Research Topics
Genomes and Genes | Stefan HuttelmaierSummaryAffiliation: Martin Luther University Country: Germany Publications
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Publications
Pathogenic mechanisms of deregulated microRNA expression in thyroid carcinomas of follicular originJuliane Braun
Institute of Molecular Medicine, Section for Molecular Cell Biology, Martin Luther University of Halle Wittenberg, ZAMED Heinrich Damerow Str, 1, 06120 Halle, Germany
Thyroid Res 4:S1. 2011..Here, we summarize recent findings on microRNA signatures in thyroid carcinomas of follicular origin and discuss how deregulated microRNA expression could promote cancer progression...
Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1Stefan Huttelmaier
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Nature 438:512-5. 2005..These sequential events provide both temporal and spatial control over beta-actin mRNA translation, which is important for cell migration and neurite outgrowth...- ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcriptionFeng Pan
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
Mol Cell Biol 27:8340-51. 2007..ZBP1 then associates with the RNA throughout the nuclear export and cytoplasmic localization process... - IGF2BP1 promotes cell migration by regulating MK5 and PTEN signalingNadine Stöhr
Section for Molecular Cell Biology, Institute of Molecular Medicine, Martin Luther University of Halle, Halle, Germany
Genes Dev 26:176-89. 2012..This fine-tunes and connects intracellular signaling networks in order to enhance actin dynamics and cell polarization... - ZBP1 regulates mRNA stability during cellular stressNadine Stöhr
NBL3 Research Group, Zentrum für Angewandte Medizinische und Humanbiologische Forschung, Department of Medicine, Martin Luther University, 06120 Halle, Germany
J Cell Biol 175:527-34. 2006..These retain mRNAs in SGs and prevent premature decay in PBs. Hence, mRNA-binding proteins are essential for translational adaptation during cellular stress by modulating mRNA turnover... - Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPsDoreen Weidensdorfer
NBL3 NWG6 ZAMED, Department of Medicine, Martin Luther University Halle Wittenberg, 06120 Halle, Germany
RNA 15:104-15. 2009..Complex formation at the CRD presumably limits the transfer of c-myc mRNA to the polysomal fraction and subsequent translation-coupled decay... - Two ZBP1 KH domains facilitate beta-actin mRNA localization, granule formation, and cytoskeletal attachmentKim L Farina
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Cell Biol 160:77-87. 2003.... - Near-infrared (NIR) dye-labeled RNAs identify binding of ZBP1 to the noncoding Y3-RNAMarcel Köhn
Department of Molecular Cell Biology, Martin Luther University of Halle Wittenberg, D 06120 Halle, Germany
RNA 16:1420-8. 2010..The most prominent advantage of probes labeled by NIR dyes is the option to color-code distinct transcripts, allowing the unbiased identification of distinct protein-RNA complexes in one sample... - Asymmetric arginine dimethylation of heterogeneous nuclear ribonucleoprotein K by protein-arginine methyltransferase 1 inhibits its interaction with c-SrcAntje Ostareck-Lederer
Institute of Biochemistry, Martin Luther University Halle Wittenberg, Kurt Mothes Strasse 3, 06120 Halle Saale, Germany
J Biol Chem 281:11115-25. 2006..This led to an inhibition of c-Src activation and hnRNP K phosphorylation. These findings support the role of arginine methylation in the regulation of protein-protein interactions... - Ezrin expression is related to poor prognosis in FIGO stage I endometrioid carcinomasMartin Köbel
Institute of Pathology, Martin Luther University Halle Wittenberg, Halle, Germany
Mod Pathol 19:581-7. 2006..0-5.4, P = 0.047). Hence, elevated ezrin expression is a new independent prognostic marker in FIGO stage I endometrioid carcinoma, and thus provides further evidence for an important role of ezrin in tumor progression... - Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3Christian Faul
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Cell Biol 169:415-24. 2005..They provide a molecular explanation for the phosphorylation-dependent nuclear import of nuclear localization signal-containing cargo proteins... - Asymmetric sorting of ash1p in yeast results from inhibition of translation by localization elements in the mRNAPascal Chartrand
Department of Anatomy and Structural Biology, Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Mol Cell 10:1319-30. 2002..In support of this, Ash1p asymmetry could be rescued by slowing its translation... - IGF2BP1: a post-transcriptional "driver" of tumor cell migrationNadine Stöhr
Section for Molecular Cell Biology, Institute of Molecular Medicine, Martin Luther University of Halle, Halle, Germany
Cell Adh Migr 6:312-8. 2012..These findings identify IGF2BP1 as a potent oncogenic factor that regulates the adhesion, migration and invasiveness of tumor cells by modulating intracellular signaling...