M Maegele

Summary

Country: Germany

Publications

  1. pmc Trauma registry record linkage: methodological approach to benefit from complementary data using the example of the German Pelvic Injury Register and the TraumaRegister DGU(®)
    Markus Burkhardt
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstrasse 100, 66421, Homburg Saar, Germany
    BMC Med Res Methodol 13:30. 2013
  2. doi request reprint Coagulopathy after traumatic brain injury: incidence, pathogenesis, and treatment options
    Marc Maegele
    Department of Trauma and Orthopedic Surgery, Institute for Research in Operative Medicine IFOM, University of Witten Herdecke, Cologne Merheim Medical Center, Cologne, Germany
    Transfusion 53:28S-37S. 2013
  3. pmc The trauma patient in hemorrhagic shock: how is the C-priority addressed between emergency and ICU admission?
    Sigune Peiniger
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Centre CMMC, Cologne, Germany
    Scand J Trauma Resusc Emerg Med 20:78. 2012
  4. doi request reprint The acute coagulopathy of trauma: mechanisms and tools for risk stratification
    Marc Maegele
    Department of Traumatology and Orthopedic Surgery, Cologne Merheim Medical Center, University of Witten Herdecke, Cologne, Germany
    Shock 38:450-8. 2012
  5. pmc Early and individualized goal-directed therapy for trauma-induced coagulopathy
    Herbert Schöchl
    Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Vienna, Austria
    Scand J Trauma Resusc Emerg Med 20:15. 2012
  6. pmc Acute traumatic coagulopathy in severe injury: incidence, risk stratification, and treatment options
    Marc Maegele
    Klinik für Unfallchirurgie, Orthopädie und Sporttraumatologie, Kliniken der Stadt Köln gGmbH
    Dtsch Arztebl Int 108:827-35. 2011
  7. pmc Pelvic digit as a rare cause of chronic hip pain and functional impairment: a case report and review of the literature
    Marc Maegele
    Department of Trauma and Orthopedic Surgery, Intensive Care Unit, University of Witten Herdecke, Cologne Merheim Medical Center CMMC, Ostmerheimerstr 200, D 51109 Cologne, Germany
    J Med Case Reports 3:139. 2009
  8. pmc Reappraising the concept of massive transfusion in trauma
    Simon J Stanworth
    NHS Blood and Transplant, Oxford Radcliffe Hospitals Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9BQ, UK
    Crit Care 14:R239. 2010
  9. pmc Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy
    Herbert Schöchl
    Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Donaueschingenstrasse 13, A 1200 Vienna, Austria
    Crit Care 15:R83. 2011
  10. ncbi request reprint Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients
    Marc Maegele
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Center, Ostmerheimerstr 200, D 51109 Cologne, Germany
    Injury 38:298-304. 2007

Collaborators

Detail Information

Publications47

  1. pmc Trauma registry record linkage: methodological approach to benefit from complementary data using the example of the German Pelvic Injury Register and the TraumaRegister DGU(®)
    Markus Burkhardt
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstrasse 100, 66421, Homburg Saar, Germany
    BMC Med Res Methodol 13:30. 2013
    ..The aim of the approach is to create an intersection set that benefit from complementary data of each registry, respectively. Furthermore, the concordance of data entry of some clinical variables entered in both registries was evaluated...
  2. doi request reprint Coagulopathy after traumatic brain injury: incidence, pathogenesis, and treatment options
    Marc Maegele
    Department of Trauma and Orthopedic Surgery, Institute for Research in Operative Medicine IFOM, University of Witten Herdecke, Cologne Merheim Medical Center, Cologne, Germany
    Transfusion 53:28S-37S. 2013
    ..This review summarizes the current understanding with regard to frequency, pathogenesis, diagnosis, and treatment of the coagulopathy after TBI...
  3. pmc The trauma patient in hemorrhagic shock: how is the C-priority addressed between emergency and ICU admission?
    Sigune Peiniger
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Centre CMMC, Cologne, Germany
    Scand J Trauma Resusc Emerg Med 20:78. 2012
    ....
  4. doi request reprint The acute coagulopathy of trauma: mechanisms and tools for risk stratification
    Marc Maegele
    Department of Traumatology and Orthopedic Surgery, Cologne Merheim Medical Center, University of Witten Herdecke, Cologne, Germany
    Shock 38:450-8. 2012
    ..Point-of-care viscoelastic testing may be an alternative to early recognize trauma-induced coagulopathy with the risk of ongoing hemorrhage and transfusion...
