Mechthild Hatzfeld

Summary

Affiliation: Martin Luther University
Country: Germany

Publications

  1. pmc The function of plakophilin 1 in desmosome assembly and actin filament organization
    M Hatzfeld
    Molecular Biology Group of the Medical Faculty, University of Halle, 06097 Halle Saale, Germany
    J Cell Biol 149:209-22. 2000
  2. ncbi request reprint Plakophilins: Multifunctional proteins or just regulators of desmosomal adhesion?
    Mechthild Hatzfeld
    Institute of Pathophysiology, Division of Pathobiochemistry, University of Halle, Hollystrasse 1, 06097 Halle, Germany
    Biochim Biophys Acta 1773:69-77. 2007
  3. ncbi request reprint The p120 family of cell adhesion molecules
    Mechthild Hatzfeld
    Institute of Physiological Chemistry, University of Halle, Hollystrasse 1, D 06097 Halle, Germany
    Eur J Cell Biol 84:205-14. 2005
  4. ncbi request reprint Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains
    Mechthild Hatzfeld
    Institute of Physiological Chemistry, Medical Faculty of the University of Halle, 06097 Halle Saale, Germany
    J Cell Sci 116:1219-33. 2003
  5. ncbi request reprint Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin
    Rene Keil
    Institute for Pathophysiology, Division of Pathobiochemistry, Martin Luther University Halle, Halle, Germany
    Cell Cycle 6:122-7. 2007
  6. doi request reprint Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation
    Annika Wolf
    Institute of Molecular Medicine, Division of Pathobiochemistry, Martin Luther University Halle Wittenberg, 06114 Halle, Germany
    J Cell Sci 126:1832-44. 2013
  7. doi request reprint Targeting of p0071 to the midbody depends on KIF3
    Rene Keil
    Institute for Pathophysiology, Division of Pathobiochemistry, Martin Luther University Halle, 06114 Halle, Germany
    J Cell Sci 122:1174-83. 2009
  8. doi request reprint A role of plakophilins in the regulation of translation
    Annika Wolf
    Institute for Pathophysiology, Division of Pathobiochemistry, Martin Luther University Halle Wittenberg, Halle, Germany
    Cell Cycle 9:2973-8. 2010
  9. pmc Plakophilin 1 stimulates translation by promoting eIF4A1 activity
    Annika Wolf
    Division of Pathobiochemistry, Martin Luther University Halle Wittenberg, 06097 Halle, Germany
    J Cell Biol 188:463-71. 2010
  10. doi request reprint A nuclear function for plakophilin-1 in the DNA damage response?
    Mechthild Hatzfeld
    Division of Pathobiochemistry, University of Halle, Halle, Germany
    J Invest Dermatol 130:2538-40. 2010

Collaborators

  • Stefan Huttelmaier
  • Andrea Sinz
  • KATHLEEN JANEE GREEN
  • Werner W Franke
  • Andre Le Bivic
  • Sylke Meyer
  • T M Magin
  • Andrew Kowalczyk
  • Xinyu Chen
  • D Birnbaum
  • Rene Keil
  • Annika Wolf
  • Andrej Mun
  • Nadine Stöhr
  • Marcell Lederer
  • Stefan Bonne
  • Beate K Straub
  • Catharine C Calkins
  • Fanny Jaulin-Bastard
  • Jens Gruber
  • Christian Ihling
  • Aileen Wingenfeld
  • Markus Glaß
  • Jenny Schulz
  • Mike Schutkowski
  • Katrin Rietscher
  • Olaf Birkenmeier
  • Malgorzata Krause-Gruszczynska
  • Antje Ostareck-Lederer
  • Christina Kiessling
  • Oliver Götzl
  • Claudia Reinke
  • Robert H Singer
  • Katrin Schwarze
  • Bridgett L Hoepner
  • Martina Schnoelzer
  • Herbert Spring
  • Tore Kempf
  • Caecilia Kuhn
  • Matthew R Novak
  • Ulrike Korf
  • Barbara Gilbert
  • Christine M Law
  • Judit Boda
  • Frans van Roy
  • Shannon V Setzer
  • Christel Navarro
  • Marie Josée Santoni
  • Jörg Schnabel
  • Jean Paul Borg
  • Klaus Weber
  • Hiroko Saito
  • Jean Pierre Arsanto
  • Frederic Vely
  • Jens Harborth
  • Sylvie Marchetto

