Affiliation: Martin Luther University
Gergs U, Berndt T, Buskase J, Jones L, Kirchhefer U, Müller F, et al
. On the role of junctin in cardiac Ca2+ handling, contractility, and heart failure. Am J Physiol Heart Circ Physiol. 2007;293:H728-34 pubmed
..Our results demonstrate that an increased expression of junctin is associated with an impaired Ca(2+) homeostasis. Downregulation of junctin in human heart failure may thus be a compensatory mechanism. ..
Gergs U, Mangold W, Langguth F, Hatzfeld M, Hauptmann S, Bushnaq H, et al
. Alterations of protein expression of phospholamban, ZASP and plakoglobin in human atria in subgroups of seniors. Sci Rep. 2019;9:5610 pubmed publisher
..It is tempting to speculate that increased expression of Cypher/ZASP may contribute to mechanical changes in the aging human myocardium. ..
Keller N, Dhein S, Neumann J, Gergs U. Cardiovascular effects of cisapride and prucalopride on human 5-HT4 receptors in transgenic mice. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:975-985 pubmed publisher
..We suggest that the present TG mouse model might be useful to predict at least some important cardiac effects of 5-HT4 receptor agonists in the human heart. ..
Gergs U, Boknik P, Buchwalow I, Fabritz L, Gründker N, Kucerova D, et al
. Modulation of cardiac contractility by serine/threonine protein phosphatase type 5. Int J Cardiol. 2012;154:116-21 pubmed publisher
..Overexpression of PP5 affected contractility and ?-adrenergic signaling in the hearts of transgenic mice. Taken together, these findings are indicative of a regulatory role of PP5 in cardiac function. ..
Gergs U, Böckler A, Ebelt H, Hauptmann S, Keller N, Otto V, et al
. Human 5-HT?receptor stimulation in atria of transgenic mice. Naunyn Schmiedebergs Arch Pharmacol. 2013;386:357-67 pubmed publisher
..The present data indicate that the human 5-HT4 receptors expressed in mouse atria are functional. This is the first transgenic model to study this human receptor in the atrium ex vivo or in vivo. ..
Gergs U, Fritsche J, Fabian S, Christ J, Neumann J. Desensitization of the human 5-HT4 receptor in isolated atria of transgenic mice. Naunyn Schmiedebergs Arch Pharmacol. 2017;390:987-996 pubmed publisher
..The exact mechanism and a potentially heterologous desensitization have to be elucidated by further investigations. ..
Gergs U, Jung F, Buchwalow I, Hofmann B, Simm A, Treede H, et al
. Pharmacological and physiological assessment of serotonin formation and degradation in isolated preparations from mouse and human heart. Am J Physiol Heart Circ Physiol. 2017;:ajpheart.00350.2017 pubmed publisher
..Conceivably, this formation of 5-HT and possibly impaired degradation may be clinically relevant in cases of unexplained tachycardia and other arrhythmias. ..