Research Topics
Genomes and GenesSpecies | Ulrich W PreussSummaryAffiliation: Martin Luther University Country: Germany Publications
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Publications
Commentary on the study: impact of depressive symptoms on future alcohol use in patients with co-occurring bipolar disorder and alcohol dependence: a prospective analysis in an 8-week randomized controlled trial of acamprosate (Prisciandaro et al.)Ulrich W Preuss
Department of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University of Halle Wittenberg, Halle Saale, Germany
Alcohol Clin Exp Res 36:967-9. 2012..The aim of this short commentary is to review a current study investigating the impact of depressive symptoms and craving on alcohol use in individuals with co-occurring bipolar disorder and alcohol dependence...
Personality disorders in alcohol-dependent individuals: relationship with alcohol dependence severityU W Preuss
Department of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University of Halle Wittenberg, E 06097 Halle Saale, Germany
Eur Addict Res 15:188-95. 2009..The majority of alcohol-dependent individuals had one or more comorbid axis II disorders. Univariate and multivariate analyses indicate that different PDs are related to age at first dinking and alcoholism severity...
Cannabis withdrawal severity and short-term course among cannabis-dependent adolescent and young adult inpatientsU W Preuss
Department of Psychiatry, Psychotherapie and Psychosomatics, Martin Luther University, Julius Kuhn Strasse 7, Halle Wittenberg MLU, Halle Saale, Germany
Drug Alcohol Depend 106:133-41. 2010..The aim of this study is to prospectively assess the course of CWS in a sample of cannabis-dependent inpatients and to provide an estimate of the proportion of subjects experiencing CWS...
No association of alcohol dependence with HOMER 1 and 2 genetic variantsU W Preuss
Department of Psychiatry, Psychotherapy and Psychosomatics, University of Halle Wittenberg, Halle Saale, Germany
Am J Med Genet B Neuropsychiatr Genet 153:1102-9. 2010..In conclusion, our results suggest that single SNPs, respectively, haplotypes of the HOMER 1 and 2 genes are unlikely to play a major role in the pathophysiology of AD...
Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association studyUlrich W Preuss
Department of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University, Halle Wittenberg, Julius Kühn Str 7, D 06112 Halle, Germany
Addict Biol 16:323-33. 2011....
Anterior cingulum volumetry, auditory P300 in schizophrenia with negative symptomsUlrich W Preuss
Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, D 80336 Munich, Germany
Psychiatry Res 183:133-9. 2010..In addition, while right hemisphere ACC volumes significantly differ between schizophrenia subgroups, combining measures of event-related potential (ERP) and ACC volumetry does not add additional information...
Diagnostic correlates of Alzheimer dementia in a U.S. Nationwide inpatient sampleUlrich W Preuss
Department of Psychiatry, Psychotherapy and Psychosomatics, University of Halle Wittenberg, Germany
Am J Geriatr Psychiatry 18:821-9. 2010..The aim of this analysis of a large and representative U.S. nationwide inpatient sample (NIS) was to identify diagnostic correlates of ALZ-D in subjects aged 60 years and older...
Short-term prospective comparison of prepulse inhibition between schizophrenic patients and healthy controlsU W Preuss
Department of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University of Halle Wittenberg, Halle Saale, Germany
Pharmacopsychiatry 44:102-8. 2011....
[Psychometric evaluation of the German version of the Barratt Impulsiveness Scale]U W Preuss
Klinik fur Psychiatrie und Psychotherapie, Martin Luther Universitat, Halle Wittenberg, Julius Kuhn Strasse 7, 06097 Halle Saale
Nervenarzt 79:305-19. 2008..e. the Barratt Impulsiveness Scale Version 11 (BIS11). However, it lacks adequate psychometric characterization for German speakers...
D2 dopamine receptor gene haplotypes and their influence on alcohol and tobacco consumption magnitude in alcohol-dependent individualsU W Preuss
Pediatric Hospital of Ludwig Maximilians University, Munich, Germany
Alcohol Alcohol 42:258-66. 2007....
Amygdala volume and depressive symptoms in patients with borderline personality disorderThomas Zetzsche
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Munich, Germany
Biol Psychiatry 60:302-10. 2006..Future studies should clarify whether amygdala enlargement is a risk factor for MD in BPD patients or a consequence of the affective disorder...
