Henning Madry

Summary

Country: Germany

Publications

  1. ncbi request reprint Cartilage constructs engineered from chondrocytes overexpressing IGF-I improve the repair of osteochondral defects in a rabbit model
    H Madry
    Centre of Experimental Orthopaedics, Medical Faculty, Building 37, Saarland University, D 66421 Homburg, Germany
    Eur Cell Mater 25:229-47. 2013
  2. doi request reprint Effect of open wedge high tibial osteotomy on the lateral compartment in sheep. Part I: Analysis of the lateral meniscus
    Henning Madry
    Center of Experimental Orthopaedics, Saarland University, Kirrbergerstr 1, Bldg 37, 66421, Homburg, Saar, Germany
    Knee Surg Sports Traumatol Arthrosc 21:39-48. 2013
  3. doi request reprint Biological aspects of early osteoarthritis
    Henning Madry
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University, Kirrbergerstrasse, Building 37, 66421, Homburg, Germany
    Knee Surg Sports Traumatol Arthrosc 20:407-22. 2012
  4. pmc Cartilage repair and joint preservation: medical and surgical treatment options
    Henning Madry
    Lehrstuhl für Experimentelle Orthopädie und Arthroseforschung, Universitat des Saarlandes, 66421 Homburg, Germany
    Dtsch Arztebl Int 108:669-77. 2011
  5. pmc Clinical potential and challenges of using genetically modified cells for articular cartilage repair
    Henning Madry
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University Medical Center, Homburg Saar, Germany
    Croat Med J 52:245-61. 2011
  6. pmc The diagnosis and treatment of eating disorders
    Stephan Herpertz
    Lehrstuhl für Experimentelle Orthopädie und Arthroseforschung, Universitat des Saarlandes, 66421 Homburg, Germany
    Dtsch Arztebl Int 108:678-85. 2011
  7. ncbi request reprint Local stimulation of articular cartilage repair by transplantation of encapsulated chondrocytes overexpressing human fibroblast growth factor 2 (FGF-2) in vivo
    Gunter Kaul
    Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Germany
    J Gene Med 8:100-11. 2006
  8. doi request reprint Effective, safe nonviral gene transfer to preserve the chondrogenic differentiation potential of human mesenchymal stem cells
    Sebastian Elsler
    Center of Experimental Orthopaedics, Saarland University Medical Center, Saarland University, Homburg Saar, Germany
    J Gene Med 14:501-11. 2012
  9. ncbi request reprint Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2
    Magali Cucchiarini
    Laboratory for Experimental Orthopaedics, Department of Orthopaedics and Orthopaedic Surgery, Saarland University Medical Center, D 66421 Homburg, Germany
    Mol Ther 12:229-38. 2005
  10. pmc SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells
    Jagadeesh K Venkatesan
    Center of Experimental Orthopaedics, Saarland University Medical CenterHomburg Saar, Germany
    Stem Cell Res Ther 3:22. 2012

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Cartilage constructs engineered from chondrocytes overexpressing IGF-I improve the repair of osteochondral defects in a rabbit model
    H Madry
    Centre of Experimental Orthopaedics, Medical Faculty, Building 37, Saarland University, D 66421 Homburg, Germany
    Eur Cell Mater 25:229-47. 2013
    ..Insights gained with additional exploration using this model may lead to more effective treatment options for acute cartilage defects...
  2. doi request reprint Effect of open wedge high tibial osteotomy on the lateral compartment in sheep. Part I: Analysis of the lateral meniscus
    Henning Madry
    Center of Experimental Orthopaedics, Saarland University, Kirrbergerstr 1, Bldg 37, 66421, Homburg, Saar, Germany
    Knee Surg Sports Traumatol Arthrosc 21:39-48. 2013
    ..To evaluate whether medial open wedge high tibial osteotomy (HTO) results in structural and biochemical changes in the lateral meniscus in adult sheep...
