H Dralle

Summary

Affiliation: Martin Luther University
Country: Germany

Publications

  1. ncbi request reprint The prognostic value of primary tumor size in papillary and follicular thyroid carcinoma
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Cancer 103:2269-73. 2005
  2. ncbi request reprint [European consensus on the management of patients with differentiated carcinoma of the thyroid from follicular epithelium]
    F Pacini
    Vestn Khir Im I I Grek 167:52-6. 2008
  3. ncbi request reprint Minimally invasive video-assisted parathyroidectomy--selective approach to localized single gland adenoma
    H Dralle
    Zentrum für Chirurgie I, Martin Luther University, Halle, Germany
    Langenbecks Arch Surg 384:556-62. 1999
  4. ncbi request reprint Extended surgery and early postoperative radiotherapy for undifferentiated thyroid carcinoma
    A Machens
    Department of General Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Thyroid 11:373-80. 2001
  5. ncbi request reprint Prophylactic completion thyroidectomy for differentiated thyroid carcinoma: prediction of extrathyroidal soft tissue infiltrates
    A Machens
    Department of General Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Thyroid 11:381-4. 2001
  6. ncbi request reprint Codon-specific development of pheochromocytoma in multiple endocrine neoplasia type 2
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    J Clin Endocrinol Metab 90:3999-4003. 2005
  7. ncbi request reprint [Morbidity after subtotal and total thyroidectomy in patients with Graves' disease: the basis for decision-making regarding surgical indication and extent of resection]
    Henning Dralle
    Klinik fUr Allgemein, Viszeral und Geässchirurgie, Martin Luther Universitat Halle Wittenberg, Klinikum Kröllwitz, Halle Saale
    Z Arztl Fortbild Qualitatssich 98:45-53. 2004
  8. ncbi request reprint Surgery of resectable nonfunctioning neuroendocrine pancreatic tumors
    Henning Dralle
    Department of General, Visceral, and Vascular Surgery, Medical Faculty, University of Halle Wittenberg, Halle Saale, Ernst Grube Strasse 40, D 06097 Halle, Germany
    World J Surg 28:1248-60. 2004
  9. ncbi request reprint Diversification of minimally invasive parathyroidectomy for primary hyperparathyroidism: minimally invasive video-assisted parathyroidectomy and minimally invasive open videoscopically magnified parathyroidectomy with local anesthesia
    Kerstin Lorenz
    Department of Surgery, University of Halle Wittenberg, Ernst Grube Strasse 40, 06120 Halle Saale, Germany
    World J Surg 26:1066-70. 2002
  10. ncbi request reprint Multivariate analysis of clinicopathologic parameters for the insular subtype of differentiated thyroid carcinoma
    A Machens
    Department of General Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, D 06097 Halle Saale, Germany
    Arch Surg 136:941-4. 2001

Detail Information

Publications98

  1. ncbi request reprint The prognostic value of primary tumor size in papillary and follicular thyroid carcinoma
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Cancer 103:2269-73. 2005
    ..Threshold tumor diameters for extrathyroidal growth, lymph node spread, and distant metastasis in papillary (PTC) and follicular thyroid carcinoma (FTC) remain to be defined...
  2. ncbi request reprint [European consensus on the management of patients with differentiated carcinoma of the thyroid from follicular epithelium]
    F Pacini
    Vestn Khir Im I I Grek 167:52-6. 2008
  3. ncbi request reprint Minimally invasive video-assisted parathyroidectomy--selective approach to localized single gland adenoma
    H Dralle
    Zentrum für Chirurgie I, Martin Luther University, Halle, Germany
    Langenbecks Arch Surg 384:556-62. 1999
    ..The increasing sensitivity of preoperative localization methods and the possibility of intra-operative measurement of parathyroid hormone prepared the way for minimally invasive procedures...
  4. ncbi request reprint Extended surgery and early postoperative radiotherapy for undifferentiated thyroid carcinoma
    A Machens
    Department of General Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Thyroid 11:373-80. 2001
    ..Because pN1 and R2 patients with radiotherapy of 30 Gy or less comprised most UTC patients, only 1-year, but not median, survival improved compared to literature controls...
  5. ncbi request reprint Prophylactic completion thyroidectomy for differentiated thyroid carcinoma: prediction of extrathyroidal soft tissue infiltrates
    A Machens
    Department of General Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Thyroid 11:381-4. 2001
    ..Selective lymph node dissection alone does not seem capable of eliminating these soft tissue infiltrates from the cervicocentral compartment...
  6. ncbi request reprint Codon-specific development of pheochromocytoma in multiple endocrine neoplasia type 2
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    J Clin Endocrinol Metab 90:3999-4003. 2005
    ..Recent data suggest a codon-specific, age-related development of multiple endocrine neoplasia type 2...
