Hartmut Vatter

Summary

Affiliation: Malteser Krankenhaus St. Josef
Country: Germany

Publications

  1. ncbi request reprint Effect of the novel endothelin(A) receptor antagonist LU 208075 on contraction and relaxation of isolated rat basilar artery
    Hartmut Vatter
    Department of Neurosurgery, Johann Wolfgang Goethe University, Schleusenweg 2 16, D 60528 Frankfurt am Main, Germany
    Clin Sci (Lond) 103:408S-413S. 2002
  2. ncbi request reprint Characterization of the endothelin-B receptor expression and vasomotor function during experimental cerebral vasospasm
    Hartmut Vatter
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Neurosurgery 60:1100-8; discussion 1108-9. 2007
  3. doi request reprint Bone flap resorption: risk factors for the development of a long-term complication following cranioplasty after decompressive craniectomy
    Patrick Schuss
    Department of Neurosurgery, Johann Wolfgang Goethe University, Schleusenweg 2 16, Frankfurt am Main, Germany
    J Neurotrauma 30:91-5. 2013
  4. doi request reprint Histological evidence of delayed ischemic brain tissue damage in the rat double-hemorrhage model
    Erdem Güresir
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurol Sci 293:18-22. 2010
  5. doi request reprint Perfusion-diffusion mismatch in MRI to indicate endovascular treatment of cerebral vasospasm after subarachnoid haemorrhage
    Hartmut Vatter
    Department of Neurosurgery, Goethe University, Schleusenweg, 2 16, Frankfurt Main D 60528, Germany
    J Neurol Neurosurg Psychiatry 82:876-83. 2011
  6. ncbi request reprint Effect of delayed cerebral vasospasm on cerebrovascular endothelin A receptor expression and function
    Hartmut Vatter
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurosurg 107:121-7. 2007
  7. ncbi request reprint Cerebrovascular characterization of clazosentan, the first nonpeptide endothelin receptor antagonist shown to be clinically effective for the treatment of cerebral vasospasm. Part II: effect on endothelin(B) receptor-mediated relaxation
    Hartmut Vatter
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main
    J Neurosurg 102:1108-14. 2005
  8. ncbi request reprint Focal laminar cortical infarcts following aneurysmal subarachnoid haemorrhage
    Stefan Weidauer
    Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, 60528, Frankfurt, Germany
    Neuroradiology 50:1-8. 2008
  9. doi request reprint Unsecured intracranial aneurysms and induced hypertension in cerebral vasospasm: is induced hypertension safe?
    Johannes Platz
    Department of Neurosurgery, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany
    Neurocrit Care 14:168-75. 2011
  10. doi request reprint Subarachnoid hemorrhage and intracerebral hematoma: incidence, prognostic factors, and outcome
    Erdem Güresir
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Neurosurgery 63:1088-93; discussion 1093-4. 2008

Detail Information

Publications45

  1. ncbi request reprint Effect of the novel endothelin(A) receptor antagonist LU 208075 on contraction and relaxation of isolated rat basilar artery
    Hartmut Vatter
    Department of Neurosurgery, Johann Wolfgang Goethe University, Schleusenweg 2 16, D 60528 Frankfurt am Main, Germany
    Clin Sci (Lond) 103:408S-413S. 2002
    ..The pronounced effect on E-vessels and the inhibition of relaxation may suggest an ET(B) receptor affinity...
  2. ncbi request reprint Characterization of the endothelin-B receptor expression and vasomotor function during experimental cerebral vasospasm
    Hartmut Vatter
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Neurosurgery 60:1100-8; discussion 1108-9. 2007
    ..The aim of the present investigation is, therefore, to characterize the function and the expression of the ET(B) receptor in the cerebrovasculature during CVS...
  3. doi request reprint Bone flap resorption: risk factors for the development of a long-term complication following cranioplasty after decompressive craniectomy
    Patrick Schuss
    Department of Neurosurgery, Johann Wolfgang Goethe University, Schleusenweg 2 16, Frankfurt am Main, Germany
    J Neurotrauma 30:91-5. 2013
    ..3) as independent risk factors for the development of BFR after CP in a large series with long-term follow-up. This might influence future surgical decision making, especially in patients fulfilling high risk criteria for developing BFR...
