Cuong Hoang-Vu

Summary

Affiliation: Martin Luther University
Country: Germany

Publications

  1. pmc Down-regulation of TM4SF is associated with the metastatic potential of gastric carcinoma TM4SF members in gastric carcinoma
    Zhouxun Chen
    Department of General Surgery, The first affiliated Hospital of Wenzhou medical School, Wenzhou 325000, Zhejiang, PR, China
    World J Surg Oncol 9:43. 2011
  2. ncbi request reprint Regulation of CD97 protein in thyroid carcinoma
    C Hoang-Vu
    Klinik für Allgemeinchirurgie, Martin Luther Universitat Halle Wittenberg, Halle, Germany
    J Clin Endocrinol Metab 84:1104-9. 1999
  3. pmc AUF1 and HuR: possible implications of mRNA stability in thyroid function and disorders
    Bogusz Trojanowicz
    Universitätsklinik und Poliklinik für Allgemein, Viszeral und Gefäßchirurgie, Martin Luther Universitat, Halle
    Thyroid Res 4:S5. 2011
  4. ncbi request reprint Expression of telomerase genes in thyroid carcinoma
    Cuong Hoang-Vu
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Germany
    Int J Oncol 21:265-72. 2002
  5. ncbi request reprint CD82, and CD63 in thyroid cancer
    Zhouxun Chen
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Magdeburger Strasse 18, D 06097 Halle, Germany
    Int J Mol Med 14:517-27. 2004
  6. ncbi request reprint Expression, regulation and function of autotaxin in thyroid carcinomas
    Astrid Kehlen
    Institute of Medical Immunology, University of Halle Wittenberg, Halle, Germany
    Int J Cancer 109:833-8. 2004
  7. ncbi request reprint INSL-3 is expressed in human hyperplastic and neoplastic thyrocytes
    Sabine Hombach-Klonisch
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, 06097 Halle, Germany
    Int J Oncol 22:993-1001. 2003
  8. doi request reprint Relaxin enhances S100A4 and promotes growth of human thyroid carcinoma cell xenografts
    Yvonne Radestock
    Clinics of General, Visceral and Vascular SurgeryMartin Luther University Halle Wittenberg, Halle, Germany
    Mol Cancer Res 8:494-506. 2010
  9. doi request reprint Retinoic acid-mediated down-regulation of ENO1/MBP-1 gene products caused decreased invasiveness of the follicular thyroid carcinoma cell lines
    Bogusz Trojanowicz
    AG Experimentelle and Chirurgische Onkologie, Universitätsklinik und Poliklinik für Allgemein, Viszeral und Gefässchirurgie, Martin Luther Universitat, Halle S, Germany
    J Mol Endocrinol 42:249-60. 2009
  10. ncbi request reprint Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma
    Reinhard Dammann
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, 06097 Halle Saale, Germany
    Oncogene 22:3806-12. 2003

Collaborators

Detail Information

Publications49

  1. pmc Down-regulation of TM4SF is associated with the metastatic potential of gastric carcinoma TM4SF members in gastric carcinoma
    Zhouxun Chen
    Department of General Surgery, The first affiliated Hospital of Wenzhou medical School, Wenzhou 325000, Zhejiang, PR, China
    World J Surg Oncol 9:43. 2011
    ..The aim of this study was to clarify the clinical significance of TM4SF members CD9, CD63 and CD82 in human gastric carcinoma...
  2. ncbi request reprint Regulation of CD97 protein in thyroid carcinoma
    C Hoang-Vu
    Klinik für Allgemeinchirurgie, Martin Luther Universitat Halle Wittenberg, Halle, Germany
    J Clin Endocrinol Metab 84:1104-9. 1999
    ..These data suggest that CD97 expression may play an important role in the dedifferentiation of thyroid tumors, and RA might interfere with this process in thyroid carcinoma by suppressing the dedifferentiation marker CD97...