  7. ncbi request reprint [Morbidity after subtotal and total thyroidectomy in patients with Graves' disease: the basis for decision-making regarding surgical indication and extent of resection]
    Henning Dralle
    Klinik fUr Allgemein, Viszeral und Geässchirurgie, Martin Luther Universitat Halle Wittenberg, Klinikum Kröllwitz, Halle Saale
    Z Arztl Fortbild Qualitatssich 98:45-53. 2004
    ..Subtotal thyroidectomy should be reserved for patients with low activity of Graves' goitre, where radioiodine treatment has a similar effect but without the risks associated with surgery...
  8. ncbi request reprint Surgery of resectable nonfunctioning neuroendocrine pancreatic tumors
    Henning Dralle
    Department of General, Visceral, and Vascular Surgery, Medical Faculty, University of Halle Wittenberg, Halle Saale, Ernst Grube Strasse 40, D 06097 Halle, Germany
    World J Surg 28:1248-60. 2004
    ..Adjuvant regimens in these tumor stages are mandatory and should be further optimized...
  9. ncbi request reprint Diversification of minimally invasive parathyroidectomy for primary hyperparathyroidism: minimally invasive video-assisted parathyroidectomy and minimally invasive open videoscopically magnified parathyroidectomy with local anesthesia
    Kerstin Lorenz
    Department of Surgery, University of Halle Wittenberg, Ernst Grube Strasse 40, 06120 Halle Saale, Germany
    World J Surg 26:1066-70. 2002
    ....
  10. ncbi request reprint Multivariate analysis of clinicopathologic parameters for the insular subtype of differentiated thyroid carcinoma
    A Machens
    Department of General Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, D 06097 Halle Saale, Germany
    Arch Surg 136:941-4. 2001
    ..Insular carcinoma represents a more aggressive subtype of differentiated thyroid cancer on multivariate analysis after controlling for various clinicopathologic parameters...
  11. ncbi request reprint Mycotic aneurysm of common carotid artery induced by Staphylococcus aureus infection after cervical reoperation
    A Machens
    Department of General Surgery, Martin Luther University, Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    World J Surg 25:1113-6. 2001
    ..It is important to recognize this novel type of mycotic aneurysm, as it must be repaired immediately to anticipate imminent rupture...
  12. ncbi request reprint The tall-cell variant of papillary thyroid carcinoma: a multivariate analysis of clinical risk factors
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University of Halle Wittenberg, Ernst Grube Strasse 40, 06097 Halle Saale, Germany
    Langenbecks Arch Surg 389:278-82. 2004
    ..The biological behaviour of the tall-cell variant (TCV) of papillary thyroid carcinoma (PTC) remains to be clarified in a multivariate analysis that controls for all relevant clinicopathological parameters...
  13. ncbi request reprint Surgery on the cervicovisceral axis for invasive thyroid cancer
    A Machens
    Department of General Surgery, Martin Luther University, Halle Wittenberg, Ernst Grube Strasse 40, 06097 Halle Saale, Germany
    Langenbecks Arch Surg 386:318-23. 2001
    ..Invasion of the cervicovisceral axis (i.e., larynx trachea esophagus) by thyroid cancers still poses a surgical challenge...
  14. ncbi request reprint Contralateral cervical and mediastinal lymph node metastasis in medullary thyroid cancer: systemic disease?
    Andreas Machens
    Departments of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Salle, Germany
    Surgery 139:28-32. 2006
    ....
  15. ncbi request reprint The impact of HLA on long-term outcome after thymectomy for myasthenia gravis
    A Machens
    Department of Surgery, University Hospital Eppendorf, Hamburg, Germany
    J Neuroimmunol 88:177-81. 1998
    ..The observation that an MHC class I allele is associated with clinical improvement after thymectomy suggests that the clinical course of myasthenia may be influenced by class I restricted T-cells...
  16. ncbi request reprint Skip metastases in thyroid cancer leaping the central lymph node compartment
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle, Germany
    Arch Surg 139:43-5. 2004
    ..Discontinuous nodal metastasis, or skip metastasis, in thyroid cancer may display clinicopathologic features different from those seen in continuous nodal metastasis and thus may have a different prognosis...
  17. ncbi request reprint Prospects of remission in medullary thyroid carcinoma according to basal calcitonin level
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, 06097 Halle Saale, Germany
    J Clin Endocrinol Metab 90:2029-34. 2005
    ..Preoperative basal calcitonin levels may thus help individualize the extent of surgery and postoperative follow-up intervals for MTC...
  18. ncbi request reprint Are there acid base changes during transurethral resection of the prostate (TURP)?
    S Scheingraber
    Clinic of Anesthesiology, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany
    Anesth Analg 90:946-50. 2000
    ..As the constellation of independently pH regulating variables appears to be typical for TURP, this acidosis could be named "TURP-acidosis."..
  19. ncbi request reprint Enhancement of lymph node metastasis and distant metastasis of thyroid carcinoma
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Cancer 98:712-9. 2003
    ..The mechanisms of local and distant metastases are imperfectly understood. The goal of the current study was to add to the body of knowledge regarding local and distant metastases of thyroid malignancies...
