A Mansouri

Summary

Country: Germany

Publications

  1. doi request reprint Hair-zinc levels determination in Algerian psoriatics using Instrumental Neutron Activation Analysis (INAA)
    A Mansouri
    Nuclear Research Centre of Algiers, 02, Frantz Fanon Street, P O Box 399, Algiers 16000, Algeria
    Appl Radiat Isot 72:177-81. 2013
  2. pmc Generation of animals allowing the conditional inactivation of the Pax4 gene
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, 37077 Gottingen, Germany
    Transgenic Res 21:1215-20. 2012
  3. pmc The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation
    Tamara I Rabe
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, Goettingen, 37077, Germany
    Neural Dev 7:39. 2012
  4. pmc Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain
    Andreas Zembrzycki
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Goettingen, Germany
    Neural Dev 2:8. 2007
  5. pmc Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, Gottingen, Germany
    BMC Dev Biol 11:52. 2011
  6. pmc Pax7 is requisite for maintenance of a subpopulation of superior collicular neurons and shows a diverging expression pattern to Pax3 during superior collicular development
    Jennifer A Thompson
    School of Exercise, Biomedical and Health Science, Edith Cowan University, Joondalup Drive, Joondalup, Western Australia 6027, Australia
    BMC Dev Biol 8:62. 2008
  7. ncbi request reprint Pax genes and their roles in cell differentiation and development
    A Mansouri
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
    Curr Opin Cell Biol 8:851-7. 1996
  8. pmc mBtd is required to maintain signaling during murine limb development
    Dieter Treichel
    MPI für Biophysikalische Chemie, Abt Molekulare Zellbiologie, Am Fassberg, 37077 Gottingen, Germany
    Genes Dev 17:2630-5. 2003
  9. ncbi request reprint Pax3 acts cell autonomously in the neural tube and somites by controlling cell surface properties
    A Mansouri
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D 37077 Gottingen, Germany
    Development 128:1995-2005. 2001
  10. ncbi request reprint Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord
    A Mansouri
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, 37077, Gottingen, Germany
    Mech Dev 78:171-8. 1998

