Affiliation: Martin Luther University
- Sudden cardiac death in hereditary hemochromatosis: an underestimated cause of death?M Klintschar
Institute for Legal Medicine, University Halle Wittenberg, Franzosenweg 1, 06112 Halle, Germany
Int J Legal Med 118:174-7. 2004..This case demonstrates that genetic screening alone might not be sufficient to identify all persons at risk to developing HH...
- TH01, a tetrameric short tandem repeat locus in the tyrosine hydroxylase gene: association with myocardial hypertrophy and death from myocardial infarction?Michael Klintschar
Institut fur Rechtsmedizin, Martin Luther Universitat Halle Wittenberg, Franzosenweg 1, 06097 Halle Saale, Germany
Dis Markers 21:9-13. 2005..This could be explained by a relatively small impact of the TH01 genotype on the blood pressure or by counteraction of another mechanism related to catecholamines and their effect on the human body...
- DNA polymorphisms in the tyrosine hydroxylase and GNB3 genes: association with unexpected death from acute myocardial infarction and increased heart weightM Klintschar
Institute of Legal Medicine, Martin Luther University Halle Wittenberg, Franzosenweg 1, D06112 Halle, Germany
Forensic Sci Int 153:142-6. 2005....
- Persisting fetal microchimerism does not interfere with forensic Y-chromosome typingM Klintschar
Institute of Legal Medicine, University Halle Wittenberg, Franzosenweg 1, Halle D 06112, Germany
Forensic Sci Int 139:151-4. 2004....
- Fetal microchimerism in Hashimoto's thyroiditis: a quantitative approachMichael Klintschar
Institute of Legal Medicine, University Halle Wittenberg, Halle Saale, Germany
Eur J Endocrinol 154:237-41. 2006..The goal of the study was to reliably estimate the number of fetal engrafted cells and to further investigate factors influencing the development of MCH...
- Fatal truck-bicycle accident involving dragging for 45 kmM Klintschar
Institut fur Rechtsmedizin, Martin Luther Universitat Halle Wittenberg, Franzosenweg 1, 06112, Halle Saale, Germany
Int J Legal Med 117:226-8. 2003..The reports of the technical expert and the forensic pathologist led the prosecutor to drop the case against the truck driver for manslaughter...
- Evidence of fetal microchimerism in Hashimoto's thyroiditisM Klintschar
Institute of Legal Medicine, Martin Luther University Halle Wittenberg, D06112 Halle Saale Germany
J Clin Endocrinol Metab 86:2494-8. 2001....
- Significant differences between Yemenite and Egyptian STR profiles and the influence on frequency estimations in ArabsM Klintschar
Department of Legal Medicine, University of Halle, Franzosenweg 1, D 06112 Halle Saale, Germany
Int J Legal Med 114:211-4. 2001....
- Haplotype studies support slippage as the mechanism of germline mutations in short tandem repeatsMichael Klintschar
Institute of Legal Medicine, University Halle, Germany
Electrophoresis 25:3344-8. 2004..By doing so we were able to exclude UCO in each case. Moreover, we were able to identify the mutations as one-repeat contractions/expansions. Our data thus support slippage as the mechanism of germline mutations in STRs...
- Population genetic data, comparison of the repeat structure and mutation events of two short STRsPeter Wiegand
Institute of Pathology and Legal Medicine, Department of Legal Medicine, University Hospital, Prittwitzstrasse 6, 89075 Ulm, Germany
Int J Legal Med 116:258-61. 2002..Two isolated cases of a new mutation could be confirmed for D7S1517. The alleles of these two family constellations were characterised by sequencing and the probable mutational events were demonstrated...
- "Paterniplex", a highly discriminative decaplex STR multiplex tailored for investigating special problems in paternity testingThomas Betz
Institute for Legal Medicine, Martin Luther University Halle Wittenberg, Halle, Germany
Electrophoresis 28:3868-74. 2007....
- Y-chromosomal STR haplotype analysis reveals surname-associated strata in the East-German populationUta Dorothee Immel
Department of Legal Medicine, Martin Luther University, Halle Saale, Germany
Eur J Hum Genet 14:577-82. 2006..Our results suggest that surnames may provide a simple means to stratify, and thereby to render more efficient, Y-chromosomal analyses of Central Europeans that target more ancient events...