  20. ncbi request reprint Differential diagnosis of calcitonin-secreting neuroendocrine carcinoma of the foregut by pentagastrin stimulation
    A Machens
    Department of General Surgery, Martin Luther University Halle Wittenberg, Germany
    Langenbecks Arch Surg 385:398-401. 2000
    ..This study assessed the suitability of pentagastrin stimulation in hypercalcitoninaemia for differential diagnosis of neuroendocrine carcinoma of the foregut...
  21. ncbi request reprint Primary hereditary medullary thyroid carcinoma--C-cell morphology and correlation with preoperative calcitonin levels
    R Hinze
    Martin Luther University of Halle Wittenberg, Institute of Pathology, Faculty of Medicine, Halle, Germany
    Virchows Arch 433:203-8. 1998
    ..Prophylactic thyroidectomy is justified at the age of 6 to anticipate development of a MTC. Lymphadenectomy is necessary in children if they are older than 10 years or have elevated plasma CT levels...
  22. ncbi request reprint Simultaneously occurring liver metastases of pheochromocytoma and medullary thyroid carcinoma--a diagnostic pitfall with clinical implications for patients with multiple endocrine neoplasia type 2a
    R Hinze
    Institute of Pathology, Martin Luther University, Halle, Germany
    Pathol Res Pract 196:477-81. 2000
    ..A misinterpretation could lead to harmful clinical complications, as shown in the present case...
  23. ncbi request reprint Advances in the management of hereditary medullary thyroid cancer
    A Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Intern Med 257:50-9. 2005
    ..Uncovering molecular pathways from RET genotype to MEN 2 phenotype should provide treatment options for RET mutation carriers whose MTC currently is too advanced for cure...
  24. ncbi request reprint [Lymphadenectomy for thyroid and lymph node carcinomas]
    O Gimm
    Universitäts und Poliklinik für Allgemein, Viszeral und Gefässchirurgie, Martin Luther Universitat Halle Wittenberg, Halle Saale
    Chirurg 78:182, 184-8, 190-3. 2007
    ..Lymph node dissection should always be performed systematically, since lymph node metastases may be missed both clinically and by imaging techniques...
  25. ncbi request reprint Medullary thyroid carcinoma
    M Brauckhoff
    Department of General, Visceral, and Vascular Surgery, Martin Luther University of Halle Wittenberg, Halle Saale, Germany
    Scand J Surg 93:249-60. 2004
    ....
  26. ncbi request reprint An update on thyroid surgery
    O Gimm
    Universität und Poliklinik für Allgemein, Viszeral und Gefässchirurgie, Ernst Grube Strasse 40, 06097 Halle, Germany
    Eur J Nucl Med Mol Imaging 29:S447-52. 2002
    ..Surgery will certainly continue to play an important role in the treatment of thyroid diseases and may be increasingly based on individual findings instead of general recommendations...
  27. ncbi request reprint Monitoring of acid-base and regulating variables during abdominal lavage
    S Scheingraber
    Department of Surgery, University Hospital, Homburg Saar, Halle Saale, Germany
    Anaesth Intensive Care 32:637-43. 2004
    ..Monitoring of the Stewart variables is an easily applicable method of monitoring acid-base regulating variables in the perioperative course of patients undergoing abdominal lavage therapy...
  28. doi request reprint Intraoperative monitoring of the recurrent laryngeal nerve in thyroid surgery
    H Dralle
    Department of General, Visceral and Vascular Surgery, Martin Luther University of Halle, Ernst Grube Str 40, D 06097 Halle Saale, Germany
    World J Surg 32:1358-66. 2008
    ..Nevertheless, a systematic evidence-based assessment of this novel health technology has not been performed...
  29. ncbi request reprint Thyroid carcinoma invading the cervicovisceral axis: routes of invasion and clinical implications
    A Machens
    Department of General Surgery, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany
    Surgery 129:23-8. 2001
    ..To keep nodal metastasis from encroaching onto the cervicovisceral axis, paratracheal and paraesophageal lymph nodes should be cleared from the cervicocentral compartment at the primary operation...
  30. ncbi request reprint Importance of early screening and prophylactic thyroidectomy in asymptomatic nonindex RET germline carriers
    J Ukkat
    Department of General Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    World J Surg 25:713-7. 2001
    ..Pathologic conversion of stimulated serum calcitonin obviously marks the time in carriers of RET germline mutations when surgery should be scheduled at the latest to be prophylactic...
  31. doi request reprint [Current TNM system of the UICC/AJCC : the prognostic significance for differentiated thyroid carcinoma]
    M Stratmann
    Klinik fUr Allgemein, Viszeral und Gefäßchirurgie, Universitätsklinikum Halle, Halle, Deutschland
    Chirurg 83:646-51. 2012
    ..The aim of study was an evaluation of prognostic factors of the current TNM version (UICC/AJCC 2009, 7th revision) for differentiated thyroid carcinoma (DTC)...
  32. ncbi request reprint Minimally invasive video-assisted parathyroidectomy: multiinstitutional study
    K Lorenz
    Department of General Surgery, Martin-Luther-University of Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097 Halle/Saale, Germany
    World J Surg 25:704-7. 2001
    ..Further studies are necessary to evaluate the efficacy and rationale of MIVAP compared to other techniques for parathyroidectomy in pHPT patients...
