Michael Gekle

Summary

Affiliation: Martin Luther University
Country: Germany

Publications

  1. doi request reprint Actions of aldosterone in the cardiovascular system: the good, the bad, and the ugly?
    Michael Gekle
    Julius Bernstein Institut für Physiologie, Universität Halle Wittenberg, Magdeburger Strasse 6, 06097 Halle Saale, Germany
    Pflugers Arch 458:231-46. 2009
  2. doi request reprint Influence of aldosterone and salt or ouabain in a10 rat aorta smooth muscle cells
    Gerald Schwerdt
    Julius Bernstein Institut für Physiologie, Martin Luther Universitat Halle Wittenberg, Halle, Germany
    J Vasc Res 49:231-41. 2012
  3. doi request reprint Aldosterone/NaCl-induced renal and cardiac fibrosis is modulated by TGF-β responsiveness of T cells
    Barbara Schreier
    Medical Faculty, Julius Bernstein Institut für Physiologie, Universität Halle Wittenberg, Halle, Germany
    Hypertens Res 34:623-9. 2011
  4. doi request reprint Interaction between mineralocorticoid receptor and cAMP/CREB signaling
    Claudia Grossmann
    Julius Bernstein Institute of Physiology, Martin Luther University Halle Wittenberg, Magdeburger Str 6, 06097 Halle Saale, Germany
    Steroids 75:539-43. 2010
  5. doi request reprint Colocalization of mineralocorticoid and EGF receptor at the plasma membrane
    Claudia Grossmann
    Julius Bernstein Institut für Physiologie, Universität Halle Wittenberg, Halle, Germany
    Biochim Biophys Acta 1803:584-90. 2010
  6. pmc Mineralocorticoid receptor interaction with SP1 generates a new response element for pathophysiologically relevant gene expression
    Sandra Meinel
    Julius Bernstein Institut für Physiologie, Universität Halle Wittenberg, 06112 Halle Saale, Germany, Institut fur Informatik, Universität Halle Wittenberg, 06120 Halle Saale, Germany and Abteilung Molekulare Genetik, Leibniz Institut für Pflanzengenetik und Kulturpflanzenforschung IPK, 06466 Gatersleben, Germany
    Nucleic Acids Res 41:8045-60. 2013
  7. doi request reprint EF domains are sufficient for nongenomic mineralocorticoid receptor actions
    Claudia Grossmann
    Julius Bernstein Institut für Physiologie, Universität Halle Wittenberg, 06097 Halle, Germany
    J Biol Chem 283:7109-16. 2008
  8. doi request reprint The phosphatase calcineurin PP2BAβ mediates part of mineralocorticoid receptor transcriptional activity
    Anja Seiferth
    Julius Bernstein Institut für Physiologie, Universität Halle Wittenberg, Magdeburger Strasse 6, 06112 Halle Saale, Germany
    FASEB J 26:2327-37. 2012
  9. doi request reprint Nongenotropic aldosterone effects and the EGFR: interaction and biological relevance
    Claudia Grossmann
    Julius Bernstein Institute of Physiology, Martin Luther University Halle Wittenberg, Magdeburger Str 6, 06097 Halle Saale, Germany
    Steroids 73:973-8. 2008
  10. doi request reprint Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1
    Barbara Schreier
    Julius Bernstein Institute of Physiology, University of Halle Wittenberg, Halle, Germany
    Arterioscler Thromb Vasc Biol 31:1643-52. 2011

