D H Nies

Summary

Affiliation: Martin Luther University
Country: Germany

Publications

  1. pmc The metal permease ZupT from Escherichia coli is a transporter with a broad substrate spectrum
    Gregor Grass
    Institut fur Mikrobiologie, Martin Luther Universitat, Halle, Germany
    J Bacteriol 187:1604-11. 2005
  2. pmc Role of the extracytoplasmic function protein family sigma factor RpoE in metal resistance of Escherichia coli
    Monique Egler
    Institut fur Mikrobiologie, Kurt Mothes Str 3, 06099 Halle, Germany
    J Bacteriol 187:2297-307. 2005
  3. pmc Insights into genome plasticity and pathogenicity of the plant pathogenic bacterium Xanthomonas campestris pv. vesicatoria revealed by the complete genome sequence
    Frank Thieme
    Martin Luther Universitat, Institut fur Genetik, Weinbergweg 10, D 06120 Halle Saale, Germany
    J Bacteriol 187:7254-66. 2005
  4. ncbi Paralogs of genes encoding metal resistance proteins in Cupriavidus metallidurans strain CH34
    Dietrich H Nies
    Institut fur Mikrobiologie, Halle, Germany
    J Mol Microbiol Biotechnol 11:82-93. 2006
  5. ncbi The RcnRA (YohLM) system of Escherichia coli: a connection between nickel, cobalt and iron homeostasis
    Doreen Koch
    Molecular Microbiology, Martin Luther University Halle Wittenberg, Kurt Mothes Str 3, 06099, Halle Saale, Germany
    Biometals 20:759-71. 2007
  6. doi Deletion of the zupT gene for a zinc importer influences zinc pools in Cupriavidus metallidurans CH34
    M Herzberg
    Molecular Microbiology, University of Halle, Kurt Mothes Str 3, 06099 Halle Saale, Germany, EU
    Metallomics 6:421-36. 2014
  7. doi A fresh view of the cell biology of copper in enterobacteria
    Dietrich H Nies
    Molecular Microbiology, Institute for Biology Microbiology, Martin Luther University Halle Wittenberg, Kurt Mothes Str 3, 06120 Halle Saale, Germany
    Mol Microbiol 87:447-54. 2013
  8. doi How iron is transported into magnetosomes
    Dietrich H Nies
    Inst Microbiology, University of Halle, Kurt Mothes Str 3, Halle Saale 06099, Germany
    Mol Microbiol 82:792-6. 2011
  9. pmc CHR, a novel family of prokaryotic proton motive force-driven transporters probably containing chromate/sulfate antiporters
    D H Nies
    Institut fur Mikrobiologie, D 06099 Halle, Germany
    J Bacteriol 180:5799-802. 1998
  10. ncbi Incidence and function of sigma factors in Ralstonia metallidurans and other bacteria
    Dietrich H Nies
    Institut fur Mikrobiologie, Martin Luther Universitat Halle Wittenberg, Kurt Mothes Strasse 3, 06099 Halle, Germany
    Arch Microbiol 181:255-68. 2004

Collaborators

  • Gregor Grass
  • Christopher Rensing
  • G Mittenhuber
  • Michael E Maguire
  • P Neubauer
  • Yahya Mrestani
  • S Clemens
  • David Stroebel
  • Alice Carolyn McHardy
  • Ernst Weber
  • Daniela Büttner
  • Christian Ruckert
  • Ralf Koebnik
  • N L Brown
  • U Bonas
  • B P Rosen
  • Folker Meyer
  • Alexander Steinbüchel
  • Cornelia Grosse
  • Andreas Anton
  • André Mikolay
  • Judith Scherer
  • Kerstin Helbig
  • Sylvia Franke
  • Antje Legatzki
  • Corinna Bleuel
  • M Herzberg
  • Andreas Kirsten
  • Torsten von Rozycki
  • Sayed H Auda
  • Christophe Espirito Santo
  • Daniel Thieme
  • Jeannette Marrero
  • Doreen Koch
  • Gerd J Krauss
  • Nadine Taudte
  • S Franke
  • Frank Thieme
  • Monique Egler
  • Doreen Munkelt
  • Daniel Bröker
  • Toni Hoffmann
  • Christopher J Haney
  • Tanja Bloss
  • L Bauer
  • Sun Mi Lee
  • Susanne Juhnke
  • Javier Seravalli
  • Martin Herzberg
  • Alexander Voigt
  • Jörg Braun
