041, p<0.05) in the ApoE4 negative group only. These results indicate that cortical AChE activity is relatively well preserved in ApoE4 carriers, either by preservation of its cellular expression or as AChE activity in amyloid plaques...
  52. ncbi request reprint Evaluation of primary brain tumors using 11C-methionine PET with reference to a normal methionine uptake map
    David J Coope
    Wolfson Molecular Imaging Centre, The University of Manchester, Manchester, United Kingdom
    J Nucl Med 48:1971-80. 2007
    ....
  53. doi request reprint Acetylcholine esterase activity in mild cognitive impairment and Alzheimer's disease
    Karl Herholz
    Wolfson Molecular Imaging Centre, Clinical Neuroscience, University of Manchester, 27 Palatine Road, Manchester, UK
    Eur J Nucl Med Mol Imaging 35:S25-9. 2008
    ..Impairment of cholinergic neurotransmission is a well-established fact in Alzheimer's disease (AD), but there is controversy about its relevance at the early stages of the disease and in mild cognitive impairment (MCI)...
  54. ncbi request reprint Predominant ventromedial frontopolar metabolic impairment in frontotemporal dementia
    Eric Salmon
    The Cyclotron Research Center, University of Liege, 4000 Liege, Belgium
    Neuroimage 20:435-40. 2003
    ....
  55. pmc Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias
    Lisa Mosconi
    Center for Brain Health, New York University School of Medicine, New York, New York 10016, USA
    J Nucl Med 49:390-8. 2008
    ....
  56. ncbi request reprint 18FDG PET in vascular dementia: differentiation from Alzheimer's disease using voxel-based multivariate analysis
    Nacer Kerrouche
    INSERM U320, University of Caen, Caen, France
    J Cereb Blood Flow Metab 26:1213-21. 2006
    ..By maximizing the separation between groups, this method extracted a metabolic pattern that efficiently differentiated VaD and AD...
  57. ncbi request reprint Reduced glucose metabolism in temporo-parietal cortices of women with borderline personality disorder
    Claudia Lange
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
    Psychiatry Res 139:115-26. 2005
    ..Decreased resting metabolic rate of these regions may reflect dissociative symptoms and possibly also identity disturbances and interpersonal difficulties of individuals with BPD...
  58. ncbi request reprint Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression
    Vjera A Holthoff
    Department of Psychiatry and Psychotherapy, Dresden University of Technology, Germany
    Biol Psychiatry 57:412-21. 2005
    ..Alzheimer's disease (AD) is clinically characterized by cognitive impairment and behavioral disturbances. The aim of the study was to identify regional alterations in brain function associated with neuropsychiatric symptoms in early AD...
  59. ncbi request reprint Neural correlates of anosognosia for cognitive impairment in Alzheimer's disease
    Eric Salmon
    Cyclotron Research Centre, University of Liege, Liege, Belgium
    Hum Brain Mapp 27:588-97. 2006
    ....
  60. ncbi request reprint Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer disease
    Davide Anchisi
    Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, Milan, Italy
    Arch Neurol 62:1728-33. 2005
    ..Subjects with amnesic mild cognitive impairment (aMCI) may include patients at high risk for progression to Alzheimer disease (AD) and a population with different underlying pathologic conditions...
  61. ncbi request reprint Decomposition of metabolic brain clusters in the frontal variant of frontotemporal dementia
    Eric Salmon
    Cyclotron Research Centre, University of Liege, B30 Sart Tilman, 4000 Liege, Belgium
    Neuroimage 30:871-8. 2006
    ..The study provides original data-driven arguments for metabolic involvement of separate brain clusters in the rostral limbic system, corresponding to pathological poles differentially affected in each FTD patient...
  62. ncbi request reprint Age and ApoE genotype interaction in Alzheimer's disease: an FDG-PET study
    Lisa Mosconi
    Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Psychiatry Res 130:141-51. 2004
    ..These results indicate that age-related regional rCMRglu decreases within the frontal and anterior cingulate areas may be more severe in AD patients carrying the ApoE4 allele...
  63. ncbi request reprint Functional interactions of the entorhinal cortex: an 18F-FDG PET study on normal aging and Alzheimer's disease
    Lisa Mosconi
    Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Italy
    J Nucl Med 45:382-92. 2004
    ..This (18)F-FDG PET study assessed the functional interactions-that is, the intercorrelations between the EC and the whole brain in vivo-in normal aging and AD...
  64. ncbi request reprint Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal dementia
    Frederic Peters
    Cyclotron Research Center, University of Liege, Liege, Belgium
    Dement Geriatr Cogn Disord 21:373-9. 2006
    ....
  65. ncbi request reprint Fast and robust registration of PET and MR images of human brain
    Jiri Cizek
    Max Planck Institute for Neurological Research, 50931 Cologne, Germany
    Neuroimage 22:434-42. 2004
    ..Registration progress is presented on the fly on a fusion of images and enables visual checking during a registration...
  66. doi request reprint Deficits of the cholinergic system in early AD
    Karl Herholz
    University of Manchester, United Kingdom
    Neuropsychologia 46:1642-7. 2008
    ..The relation of these findings to neuronal function and post-mortem findings is being discussed...
  67. ncbi request reprint Metabolic and molecular imaging in neuro-oncology
    Karl Herholz
    Wolfson Molecular Imaging Centre, University of Manchester, Oxford Road, Manchester, UK
    Lancet Neurol 6:711-24. 2007
    ..Functional and metabolic imaging can improve the planning and monitoring of radiation and chemotherapy and contribute to the development of new therapies...
  68. ncbi request reprint The nucleus accumbens: a target for deep brain stimulation in obsessive-compulsive- and anxiety-disorders
    Volker Sturm
    Department of Stereotactic and Functional Neurosurgery, University of Cologne, 50924, Koln, Germany
    J Chem Neuroanat 26:293-9. 2003
    ....
  69. ncbi request reprint Cognitive dysfunction and emotional-behavioural changes in MS: the potential of positron emission tomography
    Karl Herholz
    University of Manchester, Wolfson Molecular Imaging Centre, 27 Palatine Road, Manchester M20 3LJ, UK
    J Neurol Sci 245:9-13. 2006
    ..Other tracers offer a broad spectrum of measuring local physiological functions and pathophysiological processes, but some of them are still limited to experimental animal research...