U Muller-Werdan

Summary

Affiliation: Martin Luther University
Country: Germany

Publications

  1. ncbi [Septic shock and systemic inflammatory response syndrome--case report]
    U Muller-Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Halle Wittenberg
    Dtsch Med Wochenschr 128:2367. 2003
  2. ncbi [Septic shock and systemic inflammatory response syndrome--diagnosis]
    U Muller-Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Halle Wittenberg
    Dtsch Med Wochenschr 128:2368-71. 2003
  3. ncbi [End-organ damage in inflammation and sepsis]
    U Muller-Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Universität Halle Wittenberg
    Internist (Berl) 44:864-71. 2003
  4. ncbi [Specific aspects in septic patients: initial phase in the emergency department, age, sex and post-ICU-care]
    U Muller-Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Universitätsklinikum Halle Saale der Martin Luther Universität Halle Wittenberg, Ernst Grube Strasse 40, 06120, Halle Saale, Deutschland
    Internist (Berl) 50:828, 830-2, 834-6, passim. 2009
  5. ncbi Inflammation and ageing
    U Muller-Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Klinikum der Martin Luther Universität Halle Wittenberg, Ernst Grube Strasse 40, 06097, Halle, Germany
    Z Gerontol Geriatr 40:362-5. 2007
  6. ncbi [Elderly patients with cardiovascular diseases]
    U Muller-Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Universitätsklinikum der Martin Luther Universität Halle Wittenberg, Ernst Grube Strasse 40, 06097, Halle Saale, Deutschland
    Internist (Berl) 48:1211-9. 2007
  7. ncbi [Septic shock and systemic inflammatory response syndrome--treatment]
    U Muller-Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Halle Wittenberg
    Dtsch Med Wochenschr 128:2372-6. 2003
  8. ncbi [Medical geriatric aspects in intensive care therapy of elderly patients]
    U Muller-Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Universitätsklinikum Halle Saale der Martin Luther Universität Halle Wittenberg, Halle Saale, Deutschland
    Med Klin Intensivmed Notfmed 106:10-5. 2011
  9. ncbi [Anaphylactic shock]
    U Muller-Werdan
    Klinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg, Bundesrepublik Deutschland
    Wien Klin Wochenschr 112:149-56. 2000
  10. ncbi Immune modulation by catecholamines--a potential mechanism of cytokine release in heart failure?
    U Muller-Werdan
    Department of Medicine III, Martin Luther University Halle Wittenberg, Germany
    Herz 25:271-3. 2000

Detail Information

Publications59

  1. ncbi [Septic shock and systemic inflammatory response syndrome--case report]
    U Muller-Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Halle Wittenberg
    Dtsch Med Wochenschr 128:2367. 2003
  2. ncbi [Septic shock and systemic inflammatory response syndrome--diagnosis]
    U Muller-Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Halle Wittenberg
    Dtsch Med Wochenschr 128:2368-71. 2003
  3. ncbi [End-organ damage in inflammation and sepsis]
    U Muller-Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Universität Halle Wittenberg
    Internist (Berl) 44:864-71. 2003
    ..In contrast therapy of organ damage in severe septic and non-septic inflammatory processes presently is mainly still based on supportive therapeutic measures...
  4. ncbi [Specific aspects in septic patients: initial phase in the emergency department, age, sex and post-ICU-care]
    U Muller-Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Universitätsklinikum Halle Saale der Martin Luther Universität Halle Wittenberg, Ernst Grube Strasse 40, 06120, Halle Saale, Deutschland
    Internist (Berl) 50:828, 830-2, 834-6, passim. 2009
    ..Taking care for the patient in a post-ICU outpatient department during this time will help to recognize these problems and to effectively treat the patient as soon as possible...
  5. ncbi Inflammation and ageing
    U Muller-Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Klinikum der Martin Luther Universität Halle Wittenberg, Ernst Grube Strasse 40, 06097, Halle, Germany
    Z Gerontol Geriatr 40:362-5. 2007
    ..This hypothesis is grounded on the fact that a characteristic feature of the ageing heart - a narrowed heart rate variability - can be experimentally induced in humans by an inflammatory stimulus (endotoxin)...
  6. ncbi [Elderly patients with cardiovascular diseases]
    U Muller-Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Universitätsklinikum der Martin Luther Universität Halle Wittenberg, Ernst Grube Strasse 40, 06097, Halle Saale, Deutschland
    Internist (Berl) 48:1211-9. 2007
    ..Influenza and pneumococcus vaccinations are effective in preventing cardiovascular events...