Detail Information

Publications21

  1. pmc The function of plakophilin 1 in desmosome assembly and actin filament organization
    M Hatzfeld
    Molecular Biology Group of the Medical Faculty, University of Halle, 06097 Halle Saale, Germany
    J Cell Biol 149:209-22. 2000
    ....
  2. ncbi request reprint Plakophilins: Multifunctional proteins or just regulators of desmosomal adhesion?
    Mechthild Hatzfeld
    Institute of Pathophysiology, Division of Pathobiochemistry, University of Halle, Hollystrasse 1, 06097 Halle, Germany
    Biochim Biophys Acta 1773:69-77. 2007
    ..This review aims to summarize the current knowledge of plakophilin function in the context of cell adhesion, signaling and their putative role in diseases...
  3. ncbi request reprint The p120 family of cell adhesion molecules
    Mechthild Hatzfeld
    Institute of Physiological Chemistry, University of Halle, Hollystrasse 1, D 06097 Halle, Germany
    Eur J Cell Biol 84:205-14. 2005
    ..Thus, p120 proteins may not only be master regulators of cadherin abundance and activity but play additional roles in regulating cell polarity. This review focuses on the putative roles of p120 proteins in cell polarity...
  4. ncbi request reprint Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains
    Mechthild Hatzfeld
    Institute of Physiological Chemistry, Medical Faculty of the University of Halle, 06097 Halle Saale, Germany
    J Cell Sci 116:1219-33. 2003
    ..Our data suggest that, in addition to plakoglobin, p0071 is the second armadillo protein present in both types of adhesive junctions and may play a role in regulating crosstalk between adherens junctions and desmosomes...
  5. ncbi request reprint Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin
    Rene Keil
    Institute for Pathophysiology, Division of Pathobiochemistry, Martin Luther University Halle, Halle, Germany
    Cell Cycle 6:122-7. 2007
    ....
  6. doi request reprint Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation
    Annika Wolf
    Institute of Molecular Medicine, Division of Pathobiochemistry, Martin Luther University Halle Wittenberg, 06114 Halle, Germany
    J Cell Sci 126:1832-44. 2013
    ..This supports the view that the deregulation of plakophilin 1, as observed in several tumors, directly contributes to hyperproliferation and carcinogenesis in a context-dependent manner...
  7. doi request reprint Targeting of p0071 to the midbody depends on KIF3
    Rene Keil
    Institute for Pathophysiology, Division of Pathobiochemistry, Martin Luther University Halle, 06114 Halle, Germany
    J Cell Sci 122:1174-83. 2009
    ..These data indicate that p0071 and Ect2 are transported via distinct motors and identify a novel pathway implicating KIF3 in the regulation of actin organization during cytokinesis...
  8. doi request reprint A role of plakophilins in the regulation of translation
    Annika Wolf
    Institute for Pathophysiology, Division of Pathobiochemistry, Martin Luther University Halle Wittenberg, Halle, Germany
    Cell Cycle 9:2973-8. 2010
    ..Elucidating the regulation of plakophilin's function in adhesion versus translation will help to understand this context-dependent phenomenon...
  9. pmc Plakophilin 1 stimulates translation by promoting eIF4A1 activity
    Annika Wolf
    Division of Pathobiochemistry, Martin Luther University Halle Wittenberg, 06097 Halle, Germany
    J Cell Biol 188:463-71. 2010
    ..In conclusion, these findings identify PKP1 as a regulator of translation and proliferation via modulation of eIF4A1 activity and suggest that PKP1 controls cell growth in physiological and pathological conditions...
  10. doi request reprint A nuclear function for plakophilin-1 in the DNA damage response?
    Mechthild Hatzfeld
    Division of Pathobiochemistry, University of Halle, Halle, Germany
    J Invest Dermatol 130:2538-40. 2010
    ..In this issue, Sobolik-Delmaire et al. address the nuclear function of Plakophilin-1. The authors show that Plakophilin-1 interacts with ssDNA in vitro and may have a function in protecting cells from DNA damage...