Collaborators

Detail Information

Publications44

  1. doi request reprint Hair-zinc levels determination in Algerian psoriatics using Instrumental Neutron Activation Analysis (INAA)
    A Mansouri
    Nuclear Research Centre of Algiers, 02, Frantz Fanon Street, P O Box 399, Algiers 16000, Algeria
    Appl Radiat Isot 72:177-81. 2013
    ..05). Zn concentration for males and females controls and patients were 171±27 μg/g, 151±37 μg/g and 145 ± 59 μg/g, 178 ± 58 μg/g respectively. However, for females we have observed a significant difference (p<0.05)...
  2. pmc Generation of animals allowing the conditional inactivation of the Pax4 gene
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, 37077 Gottingen, Germany
    Transgenic Res 21:1215-20. 2012
    ..Herein, we report the generation of Pax4 conditional knockout mice that will allow the analysis of Pax4 function in mature beta-cells, as well as in the adult central nervous system...
  3. pmc The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation
    Tamara I Rabe
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, Goettingen, 37077, Germany
    Neural Dev 7:39. 2012
    ..The goal of the current study was to analyze in which midbrain neuronal subgroups Uncx4.1 is expressed and to examine whether this factor plays a role in the early development of these neuronal subgroups...
  4. pmc Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain
    Andreas Zembrzycki
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Goettingen, Germany
    Neural Dev 2:8. 2007
    ..Proper patterning is, therefore, a prerequisite for the generation of optimal functional areas. Only a few factors have been shown to control the genetic networks that establish early forebrain patterning...
  5. pmc Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, Gottingen, Germany
    BMC Dev Biol 11:52. 2011
    ..2-deficient pancreata. Hence in order to precise the functional link between both factors we performed a comparative analysis of Nkx2.2/Arx single- and double-mutants but also of Pax6-deficient animals...
  6. pmc Pax7 is requisite for maintenance of a subpopulation of superior collicular neurons and shows a diverging expression pattern to Pax3 during superior collicular development
    Jennifer A Thompson
    School of Exercise, Biomedical and Health Science, Edith Cowan University, Joondalup Drive, Joondalup, Western Australia 6027, Australia
    BMC Dev Biol 8:62. 2008
    ..We also assess its spatiotemporal relationship with Pax3 during embryonic development...
  7. ncbi request reprint Pax genes and their roles in cell differentiation and development
    A Mansouri
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
    Curr Opin Cell Biol 8:851-7. 1996
    ..Additionally, recent experimental in vivo and in vitro approaches have led to the identification of molecules that interact with Pax proteins...
  8. pmc mBtd is required to maintain signaling during murine limb development
    Dieter Treichel
    MPI für Biophysikalische Chemie, Abt Molekulare Zellbiologie, Am Fassberg, 37077 Gottingen, Germany
    Genes Dev 17:2630-5. 2003
    ..The data indicate that mBtd represents a novel key player mediating proximodistal outgrowth of the limb...
  9. ncbi request reprint Pax3 acts cell autonomously in the neural tube and somites by controlling cell surface properties
    A Mansouri
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D 37077 Gottingen, Germany
    Development 128:1995-2005. 2001
    ..We propose that although Pax3 function is related to cell surface properties, its role may differ in various tissues. In fact, apoptosis was found in Pax3-deficient cells of the lateral dermomyotome but not in the neural tube...
  10. ncbi request reprint Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord
    A Mansouri
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, 37077, Gottingen, Germany
    Mech Dev 78:171-8. 1998
    ..Our findings reveal two distinct regulatory pathways for spinal cord neurogenesis, only one of which is dependent on Pax3/7 and 6...
  11. ncbi request reprint Uncx4.1 is required for the formation of the pedicles and proximal ribs and acts upstream of Pax9
    A Mansouri
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D 37077 Gottingen, Germany
    Development 127:2251-8. 2000
    ..1 upstream of Pax9 in the caudolateral sclerotome. Our results further indicate that Uncx4.1 may be involved in the differential cell adhesion properties of the somite...
  12. ncbi request reprint Pax genes and their role in organogenesis
    A Mansouri
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Cancer Res 59:1707s-1709s; discussion 1709s-1710s. 1999
    ..In particular, they are involved in the regulation of early steps in organ development. They act to define the regional specification of distinct germ layers...
  13. ncbi request reprint Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant mice
    A Mansouri
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Development 122:831-8. 1996
    ..No obvious phenotype could be detected in the central nervous system and skeletal muscle. Functional redundancy between Pax7 and Pax3 is discussed...
  14. ncbi request reprint Fkh5-deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body
    R Wehr
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Goettingen, Germany
    Development 124:4447-56. 1997
    ..Furthermore, the hypothalamic mammillary body of Fkh5-deficient brains lacks the medial mammillary nucleus. These results suggest that Fkh5 plays a major role during CNS development...
  15. ncbi request reprint Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
    Y Yokota
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Nature 397:702-6. 1999