  4. doi request reprint Histological evidence of delayed ischemic brain tissue damage in the rat double-hemorrhage model
    Erdem Güresir
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurol Sci 293:18-22. 2010
    ..Accordingly, our data suggest that the rat double-SAH model may be suitable to mimic delayed ischemic brain damage due to CVS and to investigate the neuroprotective effects of drugs...
  5. doi request reprint Perfusion-diffusion mismatch in MRI to indicate endovascular treatment of cerebral vasospasm after subarachnoid haemorrhage
    Hartmut Vatter
    Department of Neurosurgery, Goethe University, Schleusenweg, 2 16, Frankfurt Main D 60528, Germany
    J Neurol Neurosurg Psychiatry 82:876-83. 2011
    ..Therefore, an MR based perfusion weighted imaging/diffusion weighted imaging (PWI/DWI) mismatch was used to indicate this treatment and to characterise its effectiveness...
  6. ncbi request reprint Effect of delayed cerebral vasospasm on cerebrovascular endothelin A receptor expression and function
    Hartmut Vatter
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurosurg 107:121-7. 2007
    ..Therefore, the aim in the present study was to characterize these alterations, with the emphasis on the ET(A) receptor...
  7. ncbi request reprint Cerebrovascular characterization of clazosentan, the first nonpeptide endothelin receptor antagonist shown to be clinically effective for the treatment of cerebral vasospasm. Part II: effect on endothelin(B) receptor-mediated relaxation
    Hartmut Vatter
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main
    J Neurosurg 102:1108-14. 2005
    ..The aim of the present study was to define the actual selectivity of clazosentan, the first putative highly ET(A) receptor-selective antagonist clinically proven to be effective in the treatment of vasospasm in the cerebrovasculature...
  8. ncbi request reprint Focal laminar cortical infarcts following aneurysmal subarachnoid haemorrhage
    Stefan Weidauer
    Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, 60528, Frankfurt, Germany
    Neuroradiology 50:1-8. 2008
    ..The aim of this prospective study was to analyse small band-like cortical infarcts after subarachnoid haemorrhage (SAH) using magnetic resonance imaging (MRI) with reference to additional digital subtraction angiography (DSA)...
  9. doi request reprint Unsecured intracranial aneurysms and induced hypertension in cerebral vasospasm: is induced hypertension safe?
    Johannes Platz
    Department of Neurosurgery, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany
    Neurocrit Care 14:168-75. 2011
    ..The aim of this study was to investigate the impact of induced hypertension on the rupturing of unsecured aneurysms in treating CVS...
  10. doi request reprint Subarachnoid hemorrhage and intracerebral hematoma: incidence, prognostic factors, and outcome
    Erdem Güresir
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Neurosurgery 63:1088-93; discussion 1093-4. 2008
    ..To analyze the incidence and impact of an intracerebral hematoma (ICH) on treatment and outcome in patients with aneurysmal subarachnoid hemorrhage...
  11. doi request reprint Aneurysm-related subarachnoid hemorrhage and acute subdural hematoma: single-center series and systematic review
    Patrick Schuss
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurosurg 118:984-90. 2013
    ..The authors' objective was to analyze the incidence, prognosis, and clinical outcome of patients suffering from aneurysm-related SAH and space-occupying acute SDH...
  12. ncbi request reprint Characterization of the potent combined endothelin(A/B)-antagonist PD 142893 on cerebral vessels
    Michael Zimmermann
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt, Germany
    Neurol Res 26:692-7. 2004
    ..The ET(B)-dependent relaxation of the cerebrovasculature is inhibited by PD 142893 at least in a comparable amount of contraction...
  13. doi request reprint Treatment results for complex middle cerebral artery aneurysms. A prospective single-center series
    Erdem Güresir
    Department of Neurosurgery, Johann Wolfgang Goethe University, Schleusenweg 2 16, 60528, Frankfurt am Main, Germany
    Acta Neurochir (Wien) 153:1247-52. 2011
    ..The objective was to assess the surgical results in complex middle cerebral artery (MCA) aneurysms...
