- The pro-form of BMP-2 exhibits a delayed and reduced activity when compared to mature BMP-2Sabrina von Einem
Institut für Biochemie und Biotechnologie, Martin Luther Universitat Halle Wittenberg, Halle, Germany
Growth Factors 29:63-71. 2011..The data presented here suggest that proBMP-2 elicits biological functions as mature BMP-2 at a delayed and reduced level, which might depend on intracellular cleavage and subsequent secretion as mature BMP-2...
- The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor bindingAnja Hauburger
Institut für Biochemie und Biotechnologie, Martin Luther Universitat Halle Wittenberg, Germany
FEBS J 276:6386-98. 2009..The data presented here suggest that the pro-domain of BMP-2 can alter the signalling properties of the growth factor by modulating the ability of the mature part to interact with the receptors...