    ..Our results indicate that Id2 has an essential role in the generation of peripheral lymphoid organs and NK cells...
  16. ncbi request reprint Paired-related murine homeobox gene expressed in the developing sclerotome, kidney, and nervous system
    A Mansouri
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Gottingen, Germany
    Dev Dyn 210:53-65. 1997
    ..The temporal and spatial expression pattern suggests that Uncx4.1 may play an important role in kidney development and in the differentiation of the sclerotome and the nervous system...
  17. ncbi request reprint Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border
    Gundula Griesel
    Max Planck Institute for Biophysical Chemistry, Dept of Molecular Cell Biology, Am Fassberg, 37077 Gottingen, Germany
    Development 133:1779-87. 2006
    ..Furthermore, we provide evidence that cell proliferation in the mid- and hindbrain is tightly controlled by Sp8 activity. Our observations are consistent with a role for Sp8 in restricting Fgf8 expression at the IsO...
  18. ncbi request reprint Behavioral changes in unilaterally 6-hydroxy-dopamine lesioned rats after transplantation of differentiated mouse embryonic stem cells without morphological integration
    Paul Christian Baier
    Department of Clinical Neurophysiology, Georg August University Gottingen, Gottingen, Germany
    Stem Cells 22:396-404. 2004
    ..In this study, we aimed to investigate differentiated mouse ES cells regarding their in vivo development and fate after transplantation in the striatum in the 6-OHDA rat model and the behavioral changes induced after transplantation...
  19. ncbi request reprint Specifying pancreatic endocrine cell fates
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D 37077 Gottingen, Germany
    Mech Dev 123:501-12. 2006
    ..This review focuses on the mechanisms regulating the morphogenesis of the pancreas with particular emphasis on recent findings concerning the transcription factor hierarchy orchestrating endocrine cell fate allocation...
  20. pmc The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, D 37077 Gottingen, Germany
    Cell 138:449-62. 2009
    ....
  21. ncbi request reprint The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Gottingen, Germany
    Development 132:2969-80. 2005
    ..Finally, our data provide evidence that both Arx and Pax4 act as transcriptional repressors that control the expression level of one another, thereby mediating proper endocrine fate allocation...
  22. pmc The tumorigenicity of mouse embryonic stem cells and in vitro differentiated neuronal cells is controlled by the recipients' immune response
    Ralf Dressel
    Department of Cellular and Molecular Immunology, University of Gottingen, Gottingen, Germany
    PLoS ONE 3:e2622. 2008
    ..Interestingly, the differentiated cells must contain a tumorigenic cell population that is not present among ES cells and which might be resistant to NK cell-mediated killing...
  23. pmc Reprogramming into pancreatic endocrine cells based on developmental cues
    Simon Kordowich
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, D 37077 Gottingen, Germany
    Mol Cell Endocrinol 315:11-8. 2010
    ..Furthermore, an emphasis is made on beta-cell regeneration and the determinants implicated...
  24. pmc Opposing actions of Arx and Pax4 in endocrine pancreas development
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    Genes Dev 17:2591-603. 2003
    ..We propose that the antagonistic functions of Arx and Pax4 for proper islet cell specification are related to the pancreatic levels of the respective transcripts...
  25. ncbi request reprint Targeted mutation of the murine goosecoid gene results in craniofacial defects and neonatal death
    G Yamada
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Development 121:2917-22. 1995
    ..Although the observed phenotype is in accordance with the late expression domains of goosecoid in wild-type embryos, we suggest that the lack of an earlier phenotype is the result of functional compensation by other genes...
  26. pmc Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    J Clin Invest 117:961-70. 2007
    ..These results provide important insights into the complex mechanisms underlying proper pancreatic endocrine cell allocation and cell identity acquisition...
  27. doi request reprint Reprogramming into pancreatic endocrine cells based on developmental cues
    Simon Kordowich
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, D 37077 Gottingen, Germany
    Mol Cell Endocrinol 323:62-9. 2010
    ..Furthermore, an emphasize is made on beta-cell regeneration and the determinants implicated...
  28. doi request reprint Differentiation of embryonic stem cells
    Ahmed Mansouri
    Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Curr Protoc Neurosci . 2009
    ..Furthermore, this procedure permits the isolation of neural stem cell lines from mouse ES cells...
  29. pmc Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons
    Gaia Colasante
    Department of Biological and Technological Research, San Raffaele Scientific Institute, Stem Cell Research Institute, Vita e Salute San Raffaele University, 20132 Milan, Italy
    J Neurosci 28:10674-86. 2008
    ..These findings contribute elucidating the genetic hierarchy that likely underlies the etiology of a variety of human neurodevelopmental disorders...
  30. pmc IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas
    Georg Mellitzer
    INSERM U682, Development and Physiopathology of the Intestine and Pancreas, Universite Louis Pasteur, Strasbourg, France
    EMBO J 25:1344-52. 2006
    ..IA1 is therefore a novel Ngn3-regulated factor required for normal differentiation of pancreatic endocrine cells...
