Ramon Martinez

Summary

Country: Germany

Publications

  1. ncbi request reprint Cytogenetic and molecular genetic analyses of giant cell glioblastoma multiforme reveal distinct profiles in giant cell and non-giant cell subpopulations
    Ramon Martinez
    Department of Neurosurgery, University of Dresden, Fetscherstr 74, D 01307 Dresden, Germany
    Cancer Genet Cytogenet 175:26-34. 2007
  2. ncbi request reprint Gross-total resection of malignant gliomas in elderly patients: implications in survival
    R Martinez
    Department of Neurosurgery, Klinikum Fulda, Fulda, Germany
    Zentralbl Neurochir 68:176-81. 2007
  3. ncbi request reprint Comparative genetic analysis of metachronous anaplastic oligoastrocytomas with extended recurrence-free interval
    Ramon Martinez
    Department of Neurosurgery, University of Dresden, Fetscherstr 74, D 01307, Dresden, Germany
    J Neurooncol 72:95-102. 2005
  4. ncbi request reprint Molecular mechanisms associated with chromosomal and microsatellite instability in sporadic glioblastoma multiforme
    Ramon Martinez
    Department of Neurosurgery, Institute of Pathology of the University of Dresden, Dresden, Germany
    Oncology 66:395-403. 2004
  5. ncbi request reprint A microarray-based DNA methylation study of glioblastoma multiforme
    Ramon Martinez
    Department of Neurosurgery, University of Goettingen, Goettingen WT 084071, Germany
    Epigenetics 4:255-64. 2009
  6. ncbi request reprint Independent molecular development of metachronous glioblastomas with extended intervening recurrence-free interval
    Ramon Martinez
    Department of Neurosurgery, University of Dresden, Germany
    Brain Pathol 13:598-607. 2003
  7. ncbi request reprint CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme
    Ramon Martinez
    Department of Neurosurgery, University of Dresden, Fetscherstrasse 74, Dresden, Germany
    Carcinogenesis 28:1264-8. 2007
  8. pmc DNA methylation alterations in grade II- and anaplastic pleomorphic xanthoastrocytoma
    Ramon Martinez
    Department of Neurosurgery, University of Goettingen, Robert Koch, Str, 40, 37075 Goettingen, Germany
    BMC Cancer 14:213. 2014
  9. pmc Different molecular patterns in glioblastoma multiforme subtypes upon recurrence
    Ramon Martinez
    Department of Neurosurgery, University of Gottingen, Robert Koch Str 40, 37075, Gottingen, Germany
    J Neurooncol 96:321-9. 2010
  10. doi request reprint The DNA methylome of glioblastoma multiforme
    Ramon Martinez
    Department of Neurosurgery, University of Goettingen, Germany
    Neurobiol Dis 39:40-6. 2010

