Elmar Peschke

Summary

Affiliation: Martin Luther University
Country: Germany

Publications

  1. pmc Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon
    Elmar Peschke
    Saxon Academy of Sciences, Leipzig 04107, Germany
    Int J Mol Sci 14:6981-7015. 2013
  2. doi request reprint Catecholamines are the key for explaining the biological relevance of insulin-melatonin antagonisms in type 1 and type 2 diabetes
    E Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Pineal Res 52:389-96. 2012
  3. ncbi request reprint Circannual morphometric investigations of the rat suprachiasmatic nucleus after pinealectomy, ganglionectomy and thyroidectomy
    E Peschke
    Department of Anatomy and Cell Biology, Martin Luther University, Halle Saale, Germany
    Brain Res 740:81-8. 1996
  4. doi request reprint New evidence for a role of melatonin in glucose regulation
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Grosse Steinstrasse 52, 06097 Halle, Germany
    Best Pract Res Clin Endocrinol Metab 24:829-41. 2010
  5. doi request reprint Long-term enteral administration of melatonin reduces plasma insulin and increases expression of pineal insulin receptors in both Wistar and type 2-diabetic Goto-Kakizaki rats
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Pineal Res 49:373-81. 2010
  6. ncbi request reprint Doctor medicinae honoris causa of the Medical Faculty of the Martin Luther University of Halle-Wittenberg for the anatomist and researcher of the pineal gland Professor Dr. Lutz Vollrath from Mainz
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther Universität of Halle Wittenberg, Grosse Steinstrasse 52, 06108 Halle Saale, Germany
    Ann Anat 190:199-207. 2008
  7. doi request reprint Increased melatonin synthesis in pineal glands of rats in streptozotocin induced type 1 diabetes
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University, Halle Wittenberg, Halle, Germany
    J Pineal Res 45:439-48. 2008
  8. ncbi request reprint Melatonin, endocrine pancreas and diabetes
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Germany
    J Pineal Res 44:26-40. 2008
  9. ncbi request reprint Melatonin and type 2 diabetes - a possible link?
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle, Germany
    J Pineal Res 42:350-8. 2007
  10. ncbi request reprint Evidence for a melatonin receptor within pancreatic islets of neonate rats: functional, autoradiographic, and molecular investigations
    E Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Pineal Res 28:156-64. 2000