White matter alterations in schizophrenic patients with pronounced negative symptomatology and with positive family history for schizophreniaThomas Zetzsche
Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, 80336, Munich, Germany
Eur Arch Psychiatry Clin Neurosci 258:278-84. 2008..The aim of our analysis was to investigate potential changes of white matter in schizophrenic patients compared to controls, and the relationship to clinical characteristics...
Hippocampal volume reduction and history of aggressive behaviour in patients with borderline personality disorderThomas Zetzsche
Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, D 80336 Munich, Germany
Psychiatry Res 154:157-70. 2007..Furthermore, this structural change might facilitate aggressive behaviour. Subsequent studies are required to clarify whether the reduction of hippocampal volume is a trait and risk factor for increased aggression...
Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol dependence symptomsGabriele Koller
Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
Alcohol Clin Exp Res 36:1230-6. 2012..Conflicting results were reported on the role of the mu-opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism...
Analysis of single nucleotide polymorphisms and haplotypes in the neuropeptide Y gene: no evidence for association with alcoholism in a German population samplePeter Zill
Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
Alcohol Clin Exp Res 32:430-4. 2008..The aim of the present study was to analyze these variants in a large sample of the Munich Gene Bank of Alcoholism...
Suicidal behavior in alcohol-dependent subjects: the role of personality disordersUlrich W Preuss
Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Germany
Alcohol Clin Exp Res 30:866-77. 2006....
SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicidePeter Zill
Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
Neuropsychopharmacology 32:1687-94. 2007..Further analysis are needed to confirm these results...
Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient samplePeter Zill
Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
Psychiatry Res 187:220-3. 2011..Our results do not provide evidence for an involvement of NEUROD2 polymorphisms in the pathophysiology of alcohol dependence. Further association studies are needed to confirm our findings...
Association of personality disorders with Type A and Type B alcoholicsMiriam Bottlender
Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Muenchen, Germany
Eur Arch Psychiatry Clin Neurosci 256:55-61. 2006..The impact of other personality disorders does not play a substantial role in subtyping alcoholics...
Efficacy and safety of levetiracetam for the prevention of alcohol relapse in recently detoxified alcohol-dependent patients: a randomized trialChristoph Richter
Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Charite Campus Mitte, Berlin, Germany
J Clin Psychopharmacol 32:558-62. 2012..Antiepileptics have been shown to reduce alcohol intake or to prevent relapse in patients with alcoholism...
Temperament and character in patients with borderline personality disorder taking gender and comorbidity into accountSven Barnow
Department of Psychiatry and Psychotherapy, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany
Psychopathology 40:369-78. 2007..The results provide support for the importance of controlling for gender effects when investigating the applicability of dimensional models with respect to personality disorders...
[Turner-syndrome and psychosis: a case report and brief review of the literature]Tobias Wustmann
Klinik fur Psychiatrie, Psychotherapie und Psychosomatik, Martin Luther Universitat Halle Wittenberg, Halle Saale
Psychiatr Prax 36:243-5. 2009..While common somatic symptoms are often described, neuropsychiatric alterations are rare and not frequently mentioned in the literature...
Levetiracetam for the treatment of alcohol withdrawal syndrome: a multicenter, prospective, randomized, placebo-controlled trialChristoph Richter
Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Charite Campus Mitte, Germany
J Clin Psychopharmacol 30:720-5. 2010..We therefore investigated the safety and efficacy of levetiracetam (LV), a newer antiepileptic with a potentially favorable adverse-effect profile, for the treatment of AWS...
No association of CRH1 receptor polymorphism haplotypes, harm avoidance and other personality dimensions in alcohol dependence: results from the Munich gene bank project for alcoholismM Soyka
Psychiatric Hospital of Ludwig Maximilians University Munich, Munich, Germany
Addict Biol 9:73-9. 2004..The possible implications of these findings are discussed...
Handedness and corpus callosum morphologyUlrich W Preuss
Department of Psychiatry, , Nussbaumstr. 7, D-80336 Munich, Germany
Psychiatry Res 116:33-42. 2002..No significant difference between handedness subgroups in CC regions and no significant correlations between HDT values and CC areas were detected...
