Moritz Helmstaedter

Summary

Affiliation: Max-Planck-Institute of Neurobiology
Country: Germany

Publications

  1. ncbi request reprint Connectomic reconstruction of the inner plexiform layer in the mouse retina
    Moritz Helmstaedter
    Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Nature 500:168-74. 2013
  2. ncbi request reprint Cellular-resolution connectomics: challenges of dense neural circuit reconstruction
    Moritz Helmstaedter
    Structure of Neocortical Circuits Group, Max Planck Institute of Neurobiology, Munich Martinsried, Germany
    Nat Methods 10:501-7. 2013
  3. pmc Computational methods and challenges for large-scale circuit mapping
    Moritz Helmstaedter
    Structure of Neocortical Circuits Group, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
    Curr Opin Neurobiol 22:162-9. 2012
  4. pmc Number and laminar distribution of neurons in a thalamocortical projection column of rat vibrissal cortex
    Hanno S Meyer
    Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Cereb Cortex 20:2277-86. 2010
  5. ncbi request reprint L2/3 interneuron groups defined by multiparameter analysis of axonal projection, dendritic geometry, and electrical excitability
    Moritz Helmstaedter
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse, Heidelberg, Germany
    Cereb Cortex 19:951-62. 2009
  6. ncbi request reprint Wiring specificity in the direction-selectivity circuit of the retina
    Kevin L Briggman
    Max Planck Institute for Medical Research, Department of Biomedical Optics, Heidelberg 69120, Germany
    Nature 471:183-8. 2011
  7. pmc Inhibitory interneurons in a cortical column form hot zones of inhibition in layers 2 and 5A
    Hanno S Meyer
    Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 108:16807-12. 2011
  8. ncbi request reprint High-accuracy neurite reconstruction for high-throughput neuroanatomy
    Moritz Helmstaedter
    Max Planck Institute for Medical Research, Heidelberg, Germany
    Nat Neurosci 14:1081-8. 2011
  9. ncbi request reprint Neuronal correlates of local, lateral, and translaminar inhibition with reference to cortical columns
    Moritz Helmstaedter
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse, Heidelberg, Germany
    Cereb Cortex 19:926-37. 2009
  10. ncbi request reprint The relation between dendritic geometry, electrical excitability, and axonal projections of L2/3 interneurons in rat barrel cortex
    Moritz Helmstaedter
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse, Heidelberg, Germany
    Cereb Cortex 19:938-50. 2009

Detail Information

Publications13

  1. ncbi request reprint Connectomic reconstruction of the inner plexiform layer in the mouse retina
    Moritz Helmstaedter
    Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Nature 500:168-74. 2013
    ..Circuit motifs that emerge from our data indicate a functional mechanism for a known cellular response in a ganglion cell that detects localized motion, and predict that another ganglion cell is motion sensitive...
  2. ncbi request reprint Cellular-resolution connectomics: challenges of dense neural circuit reconstruction
    Moritz Helmstaedter
    Structure of Neocortical Circuits Group, Max Planck Institute of Neurobiology, Munich Martinsried, Germany
    Nat Methods 10:501-7. 2013
    ..The aim of this perspective is to summarize and quantify the challenges for data analysis in cellular-resolution connectomics and describe current solutions involving online crowd-sourcing and machine-learning approaches...
  3. pmc Computational methods and challenges for large-scale circuit mapping
    Moritz Helmstaedter
    Structure of Neocortical Circuits Group, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
    Curr Opin Neurobiol 22:162-9. 2012
    ..Here we review this growing field of neuronal data analysis with emphasis on reconstructing neurons from EM data cubes...
  4. pmc Number and laminar distribution of neurons in a thalamocortical projection column of rat vibrissal cortex
    Hanno S Meyer
    Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Cereb Cortex 20:2277-86. 2010
    ..The number of APs evoked in a column by a sensory stimulus (principal whisker deflection) was estimated as 4441 within 100 ms post-stimulus...
  5. ncbi request reprint L2/3 interneuron groups defined by multiparameter analysis of axonal projection, dendritic geometry, and electrical excitability
    Moritz Helmstaedter
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse, Heidelberg, Germany
    Cereb Cortex 19:951-62. 2009
    ..This scheme of identifying L2/3 INs may help to quantitatively describe inhibitory effects on sensory stimulus representations in L2/3 of cortical columns...
  6. ncbi request reprint Wiring specificity in the direction-selectivity circuit of the retina
    Kevin L Briggman
    Max Planck Institute for Medical Research, Department of Biomedical Optics, Heidelberg 69120, Germany
    Nature 471:183-8. 2011
    ..Our study demonstrates how otherwise intractable neurobiological questions can be addressed by combining functional imaging with the analysis of neuronal connectivity using large-scale electron microscopy...
  7. pmc Inhibitory interneurons in a cortical column form hot zones of inhibition in layers 2 and 5A
    Hanno S Meyer
    Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 108:16807-12. 2011
    ..The "hot zones" of inhibition in L2 and L5A match the reported low stimulus-evoked spiking rates of excitatory neurons in these layers, suggesting that these inhibitory hot zones substantially suppress activity in the neocortex...
  8. ncbi request reprint High-accuracy neurite reconstruction for high-throughput neuroanatomy
    Moritz Helmstaedter
    Max Planck Institute for Medical Research, Heidelberg, Germany
    Nat Neurosci 14:1081-8. 2011
    ..Focused reannotation of difficult locations promises a rather steep increase of reliability as a function of the average skeleton redundancy and thus the nearly error-free analysis of large neuroanatomical datasets...
  9. ncbi request reprint Neuronal correlates of local, lateral, and translaminar inhibition with reference to cortical columns
    Moritz Helmstaedter
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse, Heidelberg, Germany
    Cereb Cortex 19:926-37. 2009
    ....
  10. ncbi request reprint The relation between dendritic geometry, electrical excitability, and axonal projections of L2/3 interneurons in rat barrel cortex
    Moritz Helmstaedter
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse, Heidelberg, Germany
    Cereb Cortex 19:938-50. 2009
    ..We conclude that 1) dendritic polarity is correlated to intrinsic electrical excitability, and 2) the axonal projection pattern represents an independent classifier of interneurons...
  11. ncbi request reprint Structural neurobiology: missing link to a mechanistic understanding of neural computation
    Winfried Denk
    Max Planck Institute for Medical Research, Heidelberg 69120, Germany
    Nat Rev Neurosci 13:351-8. 2012
    ..Given that the brain's algorithms are ultimately encoded by this network, knowing where all of these connections are should, at the very least, provide the data needed to distinguish between models of neural computation...
  12. pmc Cell type-specific thalamic innervation in a column of rat vibrissal cortex
    Hanno S Meyer
    Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Cereb Cortex 20:2287-303. 2010
    ....
  13. ncbi request reprint 3D structural imaging of the brain with photons and electrons
    Moritz Helmstaedter
    Max Planck Institute for Medical Research, Department of Biomedical Optics, Heidelberg, Germany
    Curr Opin Neurobiol 18:633-41. 2008
    ..Both photon-based and electron-based imaging methods will ultimately need highly automated data analysis, because the manual tracing of most networks of interest would require hundreds to tens of thousands of years in human labor...