M Achtman

Summary

Affiliation: Max-Planck-Institute for Infection Biology
Country: Germany

Publications

  1. ncbi request reprint Population structure of pathogenic bacteria revisited
    Mark Achtman
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, Schumannstrasse 21122, D 10117 Berlin, Germany
    Int J Med Microbiol 294:67-73. 2004
  2. pmc Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity
    Giovanna Morelli
    Max Planck Institut für Infektionsbiologie, Department of Molecular Biology, Berlin, Germany
    Nat Genet 42:1140-3. 2010
  3. pmc Molecular epidemiology of serogroup a meningitis in Moscow, 1969 to 1997
    M Achtman
    Max Planck Institut fur Molekulare Genetik, Berlin, Germany
    Emerg Infect Dis 7:420-7. 2001
  4. pmc Fit genotypes and escape variants of subgroup III Neisseria meningitidis during three pandemics of epidemic meningitis
    P Zhu
    Max Planck Institut fur Molekulare Genetik, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 98:5234-9. 2001
  5. ncbi request reprint Recombination and clonal groupings within Helicobacter pylori from different geographical regions
    M Achtman
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, 14195 Berlin, Germany
    Mol Microbiol 32:459-70. 1999
  6. pmc Molecular and biological analysis of eight genetic islands that distinguish Neisseria meningitidis from the closely related pathogen Neisseria gonorrhoeae
    S R Klee
    Max Planck Institut fur Molekulare Genetik, 14195 Berlin, Germany
    Infect Immun 68:2082-95. 2000
  7. ncbi request reprint Microevolution and epidemic spread of serogroup A Neisseria meningitidis--a review
    M Achtman
    Max Planck Institut fur Molekulare Genetik, Berlin, Germany
    Gene 192:135-40. 1997
  8. pmc Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
    M Achtman
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 96:14043-8. 1999
  9. ncbi request reprint Human antibody responses to A and C capsular polysaccharides, IgA1 protease and transferrin-binding protein complex stimulated by infection with Neisseria meningitidis of subgroup IV-1 or ET-37 complex
    N Brieske
    , Berlin, Germany
    Vaccine 17:731-44. 1999
  10. ncbi request reprint The opcA and (psi)opcB regions in Neisseria: genes, pseudogenes, deletions, insertion elements and DNA islands
    P Zhu
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, D 14195 Berlin, Germany
    Mol Microbiol 33:635-50. 1999

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Population structure of pathogenic bacteria revisited
    Mark Achtman
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, Schumannstrasse 21122, D 10117 Berlin, Germany
    Int J Med Microbiol 294:67-73. 2004
    ..quot;genoclouds" in subgroup III Neisseria meningitidis arise because of the accumulation of diversity due to herd immunity, which is then purified during subsequent epidemic spread...
  2. pmc Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity
    Giovanna Morelli
    Max Planck Institut für Infektionsbiologie, Department of Molecular Biology, Berlin, Germany
    Nat Genet 42:1140-3. 2010
    ..All 626 current isolates from the United States reflect one radiation, and 82 isolates from Madagascar represent a second radiation. Subsequent local microevolution of Y. pestis is marked by sequential, geographically specific SNPs...
  3. pmc Molecular epidemiology of serogroup a meningitis in Moscow, 1969 to 1997
    M Achtman
    Max Planck Institut fur Molekulare Genetik, Berlin, Germany
    Emerg Infect Dis 7:420-7. 2001
    ..A 1996 epidemic was part of the pandemic spread from Asia of genocloud 8 of subgroup III. Recent genocloud 8 epidemic disease in Moscow may represent an early warning for spread of these bacteria to other countries in Europe...
  4. pmc Fit genotypes and escape variants of subgroup III Neisseria meningitidis during three pandemics of epidemic meningitis
    P Zhu
    Max Planck Institut fur Molekulare Genetik, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 98:5234-9. 2001
    ..Competition between fit genotypes results in dramatic changes in population composition over short time periods...
