N G Rainov

Summary

Affiliation: Martin Luther University
Country: Germany

Publications

  1. ncbi request reprint Overall survival in patients with malignant glioma may be significantly longer with tumors located in deep grey matter
    Ramachandran Ramnarayan
    Department of Neurosurgery, The Walton Centre for Neurology and Neurosurgery, Liverpool L9 7LJ, UK
    J Neurol Sci 260:49-56. 2007
  2. ncbi request reprint Clinical trials with intracerebral convection-enhanced delivery of targeted toxins in malignant glioma
    N G Rainov
    Department of Neurosurgery, Klinikum Augsburg, Stenglinstr 2, D 86156 Augsburg, Germany
    Rev Recent Clin Trials 3:2-9. 2008
  3. ncbi request reprint A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme
    N G Rainov
    Department of Neurosurgery, Martin Luther Universitat, Halle Wittenberg, D 06097 Halle, Germany
    Hum Gene Ther 11:2389-401. 2000
  4. ncbi request reprint Management of chronic back and leg pain by intrathecal drug delivery
    N G Rainov
    Department of Neurosurgery, Central Clinic Augsburg, Augsburg, Germany
    Acta Neurochir Suppl 97:49-56. 2007
  5. ncbi request reprint Dual electrode spinal cord stimulation in chronic leg and back pain
    N G Rainov
    Department of Neurosurgery, Central Clinic Augsburg, Augsburg, Germany
    Acta Neurochir Suppl 97:85-9. 2007
  6. ncbi request reprint Experimental therapies for chronic pain
    N G Rainov
    Department of Neurosurgery, Central Clinic Augsburg, Augsburg, Germany
    Acta Neurochir Suppl 97:473-7. 2007
  7. ncbi request reprint Temozolomide enhances herpes simplex virus thymidine kinase/ganciclovir therapy of malignant glioma
    N G Rainov
    Department of Neurosurgery, Martin Luther University Halle Wittenberg, Halle, Germany
    Cancer Gene Ther 8:662-8. 2001
  8. ncbi request reprint Novel therapies for malignant gliomas: a local affair?
    Nikolai G Rainov
    Department of Neurosurgery, Central Clinic Augsburg, Germany
    Neurosurg Focus 20:E9. 2006
  9. ncbi request reprint Hardware failures in spinal cord stimulation (SCS) for chronic benign pain of spinal origin
    N G Rainov
    Department of Neurosurgery, Central Clinic Augsburg, Augsburg, Germany
    Acta Neurochir Suppl 97:101-4. 2007
  10. ncbi request reprint Coronally oriented vertical fracture of the axis body: surgical treatment of a rare condition
    N G Rainov
    Department of Neurosurgery, Faculty of Medicine, Martin Luther University Halle Wittenberg, Germany
    Minim Invasive Neurosurg 41:93-6. 1998

Collaborators

  • V Heidecke
  • T Shibata
  • J B Weise
  • A Quinones
  • S Koch
  • A Vighetto
  • P Krolak-Salmon
  • K Doh ura
  • Karen Aboody
  • Peter Black
  • Christof M Kramm
  • Jiang Qian
  • H Ohgaki
  • Huan Ren
  • Susan Chang
  • A Perry
  • Manfred Westphal
  • Stephen Dealler
  • Ariane Söling
  • D Schaarschmidt
  • G Reifenberger
  • Ute Fischer
  • Sabine Steffens
  • Susanne Frank
  • M Lajcak
  • Y J Cao
  • Ramachandran Ramnarayan
  • Brigitte Schneider
  • Sonja Horstmann
  • Constanze Nafe
  • Alice B Brown
  • Friedrich Weber
  • M Figul
  • Helmut K G Machulla
  • K H Haude
  • T Marx
  • C Schafer
  • Kumar Das
  • Susanna Dodd
  • Bernd Röhrig
  • Klaus Schulze-Osthoff
  • Heinke Pulhorn
  • Frank L Heppner
  • V V Radhakrishnan
  • Paul Kleihues
  • Leila Chimelli
  • Nádia Montagna
  • Emmanuelle Uro-Coste
  • Figen Soylemezoglu
  • Anke Sandquist
  • Akira Hara
  • Roy O Weller
  • William R Markesbery
  • David W Ellison
  • Jun Masuoka
  • Felice Giangaspero
  • Daron G Davis
  • Herve Huang
  • Thad Jackson
  • Gian L Taddei
  • Sebastian Brandner
  • Markus Bergmann
  • Ricardo Gonzalez-Campora
  • Renato Conti
  • Marc R Del Bigio
  • Christiane Lex
  • Rona Carroll
  • Nils O Schmidt
  • Richard Bucholz
  • Xandra O Breakefield
  • Anthony Asher
  • Frank Steinborn
  • Kim K Leishear
  • Karl Ulrich Dobberstein
  • Frank Rommel
  • Wendy Yang
  • H J Dong
  • Yong Jiang Cao