Collaborators

Detail Information

Publications17

  1. doi request reprint Actions of aldosterone in the cardiovascular system: the good, the bad, and the ugly?
    Michael Gekle
    Julius Bernstein Institut für Physiologie, Universität Halle Wittenberg, Magdeburger Strasse 6, 06097 Halle Saale, Germany
    Pflugers Arch 458:231-46. 2009
    ..In this way, aldosterone/MR induces or facilitates inflammatory and fibrotic processes in a permissive milieu, created for example by angiotensin II or NaCl and characterized by enhanced oxidative stress, in vascular walls...
  2. doi request reprint Influence of aldosterone and salt or ouabain in a10 rat aorta smooth muscle cells
    Gerald Schwerdt
    Julius Bernstein Institut für Physiologie, Martin Luther Universitat Halle Wittenberg, Halle, Germany
    J Vasc Res 49:231-41. 2012
    ..It is currently under debate whether aldosterone is able to induce fibrosis or whether it acts only as a cofactor under pathological conditions, e.g. as an elevated salt (NaCl) load...
  3. doi request reprint Aldosterone/NaCl-induced renal and cardiac fibrosis is modulated by TGF-β responsiveness of T cells
    Barbara Schreier
    Medical Faculty, Julius Bernstein Institut für Physiologie, Universität Halle Wittenberg, Halle, Germany
    Hypertens Res 34:623-9. 2011
    ....
  4. doi request reprint Interaction between mineralocorticoid receptor and cAMP/CREB signaling
    Claudia Grossmann
    Julius Bernstein Institute of Physiology, Martin Luther University Halle Wittenberg, Magdeburger Str 6, 06097 Halle Saale, Germany
    Steroids 75:539-43. 2010
    ....
  5. doi request reprint Colocalization of mineralocorticoid and EGF receptor at the plasma membrane
    Claudia Grossmann
    Julius Bernstein Institut für Physiologie, Universität Halle Wittenberg, Halle, Germany
    Biochim Biophys Acta 1803:584-90. 2010
    ..In conclusion, a subfraction of MR interacts with EGFR at the plasma membrane in our heterologous expression system, possibly at cholesterol-rich domains, to form a steroid receptor/growth factor receptor signaling module...
  6. pmc Mineralocorticoid receptor interaction with SP1 generates a new response element for pathophysiologically relevant gene expression
    Sandra Meinel
    Julius Bernstein Institut für Physiologie, Universität Halle Wittenberg, 06112 Halle Saale, Germany, Institut fur Informatik, Universität Halle Wittenberg, 06120 Halle Saale, Germany and Abteilung Molekulare Genetik, Leibniz Institut für Pflanzengenetik und Kulturpflanzenforschung IPK, 06466 Gatersleben, Germany
    Nucleic Acids Res 41:8045-60. 2013
    ..Overall, a novel principle of MR-specific gene expression is explored that applies to the pathophysiologically relevant expression of the EGFR and potentially also to other genes. ..
  7. doi request reprint EF domains are sufficient for nongenomic mineralocorticoid receptor actions
    Claudia Grossmann
    Julius Bernstein Institut für Physiologie, Universität Halle Wittenberg, 06097 Halle, Germany
    J Biol Chem 283:7109-16. 2008
    ..The minimum amino acid motif required for nongenomic MR signaling and its importance in various effects have yet to be determined...
  8. doi request reprint The phosphatase calcineurin PP2BAβ mediates part of mineralocorticoid receptor transcriptional activity
    Anja Seiferth
    Julius Bernstein Institut für Physiologie, Universität Halle Wittenberg, Magdeburger Strasse 6, 06112 Halle Saale, Germany
    FASEB J 26:2327-37. 2012
    ..Mechanistically, the crosstalk results from HSP90-mediated cytosolic protein complex formation, altered subcellular distribution, and altered endogenous inhibitor expression...
  9. doi request reprint Nongenotropic aldosterone effects and the EGFR: interaction and biological relevance
    Claudia Grossmann
    Julius Bernstein Institute of Physiology, Martin Luther University Halle Wittenberg, Magdeburger Str 6, 06097 Halle Saale, Germany
    Steroids 73:973-8. 2008
    ....
