Research Topics
Species | Mark HübenerSummaryAffiliation: Max-Planck-Institute of Neurobiology Country: Germany Publications
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Detail Information
Publications
Experience leaves a lasting structural trace in cortical circuitsSonja B Hofer
Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
Nature 457:313-7. 2009..These results provide a strong link between functional plasticity and specific synaptic rearrangements, revealing a mechanism of how prior experiences could be stored in cortical circuits...
Mouse visual cortexMark Hübener
Max Planck Institut fur Neurobiologie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
Curr Opin Neurobiol 13:413-20. 2003....
Visual cortex: two-photon excitementMark Hübener
Max Planck Institut fur Neurobiologie, Martinsried, Germany
Curr Biol 15:R205-8. 2005..Current in vivo methods for imaging the visual cortex lack the ability to map response properties at the level of single cells. A new technique using two-photon imaging of calcium signals has now overcome this limitation...
Searching for engramsMark Hübener
Max Planck Institute of Neurobiology, Martinsried, Germany
Neuron 67:363-71. 2010..quot; In the not too distant future we will be able to observe physical changes that occur during learning in the intact animal in real time, leading the way to understanding these processes in unprecedented detail...
Loss of sensory input causes rapid structural changes of inhibitory neurons in adult mouse visual cortexTara Keck
Max Planck Institute of Neurobiology, Am Klopferspitz 18, D 82152 Martinsried, Germany
Neuron 71:869-82. 2011..Together, these data suggest that structural changes in inhibitory neurons may precede structural changes in excitatory circuitry, which ultimately result in functional adaptation following sensory deprivation...
Massive restructuring of neuronal circuits during functional reorganization of adult visual cortexTara Keck
Max Planck Institute of Neurobiology, Am Klopfersptiz 18, D 82152 Martinsried, Germany
Nat Neurosci 11:1162-7. 2008..Because this massive remodeling of synaptic structures did not occur when all visual input was removed, it likely reflects the activity-dependent establishment of new cortical circuits that serve the recovery of visual responses...
Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticityThomas D Mrsic-Flogel
Department of Cellular and Systems Neurobiology, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
Neuron 54:961-72. 2007....
Sensorimotor mismatch signals in primary visual cortex of the behaving mouseGeorg B Keller
Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
Neuron 74:809-15. 2012..These data suggest that processing in visual cortex may be based on predictive coding strategies that use motor-related and visual input to detect mismatches between predicted and actual visual feedback...
Visual cortex: suppression by depression?Thomas Mrsic-Flogel
Max Planck Institut fur Neurobiologie, Am Klopferspitz 18a, D 82152, Martinsried, Germany
Curr Biol 12:R547-9. 2002..New data suggest this 'cross-orientation suppression' is caused, not by intracortical inhibition, but by rapid depression of thalamocortical synapses...
A genetically encoded calcium indicator for chronic in vivo two-photon imagingMarco Mank
Max Planck Institute of Neurobiology, Am Klopferspitz 18, D 82152 Martinsried, Germany
Nat Methods 5:805-11. 2008....
Altered visual experience induces instructive changes of orientation preference in mouse visual cortexAnne K Kreile
Department of Cellular and Systems Neurobiology, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
J Neurosci 31:13911-20. 2011..Thus, diverse mechanisms contribute to the overall stripe rearing effect, but for neurons in lower layer 2/3 the effect is mediated by an instructive mechanism, which alters the orientation tuning of individual neurons...
Altered map of visual space in the superior colliculus of mice lacking early retinal wavesThomas D Mrsic-Flogel
Max Planck Institut fur Neurobiologie, D 82152 Martinsried, Germany
J Neurosci 25:6921-8. 2005..Thus, patterned neuronal activity in the early retina has a substantial influence on the coarse retinotopic organization of the SC...
Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injuryAli Erturk
Max Planck Institute of Neurobiology, Axonal Growth and Regeneration, Martinsried, Germany
Nat Med 18:166-71. 2012..Our clearing procedure also renders other organs transparent, which makes this approach useful for a large number of preclinical paradigms...
Brain mapping: new wave optical imagingThomas Mrsic-Flogel
Max Planck Institut fur Neurobiologie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
Curr Biol 13:R778-80. 2003..A new approach using continuous data acquisition and Fourier decomposition of the signal allows for much faster mapping, opening up the possibility of applying this method to new experimental questions...
