Research Topics
Genomes and Genes
| Jürgen MachannSummaryCountry: Germany Publications
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Detail Information
Publications
Fraction of unsaturated fatty acids in visceral adipose tissue (VAT) is lower in subjects with high total VAT volume - a combined 1 H MRS and volumetric MRI study in male subjectsJürgen Machann
Institute for Diabetes Research and Metabolic Diseases IDM of the Helmholtz Centre Munich at the University of Tübingen Paul Langerhans Institute Tübingen, Tubingen, Germany
NMR Biomed 26:232-6. 2013..Furthermore, changes in VAT composition during weight loss or different forms of diet have yet to be examined...
An interleaved sampling strategy for MR spectroscopy in vivo: applications on human calf musculatureJ Machannab
Radiologische Klinik, Abteilung für Radiologische Diagnostik, Eberhard Karls Universitat Tubingen, Tubingen, Germany
Magn Reson Imaging 18:189-97. 2000..59 +/- 0.19 x 10(-3) mm(2)/s versus 1.20 +/- 0.08 x 10(-3) mm(2)/s in m. tib. ant.). Magnetization transfer experiments with various RF preparation pulse amplitudes led to very similar results for m. tib. ant. and m. soleus...- Follow-up whole-body assessment of adipose tissue compartments during a lifestyle intervention in a large cohort at increased risk for type 2 diabetesJürgen Machann
Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
Radiology 257:353-63. 2010.... - Age and gender related effects on adipose tissue compartments of subjects with increased risk for type 2 diabetes: a whole body MRI/MRS studyJ Machann
Section on Experimental Radiology, Department of Diagnostic Radiology, Eberhard Karls University of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
MAGMA 18:128-37. 2005.... - Hepatic lipid accumulation in healthy subjects: a comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopyJürgen Machann
Section on Experimental Radiology, Department of Diagnostic Radiology, Eberhard Karls University of Tubingen, Tubingen, Germany
Magn Reson Med 55:913-7. 2006..Fat-selective images provide more spatial information about fat distribution, which makes this technique suitable for clinical imaging of patients with liver disease... - Morning to evening changes of intramyocellular lipid content in dependence on nutrition and physical activity during one single day: a volume selective 1H-MRS studyJürgen Machann
Department of Diagnostic and Interventional Radiology, Section on Experimental Radiology, Eberhard Karls University Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
MAGMA 24:29-33. 2011.... - (1)H MR spectroscopy of skeletal muscle, liver and bone marrowJürgen Machann
Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, Eberhard Karls University Tubingen, Tubingen, Germany
Eur J Radiol 67:275-84. 2008..Adapted (1)H spectroscopic techniques allow a semi-quantitative analysis of bone marrow composition... - Osteodensitometry of human heel bones by MR spin-echo imaging: comparison with MR gradient-echo imaging and quantitative computed tomographyJ Machann
Department of Diagnostic Radiology, University of Tubingen, Tubingen, Germany
J Magn Reson Imaging 14:147-55. 2001..The high correlation between FSE imaging and bone mineral density (BMD) allows possible clinical applications of FSE imaging for diagnosis of osteoporosis. Further improvements of the accuracy using reference phantoms might be possible... - Magnetic resonance osteodensitometry in human heel bones: correlation with quantitative computed tomography using different measuring parametersJ Machann
Department of Diagnostic Radiology, Institute of Physics, Eberhard Karls University Tubingen, Germany
Invest Radiol 35:393-400. 2000.... - Standardized assessment of whole body adipose tissue topography by MRIJürgen Machann
Section on Experimental Radiology, University of Tubingen, Tubingen, Germany
J Magn Reson Imaging 21:455-62. 2005.... 
