Astrid Kehlen

Summary

Affiliation: Martin Luther University
Country: Germany

Publications

  1. ncbi request reprint Biological significance of aminopeptidase N/CD13 in thyroid carcinomas
    Astrid Kehlen
    Institute of Medical Immunology, University of Halle Wittenberg, Halle, Germany
    Cancer Res 63:8500-6. 2003
  2. ncbi request reprint The cellular localization of autotaxin impacts on its biological functions in human thyroid carcinoma cells
    Anja Seifert
    Institute of Medical Immunology, University of Halle Wittenberg, Halle Saale, Germany
    Oncol Rep 19:1485-91. 2008
  3. doi request reprint Role of glutaminyl cyclases in thyroid carcinomas
    Astrid Kehlen
    Probiodrug AG, Weinbergweg 22, Halle, Saale, Germany
    Endocr Relat Cancer 20:79-90. 2013
  4. ncbi request reprint Expression, regulation and function of autotaxin in thyroid carcinomas
    Astrid Kehlen
    Institute of Medical Immunology, University of Halle Wittenberg, Halle, Germany
    Int J Cancer 109:833-8. 2004
  5. doi request reprint Relaxin enhances S100A4 and promotes growth of human thyroid carcinoma cell xenografts
    Yvonne Radestock
    Clinics of General, Visceral and Vascular SurgeryMartin Luther University Halle Wittenberg, Halle, Germany
    Mol Cancer Res 8:494-506. 2010
  6. ncbi request reprint Expression of neutral endopeptidase (NEP/CD10) on pancreatic tumor cell lines, pancreatitis and pancreatic tumor tissues
    Mabruk Erhuma
    Institute of Medical Immunology, Martin Luther University Halle Wittenberg, Germany
    Int J Cancer 120:2393-400. 2007
  7. ncbi request reprint Fetal microchimerism in Hashimoto's thyroiditis: a quantitative approach
    Michael Klintschar
    Institute of Legal Medicine, University Halle Wittenberg, Halle Saale, Germany
    Eur J Endocrinol 154:237-41. 2006
  8. ncbi request reprint INSL3 ligand-receptor system in the equine testis
    Thomas Klonisch
    Departments of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Faculty of Medicine, Halle, Germany
    Biol Reprod 68:1975-81. 2003
  9. pmc The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions
    Holger Cynis
    Probiodrug AG, Halle, Germany
    EMBO Mol Med 3:545-58. 2011
  10. ncbi request reprint INSL3 in the benign hyperplastic and neoplastic human prostate gland
    Thomas Klonisch
    Department of Human Anatomy and Cell Science, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E 0W3, Canada
    Int J Oncol 27:307-15. 2005