  5. ncbi request reprint Recombination and clonal groupings within Helicobacter pylori from different geographical regions
    M Achtman
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, 14195 Berlin, Germany
    Mol Microbiol 32:459-70. 1999
    ..The fact that clonal descent could still be discerned despite such frequent recombination possibly reflects founder effects and geographical separation and/or selection for particular alleles of these genes...
  6. pmc Molecular and biological analysis of eight genetic islands that distinguish Neisseria meningitidis from the closely related pathogen Neisseria gonorrhoeae
    S R Klee
    Max Planck Institut fur Molekulare Genetik, 14195 Berlin, Germany
    Infect Immun 68:2082-95. 2000
    ..Neither were the mutant strains altered in their ability to interact with endothelial cells, suggesting that such interactions are not encoded by large genetic islands in N. meningitidis...
  7. ncbi request reprint Microevolution and epidemic spread of serogroup A Neisseria meningitidis--a review
    M Achtman
    Max Planck Institut fur Molekulare Genetik, Berlin, Germany
    Gene 192:135-40. 1997
    ..The results are interpreted as reflecting a balance of recombination events, which disrupt clonal relationships, and sequential bottlenecks, which purify the bacterial population of genetic variants during epidemic spread...
  8. pmc Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
    M Achtman
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 96:14043-8. 1999
    ....
  9. ncbi request reprint Human antibody responses to A and C capsular polysaccharides, IgA1 protease and transferrin-binding protein complex stimulated by infection with Neisseria meningitidis of subgroup IV-1 or ET-37 complex
    N Brieske
    , Berlin, Germany
    Vaccine 17:731-44. 1999
    ..5 microg ml(-1)). The concentrations of IgG to TBP complex in acute phase sera were higher and IgG to IgA1 protease was even higher, suggesting that intermediate levels of IgG to these proteins do not protect against disease...
  10. ncbi request reprint The opcA and (psi)opcB regions in Neisseria: genes, pseudogenes, deletions, insertion elements and DNA islands
    P Zhu
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, D 14195 Berlin, Germany
    Mol Microbiol 33:635-50. 1999
    ..DNA islands in Nm and Ng seem to have been acquired by recombination via conserved flanking housekeeping genes rather than by insertion of mobile genetic elements...
  11. pmc Purification and characterization of eight class 5 outer membrane protein variants from a clone of Neisseria meningitidis serogroup A
    M Achtman
    Max Planck Institut fur Molekulare Genetik, Berlin, Federal Republic of Germany
    J Exp Med 168:507-25. 1988
    ....
  12. ncbi request reprint Two-dimensional structure of the Opc invasin from Neisseria meningitidis
    P Merker
    Max Planck Institut fur Molekulare Genetik, Berlin, Germany
    Mol Microbiol 23:281-93. 1997
    ..The results thus confirm important predictions of the model and define five permissive sites within surface-exposed loops which can be used to insert foreign epitopes...
  13. ncbi request reprint Microevolution during epidemic spread of Neisseria meningitidis
    M Achtman
    Max Planck Institut fur Molekulare Genetik, Berlin, Germany
    Electrophoresis 19:593-6. 1998
    ..These processes occur rapidly in serogroup A meningococci; such that after their descent from a common ancestor, clonally related bacteria have diversified at numerous loci within the last decades...
  14. ncbi request reprint Frequent interspecific genetic exchange between commensal Neisseriae and Neisseria meningitidis
    B Linz
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, 14195 Berlin, Germany
    Mol Microbiol 36:1049-58. 2000
    ..These observations indicate that recombination can be more frequent between related species than within a species and indicate that effective vaccination against serogroup B meningococcal disease may be difficult to achieve...
  15. ncbi request reprint Clonal descent and microevolution of Neisseria meningitidis during 30 years of epidemic spread
    G Morelli
    Max Planck Institut fur Molekulare Genetik, Berlin, Germany
    Mol Microbiol 25:1047-64. 1997
    ..The speed with which sequence variation is either eliminated or fixed may reflect sequential bottlenecks associated with epidemic spread and contrasts with the results of phylogenetic analyses from bacteria that do not cause epidemics...