  7. ncbi [Septic shock and systemic inflammatory response syndrome--treatment]
    U Muller-Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Halle Wittenberg
    Dtsch Med Wochenschr 128:2372-6. 2003
  8. ncbi [Medical geriatric aspects in intensive care therapy of elderly patients]
    U Muller-Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Universitätsklinikum Halle Saale der Martin Luther Universität Halle Wittenberg, Halle Saale, Deutschland
    Med Klin Intensivmed Notfmed 106:10-5. 2011
    ..A closer interdisciplinary cooperation of the two disciplines could be of substantial beneficial value in the care of the sick and elderly to overcome the many open questions and pressing problems...
  9. ncbi [Anaphylactic shock]
    U Muller-Werdan
    Klinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg, Bundesrepublik Deutschland
    Wien Klin Wochenschr 112:149-56. 2000
    ....
  10. ncbi Immune modulation by catecholamines--a potential mechanism of cytokine release in heart failure?
    U Muller-Werdan
    Department of Medicine III, Martin Luther University Halle Wittenberg, Germany
    Herz 25:271-3. 2000
    ..We present arguments in favor of a direct link between the chronically enhanced sympathetic tone in heart failure and the clinically overt activation of the immune system, particularly interleukin 6 release...
  11. ncbi [Catecholamine therapy in cardiogenic shock: helpful, useless or dangerous?]
    H Schwertz
    Medizinische Universitätsklinik und Poliklinik III, Klinikum der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, Halle Saale
    Dtsch Med Wochenschr 129:1925-30. 2004
    ..However, sympathomimetics are still first line therapeutics for treatment of cardiogenic shock -- with respect to dosage and duration of treatment...
  12. ncbi Heterogeneity of cardiac rat and human elongation factor 2
    D Jager
    Department of Medicine III, Martin Luther University, Halle Wittenberg, Germany
    Electrophoresis 21:2729-36. 2000
    ....
  13. ncbi [Therapy of organ failure in primary extracardiac diseases]
    S Reith
    Universitätsklinik und Poliklinik für Innere Medizin III, Klinikum Kröllwitz der Martin Luther Universität Halle Wittenberg
    Internist (Berl) 46:256-64. 2005
    ..The supportive treatment of the individual organ dysfunction is - at present - unequally efficient...
  14. ncbi [Reversible autonomic dysfunction in a young woman with septic multiple organ dysfunction syndrome]
    H Schmidt
    Universitätsklinik und Poliklinik für Innere Medizin III
    Dtsch Med Wochenschr 130:648-51. 2005
    ..A 24-year-old woman was admitted for treatment of a meningococcal infection accompanied by fulminant autonomic dysfunction...
  15. ncbi [Cardiogenic shock: pathophysiology, clinics, therapeutical options and perspectives]
    R Prondzinsky
    Universitätsklinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg, Halle Saale
    Internist (Berl) 45:284-95. 2004
    ..Facilitated PCI includes administration of glycoproteine receptor antagonists, mechanical circulation support strategies, such as, intraaortic balloon counterpulsation and potentially prehospital thrombolysis...
  16. ncbi [New pharmacological treatment approaches to cardiogenic shock]
    M Buerke
    Universitätsklinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg, Ernst Grube Strasse 40, Halle, Germany
    Internist (Berl) 48:1442-9. 2007
    ..Future therapies will likely address the anti-inflammatory aspect of cardiogenic shock...
  17. ncbi Isolated diastolic dysfunction--diagnostic value of tissue Doppler imaging, colour M-mode and N-terminal pro B-type natriuretic peptide
    S Hettwer
    Martin Luther University, Halle Wittenberg, Department of Medicine III, Ernst Grube Str 40, 06097, Halle Saale, Germany
    Clin Res Cardiol 96:874-82. 2007
    ....
  18. ncbi Thromboembolic cerebral ischaemic attack complicating cardiac catheterization. Successful local thrombolytic therapy with reduced dose rt-PA
    M Krivokuca
    Department of Medicine III, University Hospital, Martin Luther University Halle Wittenberg, 06097 Halle, Germany
    Z Kardiol 94:474-8. 2005
    ..The subsequent angiogram showed restored perfusion in the affected vessel after completion of thrombolytic therapy and resolution of neurological symptoms...
