Stefan Huttelmaier

Summary

Affiliation: Martin Luther University
Country: Germany

Publications

  1. pmc IGF2BP1: a post-transcriptional "driver" of tumor cell migration
    Nadine Stöhr
    Section for Molecular Cell Biology, Institute of Molecular Medicine, Martin Luther University of Halle, Halle, Germany
    Cell Adh Migr 6:312-8. 2012
  2. pmc IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG)
    Anne Zirkel
    Institute of Molecular Medicine, Department of Molecular Cell Biology, Martin Luther University, Heinrich Damerow Str 1, 06120 Halle, Germany
    Nucleic Acids Res 41:6618-36. 2013
  3. pmc Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?
    Jessica L Bell
    Section for Molecular Cell Biology, Institute of Molecular Medicine, Martin Luther University Halle, 06120, Halle, Germany
    Cell Mol Life Sci 70:2657-75. 2013
  4. pmc ZBP1 regulates mRNA stability during cellular stress
    Nadine Stöhr
    NBL3 Research Group, Zentrum für Angewandte Medizinische und Humanbiologische Forschung, Department of Medicine, Martin Luther University, 06120 Halle, Germany
    J Cell Biol 175:527-34. 2006
  5. pmc Pathogenic mechanisms of deregulated microRNA expression in thyroid carcinomas of follicular origin
    Juliane Braun
    Institute of Molecular Medicine, Section for Molecular Cell Biology, Martin Luther University of Halle Wittenberg, ZAMED Heinrich Damerow Str, 1, 06120 Halle, Germany
    Thyroid Res 4:S1. 2011
  6. ncbi request reprint Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1
    Stefan Huttelmaier
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nature 438:512-5. 2005
  7. pmc ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription
    Feng Pan
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Cell Biol 27:8340-51. 2007
  8. pmc IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling
    Nadine Stöhr
    Section for Molecular Cell Biology, Institute of Molecular Medicine, Martin Luther University of Halle, Halle, Germany
    Genes Dev 26:176-89. 2012
  9. pmc Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs
    Doreen Weidensdorfer
    NBL3 NWG6 ZAMED, Department of Medicine, Martin Luther University Halle Wittenberg, 06120 Halle, Germany
    RNA 15:104-15. 2009
  10. ncbi request reprint Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin
    Rene Keil
    Institute for Pathophysiology, Division of Pathobiochemistry, Martin Luther University Halle, Halle, Germany
    Cell Cycle 6:122-7. 2007