  16. pmc Recombination and mutation during long-term gastric colonization by Helicobacter pylori: estimates of clock rates, recombination size, and minimal age
    D Falush
    Max Planck Institut für Infektionsbiologie, Schumannstrasse 21 22, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 98:15056-61. 2001
    ..Thus, the panmictic population structure of H. pylori results from very frequent recombination during mixed colonization by unrelated strains...
  17. ncbi request reprint Cloning and expression in Escherichia coli of opc, the gene for an unusual class 5 outer membrane protein from Neisseria meningitidis (meningococci/surface antigen)
    A J Olyhoek
    Max Planck Institut fur Molekulare Genetik, Berlin, Germany
    Microb Pathog 11:249-57. 1991
    ..This is the first report of cloning and expression of a functional meningococcal gene encoding a class 5 outer membrane protein in E. coli...
  18. pmc Microevolution and history of the plague bacillus, Yersinia pestis
    Mark Achtman
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, D 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 101:17837-42. 2004
    ..pestis inferred here is compatible with the dates of historical pandemic plague. However, it is premature to infer an association between any modern molecular grouping and a particular pandemic wave that occurred before the 20th century...
  19. ncbi request reprint Traces of human migrations in Helicobacter pylori populations
    Daniel Falush
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, 10117 Berlin, Germany
    Science 299:1582-5. 2003
    ..Subsequent spread can be attributed to human migratory fluxes such as the prehistoric colonization of Polynesia and the Americas, the neolithic introduction of farming to Europe, the Bantu expansion within Africa, and the slave trade...
  20. pmc Evolutionary history of Salmonella typhi
    Philippe Roumagnac
    Max Planck Institut für Infektionsbiologie, Department of Molecular Biology, Chariteplatz 1, 10117 Berlin, Germany
    Science 314:1301-4. 2006
    ..Neutral evolution in Typhi appears to reflect the asymptomatic carrier state, and adaptive evolution depends on the rapid transmission of phenotypic changes through acute infections...
  21. pmc Sex and virulence in Escherichia coli: an evolutionary perspective
    Thierry Wirth
    Department of Molecular Biology, Schumannstrasse 21 22, Max Planck Institut für Infektionsbiologie, 10117 Berlin, Germany
    Mol Microbiol 60:1136-51. 2006
    ..This long-term pattern of evolution was observed in genes distributed throughout the genome, and thereby is the likely result of episodic selection for strains that can escape the host immune response...
  22. pmc Distinguishing human ethnic groups by means of sequences from Helicobacter pylori: lessons from Ladakh
    Thierry Wirth
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, Schumannstrasse 21 22, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 101:4746-51. 2004
    ..H. pylori sequence analysis has the potential to become an important tool for unraveling short-term genetic changes in human populations...
  23. ncbi request reprint Proteome analysis of Neisseria meningitidis serogroup A
    Giulia Bernardini
    Dipartimento di Biologia Molecolare, Universita degli Studi di Siena, Siena, Italy
    Proteomics 4:2893-926. 2004
    ..The results show that TbpB spot pattern variation observed in the maps of nine clinical isolates from diverse epidemic spreads, fits previous analyses based on allelic variations of the tbpB gene...
  24. pmc High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi
    Kathryn E Holt
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nat Genet 40:987-93. 2008
    ..The observed patterns of genetic isolation and drift are consistent with the proposed key role of asymptomatic carriers of Typhi as the main reservoir of this pathogen, highlighting the need for identification and treatment of carriers...
  25. pmc Ceftriaxone-resistant salmonella enterica serotype Newport, France
    Svetlana Egorova
    Institut Pasteur, Paris, France
    Emerg Infect Dis 14:954-7. 2008
    ..Because this strain was not detected in food animals, it was most likely introduced into France through imported food products...