Collaborators

Detail Information

Publications32

  1. pmc Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon
    Elmar Peschke
    Saxon Academy of Sciences, Leipzig 04107, Germany
    Int J Mol Sci 14:6981-7015. 2013
    ..Elucidation of the possible inverse interrelationship in man may open new avenues in the therapy of diabetes...
  2. doi request reprint Catecholamines are the key for explaining the biological relevance of insulin-melatonin antagonisms in type 1 and type 2 diabetes
    E Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Pineal Res 52:389-96. 2012
    ..Here, we strongly repudiate misconceptions, resulting from observations that melatonin reduces the plasma insulin level, that the blockage of melatonin receptors would be of benefit in the treatment of type 2 diabetes...
  3. ncbi request reprint Circannual morphometric investigations of the rat suprachiasmatic nucleus after pinealectomy, ganglionectomy and thyroidectomy
    E Peschke
    Department of Anatomy and Cell Biology, Martin Luther University, Halle Saale, Germany
    Brain Res 740:81-8. 1996
    ..Additionally, it could be shown that the degree of negative correlation between the pineal and the SCN was seasonally dependent. The lowest effects of PX, GX and TX were registered at short-day conditions (December, L:D = 8:16)...
  4. doi request reprint New evidence for a role of melatonin in glucose regulation
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Grosse Steinstrasse 52, 06097 Halle, Germany
    Best Pract Res Clin Endocrinol Metab 24:829-41. 2010
    ..This article summarizes interrelationships between melatonin and insulin in type 1 diabetic (T1D) and type 2 diabetic (T2D) rats and humans...
  5. doi request reprint Long-term enteral administration of melatonin reduces plasma insulin and increases expression of pineal insulin receptors in both Wistar and type 2-diabetic Goto-Kakizaki rats
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Pineal Res 49:373-81. 2010
    ..In summary, the results show that melatonin administration decreases plasma insulin levels in vivo and, furthermore, that an insulin-melatonin antagonism exists...
  6. ncbi request reprint Doctor medicinae honoris causa of the Medical Faculty of the Martin Luther University of Halle-Wittenberg for the anatomist and researcher of the pineal gland Professor Dr. Lutz Vollrath from Mainz
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther Universität of Halle Wittenberg, Grosse Steinstrasse 52, 06108 Halle Saale, Germany
    Ann Anat 190:199-207. 2008
  7. doi request reprint Increased melatonin synthesis in pineal glands of rats in streptozotocin induced type 1 diabetes
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University, Halle Wittenberg, Halle, Germany
    J Pineal Res 45:439-48. 2008
    ..The results thus prove that a melatonin-insulin antagonism exists. Astonishingly, notwithstanding the drastic metabolic disturbances in STZ-diabetic rats, the diurnal rhythms of the parameters investigated are maintained...
  8. ncbi request reprint Melatonin, endocrine pancreas and diabetes
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Germany
    J Pineal Res 44:26-40. 2008
    ..In contrast, in the pineal gland, the AANAT mRNA is increased and the insulin receptor mRNA is decreased, which indicates a close interrelationship between insulin and melatonin...
  9. ncbi request reprint Melatonin and type 2 diabetes - a possible link?
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle, Germany
    J Pineal Res 42:350-8. 2007
    ..Thus, our data demonstrate the existence of the melatonin membrane receptors MT1 and MT2 as well as mRNA expression of nuclear orphan receptors in human pancreatic tissue, with upregulated expression levels in type 2 diabetic patients...
  10. ncbi request reprint Evidence for a melatonin receptor within pancreatic islets of neonate rats: functional, autoradiographic, and molecular investigations
    E Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Pineal Res 28:156-64. 2000
    ..In summary, it may be said that our functional. autoradiographic, and molecular results indicate that the Mel1a receptor is located on the pancreatic islets, possibly in the beta cells...
  11. ncbi request reprint Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Pineal Res 33:63-71. 2002
    ..From these data we conclude that the MT1 receptor is located on the INS-1 cell and therefore in general on pancreatic beta-cells...
  12. doi request reprint The insulin-melatonin antagonism: studies in the LEW.1AR1-iddm rat (an animal model of human type 1 diabetes mellitus)
    E Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Grosse Steinstrasse 52, 06097 Halle, Germany
    Diabetologia 54:1831-40. 2011
    ....
  13. ncbi request reprint Parallel signaling pathways of melatonin in the pancreatic beta-cell
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Pineal Res 40:184-91. 2006
    ..The cAMP- and subsequently insulin-inhibiting signaling pathway involves PTX-sensitive G(i)alpha-proteins and is predominant in terms of insulin release...
  14. doi request reprint Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells
    Ina Stumpf
    Institute of Anatomy and Cell Biology, Martin Luther University, Halle Wittenberg, Halle Saale, Germany
    J Pineal Res 45:318-27. 2008
    ..In conclusion, it could be demonstrated that the melatonin receptor subtype MT2 as well as the cGMP signaling pathway are involved in mediating the insulin-inhibiting effect of melatonin...
  15. ncbi request reprint Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Pineal Res 40:135-43. 2006
    ..Our observations suggest a functional inter-relationship between melatonin and insulin, and may indicate a reduction of melatonin in the genesis of diabetes...
  16. doi request reprint Adrenoceptor expression and diurnal rhythms of melatonin and its precursors in the pineal gland of type 2 diabetic goto-kakizaki rats
    Andreas Gunter Bach
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Grosse Steinstrasse 52, 06097 Halle Saale, Germany
    Endocrinology 151:2483-93. 2010
    ..The present data unveil several reasons for a reduced melatonin secretion in diabetic animals and present an important link in the interaction between melatonin and insulin...
  17. doi request reprint Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma β-cells (INS-1)
