Harald Loppnow

Summary

Affiliation: Martin-Luther University Halle-Wittenberg
Country: Germany

Publications

  1. doi Vascular cells contribute to atherosclerosis by cytokine- and innate-immunity-related inflammatory mechanisms
    Harald Loppnow
    Martin Luther Universitat Halle Wittenberg, Universitätsklinik und Poliklinik für Innere Medizin, Halle Saale, Germany
    Innate Immun 14:63-87. 2008
  2. pmc Inflammation and renal function after a four-year follow-up in subjects with unimpaired glomerular filtration rate: results from the observational, population-based CARLA cohort
    Daniel Medenwald
    Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    PLoS ONE 9:e108427. 2014
  3. pmc Inhibition of cardiac pacemaker channel hHCN2 depends on intercalation of lipopolysaccharide into channel-containing membrane microdomains
    Udo Klockner
    Julius Bernstein Institut für Physiologie, Martin Luther Universitat Halle Wittenberg, Magdeburger Strasse 6, 06112 Halle Saale, Germany
    J Physiol 592:1199-211. 2014
  4. pmc Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures
    Harald Loppnow
    Universitätsklinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    J Cell Mol Med 15:994-1004. 2011
  5. pmc Contribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis
    Harald Loppnow
    Department of Internal Medicine III, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Cell Mol Med 15:484-500. 2011
  6. pmc Patients with insulin-dependent diabetes or coronary heart disease following rehabilitation express serum fractalkine levels similar to those in healthy control subjects
    Lars Maegdefessel
    Universitätsklinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Vasc Health Risk Manag 5:849-57. 2009
  7. doi Differential reduction of HCN channel activity by various types of lipopolysaccharide
    Udo Klockner
    Julius Bernstein Institut für Physiologie, Martin Luther Universitat Halle Wittenberg, Halle, Germany
    J Mol Cell Cardiol 51:226-35. 2011
  8. doi Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock
    Roland Prondzinsky
    Department of Medicine III, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Clin Res Cardiol 101:375-84. 2012
  9. doi Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production
    Li Chen
    Universitätsklinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Am J Physiol Heart Circ Physiol 296:H987-96. 2009
  10. doi Interleukin-1 potently contributes to 25-hydroxycholesterol-induced synergistic cytokine production in smooth muscle cell-monocyte interactions
    Hang Fu
    Universitätsklinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg, Ernst Grube Str 40, Halle Saale, Germany
    Atherosclerosis 237:443-52. 2014