  • Ladji Tikana
  • Susanne Huggett
  • Reinhard H H Neubert
  • C Grosse
  • Georg Auling
  • Susann Friedrich
  • Orquidea Coto
  • Carolin Berger
  • Lars Gaigalat
  • Alfred Pühler
  • Susanne Schneiker
  • Olaf Kaiser
  • Stephan C Schuster
  • Burkhard Linke
  • Thomas Bekel
  • Sabine Kay
  • Jens Boch
  • Alexander Goesmann
  • Oliver Kirchner
  • Thomas Patschkowski
  • Oliver Rupp
  • Camila Caldana
  • Daniela Bartels
  • Ulla Niesbach-Klösgen
  • Dirk Wesenberg
  • Frank Jörg Vorhölter
  • Christa Lanz
  • Grit Schleuder
  • Annett Weltrowski
  • Matthias Arenskötter
  • Dieter Neumann
  • Susann Lucke
  • Bin Fan
  • Nicole Hübener
  • Nicola Peitzsch
  • A N Santos
  • B Lawley
  • A Anton

Detail Information

Publications44

  1. pmc The metal permease ZupT from Escherichia coli is a transporter with a broad substrate spectrum
    Gregor Grass
    Institut fur Mikrobiologie, Martin Luther Universitat, Halle, Germany
    J Bacteriol 187:1604-11. 2005
    ..coli cells hypersensitive to Co2+ and sensitive to Mn2+. ZupT did not appear to be metal regulated: expression of a Phi(zupT-lacZ) operon fusion indicated that zupT is expressed constitutively at a low level...
  2. pmc Role of the extracytoplasmic function protein family sigma factor RpoE in metal resistance of Escherichia coli
    Monique Egler
    Institut fur Mikrobiologie, Kurt Mothes Str 3, 06099 Halle, Germany
    J Bacteriol 187:2297-307. 2005
    ..In the case of Zn(II), the double mutant was more sensitive than either single mutant. This indicates that increased expression of OmpC contributes to the RpoE modulon-mediated response to metals...
  3. pmc Insights into genome plasticity and pathogenicity of the plant pathogenic bacterium Xanthomonas campestris pv. vesicatoria revealed by the complete genome sequence
    Frank Thieme
    Martin Luther Universitat, Institut fur Genetik, Weinbergweg 10, D 06120 Halle Saale, Germany
    J Bacteriol 187:7254-66. 2005
    ..Comparisons with other completely sequenced plant pathogens predicted six novel type III effector proteins and several other virulence factors, including adhesins, cell wall-degrading enzymes, and extracellular polysaccharides...
  4. ncbi Paralogs of genes encoding metal resistance proteins in Cupriavidus metallidurans strain CH34
    Dietrich H Nies
    Institut fur Mikrobiologie, Halle, Germany
    J Mol Microbiol Biotechnol 11:82-93. 2006
    ..metallidurans CH34 carries a variety of no longer or not yet used genes that might serve as surplus material for further developments, an advantage that may compensate for the costs of maintaining these genes during evolution...
  5. ncbi The RcnRA (YohLM) system of Escherichia coli: a connection between nickel, cobalt and iron homeostasis
    Doreen Koch
    Molecular Microbiology, Martin Luther University Halle Wittenberg, Kurt Mothes Str 3, 06099, Halle Saale, Germany
    Biometals 20:759-71. 2007
    ..Thus, rcnA is part of the Fur regulon of E. coli. The implications of a connection between the homoeostasis of closely related transition metals are discussed...
  6. doi Deletion of the zupT gene for a zinc importer influences zinc pools in Cupriavidus metallidurans CH34
    M Herzberg
    Molecular Microbiology, University of Halle, Kurt Mothes Str 3, 06099 Halle Saale, Germany, EU
    Metallomics 6:421-36. 2014
    ..Thus, two zinc pools appear to exist in C. metallidurans: one pool of at least 20 000 tightly bound Zn(ii) ions, in addition to a second pool of up to 200 000 cations bound loosely and with low substrate specificity. ..