  31. ncbi request reprint A Pax3/Pax7-dependent population of skeletal muscle progenitor cells
    Frederic Relaix
    C N R S URA 2578, Department of Developmental Biology, Pasteur Institute, 75724 Paris Cedex 15, France
    Nature 435:948-53. 2005
    ....
  32. ncbi request reprint An integrated regulatory network controlling survival and migration in thyroid organogenesis
    Rosanna Parlato
    Stazione Zoologica Anton Dohrn, Naples, Italy
    Dev Biol 276:464-75. 2004
    ..In conclusion, we provide the first evidence of gene expression programs, controlled by a hierarchy of transcription factors expressed in the thyroid presumptive gut domain and directing the progression of thyroid morphogenesis...
  33. pmc Divergent functions of murine Pax3 and Pax7 in limb muscle development
    Frederic Relaix
    Centre National de la Recherche Scientifique CNRS URA 2578, Department of Developmental Biology, Pasteur Institute, 75724 Paris Cedex 15, France
    Genes Dev 18:1088-105. 2004
    ....
  34. doi request reprint T-box protein Tbx18 interacts with the paired box protein Pax3 in the development of the paraxial mesoderm
    Henner F Farin
    Institute for Molecular Biology, Medizinische Hochschule Hannover, OE5250, Carl Neuberg Strasse 1, Hannover, Germany
    J Biol Chem 283:25372-80. 2008
    ..Genetic interaction of Pax3 with Tbx18 and the closely related T-box gene Tbx15 was also observed in the development of the scapula blade, indicating an additional cooperative function for these genes in the paraxial mesoderm...
  35. ncbi request reprint Fate of pre-differentiated mouse embryonic stem cells transplanted in unilaterally 6-hydroxydopamine lesioned rats: histological characterization of the grafted cells
    Keneuoe Thinyane
    Department of Clinical Neurophysiology, University Göttingen, 37075 Gottingen, Germany
    Brain Res 1045:80-7. 2005
    ..After 5 weeks, two out of fifteen graft recipients had tumors indicating that pre-differentiation of mouse embryonic stem cells using this differentiation protocol is not sufficient to prevent tumor formation...
  36. ncbi request reprint Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation
    Elena Colombo
    Stem Cell Research Department, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Neurosci 27:4786-98. 2007
    ..Altogether, these results highlight the critical functions of Arx in promoting neural migration and regulating basal ganglia differentiation in mice, consistent with the phenotype of XLAG patients...
  37. ncbi request reprint Regulation of iodothyronine deiodinases in the Pax8-/- mouse model of congenital hypothyroidism
    Sonke Friedrichsen
    Max Planck Institut fur Experimentelle Endokrinologie, D 30625 Hannover, Germany
    Endocrinology 144:777-84. 2003
    ..In conclusion, these findings show dramatic age and thyroid state-dependent changes in the expression of deiodinases in central and peripheral tissues of mice during the first 3 wk of life...
  38. pmc Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells
    Frederic Relaix
    Unité de Génétique Moléculaire du Développement, Centre National de la Recherche Scientifique URA 2578, Departement de Biologie du Developpement
    J Cell Biol 172:91-102. 2006
    ..These findings underline the importance of cell survival in controlling the stem cell populations of adult tissues and demonstrate a role for upstream factors in this context...
  39. ncbi request reprint [Stem cell therapy in Parkinson disease]
    Jan Schindehütte
    Stadium der Humanmedizin und Promotionen an der Georg August Universität Göttingen
    Pharm Unserer Zeit 35:250-4. 2006
  40. ncbi request reprint In vivo and in vitro tissue-specific expression of green fluorescent protein using the cre-lox system in mouse embryonic stem cells
    Jan Schindehütte
    Georg August University of Gottingen, Department of Clinical Neurophysiology, Gottingen, Germany
    Stem Cells 23:10-5. 2005
    ..Transgenic mice derived from these ES cells permit the targeting of GFP-expression to specific tissues and provide material from the three germ layers suitable for molecular and biochemical analysis...
  41. ncbi request reprint A mouse model demonstrates a multigenic origin of congenital hypothyroidism
    Elena Amendola
    Stazione Zoologica A Dohrn, Laboratorio di Genetica Animale at CEINGE, Naples, Italy
    Endocrinology 146:5038-47. 2005
    ..These results show that TD can be of multigenic origin in mice and strongly suggest that a similar pathogenic mechanism may be observed in humans...
  42. ncbi request reprint Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord
    Andrea Pillai
    Biology Graduate Program, University of California, San Diego, La Jolla, CA 92037, USA
    Development 134:357-66. 2007
    ..Lhx1 and Lhx5 therefore function together with Pax2, Pax5 and Pax8 to establish a GABAergic inhibitory-neurotransmitter program in dorsal horn interneurons...
  43. ncbi request reprint Genetic determinants of pancreatic epsilon-cell development
    R Scott Heller
    Hagedorn Research Institute, Department of Developmental Biology, DK 2820 Gentofte, Denmark
    Dev Biol 286:217-24. 2005
    ....
  44. ncbi request reprint Congenital hypothyroid Pax8(-/-) mutant mice can be rescued by inactivating the TRalpha gene
    Frederic Flamant
    Laboratoire de Biologie Moléculaire et Cellulaire de l Ecole Normale Supérieure de Lyon, Unité Mixte de Recherche Centre National de la Recherche Scientifique 5665 LA INRA913, 69364 Lyon Cedex 07, France
    Mol Endocrinol 16:24-32. 2002
    ..Pax8/TRalpha compound mutants can survive to adulthood, and the expression of target genes is partially restored. This demonstrates the importance of TRalpha aporeceptor activity in several aspects of postnatal development...