  26. doi request reprint Microbial diversity and the genetic nature of microbial species
    Mark Achtman
    Environmental Research Institute, University College Cork, Ireland
    Nat Rev Microbiol 6:431-40. 2008
    ..It summarizes current approaches to defining species and the problems of these approaches, and presents selected examples of the population genetic patterns at and below the species level...
  27. pmc High-throughput genotyping of Salmonella enterica serovar Typhi allowing geographical assignment of haplotypes and pathotypes within an urban District of Jakarta, Indonesia
    Stephen Baker
    The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
    J Clin Microbiol 46:1741-6. 2008
    ..The study also provides insight into the evolution of serovar Typhi and demonstrates the value of a molecular epidemiological technique that is exchangeable, that is internet friendly, and that has global utility...
  28. pmc Clonal waves of Neisseria colonisation and disease in the African meningitis belt: eight- year longitudinal study in northern Ghana
    Julia Leimkugel
    Swiss Tropical Institute, Basel, Switzerland
    PLoS Med 4:e101. 2007
    ....
  29. pmc Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18
    Stephen D Bentley
    Wellcome Trust Sanger Institute, Hinxton, United Kingdom
    PLoS Genet 3:e23. 2007
    ....
  30. ncbi request reprint Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica
    Julian Parkhill
    The Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Nat Genet 35:32-40. 2003
    ....
  31. pmc Characterization of the pilin ortholog of the Helicobacter pylori type IV cag pathogenicity apparatus, a surface-associated protein expressed during infection
    Joanna Andrzejewska
    Hannover Medical School, Institute for Medical Microbiology, Carl Neuberg Strasse 1, Hannover 30625, Germany
    J Bacteriol 188:5865-77. 2006
    ..Pronounced strain-to-strain variability of this predicted surface-exposed part of HP0546 indicates a strong selective pressure for variation in vivo...
  32. ncbi request reprint Genetics of capsule O-acetylation in serogroup C, W-135 and Y meningococci
    Heike Claus
    Institut für Hygiene und Mikrobiologie, Universitat Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Mol Microbiol 51:227-39. 2004
    ..Our report is the first description of sequences of sialic acid O-acetyltransferase genes that have not been cloned from either other bacterial or mammalian organisms...
  33. ncbi request reprint Structural variation and immune recognition of the P1.2 subtype meningococcal antigen
    Christos Tzitzilonis
    Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
    Proteins 62:947-55. 2006
    ..Single point mutations are sufficient to remove binding capability, providing a rationale for the manner in which different meningococcal PorA escape variants arise...
  34. ncbi request reprint Prospective study of a serogroup X Neisseria meningitidis outbreak in northern Ghana
    Sébastien P Gagneux
    Swiss Tropical Institute, Socinstrasse 57, 4002 Basel, Switzerland
    J Infect Dis 185:618-26. 2002
    ..The occurrence of serogroup X outbreaks argues for the inclusion of this serogroup into a multivalent conjugate vaccine against N. meningitidis...
  35. ncbi request reprint Helicobacter pylori: recombination, population structure and human migrations
    Sebastian Suerbaum
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Int J Med Microbiol 294:133-9. 2004
    ..This review article summarizes recent developments in this rapidly moving field...
  36. pmc Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidis
    Stephen M Prince
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, Sackville Street, Manchester M60 1QD, United Kingdom
    Proc Natl Acad Sci U S A 99:3417-21. 2002
    ..The structure, therefore, suggests a model for how adhesion of this important human pathogen to proteoglycan is mediated at the molecular level...
  37. pmc Clonal groupings in serogroup X Neisseria meningitidis
    Sebastien Gagneux
    Swiss Tropical Institute, Socinstrasse 57, 4002 Basel, Switzerland
    Emerg Infect Dis 8:462-6. 2002
    ..During the last decade, these bacteria have caused meningitis outbreaks in Niger and Ghana. These results support the development of a comprehensive conjugate vaccine that would include serogroup X polysaccharide...