Research Topics
| D D MartinSummaryCountry: Germany Publications
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Detail Information
Publications
Growth hormone-induced increases in skeletal muscle mass alleviates the associated insulin resistance in short children born small for gestational age, but not with growth hormone deficiencyDavid D Martin
University Children s Hospital, Tubingen, Germany
Horm Res 72:38-45. 2009....
Comparison of radiogrammetrical metacarpal indices in children and reference data from the First Zurich Longitudinal StudyDavid D Martin
Pediatric Endocrinology and Diabetology, University Children s Hospital Tubingen, Hoppe Seyler Str 1, 72076 Tuebingen, Germany
Pediatr Radiol 42:982-91. 2012..A number of radiogrammetrical metacarpal indices are in use, some of which have been adapted for children...
Validation of automatic bone age rating in children with precocious and early pubertyDavid D Martin
Pediatric Endocrinology and Diabetology, University Children s Hospital, Tubingen, Germany
J Pediatr Endocrinol Metab 24:1009-14. 2011..Manual bone age (BA) rating in precocious puberty (PP) is associated with considerable rater variability. The aim was to evaluate a new method for automated Greulich and Pyle (GP) BA determination in children with PP...
The use of bone age in clinical practice - part 2David D Martin
Pediatric Endocrinology and Diabetology, University Children s Hospital, Tubingen, Germany
Horm Res Paediatr 76:10-6. 2011..The use of skeletal maturity, assessed on a radiograph alone to estimate chronological age for immigration authorities or criminal courts is not recommended...
The use of bone age in clinical practice - part 1David D Martin
Pediatric Endocrinology and Diabetology, University Children s Hospital, Tubingen, Germany
Horm Res Paediatr 76:1-9. 2011..The assessment of BA provides an important contribution to the diagnostic workup and management of children with short stature...
Metacarpal thickness, width, length and medullary diameter in children--reference curves from the First Zürich Longitudinal StudyD D Martin
Pediatric Endocrinology and Diabetology, University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
Osteoporos Int 22:1525-36. 2011..Reference data for the four metacarpal measures are presented...
Short children with low birth weight born either small for gestational age or average for gestational age show similar growth response and changes in insulin-like growth factor-1 to growth hormone treatment during the first prepubertal yearM B Ranke
University Children s Hospital, Tubingen, Germany
Horm Res Paediatr 76:104-12. 2011..The aim of this analysis was to compare the growth response to GH in children with low birth weight born SGA or appropriate for gestational age (AGA)...
Cortical bone density is normal in prepubertal children with growth hormone (GH) deficiency, but initially decreases during GH replacement due to early bone remodelingR Schweizer
Pediatric Endocrinology Section, University Children s Hospital, University of Tuebingen D 72076, Germany
J Clin Endocrinol Metab 88:5266-72. 2003..Thus, the manifestation of GH deficiency is evidently similar in children and adults, and pQCT provides important information in addition to DEXA measurements, as DEXA does not take bone structure into account...
The course of neonatal cholestasis in congenital combined pituitary hormone deficiencyG Binder
University Children s Hospital, Tuebingen, Germany
J Pediatr Endocrinol Metab 20:695-702. 2007..Neonatal cholestatic hepatitis is frequently associated with congenital combined pituitary hormone deficiency (CCPHD). Data on the course of this hepatopathy are scarce...
Muscle function improves during growth hormone therapy in short children born small for gestational age: results of a peripheral quantitative computed tomography study on body compositionRoland Schweizer
Pediatric Endocrinology Section, University Hospital for Children and Adolescents, Hoppe Seyler Strasse 1, D 72076 Tuebingen, Germany
J Clin Endocrinol Metab 93:2978-83. 2008..They also face a high risk of the metabolic syndrome developing after childhood. It is not known whether low muscle mass influences muscle function...
The endocrine phenotype in silver-russell syndrome is defined by the underlying epigenetic alterationGerhard Binder
Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Str 1, 72076 Tubingen, Germany
J Clin Endocrinol Metab 93:1402-7. 2008..Around 50% of children with Silver-Russell syndrome (SRS) carry a hypomethylation of the imprinting control region 1 at the IGF2/H19 locus on 11p15, the functional significance of which is unknown...
IGF-I and IGF binding protein-3 levels during initial GH dosage step-up are indicators of GH sensitivity in GH-deficient children and short children born small for gestational ageMichael B Ranke
Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
Horm Res 64:68-76. 2005..A stepwise increment of the GH dose is an approach aimed at avoiding adverse events. We investigated GH sensitivity by studying IGF-I and IGFBP-3 concentrations during the initial phase of GH treatment...
Asphyxia due to pacifiers--case report and review of the literatureFrank Wehner
Institut für Gerichtliche Medizin der Universität Tübingen, Nägelestrasse 5, D 72074 Tubingen, Germany
Forensic Sci Int 141:73-5. 2004....
The mathematical model for total pubertal growth in idiopathic growth hormone (GH) deficiency suggests a moderate role of GH doseMichael B Ranke
Pediatric Endocrinology Section, University Children s Hospital, Tubingen D 72076 Germany
J Clin Endocrinol Metab 88:4748-53. 2003..The use of a higher GH dosage at the onset of puberty should thus depend on the individual's height development. The TPG model aids in the planning of individually optimized and cost-effective GH treatment...
Prediction model of total pubertal growth in idiopathic growth hormone deficiency: analysis of data from KIGSMichael B Ranke
Paediatric Endocrinology Section, University Children's Hospital, , Germany
Horm Res 60:58-9. 2003
Similar effects of long-term exogenous growth hormone (GH) on bone and muscle parameters: a pQCT study of GH-deficient and small-for-gestational-age (SGA) childrenRoland Schweizer
Paediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076, Tubingen, Germany
Bone 41:875-81. 2007..Treatment with GH in short children has focused on height development. Little is known about the concomitant changes in muscle mass, bone structure and bone strength...
Auxology is a valuable instrument for the clinical diagnosis of SHOX haploinsufficiency in school-age children with unexplained short statureGerhard Binder
University Children s Hospital, 72076 Tubingen, Germany
J Clin Endocrinol Metab 88:4891-6. 2003..Our observations suggest that it is rational to limit SHOX mutation screening to children with an extremities-trunk ratio less than 1.95 + 1/2 height (m) and to add a critical judgment of the hand radiography...
Clinical application of automated Greulich-Pyle bone age determination in children with short statureDavid D Martin
Paediatric Endocrinology Section, University Children s Hospital, Tuebingen, Germany
Pediatr Radiol 39:598-607. 2009..Bone age (BA) rating is time consuming and highly rater dependent...
Validation of a new method for automated determination of bone age in Japanese childrenDavid D Martin
Tubingen University, Tubingen, Germany
Horm Res Paediatr 73:398-404. 2010..This study accomplishes a calibration of BoneXpert to the TW-Japan standard, which performs well for the entire BA range from 4 years up to full maturity...
