M Rauchhaus

Summary

Affiliation: Martin Luther University
Country: Germany

Publications

  1. ncbi High tumour necrosis factor-alpha levels are associated with exercise intolerance and neurohormonal activation in chronic heart failure patients
    M Cicoira
    Department of Cardiac Medicine, National Heart and Lung Institute, London, UK
    Cytokine 15:80-6. 2001
  2. ncbi The E-selectin SER128ARG gene polymorphism and restenosis after successful coronary angioplasty
    Mathias Rauchhaus
    Klinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    Int J Cardiol 83:249-57. 2002
  3. ncbi Plasma cytokine parameters and mortality in patients with chronic heart failure
    M Rauchhaus
    Clinical Cardiology, National Heart and Lung Institute, Royal Brompton Hospital, London, UK
    Circulation 102:3060-7. 2000
  4. ncbi Inflammatory cytokines and the possible immunological role for lipoproteins in chronic heart failure
    M Rauchhaus
    Department of Clinical Cardiology, Imperial College School of Medicine at the National Heart and Lung Institute, London, UK
    Int J Cardiol 76:125-33. 2000
  5. ncbi Uric acid in cachectic and noncachectic patients with chronic heart failure: relationship to leg vascular resistance
    W Doehner
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Am Heart J 141:792-9. 2001
  6. ncbi Origin of oscillatory kinetics of respiratory gas exchange in chronic heart failure
    D P Francis
    National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK
    Circulation 100:1065-70. 1999
  7. ncbi Insights into the pathogenesis of chronic heart failure: immune activation and cachexia
    S D Anker
    Department of Cardiac Medicine, National Heart and Lung Institute, London, UK
    Curr Opin Cardiol 14:211-6. 1999
  8. ncbi Leptin, insulin sensitivity and growth hormone binding protein in chronic heart failure with and without cardiac cachexia
    W Doehner
    Department of Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Eur J Endocrinol 145:727-35. 2001
  9. ncbi The endotoxin-lipoprotein hypothesis
    M Rauchhaus
    Department of Clinical Cardiology, National Heart and Lung Institute, London, UK
    Lancet 356:930-3. 2000
  10. ncbi Heart failure as a metabolic problem
    S D Anker
    Department of Cardiac Medicine, National Heart and Lung Institute, London, UK
    Eur J Heart Fail 1:127-31. 1999