  3. pmc AUF1 and HuR: possible implications of mRNA stability in thyroid function and disorders
    Bogusz Trojanowicz
    Universitätsklinik und Poliklinik für Allgemein, Viszeral und Gefäßchirurgie, Martin Luther Universitat, Halle
    Thyroid Res 4:S5. 2011
    ..In this study we shortly review the possible function of both proteins in relation to development and various physiological and pathophysiological processes, including thyroid function and disorders...
  4. ncbi request reprint Expression of telomerase genes in thyroid carcinoma
    Cuong Hoang-Vu
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Germany
    Int J Oncol 21:265-72. 2002
    ..In contrast to TP1 and hTR, hTERT and telomerase activity may be of help in identifying invasive tumors and may be additional markers for classification of benign goiter and malignant thyroid carcinoma...
  5. ncbi request reprint CD82, and CD63 in thyroid cancer
    Zhouxun Chen
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Magdeburger Strasse 18, D 06097 Halle, Germany
    Int J Mol Med 14:517-27. 2004
    ..CD82 may serve as a prognostic marker of metastasis in thyroid cancer. Constitutive expression of CD63 may indicate that this factor does not play a direct role in thyroid carcinogenesis...
  6. ncbi request reprint Expression, regulation and function of autotaxin in thyroid carcinomas
    Astrid Kehlen
    Institute of Medical Immunology, University of Halle Wittenberg, Halle, Germany
    Int J Cancer 109:833-8. 2004
    ..Further studies are needed to provide insight into the role of ATX in the normal and neoplastic thyroid gland...
  7. ncbi request reprint INSL-3 is expressed in human hyperplastic and neoplastic thyrocytes
    Sabine Hombach-Klonisch
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, 06097 Halle, Germany
    Int J Oncol 22:993-1001. 2003
    ....
  8. doi request reprint Relaxin enhances S100A4 and promotes growth of human thyroid carcinoma cell xenografts
    Yvonne Radestock
    Clinics of General, Visceral and Vascular SurgeryMartin Luther University Halle Wittenberg, Halle, Germany
    Mol Cancer Res 8:494-506. 2010
    ..In conclusion, we have identified S100A4 as a major mediator of the actions of relaxin in thyroid carcinoma cell motility and in vivo thyroid tumor angiogenesis...
  9. doi request reprint Retinoic acid-mediated down-regulation of ENO1/MBP-1 gene products caused decreased invasiveness of the follicular thyroid carcinoma cell lines
    Bogusz Trojanowicz
    AG Experimentelle and Chirurgische Onkologie, Universitätsklinik und Poliklinik für Allgemein, Viszeral und Gefässchirurgie, Martin Luther Universitat, Halle S, Germany
    J Mol Endocrinol 42:249-60. 2009
    ....
  10. ncbi request reprint Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma
    Reinhard Dammann
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, 06097 Halle Saale, Germany
    Oncogene 22:3806-12. 2003
    ..001, chi(2) test). In conclusion, our data indicate that inactivation of the RASSF1A gene is a frequent event in pancreatic cancer and suggest an inverse correlation between RASSF1A silencing and K-ras activation...
  11. doi request reprint Proteomic approach reveals novel targets for retinoic acid-mediated therapy of thyroid carcinoma
    Bogusz Trojanowicz
    Universitätsklinik und Poliklinik für Allgemein, Viszeral und Gefässchirurgie, Martin Luther Universitat, 06097 Halle, Germany
    Mol Cell Endocrinol 325:110-7. 2010
    ..These findings identify new target proteins for RA-mediated anti-tumor and re-differentiation therapies and provide novel insights into treatments for thyroid carcinoma...
  12. ncbi request reprint Biological significance of aminopeptidase N/CD13 in thyroid carcinomas
    Astrid Kehlen
    Institute of Medical Immunology, University of Halle Wittenberg, Halle, Germany
    Cancer Res 63:8500-6. 2003
    ....