  5. pmc Early and individualized goal-directed therapy for trauma-induced coagulopathy
    Herbert Schöchl
    Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Vienna, Austria
    Scand J Trauma Resusc Emerg Med 20:15. 2012
    ..The concept of early, individualized and goal-directed therapy is explored in this review and the AUVA Trauma Hospital algorithm for managing trauma-induced coagulopathy is presented...
  6. pmc Acute traumatic coagulopathy in severe injury: incidence, risk stratification, and treatment options
    Marc Maegele
    Klinik für Unfallchirurgie, Orthopädie und Sporttraumatologie, Kliniken der Stadt Köln gGmbH
    Dtsch Arztebl Int 108:827-35. 2011
    ..In this review article, we discuss the incidence and causes of ATC, the potential means of early risk stratification for it, and recommendations for its treatment...
  7. pmc Pelvic digit as a rare cause of chronic hip pain and functional impairment: a case report and review of the literature
    Marc Maegele
    Department of Trauma and Orthopedic Surgery, Intensive Care Unit, University of Witten Herdecke, Cologne Merheim Medical Center CMMC, Ostmerheimerstr 200, D 51109 Cologne, Germany
    J Med Case Reports 3:139. 2009
    ..On a plain radiography, pelvic digit typically appears as a rib- or phalanx-like bone structure with a clear cortex and medulla related to the pelvis, often with a pseudoarticulation at its base...
  8. pmc Reappraising the concept of massive transfusion in trauma
    Simon J Stanworth
    NHS Blood and Transplant, Oxford Radcliffe Hospitals Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9BQ, UK
    Crit Care 14:R239. 2010
    ..We also examined whether the concept was useful in that early prediction of massive transfusion requirements could allow early activation of blood bank protocols...
  9. pmc Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy
    Herbert Schöchl
    Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Donaueschingenstrasse 13, A 1200 Vienna, Austria
    Crit Care 15:R83. 2011
    ....
  10. ncbi request reprint Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients
    Marc Maegele
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Center, Ostmerheimerstr 200, D 51109 Cologne, Germany
    Injury 38:298-304. 2007
    ..There is increasing evidence for acute traumatic coagulopathy occurring prior to emergency room (ER) admission but detailed information is lacking...
  11. ncbi request reprint Reversal of neuromotor and cognitive dysfunction in an enriched environment combined with multimodal early onset stimulation after traumatic brain injury in rats
    Marc Maegele
    Biochemische und Experimentelle Abteilung, Medizinische Fakultät der Universität zu Köln, Chirurgische Klinik der Universität Witten Herdecke, Klinikum Köln Merheim, Germany
    J Neurotrauma 22:772-82. 2005
    ..003). These results indicate that the reversal of neuromotor and cognitive dysfunction after TBI can be substantially enhanced when MEOS is added to EE...
  12. doi request reprint Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft für Unfallchirurgie
    M Maegele
    Department of Trauma and Orthopedic Surgery, and Institute for Research in Operative Medicine IFOM, University of Witten Herdecke, Cologne Merheim Medical Center CMMC, Cologne, Germany
    Vox Sang 95:112-9. 2008
    ..To test whether an acute transfusion practice of packed red blood cells (pRBC) : fresh-frozen plasma (FFP) 1 : 1 would be associated with reduced mortality in acute bleeding multiply injury...
  13. doi request reprint Revalidation and update of the TASH-Score: a scoring system to predict the probability for massive transfusion as a surrogate for life-threatening haemorrhage after severe injury
    M Maegele
    Department of Traumatology and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Center CMMC, Cologne, Germany
    Vox Sang 100:231-8. 2011
    ..Changes with respect to management and outcome of these patients over time prompted a revalidation and an update of the TASH-Score...
  14. doi request reprint Frequency, risk stratification and therapeutic management of acute post-traumatic coagulopathy
    M Maegele
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Center, Cologne, Germany
    Vox Sang 97:39-49. 2009
    ....
  15. ncbi request reprint Incidence and outcome of traumatic brain injury in an urban area in Western Europe over 10 years
    M Maegele
    Department of Surgery, Cologne Merheim Medical Center, University of Witten Herdecke, Cologne, Germany
    Eur Surg Res 39:372-9. 2007
    ..Valid epidemiological data on incidence and outcome of traumatic brain injury (TBI) show great variability. A study on incidence, severity and outcome of TBI was conducted in an urban area of one million inhabitants...
  16. ncbi request reprint Differential immunoresponses following experimental traumatic brain injury, bone fracture and "two-hit"-combined neurotrauma
    M Maegele
    Institute for Research in Operative Medicine IFOM, University of Witten Herdecke, Ostmerheimerstr 200, D 51109 Cologne, Germany
    Inflamm Res 56:318-23. 2007
    ..e. TBI + muskuloskeletal trauma (bone fracture)...