Detail Information

Publications16

  1. ncbi request reprint Cytogenetic and molecular genetic analyses of giant cell glioblastoma multiforme reveal distinct profiles in giant cell and non-giant cell subpopulations
    Ramon Martinez
    Department of Neurosurgery, University of Dresden, Fetscherstr 74, D 01307 Dresden, Germany
    Cancer Genet Cytogenet 175:26-34. 2007
    ..Furthermore, the data point to differences in the profile of chromosomal and microsatellite instability in gcGBM and classic GBM that might underscore the distinct pathological features of both tumor subtypes...
  2. ncbi request reprint Gross-total resection of malignant gliomas in elderly patients: implications in survival
    R Martinez
    Department of Neurosurgery, Klinikum Fulda, Fulda, Germany
    Zentralbl Neurochir 68:176-81. 2007
    ..Thus, the balance of benefit versus adverse response of standard glioma therapy remains controversial. We hypothesized that older patients with malignant gliomas might also take advantage of extensive surgical procedures...
  3. ncbi request reprint Comparative genetic analysis of metachronous anaplastic oligoastrocytomas with extended recurrence-free interval
    Ramon Martinez
    Department of Neurosurgery, University of Dresden, Fetscherstr 74, D 01307, Dresden, Germany
    J Neurooncol 72:95-102. 2005
    ..Whether the paucity of accumulation of the observed genetic alterations might be associated with the unusually extended relapse-free time of the patient remains to be elucidated...
  4. ncbi request reprint Molecular mechanisms associated with chromosomal and microsatellite instability in sporadic glioblastoma multiforme
    Ramon Martinez
    Department of Neurosurgery, Institute of Pathology of the University of Dresden, Dresden, Germany
    Oncology 66:395-403. 2004
    ..We aimed to perform a comprehensive analysis of the relationship between CIN and MSI mechanisms in sporadic glioblastomas...
  5. ncbi request reprint A microarray-based DNA methylation study of glioblastoma multiforme
    Ramon Martinez
    Department of Neurosurgery, University of Goettingen, Goettingen WT 084071, Germany
    Epigenetics 4:255-64. 2009
    ..Furthermore, we identified that promoter hypermethylation of the transcription factor gene GATA6 (occurring in 30% of GBM) was significantly associated with unfavorable patient survival...
  6. ncbi request reprint Independent molecular development of metachronous glioblastomas with extended intervening recurrence-free interval
    Ramon Martinez
    Department of Neurosurgery, University of Dresden, Germany
    Brain Pathol 13:598-607. 2003
    ..Whether the molecular features of the first glioblastoma are associated with the notably extended recurrence-free period of 5 years remains to be elucidated...
  7. ncbi request reprint CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme
    Ramon Martinez
    Department of Neurosurgery, University of Dresden, Fetscherstrasse 74, Dresden, Germany
    Carcinogenesis 28:1264-8. 2007
    ..These remarkable findings may foster the development of therapeutic approaches using DNA demethylating drugs and activators of the extrinsic apoptotic pathway to improve the dismal prognosis of GBM...
  8. pmc DNA methylation alterations in grade II- and anaplastic pleomorphic xanthoastrocytoma
    Ramon Martinez
    Department of Neurosurgery, University of Goettingen, Robert Koch, Str, 40, 37075 Goettingen, Germany
    BMC Cancer 14:213. 2014
    ..Pleomorphic xanthoastrocytoma (PXA) is a rare WHO grade II tumor accounting for less than 1% of all astrocytomas. Malignant transformation into PXA with anaplastic features, is unusual and correlates with poorer outcome of the patients...
  9. pmc Different molecular patterns in glioblastoma multiforme subtypes upon recurrence
    Ramon Martinez
    Department of Neurosurgery, University of Gottingen, Robert Koch Str 40, 37075, Gottingen, Germany
    J Neurooncol 96:321-9. 2010
    ..Taken together, our results strongly suggest that recurrences of GBM may display two distinct pattern of accumulation of molecular alterations depending on the profile of the original tumor...
  10. doi request reprint The DNA methylome of glioblastoma multiforme
    Ramon Martinez
    Department of Neurosurgery, University of Goettingen, Germany
    Neurobiol Dis 39:40-6. 2010
    ..We discuss the magnitude of epigenetic alterations in the pathogenesis of GBM and their translational relevance to patient survival...
  11. doi request reprint Microsatellite instability and loss of heterozygosity in squamous cell carcinoma of the head and neck
    Susanne Koy
    Department of Oral and Maxillofacial Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Head Neck 30:1105-13. 2008
    ..The aim of our study was to disclose the frequency and basis of MSI in HNSCC and to correlate MSI and findings on loss of heterozygosity (LOH) with the clinical data...
  12. ncbi request reprint Hypermethylation of the proapoptotic gene TMS1/ASC: prognostic importance in glioblastoma multiforme
    Ramon Martinez
    Department of Neurosurgery, University of Dresden, Fetscherstr 74, D 01307, Dresden, and Klinikum Fulda, Academic Hospital Philipps University Marburg, Fulda, Germany
    J Neurooncol 82:133-9. 2007
    ..Our results strongly suggest that, compared to classic GBM, LTS GBM display distinct epigenetic characteristics which might provide additional prognostic biomarkers for the assessment of this malignancy...
  13. ncbi request reprint Epigenetic aberrations in malignant gliomas: an open door leading to better understanding and treatment
    Ramon Martinez
    Department of Neurosurgery, University of Dresden, Dresden, Germany
    Epigenetics 2:147-50. 2007
    ....
  14. pmc Necrotizing infundibulo-hypophysitis: an entity too rare to be true?
    Angelika Gutenberg
    Department of Neurosurgery, University Medical Center, Georg August University, 37099, Gottingen, Germany
    Pituitary 15:202-8. 2012
    ..The possible pathogenesis of this rare variant of hypophysitis is discussed...
  15. pmc Perioperative course and accuracy of screw positioning in conventional, open robotic-guided and percutaneous robotic-guided, pedicle screw placement
    Sven Rainer Kantelhardt
    Department of Neurosurgery, Georg August University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Eur Spine J 20:860-8. 2011
    ..The use of robotic guidance significantly increased accuracy of screw positioning while reducing the X-ray exposure. Patients seem to have a better perioperative course following percutaneous procedures...
  16. ncbi request reprint Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme
    Ramon Martinez
    J Neurooncol 83:91-3. 2007
    ..The methylation rate in LTS GBM was significantly higher (77.8% vs. 39.2%, P = 0.033) which suggests that MGMT hypermethylation is a frequent hallmark of LTS GBM and contributes to characterize this intriguing GBM subtype...