Iain W Mattaj

Summary

Country: Germany

Publications

  1. ncbi request reprint Identification of 40LoVe, a Xenopus hnRNP D family protein involved in localizing a TGF-beta-related mRNA during oogenesis
    Kevin Czaplinski
    EMBL Gene Expression Programme, Meyerhofstrasse 1, Heidelberg 69117, Germany
    Dev Cell 8:505-15. 2005
  2. ncbi request reprint Identity elements used in export of mRNAs
    Mutsuhito Ohno
    The Institute for Virus Research, Laboratory of Biochemistry, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Mol Cell 9:659-71. 2002
  3. pmc A compartmentalized phosphorylation/dephosphorylation system that regulates U snRNA export from the nucleus
    Saori Kitao
    Institute for Virus Research, Kyoto University, Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Mol Cell Biol 28:487-97. 2008
  4. pmc Importin alpha associates with membranes and participates in nuclear envelope assembly in vitro
    Virginie Hachet
    European Molecular Biology Laboratory, Meyerhofstrasse, Heidelberg, Germany
    EMBO J 23:1526-35. 2004
  5. pmc Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate
    Hideki Yokoyama
    European Molecular Biology Laboratory, Heidelberg 69117, Germany
    J Cell Biol 180:867-75. 2008
  6. pmc Nup155 regulates nuclear envelope and nuclear pore complex formation in nematodes and vertebrates
    Cerstin Franz
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 24:3519-31. 2005
  7. pmc 40LoVe interacts with Vg1RBP/Vera and hnRNP I in binding the Vg1-localization element
    Kevin Czaplinski
    EMBL Gene Expression Programme, Heidelberg, Germany
    RNA 12:213-22. 2006
  8. pmc NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules
    Katharina Ribbeck
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Mol Biol Cell 17:2646-60. 2006
  9. ncbi request reprint A role for NuSAP in linking microtubules to mitotic chromosomes
    Katharina Ribbeck
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Curr Biol 17:230-6. 2007
  10. ncbi request reprint The conserved Nup107-160 complex is critical for nuclear pore complex assembly
    Tobias C Walther
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell 113:195-206. 2003

Collaborators

  • Attila Becskei
  • Mutsuhito Ohno
  • Timothy Mitchison
  • Hideki Yokoyama
  • Katharina Ribbeck
  • Kevin Czaplinski
  • Nelly Pante
  • Gideon Dreyfuss
  • B J Blencowe
  • Puri Fortes
  • Aaron C Groen
  • Stephanie Boue
  • Y Yoneda
  • U Kutay
  • Maarten Fornerod
  • Dirk Gorlich
  • Matthias Wilm
  • Tobias C Walther
  • Peter Askjaer
  • Vincent Galy
  • Martin Hetzer
  • Wolfram Antonin
  • Catherine Mazza
  • Uta Haselmann
  • Cerstin Franz
  • Thomas Kocher
  • Alexandra Segref
  • Oliver J Gruss
  • Saori Kitao
  • Sebastian Ulbert
  • Maria D Koffa
  • Jörg Mansfeld
  • Claude Antony
  • Masami Yamada
  • Virginie Hachet
  • Carlo Petosa
  • Séverine Massenet
  • Scott Kuersten
  • Daniel Bilbao-Cortes
  • Stephen Cusack
  • Juergen Kast
  • Richard W Wozniak
  • Claudia M Casanova
  • Lisa A Hawryluk-Gara
  • Petra Mühlhäusser
  • Melpomeni Platani
  • Moritz Mall
  • Stephan Güttinger
  • Rachel Santarella
  • Ario de Marco
  • Carmen López Iglesias
  • Malgorzata Schelder
  • Ulrike Bauer
  • Montserrat Soler-Lopez
  • Christoph W Müller
  • Martine Moulin
  • Florence Baudin
  • Guy Schoehn
  • Ulrich Steuerwald
  • Bastian B Hülsmann
  • Isabelle Loiodice
  • Marc Gentzel
  • Gareth Griffiths
  • Annabelle Alves
  • Helen Pickersgill
  • Terry Allen
  • Anja Habermann
  • Valérie Doye
  • Peter B Becker
  • Malte Wittmann
  • Eva Hannak
  • Eric Karsenti
  • Sergey Paushkin
  • Volker C Cordes
  • Ludwig Englmeier
  • Herman Sillje
  • Livio Pellizzoni
  • Gert Jan Arts
  • Helen S Pickersgill
  • Rainer Pepperkok
  • Gernot Längst
  • Thomas Kufer
  • Isabelle Vernos
  • Martin W Goldberg
  • Terry D Allen