- Y chromosome polymorphisms and haplotypes in South Saxony-Anhalt (Germany)Uta Dorothee Immel
Department of Legal Medicine, Martin Luther University Halle, Franzosenweg 1, 06112 Halle, Saale, Germany
Forensic Sci Int 155:211-5. 2005..Two hundred and six different haplotypes were obtained. The haplotype diversity was 0.8915. Using AMOVA significant differences were observed to populations from Poland and Croatia...
- Serum procalcitonin levels in the postmortem diagnosis of sepsisS Bode-Jänisch
Hanover Medical School, Institute of Legal Medicine, Carl Neuberg Strasse 1, 30625 Hanover, Germany
Forensic Sci Int 226:266-72. 2013..This study shows that the semi-quantitative PCT-Q(®)-test is a useful supplementary marker in routine autopsy investigations, capable of classifying death as due to sepsis...
- Mutation rate in human microsatellites: influence of the structure and length of the tandem repeatB Brinkmann
Institut fur Rechtsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
Am J Hum Genet 62:1408-15. 1998..Our data demonstrate that mutation rates of different loci can differ by several orders of magnitude and that different alleles at one locus exhibit different mutation rates...
- Asian online Y-STR Haplotype Reference DatabaseRuediger Lessig
Institute of Legal Medicine, University of Leipzig, Johannisallee 28, D 04103 Leipzig, Germany
Leg Med (Tokyo) 5:S160-3. 2003..All databases are maintained and curated at the Institute of Legal Medicine, Humboldt-University, Berlin and will soon be fused to a global repository including populations from all continents...
- Polymerase slippage in relation to the uniformity of tetrameric repeat stretchesMichael Klintschar
Institute of Legal Medicine, Martin Luther University, Halle Wittenberg, Halle Wittenberg, Germany
Forensic Sci Int 135:163-6. 2003..82 for selected D7S1517 alleles) which confirmed the hypothesis that polymerase slippage correlates to the length of repeat stretches consisting of uniform repeats...
- A case of instantaneous rigor?J Pirch
Institute of Legal Medicine, Medical University Hannover, Carl Neuberg Str 1, D30625 Hannover, Germany
Int J Legal Med 127:971-4. 2013..Whereas the position of the body is most unusual, a detailed analysis revealed that it is a stable position even without rigor mortis. Therefore, this case does not further support the controversial concept of IR...
- A functional polymorphism in the tyrosine hydroxylase gene indicates a role of noradrenalinergic signaling in sudden infant death syndromeMichael Klintschar
Institute of Legal Medicine, Georg August University Gottingen, Gottingen, Germany
J Pediatr 153:190-3. 2008..Catecholamines may contribute to the cause of sudden infant death syndrome (SIDS). TH01, a tetrameric short tandem repeat marker in the tyrosine hydroxylase gene, regulates gene expression and catecholamine production...
- Marfan syndrome: clinical consequences resulting from a medicolegal autopsy of a case of sudden death due to aortic ruptureM Klintschar
Department of Legal Medicine, Universitatsmedizin Gottingen, Robert Koch Str 40, 37075, Gottingen, Germany
Int J Legal Med 123:55-8. 2009..We argue that in all sudden and unexpected deaths in young persons up to 35 years an autopsy should be performed, not only to detect unnatural causes of death but also to identify heritable diseases and thus aid the relatives...
- Identification of forensic samples by using an infrared-based automatic DNA sequencerUgo Ricci
Genetics and Molecular Medicine Unit, A Meyer Hospital, University of Florence, A Meyer Hospital, Via Luca Giordano 13, 50132 Florence, Italy
Croat Med J 44:299-305. 2003..The comparability of the results with the widespread UV methods suggests that it is possible to exchange data between laboratories using the same core group of markers but different primer sets and detection methods...
- Y-chromosome analysis in Egypt suggests a genetic regional continuity in Northeastern AfricaFranz Manni
Laboratoire d Anthropologie Biologique CNRS FRE 2292 Musée de l Homme MNHN, Paris, France
Hum Biol 74:645-58. 2002....
- Population data on the AmpFlSTR SGM plus PCR amplification kit in Germans and AustriansBarbara Reichenpfader
Department of Legal Medicine, University Graz, Universitatsplatz 4, A8010 Graz, Austria
Forensic Sci Int 132:84-6. 2003..All loci met Hardy-Weinberg expectations. In 212 meioses per locus, one mutation event for D19S433 was observed...
- Fetal microchimerism is common in normal and diseased vulvar skinSigrid Regauer
J Invest Dermatol 122:1059-60. 2004