5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorderT Zetzsche
Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
Genes Brain Behav 7:306-13. 2008..Future research is recommended to clarify possible interactions between this functional polymorphism and symptoms, course and treatment responses in this disorder...
Impulsive traits and 5-HT2A receptor promoter polymorphism in alcohol dependents: possible association but no influence of personality disordersU W Preuss
Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Germany
Neuropsychobiology 43:186-91. 2001..Alcohol dependents were investigated because these personality disorders and impulsive behavior are very frequent in alcohol dependence anf of clinical relevance...
Dopamine D 4 receptor gene polymorphism and extraversion revisited: results from the Munich gene bank project for alcoholismM Soyka
Psychiatric Hospital of Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
J Psychiatr Res 36:429-35. 2002..These findings are in line with a number of more recent studies questioning the association between novelty-seeking and DRD4 dopamine receptor gene polymorphism. Possible implications of these findings are discussed...
Citalopram neuropharmacological challenge in alcohol-dependent patients and controls: pharmacogenetic, endocrine and psychobehavioral resultsW M Wong
Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
Pharmacopsychiatry 41:72-8. 2008..Furthermore we wanted to know whether functional polymorphisms (5-HTTLPR and 5HT2C Ser23Cys), have any influence on this responsivity...
Serotonin transporter gene regulatory region polymorphism (5-HTTLPR), [3H]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivityU W Preuss
Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336, Munchen, Germany
Psychiatry Res 96:51-61. 2000..K(D) might be influenced by duration of alcohol dependence, but not sufficiently to yield differences between alcohol-dependent and control subjects...
Chronological relationship between antisocial personality disorder and alcohol dependenceM Bahlmann
Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
Eur Addict Res 8:195-200. 2002..This finding suggests that in patients with ASPD, alcohol dependence might be a secondary syndrome as suggested by previous research...
No association between a polymorphism in the promoter region of the MAOA gene with antisocial personality traits in alcoholicsG Koller
Psychiatrische Klinik und Poliklinik der LMU München, Nussbaumstrasse 7, 80336 Munchen, Germany
Alcohol Alcohol 38:31-4. 2003..We analysed the MAOAuVNTR functional polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. Genotypes with three-repeat alleles were reported to be associated with antisocial as well as impulsive traits...
Striatal dopamine D2 receptor binding of risperidone in schizophrenic patients as assessed by 123I-iodobenzamide SPECT: a comparative study with olanzapineG J E Schmitt
Department of Psychiatry, Ludwig-Maximilians-University Munich, Germany
J Psychopharmacol 16:200-6. 2002..0001) and olanzapine (Pearson r = -0.77, p = 0.002). There was no significant difference between the D2 receptor occupancy of the two substances when given in the clinically recommended dose range (unpaired t-test, t = -0.112, p = 0.911)...
No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individualsU W Preuss
Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336 Munchen, Germany
Alcohol Alcohol 37:174-8. 2002..The negative results in this study question the role of these polymorphisms in the pathogenesis of alcohol withdrawal-induced seizures and delirium tremens...
Thalamic volume in first-episode and chronic schizophrenic subjects: a volumetric MRI studyU W Preuss
Department of Psychiatry, Psychiatrische Klinik und Poliklinik, , Nussbaumstr. 7, , Germany
Schizophr Res 73:91-101. 2005..SUMMARY: Our findings indicate that, while the thalamus might be involved in the pathogenesis of negative symptoms, thalamic volume reduction is not a required element in the pathophysiology of the schizophrenic phenotype...
Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholicsU W Preuss
Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Munchen, Germany
Pharmacogenomics J 6:34-41. 2006..Although this result is suggestive for a significant role of this polymorphism in the pathogenesis of delirium tremens in alcohol-dependent individuals, further investigation and confirmation are warranted...
Tryptophan hydroxylase gene 1 polymorphisms are not associated with suicide attempts in alcohol-dependent individualsG Koller
Substitutionsambulanz, Pestalozzistrasse 2, 80469 München, Germany
Addict Biol 10:269-73. 2005..Our data do not support the hypothesis of A-6526G, G-5806T or A-779C polymorphisms to be associated with suicide attempts in alcohol-dependent individuals...
