Affiliation: Martin Luther University
Scheffler J, Bork K, Bezold V, Rosenstock P, Gnanapragassam V, Horstkorte R. Ascorbic acid leads to glycation and interferes with neurite outgrowth. Exp Gerontol. 2018;: pubmed publisher
..We found that both applications of ascorbic acid or dehydroascorbic acid leads to glycation of cellular proteins, but that ascorbic acid interferes more with viability and neurite outgrowth compared with dehydroascorbic acid. ..
Bork K, Wurm F, Haller H, Strauss C, Scheller C, Gnanapragassam V, et al
. Neuroprotective and neuroregenerative effects of nimodipine in a model system of neuronal differentiation and neurite outgrowth. Molecules. 2015;20:1003-13 pubmed publisher
..These results support the idea that nimodipine has general neuroprotective or neuregenerative effect beside its role in vasodilatation and is maybe useful also in other clinical applications beside aSAH. ..
Bennmann D, Kannicht C, Fisseau C, Jacobs K, Navarette Santos A, Hofmann B, et al
. Glycation of the high affinity NGF-receptor and RAGE leads to reduced ligand affinity. Mech Ageing Dev. 2015;150:1-11 pubmed publisher
..Glycation of RAGE reduced binding affinity of AGEs by 10-fold. ..
Herzfeld E, Strauss C, Simmermacher S, Bork K, Horstkorte R, Dehghani F, et al
. Investigation of the neuroprotective impact of nimodipine on Neuro2a cells by means of a surgery-like stress model. Int J Mol Sci. 2014;15:18453-65 pubmed publisher
..This model seems suitable for further investigation of the molecular mechanisms involved in the neuroprotective signal pathways influenced by nimodipine. ..
Hussain M, Bork K, Gnanapragassam V, Bennmann D, Jacobs K, Navarette Santos A, et al
. Novel insights in the dysfunction of human blood-brain barrier after glycation. Mech Ageing Dev. 2016;155:48-54 pubmed publisher
..In summary, this study provides new insights into the relationship between AGE formation by carbonyl stress and brain microvascular endothelial barrier dysfunction. ..
Wratil P, Horstkorte R, Reutter W. Metabolic Glycoengineering with N-Acyl Side Chain Modified Mannosamines. Angew Chem Int Ed Engl. 2016;55:9482-512 pubmed publisher
..MGE has intriguing biological consequences for treated cells (aliphatic MGE) and offers the opportunity to visualize the topography and dynamics of sialylated glycans in?vitro, ex?vivo, and in?vivo (bioorthogonal MGE). ..
Wratil P, Horstkorte R. Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines. J Vis Exp. 2017;: pubmed publisher
..The effects on polysialic acid expression are elucidated via Western blot using a commercially available polysialic acid antibody. ..
Goschzik T, Cremer H, Gnanapragassam V, Horstkorte R, Bork K, Diestel S. Mutation of a putative MAP kinase consensus site regulates NCAM endocytosis and NCAM-dependent neurite outgrowth. Neurosci Res. 2017;120:28-35 pubmed publisher
..Furthermore, cells expressing NCAM140-T803D developed significantly shorter neurites than NCAM140 expressing cells indicating that a potential phosphorylation of NCAM by ERK2 also regulates NCAM-dependent neurite outgrowth. ..
Bork K, Weidemann W, Berneck B, Kuchta M, Bennmann D, Thate A, et al
. The expression of sialyltransferases is regulated by the bioavailability and biosynthesis of sialic acids. Gene Expr Patterns. 2017;23-24:52-58 pubmed publisher
..This allows a cell to response to altered environmental conditions. ..