  14. ncbi request reprint Cerebrovascular characterization of the novel nonpeptide endothelin-A receptor antagonist LU 208075
    Hartmut Vatter
    Department of Neurosurgery, Johann Wolfgang Goethe University, Schleusenweg 2 16, D 60528 Frankfurt am Main, Germany
    Clin Neuropharmacol 26:73-83. 2003
    ..The selectivity for the ET(A) receptor was approximately sevenfold. Furthermore, the results may suggest an inhibition of the functional ET-converting enzyme activity by LU 208075...
  15. ncbi request reprint [D-Val22]big ET-1[16-38] inhibits endothelin-converting enzyme activity: a promising concept in the prevention of cerebral vasospasm
    Michael Zimmermann
    Department of Neurosurgery, University of Frankfurt Main, Schleusenweg 2 16, 60528 Frankfurt, Germany
    Neurosurg Rev 26:125-32. 2003
    ..Therefore, further studies of the biochemical nature of cerebrovascular ECE activity are required...
  16. doi request reprint Resection of gliomas in the cingulate gyrus: functional outcome and survival
    Agi Oszvald
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Schleusenweg 2 16, 60528, Frankfurt, Germany
    J Neurooncol 109:341-8. 2012
    ..5 months (WHO°IV), and overall survival was 34 months. Microsurgical resection of gliomas arising from the GC is feasible; gross total resection can be achieved for 90 % of gliomas arising from the GC with 5 % long-term morbidity...
  17. doi request reprint Chronic subdural haematoma in elderly patients: a retrospective analysis of 322 patients between the ages of 65-94 years
    Valeri Borger
    Department of Neurosurgery, Johann Wolfgang Goethe University Frankfurt am Main, Schleusenweg 2 16, 60528, Frankfurt am Main, Germany
    Acta Neurochir (Wien) 154:1549-54. 2012
    ..There are scarce data focussing especially on elderly patients with cSDH. This study intended to evaluate the outcome and peri-operative risks in elderly patients with cSDH...
  18. doi request reprint Oculomotor nerve palsy by posterior communicating artery aneurysms: influence of surgical strategy on recovery
    Erdem Güresir
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurosurg 117:904-10. 2012
    ..The resolution of ONP is inversely associated with the initial severity of ONP...
  19. doi request reprint Cranioplasty after decompressive craniectomy: the effect of timing on postoperative complications
    Patrick Schuss
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurotrauma 29:1090-5. 2012
    ..The present data suggest that patients who undergo late CP might benefit from a lower complication rate. This might influence future surgical decision making regarding optimal timing of cranioplasty...
  20. doi request reprint Glioblastoma therapy in the elderly and the importance of the extent of resection regardless of age
    Agi Oszvald
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurosurg 116:357-64. 2012
    ..The objective of this study was to analyze whether age influences the outcome of patients with glioblastoma and whether elderly patients with glioblastoma can tolerate the same aggressive treatment as younger patients...
  21. ncbi request reprint Time course in the development of cerebral vasospasm after experimental subarachnoid hemorrhage: clinical and neuroradiological assessment of the rat double hemorrhage model
    Hartmut Vatter
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt, Germany
    Neurosurgery 58:1190-7; discussion 1190-7. 2006
    ..Additionally, perfusion weighted imaging (PWI) at 3 tesla magnetic resonance (MR) tomography was implemented to assess the reduction in cerebral blood flow (CBF)...
  22. ncbi request reprint Cerebrovascular characterization of clazosentan, the first nonpeptide endothelin receptor antagonist clinically effective for the treatment of cerebral vasospasm. Part I: inhibitory effect on endothelin(A) receptor-mediated contraction
    Hartmut Vatter
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main
    J Neurosurg 102:1101-7. 2005
    ..The aim of the present investigation was, therefore, to define the pharmacological properties of clazosentan that affect ET(A) receptor-mediated contraction in the cerebrovasculature...
  23. doi request reprint Posterior communicating artery aneurysm-related oculomotor nerve palsy: influence of surgical and endovascular treatment on recovery: single-center series and systematic review
    Erdem Güresir
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Neurosurgery 68:1527-33; discussion 1533-4. 2011
    ..Compression of the third nerve resulting in oculomotor nerve palsy (ONP) is a common initial symptom and in some cases the only neurological deficit in patients with posterior communicating artery (PcomA) aneurysms...