[Factor structure and validity of a german version of the barratt impulsiveness scale]U W Preuss
Psychiatrische Klinik und Poliklinik Ludwig Maximilians Universität München
Fortschr Neurol Psychiatr 71:527-34. 2003..The aim of this study is to evaluate the BIS-5 in two German psychiatric inpatient samples and healthy controls proving the originally proposed four-factor structure as well as convergent and discriminate validity...
[Suicide attempts in alcohol dependents: clinical characteristics und differentiation of the applied methods]U W Preuss
Johanna Odebrecht Stiftung, Greifswald
Fortschr Neurol Psychiatr 74:77-84. 2006..In terms of methods used, violent and non-violent suicide attempts can be distinguished. To confirm the validity of this distinction from a clinical point of view a sample of inpatient alcohol-dependent subjects is explored...
Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samplesJ Treutlein
Molecular Genetics Laboratory and Department of Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
Mol Psychiatry 11:594-602. 2006..Our findings support results from animal models, suggesting an importance of CRHR1 in integrating gene-environment effects in alcohol use disorders...
No association between suicidal behavior and 5-HT2A-T102C polymorphism in alcohol dependentsU W Preuss
Am J Med Genet 96:877-8. 2000
Comparison of 3190 alcohol-dependent individuals with and without suicide attemptsU W Preuss
Department of Veterans Affairs, VA San Diego Healthcare System, Department of Psychiatry, California 92161, USA
Alcohol Clin Exp Res 26:471-7. 2002..Screening and subsequent treatment of alcohol use disorder, psychiatric comorbidity, and substance use disorders among alcoholics may be crucial in preventing suicide attempts and completions...
Association between suicide attempts and 5-HTTLPR-S-allele in alcohol-dependent and control subjects: further evidence from a German alcohol-dependent inpatient sampleU W Preuss
Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universitat Munchen, Munchen, Germany
Biol Psychiatry 50:636-9. 2001..A significant association between suicide attempts and the 5-HTT promoter polymorphisms (5-HTTLPR) S-allele has been reported in a sample of French alcohol-dependent subjects, and this paper evaluates this phenomenon in a German sample...
A comparison of alcohol-induced and independent depression in alcoholics with histories of suicide attemptsU W Preuss
Department of Psychiatry, University of California, San Diego 92161-2002, USA
J Stud Alcohol 63:498-502. 2002..CONCLUSIONS: The results indicate that a distinction between independent and alcohol-induced mood disorders in alcoholics with a history of suicide attempts may be useful...
Impulsivity and aggression as predictors of suicide attempts in alcoholicsG Koller
Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universitat, Nussbaumstr 7, 80336 Munchen, Germany
Eur Arch Psychiatry Clin Neurosci 252:155-60. 2002..Furthermore, the potential influence of concurrent personality disorders and depressive conditions were assessed...
Mood and anxiety symptoms among 140 children from alcoholic and control familiesU W Preuss
Department of Veterans Affairs, VA San Diego Healthcare System, University of California, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
Drug Alcohol Depend 67:235-42. 2002..CONCLUSIONS: The results indicate that internalizing symptoms in children of alcoholics were more strongly influenced by a positive family history of mood and anxiety disorders than the family history of alcohol use disorders...
Alcoholism-related phenotypes and genetic variants of the CB1 receptorU W Preuss
Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universität Muenchen, Nussbaumstr 7, 80336 Munchen, Germany
Eur Arch Psychiatry Clin Neurosci 253:275-80. 2003..The aim of this study is to test the potential influence of a bi-allelic cannabinoid receptor gene (CNR1) polymorphism (G1359A) on severe alcohol withdrawal syndromes...
Association of 5-HT1B receptor gene and antisocial behavior in alcoholismM Soyka
Psychiatric Hospital, University of Munich, Germany
J Neural Transm 111:101-9. 2004..Adult antisocial personality occurred more often in males than females. Possible implications of these findings are discussed...
GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependenceM Soyka
Psychiatric Hospital of Ludwig Maximilians University Munich, Germany
J Psychiatr Res 42:184-91. 2008..These findings support and extend the three previous studies implicating a GABA-A receptor subunit as contributing to the genetic risk for alcohol dependence. Possible implications of these findings are discussed...