  19. ncbi [Internists' emergency medicine]
    K Werdan
    Innere Medizin III, ,
    Internist (Berl) 46:955-6. 2005
  20. ncbi [Emergency therapy for acute heart failure]
    H Ebelt
    Universitätsklinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg, Ernst Grube Strasse 40, 06097, Halle, Deutschland
    Internist (Berl) 48:938-47. 2007
    ..Bradycardia in AHF patients should initially be treated with atropine; a temporal pacemaker has to be inserted if no response is achieved by medical therapy. Ventricular fibrillation and tachycardia require immediate cardioversion...
  21. ncbi Immunoglobulin G treatment of postcardiac surgery patients with score-identified severe systemic inflammatory response syndrome--the ESSICS study
    Karl Werdan
    Department of Medicine III, Martin Luther University Halle Wittenberg, Germany
    Crit Care Med 36:716-23. 2008
    ..We assessed whether intravenous immunoglobulin G (ivIgG) improves postoperative short-term (5-day) morbidity and reduces 28-day mortality in these patients...
  22. ncbi Pathophysiology of septic shock and multiple organ dysfunction syndrome and various therapeutic approaches with special emphasis on immunoglobulins
    K Werdan
    Department of Medicine III, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Ther Apher 5:115-22. 2001
    ..Thus, IVIg is not a magic bullet of sepsis treatment, but it may reduce morbidity and thereby may be useful in the therapeutic mosaic of sepsis treatment...
  23. ncbi Supplemental immune globulins in sepsis
    K Werdan
    Department of Medicine, Martin Luther Universitat Halle Wittenberg, Halle, Germany
    Clin Chem Lab Med 37:341-9. 1999
    ..Thus, intravenous immune globulin is not a "magic bullet"of sepsis treatment, but it may reduce morbidity and thereby represent a useful piece of stone in the therapeutic mosaic of sepsis treatment...
  24. ncbi Pathophysiology, diagnosis, and treatment of infarction-related cardiogenic shock
    M Buerke
    University Clinic of Internal Medicine III, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, 06120, Halle Saale, Germany
    Herz 36:73-83. 2011
    ..In this overview, epidemiology, pathophysiology, and guideline-oriented treatment strategies for cardiogenic shock are presented...
  25. ncbi Levosimendan in the treatment of cardiogenic shock
    Buerkem Buerkem
    Department of Medicine III, Martin Luther University, Halle, Germany
    Minerva Cardioangiol 58:519-30. 2010
    ..This review summarizes the evidence from current scientific literature including our recent trials regarding the mechanism of action, efficiency and the use of levosimendan in CS patients...
  26. ncbi [Therapeutic strategies in acute decompensated heart failure and cardiogenic shock]
    M Buerke
    Universitätsklinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg, Ernst Grube Strasse 40, 06097, Halle Saale, Germany
    Internist (Berl) 51:963-74. 2010
    ..Therefore, based on pathophysiology, different types of acute decompensated heart failure require specialized treatment strategies...
  27. ncbi Intravenous immunoglobulin for prophylaxis and therapy of sepsis
    K Werdan
    Department of Medicine III, Martin Luther Universitat Halle Wittenberg, Germany
    Curr Opin Crit Care 7:354-61. 2001
    ..IgM-specific complement inactivation may further stimulate the discussion of IVIgGMA superiority over IVIgG...
  28. ncbi [Can decubitus ulcer always be prevented?]
    K Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Klinikum Kröllwitz der Martin Luther Universität Halle Wittenberg, Ernst Grube Strasse 40, 06097 Halle, Saale
    Internist (Berl) 43:414-5. 2002
  29. ncbi [Sepsis and heart]
    H Ebelt
    Klinik und Poliklinik für Innere Medizin III, Universitätsklinikum Halle Saale, Ernst Grube Strasse 40, Halle, Germany
    Internist (Berl) 51:844-9. 2010
    ..were rather disappointing so far. Positive effects might be assumed for the administration of activated protein C thereby underlining the role of microcirculatory alterations in the development of septic cardiomyopathy...
  30. ncbi [Intensive care medicine 2007]
    K Werdan
    , , Halle (Saale, Germany
    Dtsch Med Wochenschr 132:1383-7. 2007
  31. ncbi The direct thrombin inhibitor argatroban effectively prevents cardiac catheter thrombosis in vitro
    Uwe Raaz
    Department of Medicine III, Martin Luther University, Ernst Grube Str 40, 06097 Halle, Germany
    Thromb Haemost 103:808-14. 2010
    ..However, the anticoagulatory efficacy varied, depending on the model of coagulation activation, which demonstrates the necessity for specific testing...