  13. doi request reprint Role of glutaminyl cyclases in thyroid carcinomas
    Astrid Kehlen
    Probiodrug AG, Weinbergweg 22, Halle, Saale, Germany
    Endocr Relat Cancer 20:79-90. 2013
    ..Our results reveal new evidence for a novel role of QC in thyroid carcinomas and provide an intriguing rationale for the use of QC inhibitors as a means of blocking pECCL2 formation and preventing thyroid cancer metastasis...
  14. ncbi request reprint CpG island methylation of tumor-related promoters occurs preferentially in undifferentiated carcinoma
    Undraga Schagdarsurengin
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Thyroid 16:633-42. 2006
    ..To understand the role of epigenetic inactivation of tumor-related genes in the pathogenesis of thyroid cancer, we investigated the methylation profile of distinct thyroid neoplasms...
  15. ncbi request reprint Expression of the epidermal growth factor seven-transmembrane member CD97 correlates with grading and staging in human oral squamous cell carcinomas
    Tarek Mustafa
    AG Experimentelle Chirurgie und Onkologie, Martin Luther University Halle Wittenberg, Magdeburger Strasse 18, 06097 Halle, Germany
    Cancer Epidemiol Biomarkers Prev 14:108-19. 2005
    ..The heterodimeric CD97 protein is a epidermal growth factor seven-transmembrane family member and was identified as a dedifferentiation marker in thyroid carcinomas. Nothing is known about CD97 in OSCCs. Material and..
  16. doi request reprint The role of AUF1 in thyroid carcinoma progression
    Bogusz Trojanowicz
    AG Experimentelle and Chirurgische Onkologie, Universitätsklinik und Poliklinik für Allgemein, Viszeral und Gefässchirurgie, Martin Luther Universitat, Magdeburger Strasse 18, 06097 Halle S, Germany
    Endocr Relat Cancer 16:857-71. 2009
    ..Thus, AUF1 may be considered as a new, additional marker for thyroid carcinoma...
  17. ncbi request reprint Expression of neutral endopeptidase (NEP/CD10) on pancreatic tumor cell lines, pancreatitis and pancreatic tumor tissues
    Mabruk Erhuma
    Institute of Medical Immunology, Martin Luther University Halle Wittenberg, Germany
    Int J Cancer 120:2393-400. 2007
    ..However, further studies are needed to provide more detailed information of the role of NEP/CD10 under physiological and pathophysiological conditions of the pancreas...
  18. doi request reprint Relaxin enhances the collagenolytic activity and in vitro invasiveness by upregulating matrix metalloproteinases in human thyroid carcinoma cells
    Joanna Bialek
    Clinics of General, Visceral and Vascular Surgery, Martin Luther University, Halle Saale, Saxony Anhalt, Germany
    Mol Cancer Res 9:673-87. 2011
    ..In conclusion, enhanced tumor cell invasion by RLN2 involves the formation of MT1-MMP-enriched invadopodia that lead to increased collagenolytic cell invasion by human thyroid cancer cells...
  19. ncbi request reprint Expression of CD97 and CD55 in human medullary thyroid carcinomas
    Tarek Mustafa
    Universitätsklinik und Poliklinik für Allgemein, Viszeral und Gefässchirurgie AG Experimentelle and Chirurgische Onkologie, Martin Luther Universitat, Magdeburger Strasse 18, D 06097 Halle, Germany
    Int J Oncol 24:285-94. 2004
    ..CD97 and CD55 may facilitate adhesion of C-cell carcinoma to surrounding surfaces which would result in rapid tumor cell spread...
  20. ncbi request reprint Cytoplasmic domain of proEGF affects distribution and post-translational modification of microtubuli and increases microtubule-associated proteins 1b and 2 production in human thyroid carcinoma cells
    Janette Pyka
    Clinics of Surgery, Medical Faculty, Martin Luther University Halle Wittenberg, Halle, Germany
    Cancer Res 65:1343-51. 2005
    ....