  33. doi request reprint [Intraoperative neuromonitoring of thyroid gland operations : Surgical standards and aspects of expert assessment]
    H Dralle
    Klinik fUr Allgemein, Viszeral und Gefässchirurgie, Universitätsklinikum Halle, Medizinische Fakultät der Universität Halle Wittenberg, Halle Saale
    Chirurg 81:612-9. 2010
    ..For expert assessment purposes documentation of the standardized application of IONM is of utmost importance...
  34. ncbi request reprint Regulation of proliferation and apoptosis in sporadic and hereditary medullary thyroid carcinomas and their putative precursor lesions
    R Hinze
    Martin Luther University of Halle Wittenberg, Faculty of Medicine, Institute of Pathology, Halle, Germany
    Virchows Arch 437:256-63. 2000
    ..Certain alterations of RET are supposed to have a direct or indirect implication on proliferation and, because of this, an effect on the clinical course...
  35. doi request reprint Loss of the nerve monitoring signal during bilateral thyroid surgery
    H Dralle
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle, Germany
    Br J Surg 99:1089-95. 2012
    ..It explored the willingness of surgeons to change strategy after loss of signal (LOS) on the first side of resection...
  36. ncbi request reprint [Recurrent operations on the adrenal glands]
    M Brauckhoff
    Klinik fUr Allgemein, Viszeral und Gefässchirurgie, Martin Luther Universitat Halle Wittenberg, Halle Saale
    Chirurg 76:227-37. 2005
    ..Following subtotal adrenalectomy, the risk of ipsilateral recurrence correlates with disease, follow-up, localization, size of the adrenal remnant, and, in case of familial pheochromocytoma, probably with genotype...
  37. doi request reprint Prediction of lateral lymph node metastases in medullary thyroid cancer
    A Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Br J Surg 95:586-91. 2008
    ..In medullary thyroid cancer (MTC), there is a concordance between central and lateral neck involvement, but this relationship has not been assessed quantitatively...
  38. doi request reprint [Identification of the recurrent laryngeal nerve and parathyroids in thyroid surgery]
    H Dralle
    Medizinische Fakultät der Martin Luther Universität Halle Wittenberg, Universitätsklinikum Halle Saale, Ernst Grube Strasse 40, Halle, Germany
    Chirurg 80:352-63. 2009
    ....
  39. doi request reprint [Hereditary thyroid cancer]
    H Dralle
    Universitätsklinik für Allgemein, Viszeral und Gefässchirurgie, Universitätsklinikum Halle, Medizinische Fakultät der Martin Luther Universität Halle Wittenberg, Halle Saale, Ernst Grube Strasse 40, 06097, Halle
    Chirurg 79:1017-28. 2008
    ..Regarding time and extent of prophylactic thyroidectomy (without or with lymph node dissection) a combined molecular-biochemical concept including the use of pentagastrin-stimulated calcitonin values is therefore recommended...
  40. ncbi request reprint [Surgery of the thyroid gland. I]
    C L Weiss
    Martin Luther Universitat Halle Wittenberg, Universitätsklinik für Allgemeinchirurgie, Halle Saale
    Zentralbl Chir 129:W76-83. 2004
  41. ncbi request reprint [Thyroid surgery: generalist or specialist?]
    H Dralle
    Klinik fUr Allgemein, Viszeral und Gefässchirurgie, Martin Luther Universitat Halle Wittenberg, Klinikum Kröllwitz, Halle
    Zentralbl Chir 130:428-32; discussion 433. 2005
    ..To perform thyroid operations by so called "generalists" or "specialists" have been discussed intensively, however, this issue have not been analyzed in detail...
  42. ncbi request reprint [Surgical treatment of hyperparathyroidism]
    K Lorenz
    Klinik fUr Allgemein, Viszeral und Gefässchirurgie, Martin Luther Universitat Halle Wittenberg
    Chirurg 74:593-615; quiz 615-6. 2003
  43. ncbi request reprint [Not all vocal cord failure following thyroid surgery is recurrent paresis due to damage during operation. Statement of the German Interdisciplinary Study Group on Intraoperative Neuromonitoring of Thyroid Surgery concerning recurring paresis due to intub
    H Dralle
    Universitätsklinik für Allgemein, Viszeral und Gefässchirurgie, Martin Luther Universitat Halle Wittenberg, Halle Saale
    Chirurg 75:810-22. 2004
    ..The use of these methods to identify the nature of postoperative recurrent laryngeal nerve palsy is recommended in cases of regular intraoperative neuromonitoring but postoperatively impaired function of the vocal cords...
  44. ncbi request reprint [Prophylactic parathyroidectomy for familial parathyroid carcinoma]
    O Gimm
    Klinik fUr Allgemein, Viszeral und Gefässchirurgie, Martin Luther Universitat Halle Wittenberg
    Chirurg 77:15-24. 2006
    ..Of note in patients thought to have sporadic parathyroid carcinoma, germline HRPT2 mutations are found in up to 20%. Hence, any patient with parathyroid carcinoma should undergo HRPT2 mutation analysis...