  17. pmc Transurethral catheter in the distal ureter as a cause for acute abdominal pain
    Marc Maegele
    Department of Traumatology and Orthopedic Surgery, Intensive Care Unit, University of Witten Herdecke, Cologne Merheim Medical Center, Cologne, Germany
    Emerg Med J 24:599. 2007
  18. pmc Balanced massive transfusion ratios in multiple injury patients with traumatic brain injury
    Sigune Peiniger
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Centre, Ostmerheimerstrasse 200, D 51109 Cologne, Germany
    Crit Care 15:R68. 2011
    ....
  19. pmc One year ago not business as usual: wound management, infection and psychoemotional control during tertiary medical care following the 2004 Tsunami disaster in southeast Asia
    Marc Maegele
    Department of Traumatology and Orthopedic Surgery, Cologne Merheim Medical Center CMMC, University of Witten Herdecke, Ostmerheimerstrasse, 51109 Cologne, Germany
    Crit Care 10:R50. 2006
    ..One cohort was triaged to the Cologne-Merheim Medical Center (Germany) for further medical care. We report on the tertiary medical care provided to this cohort of patients...
  20. doi request reprint The role of endothelin and endothelin antagonists in traumatic brain injury: a review of the literature
    Marc Maegele
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Center, Germany
    Neurol Res 33:119-26. 2011
    ..In addition, the role of age for the effects of endothelins on cerebral hemodynamics after traumatic brain injury is discussed...
  21. doi request reprint Changes in transfusion practice in multiple injury between 1993 and 2006: a retrospective analysis on 5389 patients from the German Trauma Registry
    Marc Maegele
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Center CMMC, Cologne, Germany
    Transfus Med 19:117-24. 2009
    ..pRBC transfusion practices in acute trauma care have changed substantially over the last one-and-half decade and were associated with better outcome...
  22. doi request reprint [Trauma-associated bleeding in the severely injured. Relevance, risk stratification and current therapy approaches]
    S Peiniger
    Klinik für Unfallchirurgie und Orthopädie, Kliniken der Stadt Köln gGmbH, Krankenhaus Köln Merheim, Universitätsklinikum Witten Herdecke, Standort Köln Merheim, Ostmerheimerstrasse 200, Koln, Germany
    Unfallchirurg 115:173-83. 2012
    ..In an extension to this work a clinical scoring system for early identification of patients at high risk for ongoing bleeding is presented. High risk patients seem to benefit from a more balanced transfusion regimen...
  23. doi request reprint [Emergency room management of multiple trauma : ATLS® and S3 guidelines]
    B Bouillon
    Klinik für Unfallchirurgie, Orthopädie und Sporttraumatologie, Lehrstuhl der Universität Witten Herdecke am Klinikum Köln Merheim, Ostmerheimerstr 200, 51109, Koln, Deutschland
    Chirurg 84:745-52. 2013
    ..Important factors are reliability of agreement between the different disciplines and continuous communication of results to the team members. In order to be successful such quality circles need people that care. ..
  24. doi request reprint [Damage Control Orthopedics. What is the current situation?]
    B Bouillon
    Klinik für Unfallchirurgie, Orthopädie und Sporttraumatologie am Klinikum Köln Merheim, Berufsgenossenschaftliche Universitätsklinikum Bergmannsheil, Bochum, Ostmerheimerstr 200, 51109, Koln
    Unfallchirurg 112:860-9. 2009
    ..A new multi-center randomized study has been started to evaluate the concept of damage control in a defined group of critically injured patients with femoral shaft fractures...
  25. doi request reprint Association of preexisting medical conditions with in-hospital mortality in multiple-trauma patients
    Sebastian Wutzler
    Institute for Research in Operative Medicine, University of Witten Herdecke, Cologne, Germany
    J Am Coll Surg 209:75-81. 2009
    ..The independent predictive value of specific PMCs for in-hospital mortality after adjustment for injury severity, injury pattern, age, and presence of other PMCs has not been fully elucidated...
  26. doi request reprint [Recombinant factor VIIa for the treatment of exsanguinating trauma patients: a matched-pair analysis from the Trauma Registry of the German Society for Trauma Surgery]
    A Wafaisade
    Lehrstuhl für Unfallchirurgie, Orthopädie und Sporttraumatologie, Universitätsklinik Witten Herdecke am Klinikum Köln Merheim, Ostmerheimerstrasse 200, 51109, Koln, Deutschland
    Unfallchirurg 116:524-30. 2013
    ..The aim of the study was to assess whether the use of recombinant factor VIIa (rFVIIa) in trauma patients was associated with improved outcome...