  21. pmc Relaxin reduces xenograft tumour growth of human MDA-MB-231 breast cancer cells
    Yvonne Radestock
    Clinics of General, Visceral and Vascular Surgery, Magdeburger Str, 18, Martin Luther University Halle Wittenberg, 06097 Halle, Germany
    Breast Cancer Res 10:R71. 2008
    ....
  22. ncbi request reprint Frequent epigenetic silencing of the CpG island promoter of RASSF1A in thyroid carcinoma
    Undraga Schagdarsurengin
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Cancer Res 62:3698-701. 2002
    ..However, RASSF1A hypermethylation was detected three times more frequently in thyroid cancers. Thus, RASSF1A inactivation may play a crucial role in the malignancy of thyroid carcinoma...
  23. ncbi request reprint Fetal microchimerism in Hashimoto's thyroiditis: a quantitative approach
    Michael Klintschar
    Institute of Legal Medicine, University Halle Wittenberg, Halle Saale, Germany
    Eur J Endocrinol 154:237-41. 2006
    ..The goal of the study was to reliably estimate the number of fetal engrafted cells and to further investigate factors influencing the development of MCH...
  24. ncbi request reprint Overexpression of cyclin E protein is closely related to the mutator phenotype of colorectal carcinoma
    Thomas Sutter
    Department of General Surgery, Martin Luther University of Halle Wittenberg, 06097 Halle, Germany
    Int J Colorectal Dis 17:374-80. 2002
    ..We examined whether the overexpression of cyclin E is related to the status of the mismatch repair system in colorectal carcinomas...
  25. ncbi request reprint Frequent promoter methylation of tumor-related genes in sporadic and men2-associated pheochromocytomas
    R Dammann
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Exp Clin Endocrinol Diabetes 113:1-7. 2005
    ..Combined methylation of RASSF1 A and p16 was found only in MEN2-related pheochromocytomas. Thus, a subset of hereditary pheochromocytomas displays preferential methylation of p16 and RASSF1 A...
  26. ncbi request reprint Distinct expression of galectin-3 in pheochromocytomas
    Oliver Gimm
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, 06097 Halle Saale, Germany
    Ann N Y Acad Sci 1073:571-7. 2006
    ..One benign sporadic pheochromocytoma had moderate cytoplasmic staining. The distinct expression in various types of pheochromocytomas is intriguing and requires further investigation...
  27. ncbi request reprint HSP90 is a key for telomerase activation and malignant transition in pheochromocytoma
    Carsten Boltze
    Department of Pathology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Endocrine 22:193-201. 2003
    ..Overexpression of HSP90 is an important factor in the activation of telomerase via hTERT. The common expression of hTERT and telomerase activity thus represents an additional prognostic marker that may identify more aggressive tumors...
  28. ncbi request reprint Germ-line mutations in nonsyndromic pheochromocytoma
    Hartmut P H Neumann
    Department of Nephrology and Hypertension, Albert Ludwigs University, Freiburg, Germany
    N Engl J Med 346:1459-66. 2002
    ....
  29. ncbi request reprint The cellular localization of autotaxin impacts on its biological functions in human thyroid carcinoma cells
    Anja Seifert
    Institute of Medical Immunology, University of Halle Wittenberg, Halle Saale, Germany
    Oncol Rep 19:1485-91. 2008
    ....
  30. ncbi request reprint Peroxisome proliferator-activated receptor gamma is frequently downregulated in a diversity of sporadic nonmedullary thyroid carcinomas
    Micheala A Aldred
    Human Cancer Genetics Program, The Ohio State University, Columbus, OH, USA
    Oncogene 22:3412-6. 2003
    ....