  45. ncbi request reprint Calcitonin kinetics in the early postoperative period of medullary thyroid carcinoma
    M Brauckhoff
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, 06097 Halle Saale, Germany
    Langenbecks Arch Surg 386:434-9. 2001
    ..Furthermore, we wanted to test the prognostic impact of the calcitonin kinetics. Therefore, only patients with postoperative normalisation of calcitonin levels (biochemical cure) were included in this study...
  46. ncbi request reprint Genotype-phenotype correlations in hereditary medullary thyroid carcinoma: oncological features and biochemical properties
    A Machens
    Department of General Surgery, Martin Luther University Halle Wittenberg, D 06097 Halle Saale, Germany
    J Clin Endocrinol Metab 86:1104-9. 2001
    ..The current data demonstrate that there is a significant genotype-phenotype correlation, allowing for a more individualized approach to the timing and extent of prophylactic surgery...
  47. doi request reprint [Endocrine surgery for neck paraganglioma: operation, radiation therapy or wait and scan?]
    R Schneider
    Universitätsklinik und Poliklinik für Allgemein, Viszeral und Gefässchirurgie, Martin Luther Universitat, Ernst Grube Str 40, 06120, Halle Saale, Deutschland
    Chirurg 83:1060-7. 2012
    ..g. tumor size, localization and dignity), age of patient and symptoms. In terms of local control radiation therapy is as equally effective as surgery but surgical morbidity rates secondary to cranial nerve injuries remain high...
  48. ncbi request reprint [Ambulatory and brief inpatient thyroid gland and parathyroid gland surgery]
    H Dralle
    Klinik fUr Allgemein, Viszeral und Gefässchirurgie, Martin Luther Universitat Halle Wittenberg, Halle Saale
    Chirurg 75:131-43. 2004
    ..Also, prophylactic calcium supplementation is not recommended to enhance early hospital discharge after bilateral thyroid or parathyroid surgery...
  49. doi request reprint Age disparities in referrals to specialist surgical care for papillary thyroid cancer
    A Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle, Saale, Germany
    Eur J Surg Oncol 35:1312-7. 2009
    ..This study sought to clarify whether younger patients with papillary thyroid cancer are referred more often because of their more frequent and more numerous lymph node metastases or because of age alone...
  50. ncbi request reprint Diagnosis and therapy of sporadic and familial medullary thyroid carcinoma
    O Gimm
    Klinik für Allgemeinchirurgie, Martin Luther Universitat Halle Wittenberg, Ernst Grube Strasse 40 42, 06097 Halle Saale, Germany
    J Cancer Res Clin Oncol 127:156-65. 2001
    ..The only indication to perform a less extensive operation may be given in young patients with hMTC. Sufficient treatment of MTC beyond local disease is still non-existent. Future research should concentrate on this issue...
  51. ncbi request reprint [Subtotal bilateral adrenalectomy preserving adrenocortical function]
    M Brauckhoff
    Klinik fUr Allgemein, Viszeral und Gefässchirurgie, Martin Luther Universitat, Halle Wittenberg, Halle Saale
    Chirurg 74:646-51. 2003
    ..At our institution, particularly in patients with inherited pheochromocytoma, subtotal adrenalectomy has become a common surgical strategy...
  52. ncbi request reprint Prediction of mediastinal lymph node metastasis in medullary thyroid carcinoma
    A Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    Br J Surg 91:709-12. 2004
    ....
  53. ncbi request reprint Referral bias in thyroid cancer surgery: direction and magnitude
    A Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    Eur J Surg Oncol 34:556-62. 2008
    ..This study was conducted to clarify the impact of referral bias in thyroid cancer surgery...
  54. doi request reprint Constitutive RET tyrosine kinase activation in hereditary medullary thyroid cancer: clinical opportunities
    A Machens
    The Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, Halle Saale D 06097, Germany
    J Intern Med 266:114-25. 2009
    ..Better comprehension of RET function should enable the design of targeted therapies for RET carriers beyond surgical cure in whom the DNA-based 'window of opportunity' has been missed...
  55. ncbi request reprint Limits of peritoneal cytokine measurements during abdominal lavage treatment for intraabdominal sepsis
    S Scheingraber
    Department of General Surgery, Rheinische Friedrich Wilhelms University, Sigmund Freud Strasse 25, D 53105, Bonn, Germany
    Am J Surg 181:301-8. 2001
    ..In the present study the clinical application of cytokine monitoring was examined in the treatment course of severe peritonitis...
  56. doi request reprint [Intraoperative parathyroid hormone determination for primary hyperparathyroidism]
    K Lorenz
    Klinik fUr Allgemein, Viszeral und Gefässchirurgie, Universitätsklinikum Halle, Universität Halle Wittenberg, Halle Saale
    Chirurg 81:636, 638-42. 2010
    ..This article gives an up-date on current knowledge and provides practical guidelines for clinical use of IOPTH...