  7. doi A fresh view of the cell biology of copper in enterobacteria
    Dietrich H Nies
    Molecular Microbiology, Institute for Biology Microbiology, Martin Luther University Halle Wittenberg, Kurt Mothes Str 3, 06120 Halle Saale, Germany
    Mol Microbiol 87:447-54. 2013
    ..The data presented in the publication by Osman et al. (2013) change our view of the cell biology of copper in enterobacteria...
  8. doi How iron is transported into magnetosomes
    Dietrich H Nies
    Inst Microbiology, University of Halle, Kurt Mothes Str 3, Halle Saale 06099, Germany
    Mol Microbiol 82:792-6. 2011
    ..Thus, these two CDF proteins not only transport iron, but they also control the magnetite biomineralization...
  9. pmc CHR, a novel family of prokaryotic proton motive force-driven transporters probably containing chromate/sulfate antiporters
    D H Nies
    Institut fur Mikrobiologie, D 06099 Halle, Germany
    J Bacteriol 180:5799-802. 1998
    ..CHR proteins occur in bacteria and archaea. They consist of about 400 amino acyl residues, appear to have 10 transmembrane alpha-helical segments in an unusual 4+6 arrangement, and arose by an intragenic duplication event...
  10. ncbi Incidence and function of sigma factors in Ralstonia metallidurans and other bacteria
    Dietrich H Nies
    Institut fur Mikrobiologie, Martin Luther Universitat Halle Wittenberg, Kurt Mothes Strasse 3, 06099 Halle, Germany
    Arch Microbiol 181:255-68. 2004
    ....
  11. ncbi Biochemistry. How cells control zinc homeostasis
    Dietrich H Nies
    Institute for Microbiology, Martin Luther University Halle Wittenberg, 06099 Halle Saale, Germany
    Science 317:1695-6. 2007
  12. ncbi Efflux-mediated heavy metal resistance in prokaryotes
    Dietrich H Nies
    Institute of Microbiology, Molecular Microbiology, Martin Luther University Halle Wittenberg, Kurt Mothes Strasse 3, 06099 Halle Saale, Germany
    FEMS Microbiol Rev 27:313-39. 2003
    ..Possession of the latter systems makes a bacterium heavy metal resistant...
  13. ncbi Microbial heavy-metal resistance
    D H Nies
    Institut fur Mikrobiologie, Martin Luther Universitat Halle Wittenberg, Germany
    Appl Microbiol Biotechnol 51:730-50. 1999
    ..After an account of the basic principles of homoeostasis for all heavy-metal ions, the transport of the 17 most important (heavy metal) elements is compared...
  14. ncbi Heavy metal-resistant bacteria as extremophiles: molecular physiology and biotechnological use of Ralstonia sp. CH34
    D H Nies
    Institut fur Mikrobiologie, Martin Luther Universitat, Halle Wittenberg, Germany
    Extremophiles 4:77-82. 2000
    ..Thus, the cell can be enabled to mediate biochemical reactions such as precipitation of heavy metals with the carbon dioxide produced during growth or degradation of xenobiotics...
  15. ncbi The product of the ybdE gene of the Escherichia coli chromosome is involved in detoxification of silver ions
    S Franke
    Institut für Mikrobiologie der Martin Luther Universität Halle Wittenberg, Kurt Mothes Str 3, 06099 Halle, Germany
    Microbiology 147:965-72. 2001
    ..Thus, in E. coli, the YlcBCD--YbdE system may be involved in silver- but not in copper resistance, and CopA may be involved in copper- but not in silver resistance...
  16. pmc The chromosomally encoded cation diffusion facilitator proteins DmeF and FieF from Wautersia metallidurans CH34 are transporters of broad metal specificity
    Doreen Munkelt
    Institut fur Mikrobiologie, Martin Luther Universität Halle, Kurt Mothes Str 3, 06120 Halle, Germany
    J Bacteriol 186:8036-43. 2004
    ..This is evidence for the periplasmic detoxification of substrates by RND transporters of the heavy metal efflux family subgroup...
