Affiliation: Martin Luther University
- A new class of potent reversible inhibitors of metallo-proteinases: C-terminal thiol-peptides as zinc-coordinating ligandsK Peters
Faculty of Medicine, Institute of Physiological Chemistry, Martin Luther University, Halle Wittenberg, Halle Saale, Germany
J Enzyme Inhib 16:339-50. 2001..The strongest inhibition was found with Z-Pro-Leu-CA-SH (Ki = 30 microM). Substitution of the N-protecting benzyloxycarbonyl residue towards the acetyl group in the peptide inhibitor, the inhibition constant decreased about 25 times...
- Crystal structure of subtilisin DY, a random mutant of subtilisin CarlsbergS Eschenburg
European Molecular Biology Laboratory, Institute of Physiological Chemistry, Hamburg, Germany
Eur J Biochem 257:309-18. 1998....
- Purification of soluble and membrane-bound proteases with substrate-analogous inhibitors by affinity chromatographyG Jahreis
Institute of Physiological Chemistry, Faculty of Medicine, Martin Luther University, Hollystrasse 1, D-06097 Halle (Saale, Germany
J Biochem Biophys Methods 49:491-505. 2001..As a new type of ligands, spacer-bound peptidyl chloromethyl ketones are presented for a specific and oriented immobilization of proteinases. Oriented-immobilized cathepsin B was used to isolate antibodies against this enzyme...