Affiliation: Martin Luther University
Bartel F, Meye A, Wurl P, Kappler M, Bache M, Lautenschlager C, et al
. Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma. Int J Cancer. 2001;95:168-75 pubmed
..01, chi(2) test). Although the presence of spliced forms was associated with late-stage tumor phenotypes (p = 0.05, chi(2) test), we observed no relationship between the presence of splice variants and patient outcome. ..
Bartel F, Jung J, Böhnke A, Gradhand E, Zeng K, Thomssen C, et al
. Both germ line and somatic genetics of the p53 pathway affect ovarian cancer incidence and survival. Clin Cancer Res. 2008;14:89-96 pubmed publisher
Bartel F, Schulz J, Böhnke A, Blümke K, Kappler M, Bache M, et al
. Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis. Int J Cancer. 2005;117:469-75 pubmed
..In summary, our data indicate that both the overexpression of the HDMX-S transcript as well as HDMX gene amplification are important prognostic markers for STS. ..