  17. pmc Transcriptional organization of the czc heavy-metal homeostasis determinant from Alcaligenes eutrophus
    C Grosse
    Institut für Mikrobiologie der Martin Luther Universität Halle Wittenberg, D 06099 Halle, Germany
    J Bacteriol 181:2385-93. 1999
    ....
  18. pmc Interplay of the Czc system and two P-type ATPases in conferring metal resistance to Ralstonia metallidurans
    Antje Legatzki
    Institut fur Mikrobiologie, 06099 Halle, Germany
    J Bacteriol 185:4354-61. 2003
    ..This indicated that CzcCBA efficiently decreased cytoplasmic cadmium and zinc concentrations. It is discussed whether these data favor a model in which the cations are removed either from the cytoplasm or the periplasm by CzcCBA...
  19. ncbi Identification of a regulatory pathway that controls the heavy-metal resistance system Czc via promoter czcNp in Ralstonia metallidurans
    Cornelia Grosse
    Institut fur Mikrobiologie, Martin Luther Universitat Halle Wittenberg, Kurt Mothes Str 3, 06099 Halle, Germany
    Arch Microbiol 182:109-18. 2004
    ..These data demonstrate that the transport protein CzcD, the two-component regulatory system CzcR, CzcS, and the periplasmic metal-binding protein CzcE exert metal-dependent control of czcNICBA expression via regulation of czcNp activity...
  20. pmc Glutathione and transition-metal homeostasis in Escherichia coli
    Kerstin Helbig
    Institute for Biology, Life Science Faculty, Martin Luther University Halle Wittenberg, Kurt Mothes Str 3, 06099 Halle, Germany
    J Bacteriol 190:5431-8. 2008
    ..Thus, GSH may play an important role in trace-element metabolism not only in higher organisms but also in bacteria...
  21. pmc Characteristics of zinc transport by two bacterial cation diffusion facilitators from Ralstonia metallidurans CH34 and Escherichia coli
    Andreas Anton
    Institut fur Mikrobiologie, Martin Luther Universitat Halle Wittenberg, Halle, Germany
    J Bacteriol 186:7499-507. 2004
    ..Probably, these amino acyl residues constituted a pathway required for export of the heavy metal cations or for import of counter-flowing protons...
  22. ncbi First step towards a quantitative model describing Czc-mediated heavy metal resistance in Ralstonia metallidurans
    Antje Legatzki
    Institut fur Mikrobiologie, Kurt Mothes Str 3, 06099 Halle, Germany
    Biodegradation 14:153-68. 2003
    ..Thus, it was possible to simulate physiological events in growing cells by quantitative models that are derived from the biochemical data of the interacting transport proteins...
  23. pmc Molecular analysis of the copper-transporting efflux system CusCFBA of Escherichia coli
    Sylvia Franke
    Molekulare Mikrobiologie, Institut fur Mikrobiologie, Martin Luther Universitat Halle Wittenberg, 06099 Halle, Germany
    J Bacteriol 185:3804-12. 2003
    ..These data provide additional evidence for the hypothesis that Cu(I) is directly transported from the periplasm across the outer membrane by the Cus complex...
  24. pmc TolC is involved in enterobactin efflux across the outer membrane of Escherichia coli
    Corinna Bleuel
    Institut fur Mikrobiologie, Martin Luther Universität Halle, Halle, Germany, Kurt Mothes Str 3, 06120 Halle, Germany
    J Bacteriol 187:6701-7. 2005
    ..However, iron starvation led to increased expression of the RND gene mdtF and a decrease in acrD...
  25. ncbi Control of expression of a periplasmic nickel efflux pump by periplasmic nickel concentrations
    Gregor Grass
    Institut fur Mikrobiologie, Martin Luther Universitat Halle Wittenberg, Kurt Mothes Str 3, 06099, Halle, Germany, European Community
    Biometals 18:437-48. 2005
    ..Experimental data provided here indicate a signal transduction chain leading from nickel in the periplasm to transcription initiation at the cnr promoters cnrYp and cnrCp, which control synthesis of the nickel efflux pump CnrCBA...
  26. ncbi FieF (YiiP) from Escherichia coli mediates decreased cellular accumulation of iron and relieves iron stress
    Gregor Grass
    Institut fur Mikrobiologie, Martin Luther Universität Halle, Kurt Mothes Str 3, Halle 06120, Germany
    Arch Microbiol 183:9-18. 2005
    ..This suggests that FieF is an iron and zinc efflux system, which would be the first example of iron detoxification by efflux in any organism...