  24. ncbi request reprint Persistence of the nitric oxide-dependent vasodilator pathway of cerebral vessels after experimental subarachnoid hemorrhage
    Hartmut Vatter
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt, Germany
    Neurosurgery 60:179-87; discussion 187-8. 2007
    ..Therefore, the aim of the present investigation was to characterize this pathway on cerebral arteries during CVS...
  25. doi request reprint Long-term effects of antiplatelet drugs on aneurysm occlusion after endovascular treatment
    Johannes Platz
    Department of Neurosurgery, Goethe University, Frankfurt, Germany
    J Neurointerv Surg 4:345-50. 2012
    ..Recently, an increasing number of patients have received antiplatelet (AP) drugs periprocedurally, possibly inhibiting early thrombus formation...
  26. ncbi request reprint Risk of shunt-dependent hydrocephalus after occlusion of ruptured intracranial aneurysms by surgical clipping or endovascular coiling: a single-institution series and meta-analysis
    Jean G de Oliveira
    Department of Neurosurgery, Neurocenter, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Neurosurgery 61:924-33; discussion 933-4. 2007
    ..To compare the risk of shunt-dependent hydrocephalus after treatment of ruptured intracranial aneurysms by clipping versus coiling...
  27. doi request reprint Influence of surgical or endovascular treatment on visual symptoms caused by intracranial aneurysms: single-center series and systematic review
    Patrick Schuss
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurosurg 115:694-9. 2011
    ..The objective of this study was to analyze the recovery of visual deficits caused by the mass effect of intracranial aneurysms after surgical clipping or endovascular treatment...
  28. doi request reprint The effect of common carotid artery occlusion on delayed brain tissue damage in the rat double subarachnoid hemorrhage model
    Erdem Güresir
    Department of Neurosurgery, Johann Wolfgang Goethe University Frankfurt am Main, Germany
    Acta Neurochir (Wien) 154:11-9. 2012
    ....
  29. doi request reprint Decompressive craniectomy in subarachnoid hemorrhage
    Erdem Güresir
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Neurosurg Focus 26:E4. 2009
    ..The aim of this study was to analyze decompressive craniectomy (DC) in the setting of subarachnoid hemorrhage (SAH) with bleeding, infarction, or brain swelling as the underlying pathology in a large cohort of consecutive patients...
  30. doi request reprint Rapid closure technique in decompressive craniectomy
    Erdem Güresir
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurosurg 114:954-60. 2011
    ..The object of this study was to describe the rapid closure technique in decompressive craniectomy without duraplasty and its use in a large cohort of consecutive patients...
  31. ncbi request reprint The influence of barometric pressure changes and standard meteorological variables on the occurrence and clinical features of subarachnoid hemorrhage
    Matthias Setzer
    Department of Neurosurgery, Johann Wolfgang Goethe University, 60526 Frankfurt Main, Germany
    Surg Neurol 67:264-72; discussion 272. 2007
    ..The purpose of this study was to examine a possible association between standard meteorological variables and their changes and the occurrence and clinical features of SAH...
  32. ncbi request reprint Functional effects of levosimendan in rat basilar arteries in vitro
    Juergen Konczalla
    Department of Neurosurgery, Johann Wolfgang Goethe University Frankfurt am Main Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    Curr Neurovasc Res 10:126-33. 2013
    ..We did not detect a vasospastic potential for levosimedan in cerebral arteries, suggesting that it would be safe for use in SAH patients...
  33. doi request reprint The Impact of the Body Mass Index on Outcome After Subarachnoid Hemorrhage: Is There an Obesity Paradox in SAH? A Retrospective Analysis
    Johannes Platz
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Neurosurgery 73:201-8. 2013
    ..However, recent studies have described favorable outcomes of obese patients after stroke, a phenomenon called the "obesity paradox."..
  34. doi request reprint "Team time-out" and surgical safety-experiences in 12,390 neurosurgical patients
    Agi Oszvald
    Department of Neurosurgery, Intensive Care Medicine, and Pain Therapy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Neurosurg Focus 33:E6. 2012
    ....
  35. doi request reprint Exclusively intradural exposure and clip reconstruction in complex paraclinoid aneurysms
    Volker Seifert
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Acta Neurochir (Wien) 153:2103-9. 2011
    ..The management of complex paraclinoid aneurysms is still challenging. In this article we describe our approach to paraclinoid aneurysms, which has evolved over several years, using an exclusively intradural approach...