  • Mitchel Berger
  • Raj K Puri
  • Robert W Rand
  • Henry Pan
  • Jeffrey Bruce
  • Ronald E Warnick
  • Jürgen Langner
  • Walter Hall
  • Michael Prados
  • T C Chou
  • Michail Tschigrjai
  • Frank Floeth

Detail Information

Publications51

  1. ncbi request reprint Overall survival in patients with malignant glioma may be significantly longer with tumors located in deep grey matter
    Ramachandran Ramnarayan
    Department of Neurosurgery, The Walton Centre for Neurology and Neurosurgery, Liverpool L9 7LJ, UK
    J Neurol Sci 260:49-56. 2007
    ..The aim of this study was to assess the correlation of overall survival with tumor location (lobar vs. deep grey matter) and with other clinical and imaging variables in a cohort of patients with high grade gliomas...
  2. ncbi request reprint Clinical trials with intracerebral convection-enhanced delivery of targeted toxins in malignant glioma
    N G Rainov
    Department of Neurosurgery, Klinikum Augsburg, Stenglinstr 2, D 86156 Augsburg, Germany
    Rev Recent Clin Trials 3:2-9. 2008
    ..It offers in addition an outlook into future areas of development of targeted toxins, such as improved delivery modes and non-invasive imaging of toxin distribution...
  3. ncbi request reprint A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme
    N G Rainov
    Department of Neurosurgery, Martin Luther Universitat, Halle Wittenberg, D 06097 Halle, Germany
    Hum Gene Ther 11:2389-401. 2000
    ....
  4. ncbi request reprint Management of chronic back and leg pain by intrathecal drug delivery
    N G Rainov
    Department of Neurosurgery, Central Clinic Augsburg, Augsburg, Germany
    Acta Neurochir Suppl 97:49-56. 2007
    ..It is concluded that further clinical research is needed in order to provide stronger evidence for the usefulness of a number of drugs currently used for intrathecal therapy on a mostly empirical basis...
  5. ncbi request reprint Dual electrode spinal cord stimulation in chronic leg and back pain
    N G Rainov
    Department of Neurosurgery, Central Clinic Augsburg, Augsburg, Germany
    Acta Neurochir Suppl 97:85-9. 2007
    ..Given the high cost of treatments for CBLP and of SCS itself, there is an urgent need for high-quality evidence for the effectiveness of dual electrode SCS in relieving pain and/or improving function in patients with CBLP...
  6. ncbi request reprint Experimental therapies for chronic pain
    N G Rainov
    Department of Neurosurgery, Central Clinic Augsburg, Augsburg, Germany
    Acta Neurochir Suppl 97:473-7. 2007
    ..Biological therapies for chronic pain hold great promise and are rapidly developing, but currently still are in a very early stage and therefore deemed experimental and not suitable for routine clinical use...
  7. ncbi request reprint Temozolomide enhances herpes simplex virus thymidine kinase/ganciclovir therapy of malignant glioma
    N G Rainov
    Department of Neurosurgery, Martin Luther University Halle Wittenberg, Halle, Germany
    Cancer Gene Ther 8:662-8. 2001
    ..The potential importance for clinical studies combining both local tumor gene therapy and systemic chemotherapy should be explored further...
  8. ncbi request reprint Novel therapies for malignant gliomas: a local affair?
    Nikolai G Rainov
    Department of Neurosurgery, Central Clinic Augsburg, Germany
    Neurosurg Focus 20:E9. 2006
    ..In addition, areas of possible improvement of these therapies and essential further developments are outlined...
  9. ncbi request reprint Hardware failures in spinal cord stimulation (SCS) for chronic benign pain of spinal origin
    N G Rainov
    Department of Neurosurgery, Central Clinic Augsburg, Augsburg, Germany
    Acta Neurochir Suppl 97:101-4. 2007
    ..This review summarizes the experience of the authors with management of hardware failures and their causes in patients treated with SCS for chronic pain of benign origin. The published literature is critically surveyed and discussed...