  27. doi request reprint A critical reappraisal of the ATLS classification of hypovolaemic shock: does it really reflect clinical reality?
    M Mutschler
    Department of Trauma and Orthopedic Surgery, Cologne Merheim Medical Center, Cologne, Germany
    Resuscitation 84:309-13. 2013
    ..The aim of this study was to validate the classification of hypovolaemic shock given by the Advanced Trauma Life Support (ATLS)...
  28. doi request reprint [Multiple femur and tibia shaft fractures in the severely injured. A therapeutic challenge]
    E S Steinhausen
    Klinik für Unfallchirurgie, Orthopädie und Sporttraumatologie, Klinikum Köln Merheim
    Unfallchirurg 112:652-5. 2009
    ..We report the primary total definitive treatment of a patient with multiple fractures of the lower extremities. Postoperative respiratory insufficiency was treated successfully by non-invasive ventilation...
  29. ncbi request reprint Trauma Associated Severe Hemorrhage (TASH)-Score: probability of mass transfusion as surrogate for life threatening hemorrhage after multiple trauma
    Nedim Yucel
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Center, Germany
    J Trauma 60:1228-36; discussion 1236-7. 2006
    ..To develop a simple scoring system that allows an early and reliable estimation for the probability of mass transfusion (MT) as a surrogate for life threatening hemorrhage following multiple trauma...
  30. ncbi request reprint Reduced colonization and infection with miconazole-rifampicin modified central venous catheters: a randomized controlled clinical trial
    Nedim Yucel
    2nd Department of Surgery, Klinikum Merheim, Germany
    J Antimicrob Chemother 54:1109-15. 2004
    ..Catheters modified with miconazole and rifampicin that constantly and slowly release antimicrobial substances are assumed to be beneficial in reducing rates of colonization and catheter-related infections...
  31. ncbi request reprint The long-distance tertiary air transfer and care of tsunami victims: injury pattern and microbiological and psychological aspects
    Marc Maegele
    Department of Traumatology and Orthopedic Surgery, University of Witten Herdecke, Ostmerheimerstr 200, 51109 Cologne, Germany
    Crit Care Med 33:1136-40. 2005
    ..The objective of this report was to characterize typical injury patterns along with microbiological findings and psychoemotional aspects unique to the tsunami disaster...
  32. doi request reprint Acute coagulopathy in isolated blunt traumatic brain injury
    Arasch Wafaisade
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Center, Ostmerheimerstr 200, 51109 Cologne, Germany
    Neurocrit Care 12:211-9. 2010
    ..This study was conducted to assess the frequency, outcome, and risk factors associated with this complication...
  33. ncbi request reprint Health-related quality of life during the first year after severe brain trauma with and without polytrauma
    Marcela Lippert-Grüner
    Department of Neurosurgery, University of Cologne, Cologne, Germany
    Brain Inj 21:451-5. 2007
    ..Investigations on health-related quality of life (HRQoL) after TBI with and without concomitant polytrauma are rare compared to other disorders...
  34. doi request reprint Pharyngeal selective brain cooling improves neurofunctional and neurocognitive outcome after fluid percussion brain injury in rats
    Hinnerk Doll
    Institute for Research in Operative Medicine IFOM, University of Witten Herdecke, Cologne, Germany
    J Neurotrauma 26:235-42. 2009
    ..01), as well as latency, distance, and mean number of errors in the BCM on DPI 14 (p < 0.01). The novel approach of pSBC was associated with improved neuromotor, sensormotor, and neurocognitive outcome after experimental TBI...
  35. pmc Systemic inflammatory effects of traumatic brain injury, femur fracture, and shock: an experimental murine polytrauma model
    C Probst
    Department of Trauma and Orthopaedic Surgery, Cologne Merheim Medical Center, Faculty of Health School of Medicine, Witten Herdecke University, Ostmerheimer Straße 200, 51109 Cologne, Germany
    Mediators Inflamm 2012:136020. 2012
    ..Experimental investigation in an animal model may provide relevant insight for therapeutic strategies. We describe the effects of a combined injury with respect to lymphocyte population and cytokine activation...
  36. doi request reprint Acalculous cholecystitis in severely burned patients: incidence and predisposing factors
    P Theodorou
    Department of Plastic and Reconstructive Surgery, University of Witten Herdecke, Cologne City Hospitals Merheim, Cologne, Germany
    Burns 35:405-11. 2009
    ..To investigate the incidence and predisposing factors of acalculous cholecystitis (AAC) in severely burned patients...