    Ivonne Bazwinsky-Wutschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle, Germany
    J Pineal Res 53:344-57. 2012
    ..Mediated via CREB, melatonin regulates the expression of genes that play an important functional role in the regulation of β-cell signalling pathways...
  18. doi request reprint Pineal melatonin synthesis is decreased in type 2 diabetic Goto-Kakizaki rats
    Thomas Frese
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Grosse Steinstrasse 52, 06097 Halle, Germany
    Life Sci 85:526-33. 2009
    ..This paper addresses the differences in the pineal melatonin synthesis of type 2 diabetic Goto-Kakizaki (GK) rats compared to non-diabetic Wistar rats (8 and 50 weeks old)...
  19. doi request reprint Evidence of the receptor-mediated influence of melatonin on pancreatic glucagon secretion via the Gαq protein-coupled and PI3K signaling pathways
    Ina Bähr
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle, Germany
    J Pineal Res 53:390-8. 2012
    ..In conclusion, these findings provide evidence that the glucagon-stimulatory effect of melatonin in pancreatic α-cells is melatonin receptor mediated, thus supporting the concept of melatonin-modulated and diurnal glucagon release...
  20. doi request reprint Distribution patterns of calcium-binding proteins in pancreatic tissue of non-diabetic as well as type 2 diabetic rats and in rat insulinoma beta-cells (INS-1)
    Ivonne Bazwinsky-Wutschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, 06097 Halle, Germany
    Histochem Cell Biol 134:115-27. 2010
    ..These results indicate that alterations of CaBPs in pancreatic islets are associated with metabolic disturbances related to type 2 diabetes...
  21. ncbi request reprint Melatonin stimulates inositol-1,4,5-trisphosphate and Ca2+ release from INS1 insulinoma cells
    Andreas G Bach
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Pineal Res 39:316-23. 2005
    ..The melatonin effect observed mimics carbachol action. It can be abolished by 30 micromol/L luzindole and is sustained in Ca2+-free medium, suggesting a mechanism that includes the depletion of Ca2+ from intracellular stores...
  22. doi request reprint Melatonin stimulates glucagon secretion in vitro and in vivo
    Ina Bähr
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Pineal Res 50:336-44. 2011
    ..In conclusion, these findings revealed evidence that melatonin influences pancreatic glucagon expression and secretion as well as the peripheral glucagon action...
  23. doi request reprint Melatonin influences insulin secretion primarily via MT(1) receptors in rat insulinoma cells (INS-1) and mouse pancreatic islets
    Eckhard Muhlbauer
    Saxon Academy of Sciences Leipzig, Leipzig, Germany
    J Pineal Res 52:446-59. 2012
    ..The data indicate that melatonin inhibits insulin secretion, primarily via the MT(1) receptor in rat INS-1 cells and isolated mouse islets...
  24. doi request reprint Modulation of the cGMP signaling pathway by melatonin in pancreatic beta-cells
    Ina Stumpf
    Institute of Anatomy and Cell Biology, Martin Luther University, Halle Wittenberg, Halle Saale, Germany
    J Pineal Res 46:140-7. 2009
    ..In addition, it was demonstrated that melatonin is involved in modulation of CNG channel mRNA...
  25. doi request reprint Development and validation of a high throughput direct radioimmunoassay for the quantitative determination of serum and plasma melatonin (N-acetyl-5-methoxytryptamine) in mice
    Andre Welp
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle, Germany
    J Immunol Methods 358:1-8. 2010
    ..In summary, it can be concluded that the developed and validated direct RIA meets the requirements for the determination of melatonin and is especially suitable for the analysis of melatonin in different mouse strains...
  26. doi request reprint History of the nervus intermedius of Wrisberg
    Alex Alfieri
    Department of Neurosurgery, University Hospital Halle, Martin Luther University Halle Wittenberg, 06120 Halle Saale, Germany
    Ann Anat 192:139-44. 2010
    ....
  27. doi request reprint Loss of melatonin signalling and its impact on circadian rhythms in mouse organs regulating blood glucose
    Eckhard Muhlbauer
    Saxon Academy of Sciences Leipzig, Leipzig, Germany
    Eur J Pharmacol 606:61-71. 2009
    ..These data support the idea that melatonin synchronises the functions of the major organs involved in blood glucose regulation and negatively acts on the insulin secretion...
  28. doi request reprint Influence of melatonin receptor signalling on parameters involved in blood glucose regulation
    Ivonne Bazwinsky-Wutschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle, Germany
    J Pineal Res 56:82-96. 2014
    ....
  29. doi request reprint The central myelin-peripheral myelin transitional zone of the nervus intermedius and its implications for microsurgery in the cerebellopontine angle
    Alex Alfieri
    Department of Neurosurgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Clin Anat 25:882-8. 2012
    ..The exact location of the ORZ may play a role in diagnostic preoperative imaging, in the planning of surgical procedures for NIN, and may offer suitable landmarks for surgeons performing microvascular decompression in NIN treatment...
  30. doi request reprint Anatomical changes after pneumonectomy
    Ivonne Bazwinsky-Wutschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Grosse Steinstrasse 52, Halle, Germany
    Ann Anat 193:168-72. 2011
    ..The findings document anatomical alterations that arise physiologically due to pneumonectomy if no pathological complications occur...
  31. ncbi request reprint Photo-degradation of melatonin: influence of argon, hydrogenperoxide, and ethanol
    Hans Jürgen Brömme
    Institutes of Pathophysiology, Martin Luther University Halle Wittenberg, Germany
    J Pineal Res 44:366-72. 2008
    ..Ethanol, as a potent scavenger of *OH, efficiently blocks the effect of this aggressive radical even at low concentrations of that scavenger (0.1% v/v) but is less effective in preventing photo-degradation of melatonin...
  32. ncbi request reprint Evidence for the expression of both the MT1- and in addition, the MT2-melatonin receptor, in the rat pancreas, islet and beta-cell
    Eckhard Muhlbauer
    J Pineal Res 42:105-6. 2007