  36. ncbi request reprint Endothelin-converting enzyme activity in human cerebral circulation
    Hartmut Vatter
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt, Germany
    Neurosurgery 51:445-51; discussion 451-2. 2002
    ..Although the receptors mediating the effects of ET-1 human cerebrovasculature are well characterized, data concerning the functionally relevant ET-converting enzyme (ECE) activity are scarce...
  37. doi request reprint Endothelin related pathophysiology in cerebral vasospasm: what happens to the cerebral vessels?
    Hartmut Vatter
    Department of Neurosurgery, Center of Clinical Neurosciences, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Acta Neurochir Suppl 110:177-80. 2011
    ..Therefore, tailored approaches for the treatment of CVS remain to be ET(A)-receptor selective antagonists...
  38. doi request reprint Antiplatelet therapy, but not intravenous thrombolytic therapy, is associated with postoperative bleeding complications after decompressive craniectomy for stroke
    Patrick Schuss
    Department of Neurosurgery, Johann Wolfgang Goethe University, Schleusenweg 2 16, 60528, Frankfurt am Main, Germany
    J Neurol 260:2149-55. 2013
    ..Patients with or without IVT prior to DC suffered significantly more often from postoperative bleeding complications if antiplatelet therapy was applied before onset of AIS. ..
  39. doi request reprint Decompressive craniectomy in children: single-center series and systematic review
    Erdem Güresir
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Neurosurgery 70:881-8; discussion 888-9. 2012
    ..However, the application of DC is as controversial in the pediatric population as it is in adults...
  40. doi request reprint Intraoperative MRI guidance and extent of resection in glioma surgery: a randomised, controlled trial
    Christian Senft
    Department of Neurosurgery, Goethe University, Frankfurt, Germany
    Lancet Oncol 12:997-1003. 2011
    ..Intraoperative MRI is increasingly used in neurosurgery, although there is little evidence for its use. We aimed to assess efficacy of intraoperative MRI guidance on extent of resection in patients with glioma...
  41. pmc Treatment related morbidity of unruptured intracranial aneurysms: results of a prospective single centre series with an interdisciplinary approach over a 6 year period (1999-2005)
    Rüdiger Gerlach
    Department of Neurosurgery, Johann Wolfgang Goethe University, Schleusenweg 2 16, 60528 Frankfurt Main, Germany
    J Neurol Neurosurg Psychiatry 78:864-71. 2007
    ..To review the angiographic and clinical outcome of patients with unruptured intracranial aneurysm(s) (UIA) with regard to complications and successful obliteration by surgical clipping or endovascular coiling...
  42. ncbi request reprint Ambrisentan, a non-peptide endothelin receptor antagonist
    Hartmut Vatter
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Cardiovasc Drug Rev 24:63-76. 2006
    ..This review may help to define pathophysiological conditions, in which ambrisentan could be indicated and further evaluated in appropriate preclinical and clinical trials...
  43. ncbi request reprint Management of spinal meningiomas: surgical results and a review of the literature
    Matthias Setzer
    Neurosurgical Clinic, Neurocenter, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Neurosurg Focus 23:E14. 2007
    ..In this report, the authors describe their experience in the surgical management of spinal meningiomas at two neurosurgical centers. The results of a literature review are also presented...
  44. ncbi request reprint Blood flow velocities in the basal cerebral vein after head trauma: a prospective study in 82 patients
    Kay Mursch
    Department of Neurosurgery, Georg August Universitat Gottingen, Germany
    J Neuroimaging 12:325-9. 2002
    ....
  45. ncbi request reprint Alteration of the cerebrovascular function of endothelin B receptor after subarachnoidal hemorrhage in the rat
    Juergen Konczalla
    Department of Neurosurgery, Institute of Neuroradiology, Johann Wolfgang Goethe University, D 60528 Frankfurt am Main, Germany
    Exp Biol Med (Maywood) 231:1064-8. 2006
    ..The present data indicate the loss of the ET(B) receptor-mediated relaxation of the cerebral arteries in cases of CVS, which is independent of the endothelial nitric oxide synthase level...