Detail Information

Publications30

  1. ncbi High tumour necrosis factor-alpha levels are associated with exercise intolerance and neurohormonal activation in chronic heart failure patients
    M Cicoira
    Department of Cardiac Medicine, National Heart and Lung Institute, London, UK
    Cytokine 15:80-6. 2001
    ..In CHF patients only the highest levels of TNF are associated with poor functional status and neurohormonal activation. This group of patients may represent the appropriate target population for TNF antagonism...
  2. ncbi The E-selectin SER128ARG gene polymorphism and restenosis after successful coronary angioplasty
    Mathias Rauchhaus
    Klinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    Int J Cardiol 83:249-57. 2002
    ..Coronary angioplasty remains plagued by the problem of restenosis. Genetic polymorphisms may contribute to the development of restenosis by mediating exaggerated inflammatory responses of the endothelium to angioplasty-induced injury...
  3. ncbi Plasma cytokine parameters and mortality in patients with chronic heart failure
    M Rauchhaus
    Clinical Cardiology, National Heart and Lung Institute, Royal Brompton Hospital, London, UK
    Circulation 102:3060-7. 2000
    ..Little is known about the prognostic importance of tumor necrosis factor-alpha (TNF-alpha), soluble TNF-receptor 1 and 2 (sTNF-R1/sTNF-R2), interleukin-6 (IL-6), and soluble CD14 receptors (sCD14) in CHF patients...
  4. ncbi Inflammatory cytokines and the possible immunological role for lipoproteins in chronic heart failure
    M Rauchhaus
    Department of Clinical Cardiology, Imperial College School of Medicine at the National Heart and Lung Institute, London, UK
    Int J Cardiol 76:125-33. 2000
    ....
  5. ncbi Uric acid in cachectic and noncachectic patients with chronic heart failure: relationship to leg vascular resistance
    W Doehner
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Am Heart J 141:792-9. 2001
    ..We aimed to study the relationship between serum uric acid levels and leg vascular resistance in patients with CHF with and without cachexia and in healthy control subjects...
  6. ncbi Origin of oscillatory kinetics of respiratory gas exchange in chronic heart failure
    D P Francis
    National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK
    Circulation 100:1065-70. 1999
    ..This necessitates hypothesizing that PB is caused by a primary oscillation in tissue metabolism or in cardiac output...
  7. ncbi Insights into the pathogenesis of chronic heart failure: immune activation and cachexia
    S D Anker
    Department of Cardiac Medicine, National Heart and Lung Institute, London, UK
    Curr Opin Cardiol 14:211-6. 1999
    ..A complex catabolic-anabolic imbalance in different body systems may cause body wasting in patients with CHF...
  8. ncbi Leptin, insulin sensitivity and growth hormone binding protein in chronic heart failure with and without cardiac cachexia
    W Doehner
    Department of Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Eur J Endocrinol 145:727-35. 2001
    ..This study aimed to examine the influence of leptin on GHBP in CHF patients with and without cardiac cachexia compared with healthy control subjects...
  9. ncbi The endotoxin-lipoprotein hypothesis
    M Rauchhaus
    Department of Clinical Cardiology, National Heart and Lung Institute, London, UK
    Lancet 356:930-3. 2000
    ..We also propose that, in patients with CHF, a non-lipid-lowering statin (with ancillary properties such as immune modulatory and anti-inflammatory actions) could be as effective or even more beneficial than a lipid-lowering statin...
  10. ncbi Heart failure as a metabolic problem
    S D Anker
    Department of Cardiac Medicine, National Heart and Lung Institute, London, UK
    Eur J Heart Fail 1:127-31. 1999
    ..Joint efforts of cardiologists, endocrinologists, and immunologists are required to develop therapeutic strategies able to improve the metabolic status of CHF patients...
  11. ncbi Attenuated autonomic function in multiple organ dysfunction syndrome across three age groups
    Hendrik Schmidt
    Martin Luther University, Halle Wittenberg, Germany
    Biomed Tech (Berl) 51:264-7. 2006
    ..In conclusion, autonomic function in MODS is attenuated. The influence of MODS on autonomic function overwhelms the age dependence of autonomic function observed in healthy subjects...
  12. ncbi Reduced peripheral skeletal muscle mass and abnormal reflex physiology in chronic heart failure
    Massimo F Piepoli
    Heart Failure Unit, Cardiology, Guglielmo da Saliceto Polichirurgico Hospital, Cantone del Cristo, Piacenza, 29100, Italy
    Circulation 114:126-34. 2006
    ....
  13. ncbi Autonomic dysfunction predicts mortality in patients with multiple organ dysfunction syndrome of different age groups
    Hendrik Schmidt
    Martin Luther University, Halle Wittenberg, Germany
    Crit Care Med 33:1994-2002. 2005
    ....
  14. ncbi Chemo- and ergoreflexes in health, disease and ageing
    Hendrik Schmidt
    University Department of Medicine III, Martin Luther University Halle Wittenberg, Klinikum Kröllwitz, Ernst Grube Str 40, D 06097 Halle Saale, Germany
    Int J Cardiol 98:369-78. 2005
    ....
  15. ncbi Impaired chemoreflex sensitivity in adult patients with multiple organ dysfunction syndrome--the potential role of disease severity
    Hendrik Schmidt
    University Department of Medicine III, Klinikum Kröllwitz, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, 06097 Halle Saale, Germany
    Intensive Care Med 30:665-72. 2004
    ..We also aimed to elucidate the effect of the severity of MODS on the assessment of cardiac chemoreflex sensitivity...