  57. ncbi request reprint Lymph node dissection and medullary thyroid carcinoma
    H Dralle
    Department of General, Visceral and Vascular Surgery, University of Halle, Klinikum Kröllwitz, Ernst Grube Strasse 40, D 06097 Halle, Germany
    Br J Surg 89:1073-5. 2002
  58. ncbi request reprint [Is primary total thyroidectomy justified in benign multinodular goiter? Results of a prospective quality assurance study of 45 hospitals offering different levels of care]
    O Thomusch
    Klinik fUr Allgemein, Viszeral und Gefässchirurgie, Martin Luther Universitat Halle Wittenberg
    Chirurg 74:437-43. 2003
    ..Because of the increased morbidity of surgery for recurrent goiter, this study evaluated the preconditions that would justify total thyroidectomy as part of the primary therapy concept for benign multinodular goiter...
  59. ncbi request reprint Frequent promoter methylation of tumor-related genes in sporadic and men2-associated pheochromocytomas
    R Dammann
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Exp Clin Endocrinol Diabetes 113:1-7. 2005
    ..Combined methylation of RASSF1 A and p16 was found only in MEN2-related pheochromocytomas. Thus, a subset of hereditary pheochromocytomas displays preferential methylation of p16 and RASSF1 A...
  60. doi request reprint [Preoperative α-adrenoceptor block in asymptomatic pheochromocytoma? Pro]
    L Bräcker
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Universitätsklinikum Halle Saale, Ernst Grube Str 40, 06120, Halle Saale, Deutschland
    Chirurg 83:546-50. 2012
    ..This article discusses the question if preoperative α-adrenoceptor block is also indicated in asymptomatic pheochromocytomas based on the current literature...
  61. doi request reprint Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas
    J Braun
    Department of Molecular Cell Biology, Martin Luther University Halle Wittenberg, Halle, Germany
    Oncogene 29:4237-44. 2010
    ..Hence, TGFBR1 inhibition could have a significant potential for the treatment of ATCs and possibly other invasive tumors...
  62. ncbi request reprint Regulation of CD97 protein in thyroid carcinoma
    C Hoang-Vu
    Klinik für Allgemeinchirurgie, Martin Luther Universitat Halle Wittenberg, Halle, Germany
    J Clin Endocrinol Metab 84:1104-9. 1999
    ..These data suggest that CD97 expression may play an important role in the dedifferentiation of thyroid tumors, and RA might interfere with this process in thyroid carcinoma by suppressing the dedifferentiation marker CD97...
  63. doi request reprint [Surgery of thyroid carcinoma]
    H Dralle
    Universitätsklinik für Allgemein, Viszeral und Gefässchirurgie, Universitätsklinikum Halle Saale, Medizinische Fakultät der Martin Luther Universität Halle Wittenberg, 06097 Halle
    Chirurg 80:1069-82; quiz 1083. 2009
    ..Differentiated carcinomas may have an acceptable prognosis despite local invasion of the cervical aerodigestive system, thus resections are justified when technical prerequisites are given...
  64. ncbi request reprint ["Physiological" and "neoplastic" C-cell hyperplasia of the thyroid. Morphologically and biologically distinct entities?]
    R Hinze
    Institut fur Pathologie, Martin Luther Universitat Halle Wittenberg
    Pathologe 22:259-65. 2001
    ..The preneoplastic potential of sporadic CCH is still obscure. A pure morphological distinction between "physiologic" and "neoplastic" CCH regardless of the RET status should not be used...
  65. ncbi request reprint [Therapy and course of disease in spontaneous esophageal perforations]
    F Thermann
    Klinik fUr Allgemein, Viszeral und Gefässchirurgie, Medizinische Fakultät Universität Halle, Universitätsklinikum Halle Kröllwitz
    Zentralbl Chir 131:454-9. 2006
    ..Esophageal perforations occur spontaneously or as a complication of endoscopic procedures. Especially in spontaneous perforation there is ongoing debate regarding the best treatment options...
  66. doi request reprint [Thyroid carcinoma found incidentally after thyroidectomy: postoperative strategy]
    H Dralle
    Universitätsklinik für Allgemein, Viszeral und Gefässchirurgie, Universitätsklinikum Halle, Medizinische Fakultät der Martin Luther Universität Halle Wittenberg, Halle Saale
    Dtsch Med Wochenschr 134:2517-20. 2009
    ..Lateral node dissection is recommended in nodal-positive MTC and in PTC with more than 5 lymph node metastases in the central compartment...
  67. ncbi request reprint [Thyroid incidentaloma. Overdiagnosis and overtreatment of healthy persons with thyroid illness?]
    H Dralle
    Klinik fUr Allgemein, Viszeral und Gefässchirurgie, Universitätsklinikum Halle Saale
    Chirurg 78:677-86. 2007
    ..Frozen selection and/or early final histopathology should be available to avoid two-stage thyroid cancer operations...