Detail Information

Publications29

  1. ncbi request reprint Identification of 40LoVe, a Xenopus hnRNP D family protein involved in localizing a TGF-beta-related mRNA during oogenesis
    Kevin Czaplinski
    EMBL Gene Expression Programme, Meyerhofstrasse 1, Heidelberg 69117, Germany
    Dev Cell 8:505-15. 2005
    ..Our results associate an hnRNP D protein with mRNA localization and have implications for several functions mediated by this important protein family...
  2. ncbi request reprint Identity elements used in export of mRNAs
    Mutsuhito Ohno
    The Institute for Virus Research, Laboratory of Biochemistry, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Mol Cell 9:659-71. 2002
    ..These data provide insight into mechanisms for discrimination of different classes of nuclear RNA and demonstrate that two RNAs of identical sequence can have distinct cytoplasmic fates depending on their mode of export...
  3. pmc A compartmentalized phosphorylation/dephosphorylation system that regulates U snRNA export from the nucleus
    Saori Kitao
    Institute for Virus Research, Kyoto University, Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Mol Cell Biol 28:487-97. 2008
    ..This finding was surprising in that such a specific system for U snRNA export regulation is composed of two such universal regulators, suggesting that this compartmentalized system is used more broadly for gene expression regulation...
  4. pmc Importin alpha associates with membranes and participates in nuclear envelope assembly in vitro
    Virginie Hachet
    European Molecular Biology Laboratory, Meyerhofstrasse, Heidelberg, Germany
    EMBO J 23:1526-35. 2004
    ..Unlike other functions of Importin alpha, this membrane-associated activity does not require interaction with NLS proteins...
  5. pmc Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate
    Hideki Yokoyama
    European Molecular Biology Laboratory, Heidelberg 69117, Germany
    J Cell Biol 180:867-75. 2008
    ..Our results indicate that Cdk11 is responsible for RanGTP-dependent MT stabilization around chromosomes and that this local stabilization is essential for normal rates of spindle assembly and spindle function...
  6. pmc Nup155 regulates nuclear envelope and nuclear pore complex formation in nematodes and vertebrates
    Cerstin Franz
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 24:3519-31. 2005
    ..Time-course experiments indicated that Nup155 is recruited to chromatin at the time of NE sealing, suggesting that nuclear pore complex assembly has to progress to a relatively late stage before NE membrane assembly occurs...
  7. pmc 40LoVe interacts with Vg1RBP/Vera and hnRNP I in binding the Vg1-localization element
    Kevin Czaplinski
    EMBL Gene Expression Programme, Heidelberg, Germany
    RNA 12:213-22. 2006
    ..We further demonstrate that titration of VM1 and E2 motif binding activity in vivo surprisingly suggests that the motif binding proteins have differing roles during Vg1LE-dependent mRNA localization...
  8. pmc NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules
    Katharina Ribbeck
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Mol Biol Cell 17:2646-60. 2006
    ..Once activated, NuSAP may aid to maintain spindle integrity by stabilizing and cross-linking microtubules around chromatin...
  9. ncbi request reprint A role for NuSAP in linking microtubules to mitotic chromosomes
    Katharina Ribbeck
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Curr Biol 17:230-6. 2007
    ..We propose that the presence of MT binding agents such as NuSAP, which can be directly immobilized on chromatin, are critical for targeting MT production to vertebrate chromosomes during spindle self-organization...
  10. ncbi request reprint The conserved Nup107-160 complex is critical for nuclear pore complex assembly
    Tobias C Walther
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell 113:195-206. 2003
    ..Depletion also prevented association of FG-repeat nucleoporins with chromatin. We propose a stepwise model in which postmitotic NPC assembly initiates on chromatin via early recruitment of the Nup107-160 complex...
  11. pmc The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway
    Séverine Massenet
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104 6148, USA
    Mol Cell Biol 22:6533-41. 2002
    ..Thus, the SMN complex is associated with snRNPs during the entire process of their biogenesis in the cytoplasm and may have multiple functions throughout this process...
  12. pmc The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import
    Tobias C Walther
    Gene Expression Program, EMBL, D 69117 Heidelberg, Germany
    J Cell Biol 158:63-77. 2002
    ..We conclude that RanBP2 is the major nucleoporin component of the cytoplasmic filaments of the NPC, and that these filaments do not have an essential role in importin alpha/beta- or transportin-dependent import...
  13. pmc Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains
    Scott Kuersten
    Gene Expression Programme, European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Mol Cell Biol 22:5708-20. 2002
    ..We propose that these interactions increase the concentration of tRNA export complexes and of empty Xpo-t in the vicinity of NPCs and thus increase the efficiency of the Xpo-t transport cycle...
  14. ncbi request reprint Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation
    Puri Fortes
    Division of Gene Therapy and Hepatology, CIMA, University of Navarra, Pamplona, Spain
    FEBS Lett 581:3087-97. 2007