  10. ncbi request reprint Coronally oriented vertical fracture of the axis body: surgical treatment of a rare condition
    N G Rainov
    Department of Neurosurgery, Faculty of Medicine, Martin Luther University Halle Wittenberg, Germany
    Minim Invasive Neurosurg 41:93-6. 1998
    ..This case illustrates the variable biomechanical response of the upper cervical spine to trauma and the advantages of a non-standard surgical approach for internal fixation of the injured cervical spine...
  11. ncbi request reprint Experimental treatments for human transmissible spongiform encephalopathies: is there a role for pentosan polysulfate?
    N G Rainov
    Klinikum Augsburg, Department of Neurosurgery, Stenglinstr 2, D 86156 Augsburg, Germany
    Expert Opin Biol Ther 7:713-26. 2007
    ..Further prospective investigations of long-term intraventricular PPS administration are essential for the assessment of its effects...
  12. ncbi request reprint A chimeric fusion protein of cytochrome CYP4B1 and green fluorescent protein for detection of pro-drug activating gene delivery and for gene therapy in malignant glioma
    N G Rainov
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Boston, USA
    Adv Exp Med Biol 451:393-403. 1998
    ....
  13. ncbi request reprint Transcranial Doppler sonography in adult hydrocephalic patients
    N G Rainov
    Department of Neurosurgery, Martin Luther University, Halle Saale, Germany
    Neurosurg Rev 23:34-8. 2000
    ..Changes in the RI and PI indices appear to be useful indicators of elevated ICP...
  14. ncbi request reprint Gamma-glutamyl transferase expression in higher-grade astrocytic glioma
    C Schafer
    Department of Neurosurgery, Martin Luther University Halle Wittenberg, Germany
    Acta Oncol 40:529-35. 2001
    ..In conclusion, GGT is expressed in a high percentage of human WHO grade III astrocytomas and GBM, but not in normal brain tissue. This molecule seems to give neoplastic cells a moderate growth advantage under in vivo conditions...
  15. ncbi request reprint Hypoxia-inducible transgene expression in differentiated human NT2N neurons--a cell culture model for gene therapy of postischemic neuronal loss
    Y J Cao
    Molecular Neuro-Oncology Laboratory, Department of Neurosurgery, Martin-Luther-University, Halle/S, Germany
    Gene Ther 8:1357-62. 2001
    ..This cell culture model may be employed for the further investigation of therapeutic proteins against ischemic brain damage due to neuronal loss...
  16. ncbi request reprint Anterior cervical fusion with the Orion locking plate system
    V Heidecke
    Department of Neurosurgery, Faculty of Medicine, Martin Luther University, Halle Wittenberg, Germany
    Spine (Phila Pa 1976) 23:1796-802; discussion 1803. 1998
    ..This study was conducted to evaluate an anterior cervical fusion plate system, the Orion locking plate, regarding its surgical handling, hardware-related failures, and short-term and long-term results...
  17. ncbi request reprint Epidural electrical stimulation of the motor cortex in patients with facial neuralgia
    N G Rainov
    Department of Neurosurgery, Martin Luther University Halle Wittenberg, Germany
    Clin Neurol Neurosurg 99:205-9. 1997
    ..One major complication of motor cortex stimulation during the follow-up period was a single generalized epileptic seizure in one of the patients...
  18. ncbi request reprint Combined effects of temozolomide and the ribonucleotide reductase inhibitors didox and trimidox in malignant brain tumor cells
    M Figul
    Department of Neurosurgery, Martin Luther University Halle Wittenberg, Halle, Germany
    Cancer Chemother Pharmacol 52:41-6. 2003
    ..Trimidox (TX) and didox (DX) are two recently synthesized specific inhibitors of RR. The combinations of TMZ with TX or DX as a basis for synergistic chemotherapy protocols were tested in this study...
  19. doi request reprint Intervertebral disc replacement for cervical degenerative disease--clinical results and functional outcome at two years in patients implanted with the Bryan cervical disc prosthesis
    V Heidecke
    Department of Neurosurgery, Klinikum Augsburg, Augsburg, Germany
    Acta Neurochir (Wien) 150:453-9; discussion 459. 2008
    ..The objective was to investigate clinical outcome at 2 years of patients implanted with the Bryan disc and to evaluate function of the implant itself...