  3. doi request reprint Biological aspects of early osteoarthritis
    Henning Madry
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University, Kirrbergerstrasse, Building 37, 66421, Homburg, Germany
    Knee Surg Sports Traumatol Arthrosc 20:407-22. 2012
    ..The aim of this review is to highlight the molecular basis and histopathological features of early OA...
  4. pmc Cartilage repair and joint preservation: medical and surgical treatment options
    Henning Madry
    Lehrstuhl für Experimentelle Orthopädie und Arthroseforschung, Universitat des Saarlandes, 66421 Homburg, Germany
    Dtsch Arztebl Int 108:669-77. 2011
    ..Reconstructive surgical treatment strategies aim to form a repair tissue or to unload compartments of the joint with articular cartilage damage...
  5. pmc Clinical potential and challenges of using genetically modified cells for articular cartilage repair
    Henning Madry
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University Medical Center, Homburg Saar, Germany
    Croat Med J 52:245-61. 2011
    ..This, in turn, may provide an important step toward the unanswered question of articular cartilage regeneration...
  6. pmc The diagnosis and treatment of eating disorders
    Stephan Herpertz
    Lehrstuhl für Experimentelle Orthopädie und Arthroseforschung, Universitat des Saarlandes, 66421 Homburg, Germany
    Dtsch Arztebl Int 108:678-85. 2011
    ..This scientifically based S3 guideline was developed with the intention of improving the treatment of eating disorders and motivating future research in this area...
  7. ncbi request reprint Local stimulation of articular cartilage repair by transplantation of encapsulated chondrocytes overexpressing human fibroblast growth factor 2 (FGF-2) in vivo
    Gunter Kaul
    Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Germany
    J Gene Med 8:100-11. 2006
    ....
  8. doi request reprint Effective, safe nonviral gene transfer to preserve the chondrogenic differentiation potential of human mesenchymal stem cells
    Sebastian Elsler
    Center of Experimental Orthopaedics, Saarland University Medical Center, Saarland University, Homburg Saar, Germany
    J Gene Med 14:501-11. 2012
    ....
  9. ncbi request reprint Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2
    Magali Cucchiarini
    Laboratory for Experimental Orthopaedics, Department of Orthopaedics and Orthopaedic Surgery, Saarland University Medical Center, D 66421 Homburg, Germany
    Mol Ther 12:229-38. 2005
    ..This process may further benefit from cosupplementation with other factors. These results provide a basis for rAAV application to sites of articular cartilage damage to deliver agents that promote tissue repair...
  10. pmc SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells
    Jagadeesh K Venkatesan
    Center of Experimental Orthopaedics, Saarland University Medical CenterHomburg Saar, Germany
    Stem Cell Res Ther 3:22. 2012
    ....
  11. doi request reprint In vitro and in vivo characterization of nonbiomedical- and biomedical-grade alginates for articular chondrocyte transplantation
    Susanne Heiligenstein
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University, Homburg, Germany
    Tissue Eng Part C Methods 17:829-42. 2011
    ..The individual characteristics of these alginates may be valuable to tailor specific experimental and clinical strategies for cartilage tissue engineering...
  12. doi request reprint Transplanted articular chondrocytes co-overexpressing IGF-I and FGF-2 stimulate cartilage repair in vivo
    Patrick Orth
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University, Kirrbergerstrasse, Building 37, 66421, Homburg, Germany
    Knee Surg Sports Traumatol Arthrosc 19:2119-30. 2011
    ..Here, the hypothesis that co-overexpression of IGF-I and FGF-2 by transplanted articular chondrocytes enhances the early repair of cartilage defects in vivo and protects the neighbouring cartilage from degeneration was tested...
  13. ncbi request reprint Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9
    Magali Cucchiarini
    Saarland University Medical Center, Homburg, Germany
    Arthritis Rheum 56:158-67. 2007
    ..The purpose of this study was to investigate the ability of rAAV-mediated SOX9 overexpression to restore major ECM components in human OA articular cartilage...