  27. ncbi Characterization of the ZAT1p zinc transporter from Arabidopsis thaliana in microbial model organisms and reconstituted proteoliposomes
    Tanja Bloss
    Institut fur Mikrobiologie, Kurt Mothes Strasse 3, 06099 Halle, Germany
    Planta 214:783-91. 2002
    ....
  28. ncbi New genes involved in chromate resistance in Ralstonia metallidurans strain CH34
    Susanne Juhnke
    Institut fur Mikrobiologie, Martin Luther Universitat Halle Wittenberg, Kurt Mothes Strasse 3, 06099 Halle, Germany, European Community
    Arch Microbiol 179:15-25. 2002
    ..Thus, possible regulators for chromate resistance (ChrI, ChrB(1), ChrB(2), ChrF(1), and ChrF(2)) and an additional detoxification system (ChrC) were newly identified as parts of chromate resistance in R. metallidurans...
  29. ncbi Contribution of extracytoplasmic function sigma factors to transition metal homeostasis in Cupriavidus metallidurans strain CH34
    Cornelia Grosse
    Institut fur Mikrobiologie, Martin Luther Universitat Halle Wittenberg, Halle, Deutschland
    J Mol Microbiol Biotechnol 12:227-40. 2007
    ..metallidurans, and, in addition to the known role of CnrH in nickel resistance, RpoE, RpoI, RpoJ, RpoK and maybe also RpoQ are required for the outstanding transition metal resistance of this bacterium...
  30. doi Preparation, physicochemical characterization and biological evaluation of cefodizime metal ion complexes
    Sayed H Auda
    Institutes of Pharmacy, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Pharm Pharmacol 61:753-8. 2009
    ..In this study, attention has been paid to the preparation, physicochemical characterization and biological evaluation of new Cu2+, Zn2+, Fe3+, Co2+ and Al3+ complexes of cefodizime...
  31. pmc Cadmium toxicity in glutathione mutants of Escherichia coli
    Kerstin Helbig
    Institute for Biology, Life Science Faculty, Martin Luther University Halle Wittenberg, Kurt Mothes Str 3, 06099 Halle, Germany
    J Bacteriol 190:5439-54. 2008
    ..General energy conservation pathways and iron uptake were down-regulated. These findings indicated that the toxic action of Cd(2+) indeed results from the binding of the metal cation to sulfur, lending support to the hypothesis tested...
  32. doi Cupriavidus metallidurans: evolution of a metal-resistant bacterium
    Torsten von Rozycki
    Institute for Biology Microbiology, Molecular Microbiology, Martin Luther University Halle Wittenberg, Kurt Mothes Str 3, 06099, Halle, Germany
    Antonie Van Leeuwenhoek 96:115-39. 2009
    ..C. metallidurans apparently evolved metal resistance by horizontal acquisition and by duplication of genes for transition metal efflux, mostly on the two plasmids, and decreased the number of uptake systems for those metals...
  33. doi CzcP is a novel efflux system contributing to transition metal resistance in Cupriavidus metallidurans CH34
    Judith Scherer
    Molecular Microbiology, Institute for Biology Microbiology, Martin Luther University, Halle Wittenberg, Germany
    Mol Microbiol 73:601-21. 2009
    ..However, a basic resistance level has to be provided by the P(IB2)-type efflux pumps because CzcP may not be able to reach all different speciations of these metals in the cytoplasm...
  34. ncbi High-level resistance to cobalt and nickel but probably no transenvelope efflux: Metal resistance in the Cuban Serratia marcescens strain C-1
    Jeannette Marrero
    Institut fur Mikrobiologie, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Microb Ecol 53:123-33. 2007
    ....
  35. pmc Contributions of five secondary metal uptake systems to metal homeostasis of Cupriavidus metallidurans CH34
    Andreas Kirsten
    Molecular Microbiology, Institute for Biology Microbiology, Martin Luther University, Halle Wittenberg, Germany
    J Bacteriol 193:4652-63. 2011
    ..Thus, metal homeostasis in C. metallidurans is achieved by highly redundant metal uptake systems, which have only minimal cation selectivity and are in combination with efflux systems that "worry later" about surplus cations...