  68. ncbi request reprint [Management of fatal postoperative hemorrhage after subtotal thyroidectomy. Individual error or structural deficit--a suitable case for discussion of the multi-specialty on-call team service? Critical comment on the decision by the Augsburg District Court
    H Dralle
    Klinik fUr Allgemein, Viszeral und Gefässchirurgie, Klinikum Kröllwitz, Martin Luther Universitat Halle Wittenberg, Ernst Grube Strasse 40, 06097 Halle Saale
    Chirurg 77:454-8. 2006
  69. doi request reprint [Surgical strategies for accidental detection of appendix carcinoids]
    H Dralle
    Universitätsklinik und Poliklinik für Allgemein, Viszeral und Gefäßchirurgie, Universitätsklinikum Halle Saale, Medizinische Fakultät der Martin Luther Universität Halle, Ernst Grube Strasse 40, Halle, Germany
    Chirurg 82:598-606. 2011
    ..Follow-up examination should therefore also consider both appendix carcinoids and synchronous or metachronous neoplasms of the gastrointestinal tract...
  70. doi request reprint [Diagnostic error and the patient's rights act]
    S Muller
    Lehrstuhl für Strafrecht, Strafprozessrecht, Rechtsvergleichung und Medizinrecht, Martin Luther Universitat Halle Wittenberg, Universitätsplatz 6, 06108, Halle Saale, Deutschland
    Chirurg 84:143-8. 2013
    ..In the new patients' rights act the burden of proof is established by law. Thereafter in principle the patient must still prove that the doctor made a mistake and that this was the cause of the damage...
  71. ncbi request reprint Primary surgery for differentiated thyroid cancer in the new millennium
    H Dralle
    Department of General, Visceral and Vascular Surgery, Medical Faculty, University of Halle Wittenberg, University Hospital, Ernst Grube Strasse 40, Halle Saale, Germany
    J Endocrinol Invest 35:10-5. 2012
    ....
  72. ncbi request reprint [Primary operative gastrostomy or percutaneous endoscopic gastrostomy (PEG) in progressive oesophageal carcinomas? A case report on abdominal wall metastases following PEG]
    F Thermann
    Klinik fUr Allgemein, Viszeral und Gefässchirurgie, Universitätsklinikum Halle Kröllwitz, Halle, Germany
    Chirurg 73:1132-5. 2002
    ..However, as a late complication, the development of abdominal wall metastases have been described, the mechanism of which is controversially...
  73. ncbi request reprint Immunohistochemical and clinical evaluation of cathepsin expression in soft tissue sarcomas
    P Wurl
    Clinic of General Surgery, Martin Luther University of Halle Wittenberg, Germany
    Virchows Arch 430:221-5. 1997
    ..Cathepsin S expression is also correlated with the local recurrence rate (P < 0.01). Lysosomal proteases may play a role in STS progression, and cathepsin expression may also have significance as a prognostic factor in STS...
  74. ncbi request reprint Management of mycoses in surgical patients -- review of the literature
    Rene G Holzheimer
    Department of Surgery, Martin Luther University, Halle Wittenberg, Germany
    Eur J Med Res 7:200-26. 2002
    ..Newer azoles, e.g. voriconazole, demonstrated stable activity against most of these strains and may offer an option in the treatment of refractory fungal infections...
  75. ncbi request reprint 25-hydroxyvitamin D3 1alpha-hydroxylase and vitamin D receptor expression in papillary thyroid carcinoma
    K Khadzkou
    Department of Surgical Sciences, University Hospital, Uppsala, Sweden
    J Histochem Cytochem 54:355-61. 2006
    ..Expression of VDR and 1-alpha-hydroxylase in PTC may be compatible with an overall favorable prognosis for this tumor type and may constitute important prerequisites for using vitamin D and/or vitamin D analogs in the treatment of PTC...
  76. ncbi request reprint Mutations of the ret protooncogene in German multiple endocrine neoplasia families: relation between genotype and phenotype. German Medullary Thyroid Carcinoma Study Group
    K Frank-Raue
    Medizinische Universitatsklinik, Heidelberg, Germany
    J Clin Endocrinol Metab 81:1780-3. 1996
    ....
  77. ncbi request reprint "Operative treatment of renal autonomous hyperparathyroidism: causes for persistent or recurrent disease in 304 patients" (comments on C. Dotzenrath et al.)
    H Dralle
    Langenbecks Arch Surg 387:392-4. 2003
  78. ncbi request reprint [Does intraoperative nerve monitoring reduce the rate of recurrent nerve palsies during thyroid surgery?]
    W Timmermann
    Chirurgische Universitätsklinik Würzburg, Grmany
    Zentralbl Chir 127:395-9. 2002
    ....
  79. ncbi request reprint [Intraoperative neuromonitoring in thyroid surgery and surgery of the parathyroid gland]
    H Dralle
    Zentralbl Chir 127:393-4. 2002
  80. ncbi request reprint [Benign and malignant pheochromocytoma]
    H Lehnert
    Klinikum der Otto von Guericke Universität Magdeburg, Klinik für Endokrinologie und Stoffwechselkrankheiten, Leipziger Strasse 44, 39120 Magdeburg
    Internist (Berl) 43:196, 199-209. 2002
  81. ncbi request reprint [Quality assurance study of benign and malignant goiter. Prospective multicenter data collection regarding 7,617 patients]
    O Thomusch
    ,
    Zentralbl Chir 126:664-71. 2001
    ..4 days longer in hospital than those with unilateral procedures. Prophylactic antibiotics were administered to 2.1% of patients and 94.6% received thrombosis prophylaxis...