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Biological significance of aminopeptidase N/CD13 in thyroid carcinomas
    Astrid Kehlen
    Institute of Medical Immunology, University of Halle Wittenberg, Halle, Germany
    Cancer Res 63:8500-6. 2003
    ....
  2. ncbi request reprint The cellular localization of autotaxin impacts on its biological functions in human thyroid carcinoma cells
    Anja Seifert
    Institute of Medical Immunology, University of Halle Wittenberg, Halle Saale, Germany
    Oncol Rep 19:1485-91. 2008
    ....
  3. doi request reprint Role of glutaminyl cyclases in thyroid carcinomas
    Astrid Kehlen
    Probiodrug AG, Weinbergweg 22, Halle, Saale, Germany
    Endocr Relat Cancer 20:79-90. 2013
    ..Our results reveal new evidence for a novel role of QC in thyroid carcinomas and provide an intriguing rationale for the use of QC inhibitors as a means of blocking pECCL2 formation and preventing thyroid cancer metastasis...
  4. ncbi request reprint Expression, regulation and function of autotaxin in thyroid carcinomas
    Astrid Kehlen
    Institute of Medical Immunology, University of Halle Wittenberg, Halle, Germany
    Int J Cancer 109:833-8. 2004
    ..Further studies are needed to provide insight into the role of ATX in the normal and neoplastic thyroid gland...
  5. doi request reprint Relaxin enhances S100A4 and promotes growth of human thyroid carcinoma cell xenografts
    Yvonne Radestock
    Clinics of General, Visceral and Vascular SurgeryMartin Luther University Halle Wittenberg, Halle, Germany
    Mol Cancer Res 8:494-506. 2010
    ..In conclusion, we have identified S100A4 as a major mediator of the actions of relaxin in thyroid carcinoma cell motility and in vivo thyroid tumor angiogenesis...
  6. ncbi request reprint Expression of neutral endopeptidase (NEP/CD10) on pancreatic tumor cell lines, pancreatitis and pancreatic tumor tissues
    Mabruk Erhuma
    Institute of Medical Immunology, Martin Luther University Halle Wittenberg, Germany
    Int J Cancer 120:2393-400. 2007
    ..However, further studies are needed to provide more detailed information of the role of NEP/CD10 under physiological and pathophysiological conditions of the pancreas...
  7. ncbi request reprint Fetal microchimerism in Hashimoto's thyroiditis: a quantitative approach
    Michael Klintschar
    Institute of Legal Medicine, University Halle Wittenberg, Halle Saale, Germany
    Eur J Endocrinol 154:237-41. 2006
    ..The goal of the study was to reliably estimate the number of fetal engrafted cells and to further investigate factors influencing the development of MCH...
  8. ncbi request reprint INSL3 ligand-receptor system in the equine testis
    Thomas Klonisch
    Departments of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Faculty of Medicine, Halle, Germany
    Biol Reprod 68:1975-81. 2003
    ..The detection of transcripts for equine Lgr8 in the testis has identified the testis as a potential target of INSL3...
  9. pmc The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions
    Holger Cynis
    Probiodrug AG, Halle, Germany
    EMBO Mol Med 3:545-58. 2011
    ..The application of small, orally available inhibitors of glutaminyl cyclases represents an alternative therapeutic strategy to treat CCL2-driven disorders such as atherosclerosis/restenosis and fibrosis...
  10. ncbi request reprint INSL3 in the benign hyperplastic and neoplastic human prostate gland
    Thomas Klonisch
    Department of Human Anatomy and Cell Science, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E 0W3, Canada
    Int J Oncol 27:307-15. 2005
    ..In conclusion, we have identified a functional INSL3-LGR8 ligand-receptor system in human prostate carcinoma cells...
  11. ncbi request reprint INSL-3 is expressed in human hyperplastic and neoplastic thyrocytes
    Sabine Hombach-Klonisch
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, 06097 Halle, Germany
    Int J Oncol 22:993-1001. 2003
    ....
  12. ncbi request reprint Seasonal expression of INSL3 and Lgr8/Insl3 receptor transcripts indicates variable differentiation of Leydig cells in the roe deer testis
    Sabine Hombach-Klonisch
    Department of Human Anatomy and Cell Science, Faculty of Medicine, University of Mannitoba, Winnipeg, MB, Canada
    Biol Reprod 71:1079-87. 2004
    ..A complex functional role of the INSL3/LGR8 ligand-receptor system in the roe deer testis was suggested by the detection of specific hybridization signals for roe deer Lgr8 transcripts in Sertoli cells of the roe deer testis...
  13. ncbi request reprint Inhibition of CD26/dipeptidyl peptidase IV enhances CCL11/eotaxin-mediated recruitment of eosinophils in vivo
    Ulf Forssmann
    Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany
    J Immunol 181:1120-7. 2008
    ..Furthermore, they illustrate that inhibitors of DPPIV have the potential to interfere with chemokine-mediated effects in vivo including but not limited to allergy...
  14. ncbi request reprint Expression of CD97 and CD55 in human medullary thyroid carcinomas
    Tarek Mustafa
    Universitätsklinik und Poliklinik für Allgemein, Viszeral und Gefässchirurgie AG Experimentelle and Chirurgische Onkologie, Martin Luther Universitat, Magdeburger Strasse 18, D 06097 Halle, Germany
    Int J Oncol 24:285-94. 2004
    ..CD97 and CD55 may facilitate adhesion of C-cell carcinoma to surrounding surfaces which would result in rapid tumor cell spread...
  15. doi request reprint Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery
    Holger Cynis
    Probiodrug AG, Weinbergweg 22, 06120 Halle Saale, Germany
    J Mol Biol 379:966-80. 2008
    ..For these enzymes, apparently similar strategies evolved to retain the proteins in the Golgi complex...
  16. ncbi request reprint CD82, and CD63 in thyroid cancer
    Zhouxun Chen
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Magdeburger Strasse 18, D 06097 Halle, Germany
    Int J Mol Med 14:517-27. 2004
    ..CD82 may serve as a prognostic marker of metastasis in thyroid cancer. Constitutive expression of CD63 may indicate that this factor does not play a direct role in thyroid carcinogenesis...
  17. ncbi request reprint Expression of the epidermal growth factor seven-transmembrane member CD97 correlates with grading and staging in human oral squamous cell carcinomas
    Tarek Mustafa
    AG Experimentelle Chirurgie und Onkologie, Martin Luther University Halle Wittenberg, Magdeburger Strasse 18, 06097 Halle, Germany
    Cancer Epidemiol Biomarkers Prev 14:108-19. 2005
    ..The heterodimeric CD97 protein is a epidermal growth factor seven-transmembrane family member and was identified as a dedifferentiation marker in thyroid carcinomas. Nothing is known about CD97 in OSCCs. Material and..
  18. pmc Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter
    Maria Strunnikova
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, 06097 Halle, Germany
    Mol Cell Biol 25:3923-33. 2005
    ..Our data suggest that in epithelial cells, histone inactivation may trigger de novo DNA methylation of the RASSF1A promoter and this system may serve as a model for CpG island inactivation of tumor suppressor genes...