  14. doi request reprint Acceleration of articular cartilage repair by combined gene transfer of human insulin-like growth factor I and fibroblast growth factor-2 in vivo
    Henning Madry
    Institute for Experimental Orthopaedics and Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Germany
    Arch Orthop Trauma Surg 130:1311-22. 2010
    ....
  15. doi request reprint Metabolic activities and chondrogenic differentiation of human mesenchymal stem cells following recombinant adeno-associated virus-mediated gene transfer and overexpression of fibroblast growth factor 2
    Magali Cucchiarini
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University Medical Center, Saarland University, Homburg Saar, Germany
    Tissue Eng Part A 17:1921-33. 2011
    ....
  16. doi request reprint Direct FGF-2 gene transfer via recombinant adeno-associated virus vectors stimulates cell proliferation, collagen production, and the repair of experimental lesions in the human ACL
    Henning Madry
    Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg, Germany
    Am J Sports Med 41:194-202. 2013
    ..Basic fibroblast growth factor (FGF-2) is a powerful stimulator of fibroblast proliferation and type I/III collagen production...
  17. doi request reprint Evaluation of nonbiomedical and biomedical grade alginates for the transplantation of genetically modified articular chondrocytes to cartilage defects in a large animal model in vivo
    Susanne Heiligenstein
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University Medical Center, Homburg, Germany
    J Gene Med 13:230-42. 2011
    ..In the present study, we tested the hypothesis that the alginate system allows for sustained transgene expression in cartilage defects in a preclinical large animal model in vivo...
  18. doi request reprint Human mesenchymal stem cells overexpressing therapeutic genes: from basic science to clinical applications for articular cartilage repair
    Magali Cucchiarini
    Center of Experimental Orthopaedics, Saarland University Medical Center, University of the Saarland, Homburg Saar, Germany
    Biomed Mater Eng 22:197-208. 2012
    ..Here, we propose an overview of the current approaches employed for cell- and gene-based treatment of articular cartilage disorders using mesenchymal stem cells...
  19. pmc Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis
    Anja Weimer
    Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg Saar, Germany
    Mol Med 18:346-58. 2012
    ..These findings show the benefits of directly providing an IGF-I sequence to articular cartilage via rAAV for the future treatment of human osteoarthritis...
  20. doi request reprint Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer
    Magali Cucchiarini
    Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Germany
    J Cell Mol Med 13:2476-88. 2009
    ..These data provide further motivation to develop coupled gene transfer approaches via rAAV for the treatment of human OA...
  21. doi request reprint Improved repair of chondral and osteochondral defects in the ovine trochlea compared with the medial condyle
    Patrick Orth
    Center of Experimental Orthopaedics, Saarland University, Building 37 38, D 66421, Homburg Saar, Germany Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg Saar, Germany
    J Orthop Res 31:1772-9. 2013
    ....
  22. doi request reprint Failed cartilage repair for early osteoarthritis defects: a biochemical, histological and immunohistochemical analysis of the repair tissue after treatment with marrow-stimulation techniques
    Gunter Kaul
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University Medical Center and Saarland University, Kirrbergerstr 1, Bldg 37, 66421, Homburg Saar, Germany
    Knee Surg Sports Traumatol Arthrosc 20:2315-24. 2012
    ..To examine the entire repair tissue resulting from marrow-stimulation techniques in patients with early osteoarthritis...
  23. doi request reprint Effect of subchondral drilling on the microarchitecture of subchondral bone: analysis in a large animal model at 6 months
    Patrick Orth
    Center of Experimental Orthopaedics, Saarland University, Homburg, Germany
    Am J Sports Med 40:828-36. 2012
    ..Marrow stimulation techniques such as subchondral drilling are clinically important treatment options for symptomatic small cartilage defects. Little is known about whether they induce deleterious changes in the subchondral bone...
