Affiliation: Martin Luther University
Thews O, Vaupel P. Spatial oxygenation profiles in tumors during normo- and hyperbaric hyperoxia. Strahlenther Onkol. 2015;191:875-82 pubmed publisher
..The results also clearly indicate that the oxygenation pattern improves disproportionally with increasing environmental pressure. ..
Allmeroth M, Moderegger D, Gündel D, Buchholz H, Mohr N, Koynov K, et al
. PEGylation of HPMA-based block copolymers enhances tumor accumulation in vivo: a quantitative study using radiolabeling and positron emission tomography. J Control Release. 2013;172:77-85 pubmed publisher
..These findings emphasize the need for reliable (non-invasive) in vivo techniques revealing overall polymer distribution and helping to identify drug carrier systems for efficient therapy. ..
Riemann A, Ihling A, Schneider B, Gekle M, Thews O. Impact of extracellular acidosis on intracellular pH control and cell signaling in tumor cells. Adv Exp Med Biol. 2013;789:221-228 pubmed publisher
..Thus, an acidic tumor microenvironment can induce a longer-lasting p38 CREB-mediated change in the transcriptional program. ..
Thews O, Riemann A, Nowak M, Gekle M. Impact of hypoxia-related tumor acidosis on cytotoxicity of different chemotherapeutic drugs in vitro and in vivo. Adv Exp Med Biol. 2014;812:51-58 pubmed publisher
Frank J, GÃ¼ndel D, Drescher S, Thews O, MÃ¤der K. Injectable LiNc-BuO loaded microspheres as in vivo EPR oxygen sensors after co-implantation with tumor cells. Free Radic Biol Med. 2015;89:741-9 pubmed publisher
Thews O, Vaupel P. Temporal changes in tumor oxygenation and perfusion upon normo- and hyperbaric inspiratory hyperoxia. Strahlenther Onkol. 2016;192:174-81 pubmed publisher
..Since the tumor pO2 directly followed the environmental pressure, teletherapy after hyperbaric conditions does not seem to be promising as the pO2 reaches baseline values again within 5-10 min after decompression. ..
Riemann A, Ihling A, Reime S, Gekle M, Thews O. Impact of the Tumor Microenvironment on the Expression of Inflammatory Mediators in Cancer Cells. Adv Exp Med Biol. 2016;923:105-111 pubmed publisher
..These results indicate that the adverse tumor microenvironment affects the expression of inflammatory mediators by tumors cells and may therefore modulate the immune response within the tumor tissue. ..
Wagener K, Moderegger D, Allmeroth M, Reibel A, Kramer S, Biesalski B, et al
. Long-term biodistribution study of HPMA-ran-LMA copolymers in vivo by means of 131I-labeling. Nucl Med Biol. 2018;58:59-66 pubmed publisher
..The in vivo behavior of the investigated HPMA-ran-LMA copolymer demonstrates great potential in terms of an effective accumulation in the tumor. ..
Thews O, Dillenburg W, Rösch F, Fellner M. PET imaging of the impact of extracellular pH and MAP kinases on the p-glycoprotein (Pgp) activity. Adv Exp Med Biol. 2013;765:279-286 pubmed publisher
..The new (68)Ga-labeled tracer is suitable for PET imaging of the tissue Pgp activity. In vivo imaging reveals that an acidosis activates the Pgp markedly, a mechanism in which the p38-MAPK pathway seems to play an important role...