  11. doi request reprint The armadillo protein p0071 is involved in Rab11-dependent recycling
    Rene Keil
    Institute of Molecular Medicine, Division of Pathobiochemistry, Martin Luther University Halle, Hollystrasse 1, 06114 Halle, Germany
    J Cell Sci 127:60-71. 2014
    ....
  12. doi request reprint p0071/PKP4, a multifunctional protein coordinating cell adhesion with cytoskeletal organization
    Rene Keil
    Institute of Molecular Medicine, Division of Pathobiochemistry, Martin Luther University of Halle Wittenberg, D 06114 Halle, Germany
    Biol Chem 394:1005-17. 2013
    ..Moreover, an initial analysis of its regulation begins to shed light on how these functions are coordinated in a cellular context...
  13. ncbi request reprint The armadillo protein p0071 regulates Rho signalling during cytokinesis
    Annika Wolf
    Institute for Pathophysiology, Division of Pathobiochemistry, Martin Luther University Halle, Hollystrasse 1, 06114 Halle, Germany
    Nat Cell Biol 8:1432-40. 2006
    ..These findings support an essential role for p0071 in spatially regulating restricted Rho signalling during cytokinesis...
  14. ncbi request reprint Interaction between Erbin and a Catenin-related protein in epithelial cells
    Fanny Jaulin-Bastard
    U119 INSERM, Molecular Oncology, Institut Paoli Calmettes, Molecular Pharmacology, 27 boulevard Lei Roure 13009 Marseille, France
    J Biol Chem 277:2869-75. 2002
    ..We propose that Erbin is connected by p0071 to cytoskeletal networks in an interaction crucial for epithelial homeostasis...
  15. ncbi request reprint Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling
    Xinyu Chen
    Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 277:10512-22. 2002
    ....
  16. ncbi request reprint A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells
    Beate K Straub
    Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Cell Sci 116:4985-95. 2003
    ..We here discuss its possible functional importance for the maintenance of lens structure and functions, notably clear and sharp vision...
  17. pmc Defining desmosomal plakophilin-3 interactions
    Stefan Bonne
    Molecular Cell Biology Unit, Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology VIB Ghent University, B 9000 Ghent, Belgium
    J Cell Biol 161:403-16. 2003
    ....
  18. ncbi request reprint The Armadillo family protein p0071 is a VE-cadherin- and desmoplakin-binding protein
    Catharine C Calkins
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:1774-83. 2003
    ....
  19. pmc ZBP1 regulates mRNA stability during cellular stress
    Nadine Stöhr
    NBL3 Research Group, Zentrum für Angewandte Medizinische und Humanbiologische Forschung, Department of Medicine, Martin Luther University, 06120 Halle, Germany
    J Cell Biol 175:527-34. 2006
    ..These retain mRNAs in SGs and prevent premature decay in PBs. Hence, mRNA-binding proteins are essential for translational adaptation during cellular stress by modulating mRNA turnover...
  20. ncbi request reprint Emerging functions: diseases and animal models reshape our view of the cytoskeleton
    Thomas M Magin
    Institut fur Physiologische Chemie, Abteilung für Zellbiochemie and LIMES, Universitatsklinikum Bonn, D 53115 Bonn, Germany
    Exp Cell Res 301:91-102. 2004
    ..Understanding how mutation-induced disruption of the cytoskeleton and its upstream regulators causes disease at the molecular level presents one of the major challenges in future research...
  21. ncbi request reprint The mitotic-spindle-associated protein astrin is essential for progression through mitosis
    Jens Gruber
    Max Planck Institute for Biophysical Chemistry, Department of Biochemistry, Am Fassberg 11 37070 Göttingen, Germany
    J Cell Sci 115:4053-9. 2002
    ..Cells depleted of astrin were normal during interphase but were unable to progress through mitosis and finally ended in apoptotic cell death. Possible functions of astrin in mitotic spindle organization are discussed...