  24. doi request reprint Analysis of novel nonviral gene transfer systems for gene delivery to cells of the musculoskeletal system
    Patrick Orth
    Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Germany
    Mol Biotechnol 38:137-44. 2008
    ..These results indicate that relatively high levels of transfection can be achieved using novel nonviral gene transfer methods...
  25. ncbi request reprint Replicative multivirus infection with cytomegalovirus, herpes simplex virus 1, and parvovirus B19, and latent Epstein-Barr virus infection in the synovial tissue of a psoriatic arthritis patient
    Yasmin Mehraein
    Department of Human Genetics, Saarland University, University Hospital, Bldg 60, 66421 Homburg Saar, Germany
    J Clin Virol 31:25-31. 2004
    ..Psoriatic arthropathy occurs as complicating feature in about 5-7% of psoriasis patients. Infectious mechanisms including viral antigens have been suggested by serologic data as CD8 T cellular specifity towards viral epitopes...
  26. ncbi request reprint Menisci are efficiently transduced by recombinant adeno-associated virus vectors in vitro and in vivo
    Henning Madry
    Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University, Homburg, Germany
    Am J Sports Med 32:1860-5. 2004
    ..Gene transfer is a potential approach to enhancing meniscal repair. Recombinant adeno-associated virus is a method of gene transfer that has advantages over previously used approaches to this problem...
  27. ncbi request reprint Gene therapy for cartilage defects
    Magali Cucchiarini
    Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University Medical Center, 66421 Homburg Saar, Germany
    J Gene Med 7:1495-509. 2005
    ..The first experimental steps provide reason for cautious optimism...
  28. doi request reprint Genetic modification of mesenchymal stem cells for cartilage repair
    Magali Cucchiarini
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University Medical Center, Homburg Saar, Germany
    Biomed Mater Eng 20:135-43. 2010
    ..The aim of this report is to provide an overview of the most recent therapeutic approaches developed in experimental orthopaedic research...
  29. pmc rAAV Vectors as Safe and Efficient Tools for the Stable Delivery of Genes to Primary Human Chondrosarcoma Cells In Vitro and In Situ
    Henning Madry
    Center of Experimental Orthopaedics, Saarland University Medical Center, Saarland, 66421 Homburg, Germany
    Sarcoma 2012:347417. 2012
    ....
  30. ncbi request reprint Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipid-mediated gene transfer in a gel suspension delivery system
    Henning Madry
    Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Germany
    J Gene Med 5:502-9. 2003
    ..We tested the hypothesis that a recombinant gene can be delivered to sites of cartilage damage in vivo using chondrocytes transfected by a lipid-mediated gene transfer method...
  31. doi request reprint Reliability, reproducibility, and validation of five major histological scoring systems for experimental articular cartilage repair in the rabbit model
    Patrick Orth
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University, Homburg Saar, Germany
    Tissue Eng Part C Methods 18:329-39. 2012
    ..Histological and biochemical evaluations may serve as complementary tools to assess articular cartilage repair in vivo...
  32. pmc rAAV-mediated overexpression of TGF-β stably restructures human osteoarthritic articular cartilage in situ
    Jagadeesh K Venkatesan
    Center of Experimental Orthopaedics, Saarland University Medical Center, Kirrbergerstr, Bldg 37, Homburg Saar 66421, Germany
    J Transl Med 11:211. 2013
    ..Therapeutic gene transfer is of significant value to elaborate efficient, durable treatments against human osteoarthritis (OA), a slow, progressive, and irreversible disorder for which there is no cure to date...
  33. ncbi request reprint Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocyte transplantation
    Henning Madry
    Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Germany
    J Gene Med 6:238-45. 2004
    ..In the present study, we tested the hypothesis that human FGF-2 (hFGF-2) gene transfer into articular chondrocytes modulates cell proliferation in an ex vivo model of chondrocyte transplantation...