  32. ncbi Are the elderly different? Factors influencing mortality after percutaneous coronary intervention with stent implantation
    J Schroder
    Universitätsklinik und Poliklinik für Innere Medizin III, Universitätsklinikum Halle Saale, Ernst Grube Str 40, 06120, Halle, Germany
    Z Gerontol Geriatr 46:144-50. 2013
    ..The aim of this study was to investigate factors influencing mortality after percutaneous coronary intervention (PCI) in patients aged ≥ 75 years compared to younger patients...
  33. ncbi [Septic circulatory shock and septic cardiomyopathy]
    K Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Universitätsklinikum Halle Saale der Martin Luther Universität Halle Wittenberg, Ernst Grube Strasse 40, 06120, Halle Saale, Deutschland
    Internist (Berl) 50:799-800, 802-6, 808-9. 2009
    ..Treatment of septic circulatory shock and of septic cardiomyopathy is predominantly symptomatic; first causal approaches are under investigation...
  34. ncbi [Autonomic dysfunction and beta-adrenergic blockers in multiple organ dysfunction syndrome]
    R Hennen
    Universitätsklinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg
    Dtsch Med Wochenschr 133:2500-4. 2008
    ..The mortality is high (40 - 60 %). The present study aimed to detect whether beta-adrenergic blockers (BAB) which may affect sympathetic-parasympathetic balance have a positive influence on outcome...
  35. ncbi Impaired energy metabolism in hearts of septic baboons: diminished activities of Complex I and Complex II of the mitochondrial respiratory chain
    F N Gellerich
    Muskellabor der Neurologischen Klinik, Kardiologische Intensivmedizin der Martin Luther Universität Halle Wittenberg, Halle Saale, Germany
    Shock 11:336-41. 1999
    ..It is concluded that E. coli-induced sepsis causes decreased activities of Complex I and Complex II in baboon heart mitochondria in a dose-dependent manner...
  36. ncbi Separation and identification of human heart proteins
    D Jager
    Department of Medicine III, Martin Luther University, Halle Wittenberg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 771:131-53. 2002
    ..In concert with genomic data functional proteomics will hold the key for a better understanding and therapeutical management of cardiovascular diseases in the future...
  37. ncbi Cardiodepression by tumor necrosis factor-alpha
    U Muller-Werdan
    Department of Medicine III, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle, Germany Tel 49 345 557 4545, Fax 49 345 557 4546, E mail
    Eur Cytokine Netw 9:689-91. 1998
    ..Whether secondary cytokines induced by TNF-alpha in cardiomyocytes contribute to cardiodepression or whether apoptotic signals activated by TNF-alpha are involved in the cardiodepressive pathways is presently unknown...
  38. ncbi Interleukin-1 and related proteins in cardiovascular disease in adults and children
    H Loppnow
    , , Saale, Germany
    Shock 16:3-9. 2001
    ..The summarized information indicates a role of these molecules in regulation of local inflammatory responses during cardiovascular disease...
  39. ncbi Sodium/hydrogen exchange inhibition with cariporide reduces leukocyte adhesion via P-selectin suppression during inflammation
    U Buerke
    Department of Internal Medicine III, Martin Luther University, Halle Saale, Germany
    Br J Pharmacol 153:1678-85. 2008
    ..We studied the effect of cariporide on thrombin and I/R induced leukocyte activation and infiltration models and examined P-selectin expression as a potential mechanism for any identified effects...
  40. ncbi Anti-inflammatory actions of aprotinin provide dose-dependent cardioprotection from reperfusion injury
    Jm Carter
    Department of Medicine III, Martin Luther University, Halle, Germany
    Br J Pharmacol 155:93-102. 2008
    ..Myocardial injury following ischaemia and reperfusion has been attributed to activation and transmigration of polymorphonuclear leukocytes (PMNs) with release of mediators including oxygen-derived radicals and proteases causing damage...
  41. ncbi Assessment of chemoreflex sensitivity in free breathing young subjects by correction for respiratory influence
    H B Schmidt
    Department of Internal Medicine III, Martin Luther University Halle Wittenberg, 06097, Halle Saale, Germany
    Int J Cardiol 78:157-65. 2001
    ..Since this is poorly tolerated by patients, they are commonly studied under hyperoxic conditions, which are not physiological...
  42. ncbi Autonomic dysfunction in the ICU patient
    H B Schmidt
    Department of Medicine 111, Martin-Luther-University Halle-Wittenberg, , Germany
    Curr Opin Crit Care 7:314-22. 2001
    ..New pathophysiologic concepts are needed for the development of treatment strategies for this life-threatening disease...