  82. ncbi request reprint Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma
    O Gimm
    Clinical Cancer Genetics and Human Cancer Genetics Programs, Comprehensive Cancer Centre, and Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, OH 43210, USA
    Oncogene 20:2161-70. 2001
    ....
  83. ncbi request reprint [Multi-modality therapy concept in metastatic follicular thyroid carcinoma with hyperthyroidism]
    M Brauckhoff
    ,
    Chirurg 72:37-42. 2001
    ..After radioiodine therapy the patient became euthyroid. Treatment of hyperthyreosis in metastatic thyroid cancer requires a multimodal therapeutic concept...
  84. pmc HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours
    V M Howell
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, Michigan 49503, USA
    J Med Genet 40:657-63. 2003
    ..Hyperparathyroidism is a common endocrinopathy characterised by the formation of parathyroid tumours. In this study, we determine the role of the recently identified gene, HRPT2, in parathyroid tumorigenesis...
  85. ncbi request reprint Calcitonin measurement to detect medullary thyroid carcinoma in nodular goiter: German evidence-based consensus recommendation
    W Karges
    Department of Internal Medicine, University of Ulm, Ulm, Germany
    Exp Clin Endocrinol Diabetes 112:52-8. 2004
    ..Therefore, regular clinical and biochemical follow-up is the preferred treatment in such patients, unless thyroid malignancy is suspected otherwise...
  86. ncbi request reprint Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome
    B T Teh
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Hum Genet 114:221. 2004
  87. ncbi request reprint Evaluation of peroxisome proliferator-activated receptor-gamma expression in benign and malignant thyroid pathologies
    S Karger
    III Medical Department, University of Leipzig, Leipzig, Germany
    Thyroid 15:997-1003. 2005
    ..The marked downregulation of PPAR-gamma in GD warrants further investigation and could be linked, for example, with changes in apoptosis...
  88. ncbi request reprint Angiography-proven liver metastases explain low efficacy of lymph node dissections in medullary thyroid cancer patients
    A Machens
    Eur J Surg Oncol 31:1051-2. 2005
  89. ncbi request reprint Evaluation of insulin-like growth factor II, cyclooxygenase-2, ets-1 and thyroid-specific thyroglobulin mRNA expression in benign and malignant thyroid tumours
    D Fuhrer
    III Medical Department, University of Leipzig, Ph Rosenthal Str 27, 04103 Leipzig, Germany
    Eur J Endocrinol 152:785-90. 2005
    ....
  90. ncbi request reprint Long-term outcome in 46 gene carriers of hereditary medullary thyroid carcinoma after prophylactic thyroidectomy: impact of individual RET genotype
    K Frank-Raue
    Endokrinologische Gemeinschaftspraxis, 69120 Heidelberg, Germany
    Eur J Endocrinol 155:229-36. 2006
    ..Recommendations on the timing and extent of thyroidectomy are based upon a model that utilises genotype-phenotype correlations to stratify mutations into three risk groups...
  91. ncbi request reprint [Surgery of the thyroid gland. 2]
    C L Weiss
    Martin Luther Universitat Halle Wittenberg, Klinikum der medizinischen Fakultät Zentrum für Chirurgie, Universitätsklinik und Poliklinik für Allgemein, Viszeral und Gefässchirurgie
    Zentralbl Chir 129:W86-97; quiz W98-9. 2004
  92. ncbi request reprint [Effectiveness and results of intraoperative neuromonitoring in thyroid surgery. Statement of the Interdisciplinary Study Group on Intraoperative Neuromonitoring of Thyroid Surgery]
    W Timmermann
    Universitatsklinik fur Chirurgie, Wurzburg, Germany
    Chirurg 75:916-22. 2004
    ..If the neuromonitoring signal changed during operation, 39% of the patients suffered from transient vocal cord immobility and 12% had permanent loss of vocal cord function...
  93. ncbi request reprint Follicular thyroid carcinoma: metastasis to the sternum or adjacent tumour invasion by continuity?
    A Machens
    Int J Clin Pract 61:521; author reply 521-2. 2007
  94. ncbi request reprint Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome
    B T Teh
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Hum Genet 114:224. 2004
  95. ncbi request reprint Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome
    B T Teh
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Hum Genet 114:223. 2004
  96. ncbi request reprint Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome
    B T Teh
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Hum Genet 114:223. 2004
  97. ncbi request reprint Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome
    B T Teh
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Hum Genet 114:222. 2004
  98. ncbi request reprint Cytology and mRNA expression analysis of fine needle aspirates of thyroid nodules in an East German region with borderline iodine deficiency
    S Karger
    III Medical Department, University of Leipzig, Ph Rosenthal Strasse 27, 04103 Leipzig, Germany
    Horm Metab Res 38:662-7. 2006
    ....