Relationships of circulating sex hormone-binding globulin with metabolic traits in humansAndreas Peter
Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
Diabetes 59:3167-73. 2010..In the present study, we investigated mechanisms by which high SHBG may prevent development to diabetes...- Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance studyMartin Heni
Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
Diabetes Metab Res Rev 26:200-5. 2010..The aim was to thoroughly quantify the fat content of pancreas sections (caput, corpus, and cauda) and to compare the impact of pancreatic, intrahepatic, and visceral fat on insulin secretion in humans... - No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetesKarsten Müssig
Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tubingen, Otfried Müller Str, 10, 72076 Tubingen, Germany
BMC Med Genet 11:84. 2010.... - Impact of variation in the FTO gene on whole body fat distribution, ectopic fat, and weight lossAxel Haupt
Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University of Tubingen, Tubingen, Germany
Obesity (Silver Spring) 16:1969-72. 2008..In conclusion, despite an association with BMI and whole body fat distribution, variation in the FTO locus has no effect on the success of a lifestyle intervention program... - Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 geneKonstantinos Kantartzis
Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
Diabetes 58:2616-23. 2009..We investigated whether the SNP determines liver fat independently of visceral adiposity and whether it may even play a role in protecting from insulin resistance... - Identification and characterization of metabolically benign obesity in humansNorbert Stefan
Department of Internal Medicine IV, University of Tubingen, D 72076 Tubingen, Germany
Arch Intern Med 168:1609-16. 2008..Conversely, even in obesity, a metabolically benign fat distribution phenotype may exist... - Variants in the CD36 gene locus determine whole-body adiposity, but have no independent effect on insulin sensitivityMartin Heni
Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tubingen, Member of the German Center for Diabetes Research DZD, Tubingen, Germany
Obesity (Silver Spring) 19:1004-9. 2011..In the long run, genetic variation within the CD36 locus may contribute to metabolic disease via its effect on body adiposity, but not via an independent effect on insulin sensitivity... - SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention--the TULIP StudyPeter Weyrich
Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tubingen, Germany
BMC Med Genet 9:100. 2008..To investigate the relevance of SIRT1 for human metabolism and caloric restriction, we analyzed SIRT1 genetic variants in respect to the outcome of a controlled lifestyle intervention in Caucasians at risk for type 2 diabetes... - Impact of variation near MC4R on whole-body fat distribution, liver fat, and weight lossAxel Haupt
Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
Obesity (Silver Spring) 17:1942-5. 2009..Thus, this candidate SNP for human obesity may preferentially affect the accumulation of subcutaneous adipose tissue. Furthermore, the variation near MC4R has no effect on success of weight loss during lifestyle intervention... - Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS studyAxel Haupt
Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
Obesity (Silver Spring) 18:1212-7. 2010..009, dominant inheritance model). Therefore, our results suggest that these new obesity SNPs, despite their influence on BMI, are neither associated with a metabolically unfavorable nor with a favorable body composition... - The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humansKonstantinos Kantartzis
Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, 72076 Tubingen, Germany
Clin Sci (Lond) 116:531-7. 2009..This finding may be important in the prevention and treatment of insulin resistance and Type 2 diabetes in subjects with fatty liver... - High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humansNorbert Stefan
Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tubingen, D 72076 Tubingen, Germany
Diabetes Care 30:1173-8. 2007..To determine which fat compartments are associated with elevated RBP4 levels in humans, we measured circulating RBP4 in 75 healthy subjects and used state-of-the-art measurements of body fat distribution... - Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitusKarsten Müssig
Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tubingen, 72076 Tubingen, Germany
Metabolism 58:1809-11. 2009..02, P = .02, P = .05, and P = .03, respectively). Our data suggest that a common genetic variation within the GPBAR1 gene may not play a major role in the development of prediabetic phenotypes in our white population... - Insulin sensitivity and liver fat: role of iron loadMichael Haap
Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, D 72076 Tubingen, Germany
J Clin Endocrinol Metab 96:E958-61. 2011..However, a considerable individual variability between LF and insulin sensitivity (IS) is observed, and at equal levels of LF, insulin-resistant as well as insulin-sensitive individuals are found... - Circulating palmitoleate strongly and independently predicts insulin sensitivity in humansNorbert Stefan
Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
Diabetes Care 33:405-7. 2010..We investigated whether palmitoleate, which prevents insulin resistance in mice, predicts insulin sensitivity in humans... - Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humansHarald Staiger
Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
Diabetes 58:579-89. 2009..Long-chain fatty acids (LCFAs) contribute to metabolic homeostasis in part via gene regulation. This study's objective was to identify novel LCFA target genes in human skeletal muscle cells (myotubes)... - Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humansNorbert Stefan