Collaborators

Detail Information

Publications15

  1. doi Vascular cells contribute to atherosclerosis by cytokine- and innate-immunity-related inflammatory mechanisms
    Harald Loppnow
    Martin Luther Universitat Halle Wittenberg, Universitätsklinik und Poliklinik für Innere Medizin, Halle Saale, Germany
    Innate Immun 14:63-87. 2008
    ..Thus, vascular cells may potently contribute to the inflammatory pathways involved in development and acceleration of atherosclerosis...
  2. pmc Inflammation and renal function after a four-year follow-up in subjects with unimpaired glomerular filtration rate: results from the observational, population-based CARLA cohort
    Daniel Medenwald
    Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    PLoS ONE 9:e108427. 2014
    ..There is evidence that chronic inflammation is associated with the progression/development of chronic renal failure; however, relations in subjects with preserved renal function remain insufficiently understood...
  3. pmc Inhibition of cardiac pacemaker channel hHCN2 depends on intercalation of lipopolysaccharide into channel-containing membrane microdomains
    Udo Klockner
    Julius Bernstein Institut für Physiologie, Martin Luther Universitat Halle Wittenberg, Magdeburger Strasse 6, 06112 Halle Saale, Germany
    J Physiol 592:1199-211. 2014
    ..Furthermore, intercalation of lipid A into target cell membranes is a prerequisite for the inhibition that is suggested to depend on the direct interaction of the LPS polysaccharide chain with cardiac pacemaker channels. ..
  4. pmc Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures
    Harald Loppnow
    Universitätsklinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    J Cell Mol Med 15:994-1004. 2011
    ..These data implicate that statins have the capacity to affect atherosclerosis by regulating cytokine-mediated innate inflammatory pathways in the vessel wall...
  5. pmc Contribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis
    Harald Loppnow
    Department of Internal Medicine III, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Cell Mol Med 15:484-500. 2011
    ..Thus, SMC-fostered inflammation, promoted by invading innate cells, may be a potent component for development and acceleration of atherosclerosis...
  6. pmc Patients with insulin-dependent diabetes or coronary heart disease following rehabilitation express serum fractalkine levels similar to those in healthy control subjects
    Lars Maegdefessel
    Universitätsklinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Vasc Health Risk Manag 5:849-57. 2009
    ..Low fractalkine levels in patients attending rehabilitation indicate a beneficial effect of the rehabilitation procedure on innate inflammatory pathways, such as the chemokine and adhesion molecule fractalkine...
  7. doi Differential reduction of HCN channel activity by various types of lipopolysaccharide
    Udo Klockner
    Julius Bernstein Institut für Physiologie, Martin Luther Universitat Halle Wittenberg, Halle, Germany
    J Mol Cell Cardiol 51:226-35. 2011
    ..In the clinical situation the observed modulation of HCN channels may slow down diastolic depolarization of pacemaker cells and, hence, influence heart rate variability and heart rate...
  8. doi Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock
    Roland Prondzinsky
    Department of Medicine III, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Clin Res Cardiol 101:375-84. 2012
    ..In an inflammatory marker substudy, we analysed the prognostic value of interleukin (IL)-1β, -6, -7, -8, and -10 in patients with acute myocardial infarction complicated by cardiogenic shock...
  9. doi Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production
    Li Chen
    Universitätsklinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Am J Physiol Heart Circ Physiol 296:H987-96. 2009
    ..The present data suggest that SMC/monocyte interactions may augment the proinflammatory status in the tissue, contributing to the acceleration of early atherogenesis...
  10. doi Interleukin-1 potently contributes to 25-hydroxycholesterol-induced synergistic cytokine production in smooth muscle cell-monocyte interactions
    Hang Fu
    Universitätsklinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg, Ernst Grube Str 40, Halle Saale, Germany
    Atherosclerosis 237:443-52. 2014
    ..Cholesterol, a cardiovascular risk factor, may activate inflammation in the vessel wall during this process. Cytokine-mediated interactions of human monocytes with vascular smooth muscle cells (SMCs) may perpetuate this process...
  11. pmc Inflammation and prolonged QT time: results from the Cardiovascular Disease, Living and Ageing in Halle (CARLA) study
    Daniel Medenwald
    Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    PLoS ONE 9:e95994. 2014
    ..Even more, there is evidence of a substantial involvement of the tumor necrosis factor-alpha system in the pathophysiology of cardiac arrhythmia, while the role of Interleukin 6 remains inconclusive...
  12. pmc Altered interleukin-1 receptor antagonist and interleukin-18 mRNA expression in myocardial tissues of patients with dilatated cardiomyopathy
    Elena Westphal
    Universitätsklinik und Poliklinik für Innere Medizin III, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Mol Med 14:55-63. 2008
    ..This dysregulation may contribute to pathogenesis and/or progression of heart disease by modulating the otherwise balanced IL-1-mediated functions in cardiovascular cells...
  13. ncbi Beta-blockade does not alter plasma cytokine concentrations and ventricular function in young adults with right ventricular dysfunction secondary to operated congenital heart disease
    Kambiz Norozi
    Department of Paediatric Cardiology and Intensive Care, Medical School Hannover, Germany
    Circ J 72:747-52. 2008
    ..Thus, the effect of bisoprolol on clinical status and plasma cytokine concentrations in ACHD patients with right heart failure after surgical correction for Tetralogy of Fallot was investigated...
  14. ncbi Surgical trauma affects the proinflammatory status after cardiac surgery to a higher degree than cardiopulmonary bypass
    Roland Prondzinsky
    Department of Medicine III, Martin Luther University Halle Wittenberg, Halle Salle, Germany
    J Thorac Cardiovasc Surg 129:760-6. 2005
    ....
  15. ncbi Cytokines in chronic heart failure: possible interaction in the neurohormonal and the cytokine system at the cAMP level?
    Claudia Werner
    Institut fur Pharmakologie und Toxikologie der Technischen Universitat Munchen, Germany
    Eur Cytokine Netw 13:407-9. 2002
    ..These alterations may result from a dysregulated interaction of beta-adrenergic pathways and the cytokine system, and are possibly related to cAMP-dependent regulation of the release or shedding of these mediators...