  20. ncbi request reprint Secondary tumor formation after stereotactic biopsy for intracerebral metastatic disease
    T Marx
    Martin-Luther-University Halle-Wittenberg, Department of Neurosurgery, Faculty of Medicine, Magdeburger Str. 16, D-06097 Halle, Germany
    Surg Neurol 55:41-5. 2001
    ..Nevertheless, neurosurgeons should be aware of the potential risk and, if necessary, should be able to modify the technical procedure and the adjuvant treatment...
  21. ncbi request reprint Autoantibodies to the inhibitor of apoptosis protein survivin in patients with brain tumors
    Ariane Söling
    Molecular Neurooncology Laboratory, Department of Neurosurgery, Martin Luther University Halle Wittenberg, D 06097 Halle, Germany
    Int J Oncol 30:123-8. 2007
    ..Anti-survivin antibodies may represent attractive tools for diagnosis and follow-up of brain tumors...
  22. ncbi request reprint Minichromosome maintenance protein 3 elicits a cancer-restricted immune response in patients with brain malignancies and is a strong independent predictor of survival in patients with anaplastic astrocytoma
    Ariane Söling
    Department of Neurosurgery, Martin Luther University Halle Wittenberg, Halle, Germany
    Clin Cancer Res 11:249-58. 2005
    ..Informative tumor markers may represent prognostic factors for response to therapy and outcome as well as potential targets for novel anticancer therapies...
  23. ncbi request reprint Bioluminescence imaging in vivo - application to cancer research
    Ariane Söling
    Molecular Neurooncology Laboratory, ZAMED, Heinrich Damerow Strasse 1, 06097, Halle, Germany
    Expert Opin Biol Ther 3:1163-72. 2003
    ..This review discusses the application of BLI to cancer research in general and to the area of experimental neuro-oncology in particular...
  24. ncbi request reprint Results and outcome of neurosurgical treatment for extradural metastases in the cervical spine
    V Heidecke
    Department of Neurosurgery, Faculty of Medicine, Martin Luther University Halle Wittenberg, Halle, Germany
    Acta Neurochir (Wien) 145:873-80; discussion 880-1. 2003
    ..Overall survival time and prognosis of the patients, however, are mainly depending on the type and the stage of the primary malignancy...
  25. ncbi request reprint Malignant growth of a recurrent macroprolactinoma after radiation therapy
    N G Rainov
    Department of Neurosurgery, Martin Luther University Halle Wittenberg, Germany
    Neurochirurgia (Stuttg) 36:172-5. 1993
    ..After radiation therapy of the subtotally excised recurrent tumor, it developed a rapid malignant-destructive growth with invasion into adjacent structures. The causal factors are discussed and the literature is briefly reviewed...
  26. ncbi request reprint Identification of genotoxic stress in human cells by fluorescent monitoring of p53 expression
    A Quinones
    Department of Neurosurgery, Martin Luther University, Magdeburger Strasse 16, D 06112, Halle, Germany
    Mutat Res 494:73-85. 2001
    ....
  27. ncbi request reprint Expression of mutant non-cleavable Fas ligand on retrovirus packaging cells causes apoptosis of immunocompetent cells and improves prodrug activation gene therapy in a malignant glioma model
    Constanze Nafe
    Department of Neurosurgery, Martin Luther University, Halle, Germany
    Life Sci 73:1847-60. 2003
    ..In conclusion, prolonged intratumoral presence of DeltaFasL-VPC seems to be a direct consequence of the expression of the membrane-bound mutant FasL, and may result in increased total RV output and improved tumor transduction with RV...
  28. ncbi request reprint Intravascular delivery of neural stem cell lines to target intracranial and extracranial tumors of neural and non-neural origin
    Alice B Brown
    Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Gene Ther 14:1777-85. 2003
    ....
  29. ncbi request reprint Alginate encapsulation of genetically engineered mammalian cells: comparison of production devices, methods and microcapsule characteristics
    S Koch
    Molecular Neurooncology Laboratory, Department of Neurosurgery, Martin Luther University, D 06097 Halle, Germany
    J Microencapsul 20:303-16. 2003
    ....