  37. ncbi request reprint [Pulmonary pseudocysts. A rare entity after thoracic injury]
    T Steinbüchel
    Klinik für Orthopädie und Unfallchirurgie, Klinikum Köln Merheim, Universitat Witten Herdecke, Ostmerheimerstrasse 200, 51109, Koln, Germany
    Unfallchirurg 110:716-9. 2007
    ....
  38. ncbi request reprint Characterization of a new rat model of experimental combined neurotrauma
    Marc Maegele
    Biochemical and Experimental Division, Medical Faculty of the University of Cologne, 51109 Cologne, Germany
    Shock 23:476-81. 2005
    ..The CNT model mimics a variety of clinically relevant features known from human multiple injury, including TBI, and offers novel approaches for investigation of interactive mechanisms and therapeutic approaches...
  39. doi request reprint Negative pressure wound therapy: a vacuum of evidence?
    Sven Gregor
    Institute for Research in Operative Medicine, University of Witten Herdecke, Ostmerheimer Str 200, 51109 Cologne, Germany
    Arch Surg 143:189-96. 2008
    ..To systematically examine the clinical effectiveness and safety of negative pressure wound therapy (NPWT) compared with conventional wound therapy...
  40. ncbi request reprint Nonoperative management of post-traumatic pulmonary pseudocyst after severe thoracic trauma and hemorrhage by coagulation management, kinetic therapy, and control of secondary infection: a case report
    Eva Steinhausen
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Hospital Cologne Merheim, Ostmerheimerstr 200, D 51109 Cologne, Germany
    J Trauma 63:1391-4. 2007
  41. doi request reprint Stem cell-based cellular replacement strategies following traumatic brain injury (TBI)
    Marc Maegele
    Institute for Research in Operative Medicine IFOM, University of Witten Herdecke, Cologne Merheim Medical Center CMMC, Cologne, Germany
    Minim Invasive Ther Allied Technol 17:119-31. 2008
    ..A review on current pre-clinical knowledge with respect to cellular replacement into the experimentally injured brain is presented...
  42. doi request reprint Venous thromboembolism after severe trauma: incidence, risk factors and outcome
    Thomas Paffrath
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Center CMMC, Ostmerheimerstr 200, D 51109 Cologne, Germany
    Injury 41:97-101. 2010
    ....
  43. ncbi request reprint Multimodal early onset stimulation combined with enriched environment is associated with reduced CNS lesion volume and enhanced reversal of neuromotor dysfunction after traumatic brain injury in rats
    Marc Maegele
    Biochemical and Experimental Division, Faculty of Medicine, University of Cologne, Germany
    Eur J Neurosci 21:2406-18. 2005
    ..0 +/- 3.4 < or = 6.5 +/- 4.3 < 10.7 +/- 1.2). This first report on the effect of EE + MEOS treatment strongly indicates that the combined exposure reduces CNS scar formation and reverses neuromotor deficits after TBI in rats...
  44. ncbi request reprint Late effects of enriched environment (EE) plus multimodal early onset stimulation (MEOS) after traumatic brain injury in rats: Ongoing improvement of neuromotor function despite sustained volume of the CNS lesion
    Marcela Lippert-Gruener
    Department of Neurosurgery, University of Cologne, Germany
    Exp Neurol 203:82-94. 2007
    ..We conclude that EE+MEOS retards, but cannot prevent the increase of lesion volume. This retardation is sufficient for a continuous restoration of neurological functions...
  45. ncbi request reprint Mechanical stimulation of paralyzed vibrissal muscles following facial nerve injury in adult rat promotes full recovery of whisking
    Doychin N Angelov
    Anatomical Institute I, University of Cologne, Germany
    Neurobiol Dis 26:229-42. 2007
    ..Our findings indicate the potential of use-specific training to enhance appropriate functional outcome after peripheral nerve injury and may be useful in a clinical rehabilitation setting...
  46. ncbi request reprint Multifactorial aspects to explain variations of control group mortality rates of randomized controlled trials
    Marc Maegele
    Crit Care Med 33:2410-1. 2005
  47. ncbi request reprint Trauma-associated inflammatory response impairs embryonic stem cell survival and integration after implantation into injured rat brain
    Marek Molcanyi
    Clinic of Neurosurgery, Faculty of Medicine, University of Cologne, Germany
    J Neurotrauma 24:625-37. 2007
    ..Our results demonstrate a significant post-traumatic inflammatory response, which impairs survival and integration of implanted stem cells and has generally not been taken into account in designs of previous transplantation studies...