  36. pmc Camelysin is a novel surface metalloproteinase from Bacillus cereus
    Gregor Grass
    Institute for Microbiology, Faculty of Life Sciences, Martin Luther University, D 06097 Halle, Germany
    Infect Immun 72:219-28. 2004
    ..Disruption of the calY gene results in a strong decrease in the cell-bound proteolytic activity on various substrates...
  37. pmc Sandwich hybridization assay for sensitive detection of dynamic changes in mRNA transcript levels in crude Escherichia coli cell extracts in response to copper ions
    Daniel Thieme
    Institut für Biologie Mikrobiologie, Martin Luther Universitat, Halle Wittenberg, Germany
    Appl Environ Microbiol 74:7463-70. 2008
    ..These characteristics make it a powerful complementary application to genetic reporter fusions and to reverse transcription-PCR...
  38. doi The ABC-transporter AtmA is involved in nickel and cobalt resistance of Cupriavidus metallidurans strain CH34
    André Mikolay
    Life Science Faculty, Institute for Biology, Martin Luther University Halle Wittenberg, Kurt Mothes Str 3, 06099, Halle, Germany
    Antonie Van Leeuwenhoek 96:183-91. 2009
    ..metallidurans, atmA expression was not significantly induced by nickel and cobalt, but repressed by zinc. AtmA was purified as a 70 kDa protein after expression in E. coli. ATPase activity of AtmA was stimulated by nickel and cobalt...
  39. doi Survival of bacteria on metallic copper surfaces in a hospital trial
    André Mikolay
    Institut fur Mikrobiologie, Martin Luther Universitat Halle Wittenberg, Kurt Mothes Str 3, 06099 Halle, Germany
    Appl Microbiol Biotechnol 87:1875-9. 2010
    ..It demonstrates that the use of copper-containing alloys may limit the spread of multiple drug-resistant bacteria in hospitals...
  40. ncbi Oligomeric behavior of the RND transporters CusA and AcrB in micellar solution of detergent
    David Stroebel
    Laboratoire des Proteines Membranaires, Institut de Biologie Structurale, Jean Pierre EBEL, UMR 5075 CNRS CEA UJF, 41, rue Jules Horowitz, 38027 Grenoble Cedex, France
    Biochim Biophys Acta 1768:1567-73. 2007
    ..This pseudo-heterogeneity does not hamper the crystallization of AcrB as a homotrimer...
  41. pmc Characterization of the 101-kilobase-pair megaplasmid pKB1, isolated from the rubber-degrading bacterium Gordonia westfalica Kb1
    Daniel Bröker
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    J Bacteriol 186:212-25. 2004
    ..Furthermore, they had lost the ability to use isoprene rubber as a sole source of carbon and energy, suggesting that genes essential for rubber degradation are encoded by pKB1...
  42. ncbi Functional analysis of the Escherichia coli zinc transporter ZitB
    Sun Mi Lee
    Department of Soil, Water, and Environmental Science, University of Arizona, Shantz Bld 38 Rm 424, Tucson 85721, USA
    FEMS Microbiol Lett 215:273-8. 2002
    ..In contrast, neither the amino-terminal nor the carboxy-terminal regions, both histidine-rich, were required for function...
  43. ncbi A transporter in the endoplasmic reticulum of Schizosaccharomyces pombe cells mediates zinc storage and differentially affects transition metal tolerance
    Stephan Clemens
    Leibniz Institut für Pflanzenbiochemie, Weinberg 3, 06120 Halle Saale, Germany
    J Biol Chem 277:18215-21. 2002
    ..Also, these observations indicate that Cd(2+) ions exert their toxic effects on cellular metabolism in the ER rather than in the cytosol...
  44. pmc Contribution of copper ion resistance to survival of Escherichia coli on metallic copper surfaces
    Christophe Espirito Santo
    Departamento de Bioquimica, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Portugal
    Appl Environ Microbiol 74:977-86. 2008
    ..Preadaptation to copper enhanced survival rates upon copper surface exposure. This study constitutes a first step toward understanding the reasons for metallic copper surface-mediated killing of bacteria...