  16. ncbi The relationship between cholesterol and survival in patients with chronic heart failure
    Mathias Rauchhaus
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    J Am Coll Cardiol 42:1933-40. 2003
    ..We sought to describe the relationship between cholesterol and survival in patients with chronic heart failure (CHF)...
  17. ncbi Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging
    Stefan D Anker
    Applied Cachexia Research Unit, Charite, Campus Virchow Klinikum, Berlin, Germany
    Circulation 107:1991-7. 2003
    ..Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF)...
  18. ncbi Body mass and survival in patients with chronic heart failure without cachexia: the importance of obesity
    Constantinos H Davos
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    J Card Fail 9:29-35. 2003
    ..Cachexia in chronic heart failure carries a poor prognosis, but little is known about the influence of body mass on the prognosis of noncachectic heart failure patients...
  19. ncbi Insulin resistance in moderate chronic heart failure is related to hyperleptinaemia, but not to norepinephrine or TNF-alpha
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse St, London SW3 6LY, UK
    Int J Cardiol 83:73-81. 2002
    ..The purpose of this study was to examine in patients with CHF and in comparison to healthy controls subjects whether norepinephrine, TNFalpha or leptin relate to insulin sensitivity...
  20. doi Autonomic dysfunction predicts both 1- and 2-month mortality in middle-aged patients with multiple organ dysfunction syndrome
    Hendrik Schmidt
    Martin Luther University Halle Wittenberg, Germany
    Crit Care Med 36:967-70. 2008
    ..The aim of the present study was evaluate whether autonomic dysfunction is also a predictor of 180-day and 365-day mortalities...
  21. ncbi Effect of interleukin-10 on the production of tumor necrosis factor-alpha by peripheral blood mononuclear cells from patients with chronic heart failure
    Aidan P Bolger
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Am J Cardiol 90:384-9. 2002
    ..IL-10 is, therefore, a potential therapy for use in chronic HF associated with inflammatory immune activation...
  22. ncbi Prevalence and natural history of heart failure in outpatient HIV-infected subjects: rationale and design of the HIV-HEART study
    Till Neumann
    Department of Cardiology, University of Duisburg Essen, Medical School, Hufelandstr 55, 45122 Essen, Germany
    Eur J Med Res 12:243-8. 2007
    ..The present study evaluates the frequency and clinical course of myocardial dysfunction and heart failure in a HIV-infected population...
  23. ncbi Secretory sphingomyelinase is upregulated in chronic heart failure: a second messenger system of immune activation relates to body composition, muscular functional capacity, and peripheral blood flow
    Wolfram Doehner
    Division of Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Eur Heart J 28:821-8. 2007
    ....
  24. ncbi Cytokines in chronic heart failure: possible interaction in the neurohormonal and the cytokine system at the cAMP level?
    Claudia Werner
    Institut fur Pharmakologie und Toxikologie der Technischen Universitat Munchen, Germany
    Eur Cytokine Netw 13:407-9. 2002
    ..These alterations may result from a dysregulated interaction of beta-adrenergic pathways and the cytokine system, and are possibly related to cAMP-dependent regulation of the release or shedding of these mediators...
  25. ncbi Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies
    Wolfram Doehner
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Circulation 105:2619-24. 2002
    ..We therefore studied the effects of XO inhibition with allopurinol on endothelial function and peripheral blood flow in CHF patients after intra-arterial infusion and after oral administration in 2 independent placebo-controlled studies...
  26. ncbi Impaired insulin sensitivity as an independent risk factor for mortality in patients with stable chronic heart failure
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Am Coll Cardiol 46:1019-26. 2005
    ..The aim of this study was to determine the significance of insulin resistance as an independent risk factor for impaired prognosis in patients with chronic heart failure (CHF)...
  27. ncbi Selective intestinal decontamination in advanced chronic heart failure: a pilot trial
    Viviane M Conraads
    Department of Cardiology, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium
    Eur J Heart Fail 6:483-91. 2004
    ....
  28. ncbi Cellular endotoxin desensitization in patients with severe chronic heart failure
    Rakesh Sharma
    Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Eur J Heart Fail 7:865-8. 2005
    ..It is not known if LPS desensitization occurs in CHF...
  29. ncbi Whole blood endotoxin responsiveness in patients with chronic heart failure: the importance of serum lipoproteins
    Rakesh Sharma
    Clinical Cardiology, NHLI, Imperial College School of Medicine, Dovehouse Street, SW3 6LY, London, UK
    Eur J Heart Fail 7:479-84. 2005
    ..We sought to investigate the relationship between whole blood endotoxin responsiveness and serum lipoprotein concentrations. It is not known if low-dose LPS is sufficient to stimulate immune activation...
  30. ncbi The cardiac component of cardiac cachexia
    Viorel G Florea
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    Am Heart J 144:45-50. 2002
    ..This study sought to assess the cardiac dimensions, mass, and function and changes in these parameters over time in patients with chronic heart failure with and without cachexia...