  30. pmc Dendritic cell therapy of primary brain tumors
    A Soling
    Department of Neurosurgery, Martin Luther University, Halle, Germany
    Mol Med 7:659-67. 2001
    ..DC therapy as an adjuvant treatment for patients with malignant glioma seems to be biologically safe. Further clinical studies are warranted...
  31. ncbi request reprint Meningioma: is there an association with human leukocyte antigens?
    Helmut K G Machulla
    Interbranch Human Leukocyte Antigen Laboratory, Institute of Medical Immunology, Martin Luther University, Halle, Germany
    Cancer Epidemiol Biomarkers Prev 12:1438-42. 2003
    ..These associations may be indicative of the involvement of the immune system in the host antitumor surveillance, recognition, and destruction of de novo arising human tumor cells...
  32. ncbi request reprint The egr-1 gene is induced by DNA-damaging agents and non-genotoxic drugs in both normal and neoplastic human cells
    Ariel Quinones
    Department of General Surgery, ECHO Laboratory, Martin Luther University, D 06097, Halle, Germany
    Life Sci 72:2975-92. 2003
    ....
  33. doi request reprint Infection rates of external ventricular drains are reduced by the use of silver-impregnated catheters
    M Lajcak
    Department of Neurosurgery, Klinikum Augsburg, Stenglinstr 2, 86156, Augsburg, Germany
    Acta Neurochir (Wien) 155:875-81. 2013
    ..Several types of EVD catheters are currently available, some of which have an antibacterial effect. This study compares the rates of CSF infections in patients with different types of EVD catheters...
  34. ncbi request reprint Liposome-mediated transfer of the bcl-2 gene results in neuroprotection after in vivo transient focal cerebral ischemia in an animal model
    Y J Cao
    Molecular Neuro oncology Laboratory, Department of Neurosurgery, Martin Luther University, Halle S, Germany
    Gene Ther 9:415-9. 2002
    ..doi: 10.1038/sj/gt/3301676..
  35. ncbi request reprint Predisposing conditions and risk factors for development of symptomatic meningioma in adults
    Brigitte Schneider
    Department of Neurosurgery, Central Clinic, Bad Berka, Germany
    Cancer Detect Prev 29:440-7. 2005
    ..Risk factors and predisposing factors for the development of symptomatic meningioma during adult life are not well known...
  36. ncbi request reprint Clinical studies with targeted toxins in malignant glioma
    Nikolai G Rainov
    The University of Liverpool, Dept Neurological Science, The Walton Centre for Neurology and Neurosurgery NHS Trust, Clinical Sciences Centre for Research and Education, Lower Lane, Liverpool L9 7LJ, UK
    Rev Recent Clin Trials 1:119-31. 2006
    ..It offers in addition an outlook into future areas of development of targeted toxins, such as improved delivery modes and non-invasive in vivo imaging of intracerebral and intratumoral distribution of toxin in patients...
  37. ncbi request reprint Technology evaluation: TransMID, KS Biomedix/Nycomed/Sosei/PharmaEngine
    Nikolai G Rainov
    The University of Liverpool, Division of Neuroscience, The Walton Centre for Neurology and Neurosurgery NHS Trust, Liverpool, UK
    Curr Opin Mol Ther 7:483-92. 2005
    ..TransMID is currently undergoing phase III clinical trials...
  38. ncbi request reprint Gene therapy for human malignant brain tumors
    Nikolai G Rainov
    Department of Neurological Science, University of Liverpool, Liverpool L9 7LJ, UK
    Cancer J 9:180-8. 2003
    ....
  39. ncbi request reprint Clinical trials with retrovirus mediated gene therapy--what have we learned?
    Nikolai G Rainov
    Department of Neurological Science, University of Liverpool, Liverpool, UK
    J Neurooncol 65:227-36. 2003
    ..Novel types of therapeutic virus vector systems are currently being designed and new clinical protocols are being created based on the lessons learned from the RV gene therapy trials in patients with malignant brain tumors...
  40. ncbi request reprint Safety, tolerability, and tumor response of IL4-Pseudomonas exotoxin (NBI-3001) in patients with recurrent malignant glioma
    Friedrich Weber
    Department of Neurological Surgery, Heinrich Heine University, Dusseldorf, Germany
    J Neurooncol 64:125-37. 2003
    ..This was an open-label, dose-escalation trial of intratumoral administration of IL-4 Pseudomonas exotoxin (NBI-3001) in patients with recurrent malignant glioma...