  31. ncbi request reprint Caveolin-1 and caveolin-2,together with three bone morphogenetic protein-related genes, may encode novel tumor suppressors down-regulated in sporadic follicular thyroid carcinogenesis
    Micheala A Aldred
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 63:2864-71. 2003
    ..PTC and anaplastic thyroid carcinomas did not show significant down-regulation, and thus, caveolin-1 may become a useful molecular marker to differentiate the various histologies of thyroid malignancies...
  32. pmc Relaxin enhances the oncogenic potential of human thyroid carcinoma cells
    Sabine Hombach-Klonisch
    Department of Human Anatomy and Cell Science, Faculty of Medicine, University of Manitoba, 130 Basic Medical Sciences, 730 William Ave, Winnipeg, MB, R3E 0W3, Canada
    Am J Pathol 169:617-32. 2006
    ..Thus, relaxin enhances the oncogenic potential and acts as novel endocrine modulator of invasiveness in human thyroid carcinoma cells...
  33. ncbi request reprint Function of HSP90 and p23 in the telomerase complex of thyroid tumors
    Carsten Boltze
    Department of Pathology, Otto von Guericke University and 2 City Hospital, Magdeburg, Germany
    Pathol Res Pract 199:573-9. 2003
    ..The expression profile of telomerase components represents an additional prognostic marker that may identify more aggressive thyroid tumors...
  34. ncbi request reprint The expression of CD97EGF and its ligand CD55 on marginal epithelium is related to higher stage and depth of tumor invasion of gastric carcinomas
    Yong Liu
    Department of Surgery, The Second Affiliated Hospital of Zhejiang University, Hangzhou, PR China
    Oncol Rep 14:1413-20. 2005
    ..Detection of the CD97EGF expression in the tumor margin could be referred to as the molecular edge of gastric carcinomas...
  35. ncbi request reprint Maspin in thyroid cancer: its relationship with p53 and clinical outcome
    Carsten Boltze
    Department of Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
    Oncol Rep 10:1783-7. 2003
    ..Our data hint of a p53-dependent regulatory pathway of the maspin protein in human cancer...
  36. ncbi request reprint Human thyroid carcinoma cell lines show different retinoic acid receptor repertoires and retinoid responses
    Cornelia Schmutzler
    Institut für Experimentelle Endokrinologie, Charite, Universitatsmedizin Berlin, Germany
    Eur J Endocrinol 150:547-56. 2004
    ..Disturbed expression of retinoic acid (RA) receptors (RAR/RXR) contributes to the pathogenesis and tumor progression of epithelial carcinomas...
  37. ncbi request reprint Proteome analysis identified maspin as a special feature of papillary thyroid carcinoma
    Carsten Boltze
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Int J Oncol 23:1323-8. 2003
    ..In conclusion, we hypothesize that maspin protein expression is a special feature in the cascade of PTC genesis and that the way of initiating PTC is different from other thyroid carcinoma types...
  38. ncbi request reprint Gene expression of parathyroid tumors: molecular subclassification and identification of the potential malignant phenotype
    Carola J Haven
    Laboratory of Cancer Genetics and Bioinformatics Special Program, Van Andel Research Institute, Grand Rapids, Michigan, USA
    Cancer Res 64:7405-11. 2004
    ..These findings provide insights into the molecular pathways involved in parathyroid tumorigenesis and will contribute to a better understanding, diagnosis, and treatment of parathyroid tumors...
  39. ncbi request reprint Expression profile of the telomeric complex discriminates between benign and malignant pheochromocytoma
    Carsten Boltze
    Department of Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
    J Clin Endocrinol Metab 88:4280-6. 2003
    ..The common expression of hTERT and telomerase activity thus represents an additional prognostic marker that may identify more aggressive tumors...
  40. ncbi request reprint Silencing of the maspin gene by promoter hypermethylation in thyroid cancer
    Carsten Boltze
    Department of Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
    Int J Mol Med 12:479-84. 2003
    ..We presume that methylation of the maspin gene promoter is a common, a likely, and an early event during the development of papillary thyroid carcinomas...