Collaborators

Detail Information

Publications22

  1. pmc IGF2BP1: a post-transcriptional "driver" of tumor cell migration
    Nadine Stöhr
    Section for Molecular Cell Biology, Institute of Molecular Medicine, Martin Luther University of Halle, Halle, Germany
    Cell Adh Migr 6:312-8. 2012
    ..These findings identify IGF2BP1 as a potent oncogenic factor that regulates the adhesion, migration and invasiveness of tumor cells by modulating intracellular signaling...
  2. pmc IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG)
    Anne Zirkel
    Institute of Molecular Medicine, Department of Molecular Cell Biology, Martin Luther University, Heinrich Damerow Str 1, 06120 Halle, Germany
    Nucleic Acids Res 41:6618-36. 2013
    ..This supports previous reports, suggesting a role of IGF2BP1 in tumor cell dissemination. ..
  3. pmc Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?
    Jessica L Bell
    Section for Molecular Cell Biology, Institute of Molecular Medicine, Martin Luther University Halle, 06120, Halle, Germany
    Cell Mol Life Sci 70:2657-75. 2013
    ..Nonetheless, IGF2BPs could provide valuable targets in cancer treatment with many of their in vivo roles to be fully elucidated. ..
  4. pmc ZBP1 regulates mRNA stability during cellular stress
    Nadine Stöhr
    NBL3 Research Group, Zentrum für Angewandte Medizinische und Humanbiologische Forschung, Department of Medicine, Martin Luther University, 06120 Halle, Germany
    J Cell Biol 175:527-34. 2006
    ..These retain mRNAs in SGs and prevent premature decay in PBs. Hence, mRNA-binding proteins are essential for translational adaptation during cellular stress by modulating mRNA turnover...
  5. pmc Pathogenic mechanisms of deregulated microRNA expression in thyroid carcinomas of follicular origin
    Juliane Braun
    Institute of Molecular Medicine, Section for Molecular Cell Biology, Martin Luther University of Halle Wittenberg, ZAMED Heinrich Damerow Str, 1, 06120 Halle, Germany
    Thyroid Res 4:S1. 2011
    ..Here, we summarize recent findings on microRNA signatures in thyroid carcinomas of follicular origin and discuss how deregulated microRNA expression could promote cancer progression...
  6. ncbi request reprint Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1
    Stefan Huttelmaier
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nature 438:512-5. 2005
    ..These sequential events provide both temporal and spatial control over beta-actin mRNA translation, which is important for cell migration and neurite outgrowth...
  7. pmc ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription
    Feng Pan
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Cell Biol 27:8340-51. 2007
    ..ZBP1 then associates with the RNA throughout the nuclear export and cytoplasmic localization process...
  8. pmc IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling
    Nadine Stöhr
    Section for Molecular Cell Biology, Institute of Molecular Medicine, Martin Luther University of Halle, Halle, Germany
    Genes Dev 26:176-89. 2012
    ..This fine-tunes and connects intracellular signaling networks in order to enhance actin dynamics and cell polarization...
  9. pmc Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs
    Doreen Weidensdorfer
    NBL3 NWG6 ZAMED, Department of Medicine, Martin Luther University Halle Wittenberg, 06120 Halle, Germany
    RNA 15:104-15. 2009
    ..Complex formation at the CRD presumably limits the transfer of c-myc mRNA to the polysomal fraction and subsequent translation-coupled decay...
  10. ncbi request reprint Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin
    Rene Keil
    Institute for Pathophysiology, Division of Pathobiochemistry, Martin Luther University Halle, Halle, Germany
    Cell Cycle 6:122-7. 2007
    ....
  11. pmc Two ZBP1 KH domains facilitate beta-actin mRNA localization, granule formation, and cytoskeletal attachment
    Kim L Farina
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 160:77-87. 2003
    ....
  12. pmc Near-infrared (NIR) dye-labeled RNAs identify binding of ZBP1 to the noncoding Y3-RNA
    Marcel Köhn
    Department of Molecular Cell Biology, Martin Luther University of Halle Wittenberg, D 06120 Halle, Germany
    RNA 16:1420-8. 2010
    ..The most prominent advantage of probes labeled by NIR dyes is the option to color-code distinct transcripts, allowing the unbiased identification of distinct protein-RNA complexes in one sample...
  13. doi request reprint Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation
    Annika Wolf
    Institute of Molecular Medicine, Division of Pathobiochemistry, Martin Luther University Halle Wittenberg, 06114 Halle, Germany
    J Cell Sci 126:1832-44. 2013
    ..This supports the view that the deregulation of plakophilin 1, as observed in several tumors, directly contributes to hyperproliferation and carcinogenesis in a context-dependent manner...
  14. ncbi request reprint Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling
    Weigang Wang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 62:6278-88. 2002
    ..We conclude that aligning cell behavior in vivo with patterns of gene expression can lead to new insights into the microenvironment of carcinoma cells in the primary tumor and the molecular mechanisms behind cell behavior...
  15. pmc Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3
    Christian Faul
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 169:415-24. 2005
    ..They provide a molecular explanation for the phosphorylation-dependent nuclear import of nuclear localization signal-containing cargo proteins...
  16. doi request reprint Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains
    Kristin Wächter
    Institute of Molecular Medicine, Section for Molecular Cell Biology, Martin Luther University Halle, 06120 Halle, Germany
    Biol Chem 394:1077-90. 2013
    ..Our findings suggest that IGF2BPs contact target RNAs via all four KH domains. This implies significant structural constraints, which presumably allow the formation of exceedingly stable protein-RNA complexes...
  17. ncbi request reprint Ezrin expression is related to poor prognosis in FIGO stage I endometrioid carcinomas
    Martin Köbel
    Institute of Pathology, Martin Luther University Halle Wittenberg, Halle, Germany
    Mod Pathol 19:581-7. 2006
    ..0-5.4, P = 0.047). Hence, elevated ezrin expression is a new independent prognostic marker in FIGO stage I endometrioid carcinoma, and thus provides further evidence for an important role of ezrin in tumor progression...
  18. ncbi request reprint Asymmetric arginine dimethylation of heterogeneous nuclear ribonucleoprotein K by protein-arginine methyltransferase 1 inhibits its interaction with c-Src
    Antje Ostareck-Lederer
    Institute of Biochemistry, Martin Luther University Halle Wittenberg, Kurt Mothes Strasse 3, 06120 Halle Saale, Germany
    J Biol Chem 281:11115-25. 2006
    ..This led to an inhibition of c-Src activation and hnRNP K phosphorylation. These findings support the role of arginine methylation in the regulation of protein-protein interactions...
  19. ncbi request reprint The armadillo protein p0071 regulates Rho signalling during cytokinesis
    Annika Wolf
    Institute for Pathophysiology, Division of Pathobiochemistry, Martin Luther University Halle, Hollystrasse 1, 06114 Halle, Germany
    Nat Cell Biol 8:1432-40. 2006
    ..These findings support an essential role for p0071 in spatially regulating restricted Rho signalling during cytokinesis...
  20. ncbi request reprint Asymmetric sorting of ash1p in yeast results from inhibition of translation by localization elements in the mRNA
    Pascal Chartrand
    Department of Anatomy and Structural Biology, Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Cell 10:1319-30. 2002
    ..In support of this, Ash1p asymmetry could be rescued by slowing its translation...
  21. ncbi request reprint Rapid identification of regulatory microRNAs by miTRAP (miRNA trapping by RNA in vitro affinity purification)
    Juliane Braun
    Division of Molecular Cell Biology, Institute of Molecular Medicine, Martin Luther University Halle Wittenberg, Heinrich Damerow Strasse 1, 06120 Halle, Germany and Interdisciplinary Center for Clinical Research, University Leipzig, Liebigstrasse 21, 04103 Leipzig, Germany
    Nucleic Acids Res 42:e66. 2014
    ..Most notably, miTRAP not only identifies in silico predictable but also unpredictable miRNAs regulating the expression of a specific target RNA. ..
  22. ncbi request reprint Extraction of protein profiles from primary neurons using active contour models and wavelets
    Danny Misiak
    Institute of Molecular Medicine, Martin Luther University Halle Wittenberg, Heinrich Damerow Str 1, 06120 Halle, Germany Electronic address
    J Neurosci Methods 225:1-12. 2014
    ....