  41. ncbi request reprint Receptor tyrosine kinases as therapeutic targets in malignant glioma
    H Ren
    Department of Immunology, Harbin Medical University, Harbin, PR China
    Rev Recent Clin Trials 2:87-101. 2007
    ..This review summarizes current basic and clinical knowledge on the role of RTK in malignant glioma and on their importance as targets for new forms of therapy...
  42. ncbi request reprint A neuroblastoma-selective suicide gene therapy approach using the tyrosine hydroxylase promoter
    Sabine Steffens
    Department of Pediatric Oncology, Hematology, and Immunology, University Children s Hospital, Heinrich Heine University, Moorenstrasse 5, D 40225 Duesseldorf, Germany
    Pediatr Res 56:268-77. 2004
    ..001). In conclusion, the present study demonstrated the feasibility of a neuroblastoma-selective gene therapy approach using the THp/HSV-tk/egfp expression cassette...
  43. ncbi request reprint Differential cytotoxicity and bystander effect of the rabbit cytochrome P450 4B1 enzyme gene by two different prodrugs: implications for pharmacogene therapy
    Susanne Frank
    Department of Pediatric Hematology and Oncology, University Children s Hospital, Heinrich Heine University, Duesseldorf, Germany
    Cancer Gene Ther 9:178-88. 2002
    ....
  44. ncbi request reprint Recombinant retrovirus vectors for treatment of malignant brain tumors
    Nikolai G Rainov
    Department of Neurological Science, University of Liverpool, Walton Centre for Neurology and Neurosurgery NHS Trust, Liverpool L9 7LJ, United Kingdom
    Int Rev Neurobiol 55:185-203. 2003
  45. ncbi request reprint Dendritic cells for treatment of human malignant brain tumours
    Nikolai G Rainov
    Expert Opin Biol Ther 2:235-6. 2002
  46. ncbi request reprint Genetic and expression profiles of cerebellar liponeurocytomas
    Sonja Horstmann
    International Agency for Research on Cancer, Lyon, France
    Brain Pathol 14:281-9. 2004
    ..Furthermore, the cDNA expression array data suggest a relationship to central neurocytomas, but the presence of TP53 mutations, which are absent in central neurocytomas, suggests that their genetic pathways are different...
  47. ncbi request reprint Experimental strategies for combined suicide and immune cancer gene therapy. An overview
    Christof M Kramm
    Department of Pediatric Hematology and Oncology, University Hospital, Heinrich Heine University, Dusseldorf, Germany
    Methods Mol Biol 215:137-52. 2003
  48. ncbi request reprint Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells
    Ute Fischer
    Institute of Molecular Medicine, Heinrich Heine University, Dusseldorf, Germany
    Oncogene 24:1231-43. 2005
    ..These data suggest that TK/GCV- and CD/5-FC-induced apoptosis does neither require p53 nor death receptors, but converges at a mitochondrial pathway triggered by different mechanisms of modulation of Bcl-2 proteins...
  49. ncbi request reprint Motor cortex stimulation for neuropathic facial pain
    Nikolai G Rainov
    University of Liverpool, Department of Neurological Science, Walton Centre for Neurology and Neurosurgery NHS Trust, Clinical Sciences Centre for Research and Education, Lower Lane, Liverpool L9 7LJ, UK
    Neurol Res 25:157-61. 2003
    ..These cases are discussed and the recent literature on MCS is reviewed in an attempt to identify indications for MCS as well as key structures in the brain for mediating the MCS effect...
  50. ncbi request reprint Pentosan polysulfate as a prophylactic and therapeutic agent against prion disease
    Stephen Dealler
    Royal Lancaster Infirmary, Ashton Road, Lancaster, LA1 4RG, UK
    IDrugs 6:470-8. 2003
    ..The prophylaxis of humans with oral PPS and the current therapeutic activity of the drug when given by intracerebroventricular infusion to symptomatic, prion-infected animals are discussed...
  51. ncbi request reprint Technology evaluation: cintredekin besudotox, NeoPharm/Nippon
    Nikolai G Rainov
    University of Liverpool, Department of Neurological Science, The Walton Centre for Neurology and Neurosurgery NHS Trust, Lower Lane, Liverpool L9 7LJ, UK
    Curr Opin Mol Ther 7:170-81. 2005
    ..This agent is currently undergoing phase III clinical trials...