  41. ncbi request reprint Selenoprotein expression in Hürthle cell carcinomas and in the human Hürthle cell carcinoma line XTC.UC1
    Marianne Menth
    Abteilung für Molekulare Innere Medizin und Klinische Forschergruppe der Medizinischen Poliklinik, Universitat Wurzburg, Wurzburg, Germany
    Thyroid 15:405-16. 2005
    ..UC1 cells, so far giving no evidence of a role of these proteins in the pathogenesis of HTCs...
  42. ncbi request reprint INSL3 in the benign hyperplastic and neoplastic human prostate gland
    Thomas Klonisch
    Department of Human Anatomy and Cell Science, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E 0W3, Canada
    Int J Oncol 27:307-15. 2005
    ..In conclusion, we have identified a functional INSL3-LGR8 ligand-receptor system in human prostate carcinoma cells...
  43. ncbi request reprint Relaxin-like ligand-receptor systems are autocrine/paracrine effectors in tumor cells and modulate cancer progression and tissue invasiveness
    Thomas Klonisch
    Department of Human Anatomy and Cell Science, Faculty of Medicine, University of Manitoba, 130 Basic Medical Science Bldg, 730 William Avenue, Winnipeg, Manitoba, Canada R3E 0W3
    Adv Exp Med Biol 612:104-18. 2007
    ..This review presents recent new findings and emphasises the important functions of the relaxin/INSL3 ligand-receptor system as novel autocrine/paracrine effectors influencing tumor progression and tissue invasiveness...
  44. ncbi request reprint Selenoproteins of the thyroid gland: expression, localization and possible function of glutathione peroxidase 3
    Cornelia Schmutzler
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Biol Chem 388:1053-9. 2007
    ..Particularly, GPx3 might use excess H2O2 and catalyze the polymerization of thyroglobulin to the highly cross-linked storage form present in the colloid...
  45. ncbi request reprint Human medullary thyroid carcinoma: a source and potential target for relaxin-like hormones
    T Klonisch
    Department of Human Anatomy and Cell Science, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E 0W3, Canada
    Ann N Y Acad Sci 1041:449-61. 2005
    ..Thus, relaxin-like hormones appear to be present early during C-cell hyperplasia and potentially functional relaxin/INSL3 ligand-receptor systems are present in human MTC tissues and in MTC cell lines...
  46. ncbi request reprint Radiation-induced thyroid carcinogenesis as a function of time and dietary iodine supply: an in vivo model of tumorigenesis in the rat
    Carsten Boltze
    Department of Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
    Endocrinology 143:2584-92. 2002
    ..This model may help to define genetic alterations long before histological changes are detectable...
  47. ncbi request reprint Relaxin downregulates the calcium binding protein S100A4 in MDA-MB-231 human breast cancer cells
    Yvonne Radestock
    Department of Human Anatomy and Cell Sciences, University of Manitoba, Faculty of Medicine, 130 Basic Medical Sciences, Winnipeg, MB, R3E 0W3, Canada
    Ann N Y Acad Sci 1041:462-9. 2005
    ....
  48. ncbi request reprint CD97, CD95 and Fas-L clearly discriminate between chronic pancreatitis and pancreatic ductal adenocarcinoma in perioperative evaluation of cryocut sections
    Carsten Boltze
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Pathol Int 52:83-8. 2002
    ..Our data demonstrate that CD97, CD95 and Fas-L can be used as additional markers to distinguish between pancreatitis and pancreatic duct cell carcinoma in cryocut sections...
  49. ncbi request reprint Expression of the cholecystokinin 2-receptor in normal human thyroid gland and medullary thyroid carcinoma
    Michael Blaker
    Medizinische Kernklinik und Poliklinik, Universitatsklinikum Hamburg Eppendorf, Germany
    Eur J Endocrinol 146:89-96. 2002
    ..The objective of this study was to analyze CCK(2)R expression in MTC samples of different tumor stages as well as in non-malignant thyroid tissues...