  10. doi request reprint Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1
    Barbara Schreier
    Julius Bernstein Institute of Physiology, University of Halle Wittenberg, Halle, Germany
    Arterioscler Thromb Vasc Biol 31:1643-52. 2011
    ..EGFR transactivation is proposed to contribute significantly to heterologous signaling and remodeling in vascular smooth muscle cells (VSMC)...
  11. doi request reprint Interaction between mineralocorticoid receptor and epidermal growth factor receptor signaling
    Claudia Grossmann
    Julius Bernstein Institute of Physiology, University of Halle Wittenberg, Magdeburger Strasse 6, Halle, Germany
    Mol Cell Endocrinol 350:235-41. 2012
    ..g. vascular function) MR effects. The current knowledge on the mechanisms of interaction and on the possible cellular and systemic physiological as well as pathophysiological relevance is reviewed in this article...
  12. doi request reprint Mineralocorticoid receptor inhibits CREB signaling by calcineurin activation
    Claudia Grossmann
    Julius Bernstein Institut für Physiologie, Universität Halle Wittenberg, Halle, Germany
    FASEB J 24:2010-9. 2010
    ..Overall, transcriptional relevant MR --> CREB crosstalk occurs at the level of CREB phosphorylation by enhanced calcineurin activity, enables GRE-independent genomic signaling of MR, and is of potential pathophysiological relevance...
  13. ncbi request reprint Cyclical mechanical stretch modulates expression of collagen I and collagen III by PKC and tyrosine kinase in cardiac fibroblasts
    Britta Husse
    Julius Bernstein Institute of Physiology, Martin Luther University of Halle, Germany
    Am J Physiol Regul Integr Comp Physiol 293:R1898-907. 2007
    ..Myocardial fibrosis due to ECM remodeling contributes to the dysfunction of the failing heart, which might be attributed to changes in hemodynamic loading...
  14. doi request reprint The food contaminant and nephrotoxin ochratoxin A enhances Wnt1 inducible signaling protein 1 and tumor necrosis factor-α expression in human primary proximal tubule cells
    Isabell Hennemeier
    Julius Bernstein Institut für Physiologie, Martin Luther Universitat Halle Wittenberg, Halle, Germany
    Mol Nutr Food Res 56:1375-84. 2012
    ..The underlying molecular mechanisms of nanomolar ochratoxin A (OTA) concentrations, especially those on pathophysiological relevant gene expression in target tissue and underlying signaling mechanisms are unknown...
  15. doi request reprint Differential reduction of HCN channel activity by various types of lipopolysaccharide
    Udo Klockner
    Julius Bernstein Institut für Physiologie, Martin Luther Universitat Halle Wittenberg, Halle, Germany
    J Mol Cell Cardiol 51:226-35. 2011
    ..In the clinical situation the observed modulation of HCN channels may slow down diastolic depolarization of pacemaker cells and, hence, influence heart rate variability and heart rate...
  16. ncbi request reprint Non-classical actions of the mineralocorticoid receptor: misuse of EGF receptors?
    Claudia Grossmann
    Julius Bernstein Institut für Physiologie, Universität Halle Wittenberg, Magdeburger Strasse 6, 06097 Halle, Saale, Germany
    Mol Cell Endocrinol 277:6-12. 2007
    ..Overall, MR's "misuse" of the EGFR is one possible explanation for the pathophysiological effects of aldosterone, making the EGFR a potential target for therapeutical interventions against reno-cardiovascular remodelling...
  17. doi request reprint Effect of ochratoxin A on cell survival and collagen homeostasis in human mesangial cells in primary culture
    Gerald Schwerdt
    Julius Bernstein Institut für Physiologie, Martin Luther Universitat Halle Wittenberg, Magdeburger Strasse 6, D 06097 Halle Saale, Germany
    Food Chem Toxicol 47:209-13. 2009
    ..We conclude that OTA has only a minor effect on human mesangial cells in primary culture. OTA did not influence collagen homeostasis substantially. Based on the data presented here, a risk of mesangial damage by OTA exposure is unlikely...