  34. pmc Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging
    Claudia E Rübe
    Department of Radiation Oncology, Saarland University, Homburg Saar, Germany
    PLoS ONE 6:e17487. 2011
    ..Here we tested this hypothesis in healthy individuals of different ages by examining unrepaired DNA double-strand breaks (DSBs) in hematopoietic stem/progenitor cells matured in their physiological microenvironment...
  35. pmc Reduction of sample size requirements by bilateral versus unilateral research designs in animal models for cartilage tissue engineering
    Patrick Orth
    1 Center of Experimental Orthopaedics, Saarland University, Homburg Saar, Germany
    Tissue Eng Part C Methods 19:885-91. 2013
    ..These findings might also be transferred to other scoring systems, defect types, or translational animal models in the field of cartilage tissue engineering. ..
  36. pmc A low morbidity surgical approach to the sheep femoral trochlea
    Patrick Orth
    Center of Experimental Orthopaedics and Osteoarthritis Research, Saarland University, Saar, Germany
    BMC Musculoskelet Disord 14:5. 2013
    ..Here, we describe a low morbidity surgical exposure of the ovine trochlea without the necessity for intraoperative patellar luxation...
  37. doi request reprint Enamel matrix derivative inhibits proteoglycan production and articular cartilage repair, delays the restoration of the subchondral bone and induces changes of the synovial membrane in a lapine osteochondral defect model in vivo
    Alice Kiss
    Department of Operative Dentistry and Periodontology, Saarland University Medical Centre, Homburg Saar, Germany
    J Tissue Eng Regen Med 8:41-9. 2014
    ..These data suggest that EMD inhibits the early repair of the osteochondral unit in vivo. Copyright © 2012 John Wiley & Sons, Ltd. ..
  38. doi request reprint Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis
    Magali Cucchiarini
    Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg Saar, Germany
    J Cell Mol Med 18:115-24. 2014
    ..While the precise functions of SMN during OA remain to be elucidated, the conclusions of this study shed light on a novel pathophysiological pathway involved in the progression of OA, potentially offering new targets for therapy. ..
  39. pmc Static winging of the scapula caused by osteochondroma in adults: a case series
    Patrick Orth
    Center of Experimental Orthopaedics, University of Saarland, Kirrberger Strasse, Building 37 38, Homburg Saar D 66421, Germany
    J Med Case Rep 6:363. 2012
    ..abstract:..
  40. doi request reprint Direct rAAV SOX9 administration for durable articular cartilage repair with delayed terminal differentiation and hypertrophy in vivo
    Magali Cucchiarini
    Center of Experimental Orthopaedics, Saarland University Medical Center, Kirrbergerstr Bldg 37, 66421, Homburg Saar, Germany
    J Mol Med (Berl) 91:625-36. 2013
    ..These findings show the potential of direct rAAV gene delivery as an efficient tool to treat cartilage lesions...
  41. doi request reprint The basic science of the subchondral bone
    Henning Madry
    Institute for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Germany
    Knee Surg Sports Traumatol Arthrosc 18:419-33. 2010
    ....
  42. doi request reprint Advances and challenges in gene-based approaches for osteoarthritis
    Henning Madry
    Center of Experimental Orthopaedics, Saarland University Medical Center, Saarland University, Homburg, Saar, Germany
    J Gene Med 15:343-55. 2013
    ..Proof-of-concept studies in patients prior to undergoing total knee replacement may be privileged in the future to identify the best mode of translating this approach to clinical application, followed by randomized controlled trials...
  43. ncbi request reprint Parvovirus B19-related chronic monoarthritis: immunohistochemical detection of virus-positive lymphocytes within the synovial tissue compartment: two reported cases
    Carsten Lennerz
    Department of Human Genetics, Institut fur Humangenetik, Saarland University, Universitätskliniken Geb 60, 66421, Homburg Saar, Germany
    Clin Rheumatol 23:59-62. 2004
    ..In conclusion, respective virus diagnostics should be considered even in chronic monosymptomatic arthritic lesions. The pathology of B19 arthropathy seems to be due to direct virus infection of cells within the synovia...