    ..These results suggest that RED120 may function to couple splicing with mRNA 3'-end formation...
  15. ncbi request reprint The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly
    Martin Hetzer
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Cell Biol 4:E177-84. 2002
    ..Ran functions in these events as a signal for chromosome position...
  16. pmc Direct membrane protein-DNA interactions required early in nuclear envelope assembly
    Sebastian Ulbert
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    J Cell Biol 173:469-76. 2006
    ..Membrane fractions that are essential for NE formation are shown to bind directly to protein-free DNA, and our data suggest that these interactions are critical for early steps in NE assembly...
  17. ncbi request reprint HURP is part of a Ran-dependent complex involved in spindle formation
    Maria D Koffa
    EMBL, Heidelberg, Germany
    Curr Biol 16:743-54. 2006
    ..The microtubule-associated protein (MAP), TPX2, can mediate Ran's role in aster formation, but factors responsible for the transition from aster-like to spindle-like structures have not been described...
  18. ncbi request reprint The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells
    Jörg Mansfeld
    Institute of Biochemistry, ETH Zurich, CH 8093 Zurich, Switzerland
    Mol Cell 22:93-103. 2006
    ..Importantly, NDC1 interacts with Nup53 in vitro. This suggests that NDC1 function involves forming a link between the NE membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane...
  19. ncbi request reprint Ran binds to chromatin by two distinct mechanisms
    Daniel Bilbao-Cortes
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Curr Biol 12:1151-6. 2002
    ..We propose that the Ran binding capacity of chromatin contributes to localized spindle and NE assembly...
  20. pmc Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos
    Peter Askjaer
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Mol Biol Cell 13:4355-70. 2002
    ..Finally, we have demonstrated that both IMA-2 and IMB-1, the homologues of vertebrate importin alpha and beta, are essential for both spindle assembly and nuclear formation in early embryos...
  21. pmc Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex
    Catherine Mazza
    European Molecular Biology Laboratory, Grenoble Outstation, c o ILL, BP 181, F 38042 Grenoble Cedex 9, France
    EMBO J 21:5548-57. 2002
    ..Implications for the transfer of capped mRNAs to eIF4E, required for translation initiation, are discussed...
  22. ncbi request reprint Quantitative models of nuclear transport
    Attila Becskei
    Department of Physics, Massachusetts Institute of Technology, 13 2009, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Curr Opin Cell Biol 17:27-34. 2005
    ..Recent evidence suggests that the distinctive kinetics and spatial organization of nuclear transport processes can be used to efficiently propagate signals by new and unexpected pathways...
  23. ncbi request reprint The integral membrane nucleoporin pom121 functionally links nuclear pore complex assembly and nuclear envelope formation
    Wolfram Antonin
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Mol Cell 17:83-92. 2005
    ....
  24. ncbi request reprint Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex
    Carlo Petosa
    European Molecular Biology Laboratory, Grenoble Outstation, B P 181, 38042 Grenoble Cedex 9, France
    Mol Cell 16:761-75. 2004
    ..Our findings indicate that a single architectural and mechanistic framework can explain the divergent effects of RanGTP on substrate binding by many import and export receptors...
  25. ncbi request reprint Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells
    Oliver J Gruss
    EMBL, Meyerhofstrasse 1, 69 117 Heidelberg, Germany
    Nat Cell Biol 4:871-9. 2002
    ..This indicates that chromosome-induced microtubule production is a general requirement for the formation of functional spindles in animal cells...
  26. ncbi request reprint Co-crystallization of the human nuclear cap-binding complex with a m7GpppG cap analogue using protein engineering
    Catherine Mazza
    European Molecular Biology Laboratory, Grenoble Outstation, c o ILL, BP 181, F 38042 Grenoble Cedex 9, France
    Acta Crystallogr D Biol Crystallogr 58:2194-7. 2002
    ..3 A resolution. In both forms, strong extra electron density is observed for the cap analogue and for the N- and C-terminal extensions of CBP20 which was absent or disordered in all previous structures...
  27. pmc Caenorhabditis elegans nucleoporins Nup93 and Nup205 determine the limit of nuclear pore complex size exclusion in vivo
    Vincent Galy
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Mol Biol Cell 14:5104-15. 2003
    ..Thus, the contribution to NPC structure of Nup93 and Nup205 is essential for establishment of normal NPC function and for cell viability...
  28. ncbi request reprint RanGTP mediates nuclear pore complex assembly
    Tobias C Walther
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 424:689-94. 2003
    ..The data demonstrate that RanGTP triggers distinct steps of NPC assembly, and suggest a mechanism for the spatial restriction of NPC assembly to the surface of chromatin...
  29. ncbi request reprint An ATP-dependent activity that releases RanGDP from NTF2
    Masami Yamada
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    J Biol Chem 279:36228-34. 2004
    ..A protein phosphatase inhibitor mixture stimulates the RanGDF activity, suggesting the activity is regulated by phosphorylation. We propose that the ATP-dependent NTF2 releasing factor may have a role in the RanGDP/GTP cycle...