  43. ncbi [Diagnosis and therapy of sepsis: guidelines of the German Sepsis Society Inc. and the German Interdisciplinary Society for Intensive and Emergency Medicine]
    K Reinhart
    Deutsche Sepsis-Gesellschaft e V c/o Universitatsklinikum Jena, Erlanger Allee 101, 07747 Jena
    Anaesthesist 55:43-56. 2006
    ..The guidelines development process was carefully planned and strictly adhered to the requirements of the Working Group of Scientific Medical Societies (AWMF)...
  44. ncbi Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial
    Kim Fox
    Royal Brompton Hospital, London, UK
    Lancet 372:807-16. 2008
    ..We aimed to test whether lowering the heart rate with ivabradine reduces cardiovascular death and morbidity in patients with coronary artery disease and left-ventricular systolic dysfunction...
  45. ncbi The BEAUTIFUL study: randomized trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction - baseline characteristics of the study population
    R Ferrari
    Royal Brompton Hospital, London, UK
    Cardiology 110:271-82. 2008
    ..This report describes the study population at baseline...
  46. ncbi [Autonomic dysfunction in heart patients]
    H Schmidt
    , , , Ernst-Grube-Strasse 40, 06097 Halle
    Internist (Berl) 43:S76-83. 2002
  47. ncbi [Intensive care medicine 2008]
    M Winkler
    , ,
    Dtsch Med Wochenschr 133:1356-61. 2008
  48. ncbi [A statement about guidelines on pacemaker therapy]
    B Lemke
    , BG-Kliniken Bergmannsheil, , Germany
    Z Kardiol 92:200-6. 2003
  49. ncbi [Diagnosis and therapy of sepsis]
    K Reinhart
    , , Jena
    Clin Res Cardiol 95:429-54. 2006
    ..The guidelines development process was carefully planned and strictly adhered to according to the requirements of the Working Group of Scientific Medical Societies (AWMF)...
  50. ncbi [Position paper on "Automatic external defibrillation"]
    H-J Trappe
    Medizinische Klinik II (Schwerpunkte Kardiologie und Angiologie, , , 44625 Herne, Germany
    Herzschrittmacherther Elektrophysiol 16:118-26. 2005
  51. ncbi [Intensive care medicine: after positive studies questions occur]
    F M Brunkhorst
    ,
    Dtsch Med Wochenschr 131:1441-4. 2006
  52. ncbi [Progress in therapy of infection]
    U Muller-Werdan
    Universitätsklinik und Poliklinik für Innere Medizin III, Klinikum Kröllwitz der Martin Luther Universität Halle Wittenberg
    Internist (Berl) 44:1531-40. 2003
  53. ncbi [S2 guideline for infectious endocarditis]
    C K Naber
    ,
    MMW Fortschr Med 146:123-35. 2004
    ..The basis for this guideline was the systematic search through the literature of the European guideline. On the 16th and 28th of June 2004, the entire guideline was formerly approved in a nominal group process...
  54. ncbi [Autonomic dysfunction in cardiopulmonary diseases]
    B E Strauer
    Internist (Berl) 43:1039-40. 2002
  55. ncbi [Policy paper to the cardiac re-sychronization therapy]
    C Stellbrink
    Medizinische Klinik I der RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Z Kardiol 92:96-103. 2003
  56. ncbi [Diagnosis and therapy of sepsis. Guidelines of the German Sepsis Society Inc. and the German Interdisciplinary Society for Intensive and Emergency Medicine]
    K Reinhart
    ,
    Internist (Berl) 47:356, 358-60, 362-8, passim. 2006
    ..The guidelines development process was carefully planned and strictly adhered to the requirements of the Working Group of Scientific Medical Societies (AWMF)...
  57. ncbi [Position paper on "automated external defibrillation" ]
    H-J Trappe
    Medizinische Klinik II (Schwerpunkte Kardiologie und Angiologie, , , 44625 Herne, Germany
    Z Kardiol 94:287-95. 2005
  58. ncbi [Again: it is important to us. The German Society for Internal Medicine and the Amendment to the (Model-) Continuing Education Rule]
    U R Folsch
    Dtsch Med Wochenschr 128:2271-2. 2003
  59. ncbi [Cardiovascular disease in the elderly]
    K Werdan
    Dtsch Med Wochenschr 130:629-30. 2005