Department of Internal Medicine, University of Tubingen, Germany
Diabetes Care 29:853-7. 2006..Therefore, we hypothesized that the AHSG plasma protein, which is exclusively secreted by the liver in humans, may not only be associated with insulin resistance but also with fat accumulation in the liver... - RARRES2, encoding the novel adipokine chemerin, is a genetic determinant of disproportionate regional body fat distribution: a comparative magnetic resonance imaging studyKarsten Müssig
Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tubingen, 72076 Tubingen, Germany
Metabolism 58:519-24. 2009..In generalized obesity, this genetic effect may be masked by the close association between whole-body obesity and visceral fat mass... - Multiple symmetric lipomatosis: a paradigm of metabolically innocent obesity?Michael Haap
Department of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Tubingen, Germany
Diabetes Care 27:794-5. 2004 - Adiponectin oligomers and ectopic fat in liver and skeletal muscle in humansKonstantinos Kantartzis
Division of Endocrinology, Nephrology, Vascular Disease and Clinical Chemistry, Department of Internal Medicine, University of Tubingen, Tubingen, Germany
Obesity (Silver Spring) 17:390-2. 2009..These data indicate that, among circulating forms of adiponectin, HMW is strongly related to ectopic fat, thus possibly representing the form of adiponectin regulating lipid oxidation in liver and skeletal muscle... - Intermuscular adipose tissue (IMAT): association with other adipose tissue compartments and insulin sensitivityMichael Boettcher
Department of Diagnostic and Interventional Radiology, Eberhard Karls University Tubingen, Tubingen, Germany
J Magn Reson Imaging 29:1340-5. 2009..To quantify intermuscular adipose tissue (IMAT) of the lower leg as well as to investigate associations with other adipose tissue (AT) compartments. The relationship between IMAT and insulin sensitivity was also examined... - Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivoAndreas Peter
Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, University of Tubingen, Tubingen, Germany
Diabetes 58:1757-65. 2009..Here, we tested the hypothesis that individual differences in the regulation of SCD1 expression by palmitate exist and influence insulin sensitivity and the cellular response to palmitate... - Assessment of relevant hepatic steatosis in obese adolescents by rapid fat-selective GRE imaging with spatial-spectral excitation: a quantitative comparison with spectroscopic findingsFabian Springer
Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
Eur Radiol 21:816-22. 2011..To test the feasibility of fat-selective GRE imaging using a spectral-spatial excitation technique for determination of intrahepatic lipid content (IHL) in obese adolescents... - Quantitative analysis of adipose tissue in single transverse slices for estimation of volumes of relevant fat tissue compartments: a study in a large cohort of subjects at risk for type 2 diabetes by MRI with comparison to anthropometric dataNina F Schwenzer
Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, Eberhard Karls University, Tubingen, Germany
Invest Radiol 45:788-94. 2010..In addition, validity of easily accessible anthropometric indices (waist-to-hip-ratio [WHR] and body mass index [BMI]) for prediction of volumes of those adipose tissue compartments were validated and compared... - Interscapular fat is strongly associated with insulin resistanceClaus Thamer
Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, Eberhard Karls University, Tubingen, Germany
J Clin Endocrinol Metab 95:4736-42. 2010..Whole-body magnetic resonance imaging and spectroscopy offer a unique approach to quantify fat depots in larger cohorts... - The D299G/T399I Toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM StudiesPeter Weyrich
Division of Endocrinology, Diabetology, Vascular Disease, Nephrology, Clinical Chemistry, Department of Internal Medicine, Paul Langerhans Institute Tübingen, University of Tubingen, Tubingen, Germany
PLoS ONE 5:e13980. 2010.... - The insulin effect on cerebrocortical theta activity is associated with serum concentrations of saturated nonesterified Fatty acidsOtto Tschritter
Department of Internal Medicine IV, University Hospital, University of Tubingen, 72076 Tubingen, Germany
J Clin Endocrinol Metab 94:4600-7. 2009..We previously demonstrated by magnetoencephalography in lean humans that insulin stimulates activity in beta and theta frequency bands, whereas this effect was abolished in obese individuals... - Liver fat content determined by magnetic resonance imaging and spectroscopyFabian Springer
Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
World J Gastroenterol 16:1560-6. 2010..In this review, the most common, non-invasive MRS/MRI techniques for assessment of intrahepatic lipid content are described with their inherent advantages and limitations... - Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetesAxel Haupt
Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
Diabetes 59:747-50. 2010..As TCF7L2 is expressed in adipose tissue and involved in Wnt-dependent regulation of adipogenesis, we studied the impact of TCF7L2 variants on body composition and weight loss during lifestyle intervention... - Upstream transcription factor 1 gene polymorphisms are associated with high antilipolytic insulin sensitivity and show gene-gene interactionsKonstantinos Kantartzis
Department of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Medicine and Clinical Chemistry, University of Tubingen, Otfried Muller Str 10, 72076, Tubingen, Germany
J Mol Med (Berl) 85:55-61. 2007..01). In conclusion, subjects carrying the T allele of SNP usf1s1 and the A allele of SNP usf1s2 have a higher antilipolytic insulin sensitivity. Moreover, both SNPs may interact with the -514C > T SNP in LIPC to determine liver fat... - T2* relaxometry in liver, pancreas, and spleen in a healthy cohort of one hundred twenty-nine subjects-correlation with age, gender, and serum ferritinNina F Schwenzer
Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, Eberhard Karls University, Tubingen, Germany
Invest Radiol 43:854-60. 2008..To assess T2* values of liver, pancreas, and spleen in a healthy cohort and to compare the gained values with serum ferritin levels and anthropometric data. In addition, the relationship of T2* between the 3 organs was investigated... - Predicting volumes of metabolically important whole-body adipose tissue compartments in overweight and obese adolescents by different MRI approaches and anthropometryFabian Springer
Section on Experimental Radiology, University Hospital Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
Eur J Radiol 81:1488-94. 2012..To evaluate 5-slice stack/single-slice MRI approaches and anthropometric measures as predictors for metabolically relevant whole-body adipose tissue (AT) compartments in overweight/obese adolescents... - New imaging techniques of fat, muscle and liver within the context of determining insulin sensitivityNorbert Stefan
Department of Internal Medicine, University of Tubingen, Tubingen, Germany
Horm Res 64:38-44. 2005..This may allow a search for new candidate genes for type 2 diabetes mellitus and identify, at an early stage, individuals at risk for decline in insulin sensitivity... - Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brainAnita M Hennige
University of Tuebingen, Department of Internal Medicine, Tubingen, Germany
J Cell Mol Med 14:903-13. 2010.... - Common genetic variation in the SERPINF1 locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levelsAnja Böhm
Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
PLoS ONE 7:e34035. 2012..Therefore, we assessed whether common genetic variation within the SERPINF1 locus contributes to adipose tissue-related prediabetic phenotypes in humans... - Genetic ablation of cGMP-dependent protein kinase type I causes liver inflammation and fasting hyperglycemiaStefan Z Lutz
Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
Diabetes 60:1566-76. 2011..However, the impact of a dysfunction of this pathway for glucose metabolism in vivo is unknown... - Liver fat and insulin resistance are independently associated with the -514C>T polymorphism of the hepatic lipase geneNorbert Stefan
Department of Internal Medicine, Division of Endocrinology, Metabolism, and Pathobiochemistry, University of Tubingen, Germany
J Clin Endocrinol Metab 90:4238-43. 2005..Liver fat predicts insulin resistance in humans. So far, there is not much information on genetic determinants of liver fat. Hepatic lipase is a liver-specific enzyme that regulates lipid metabolism... - Aging effects on human calf muscle properties assessed by MRI at 3 TeslaNina F Schwenzer
Department of Diagnostic and Interventional Radiology, Eberhard Karls University, Tubingen, Germany
J Magn Reson Imaging 29:1346-54. 2009..To determine age-related changes in MR properties as T2 and T2* relaxation times, fat content, and magnetization transfer in the human calf, and comparison of these effects in different muscle groups... - Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetesKarsten Müssig
Department of Diagnostic Radiology, Division of Endocrinology, University Hospital of Tü bingen, Tubingen, Germany
J Clin Endocrinol Metab 94:1353-60. 2009..The transcription factor forkhead box protein (FOX) O1A plays a crucial role in regulation of beta-cell function and metabolic effects of insulin in the liver... - Quantitative assessment of intrahepatic lipids using fat-selective imaging with spectral-spatial excitation and in-/opposed-phase gradient echo imaging techniques within a study population of extremely obese patients: feasibility on a short, wide-bore MR Fabian Springer
Section on Experimental Radiology, University Hospital Tubingen, Germany
Invest Radiol 45:484-90. 2010..Furthermore, image quality was assessed for both techniques. Differences in regional fat distribution were assessed using parameter maps of voxel-wise calculated IHL... - Quantification of pancreatic lipomatosis and liver steatosis by MRI: comparison of in/opposed-phase and spectral-spatial excitation techniquesNina F Schwenzer
Section on Experimental Radiology, Department of Diagnostic Radiology, Eberhard Karls University, Tubingen, Germany
Invest Radiol 43:330-7. 2008..Results of both approaches were compared, and influences of T1- and T2*-related corrections were assessed. The possibility of a correlation between pancreatic lipomatosis and liver steatosis was investigated... - High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic dietGünther Silbernagel
Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, University of Tubingen, 72076 Tubingen, Germany
J Clin Endocrinol Metab 97:E2288-92. 2012..Desaturation of fatty acids by stearoyl-CoA desaturase 1 (SCD1) can prevent these deleterious effects. Here we investigated whether DNL and SCD1 are activated in parallel by dietary sugar and influence liver fat accumulation... - Topography mapping of whole body adipose tissue using A fully automated and standardized procedureChristian Würslin
Department of Diagnostic and Interventional Radiology, University of Tubingen, Tubingen, Germany
J Magn Reson Imaging 31:430-9. 2010..To obtain quantitative measures of human body fat compartments from whole body MR datasets for the risk estimation in subjects prone to metabolic diseases without the need of any user interaction or expert knowledge... - Intramyocellular lipids and insulin resistanceJürgen Machann
Department of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Tubingen, Germany
Diabetes Obes Metab 6:239-48. 2004..Molecular mechanisms and potential genetic factors on IMCL regulation are discussed as well as possible mechanisms of current treatment strategies for improving insulin sensitivity... - Relationship of serum adiponectin and leptin concentrations with body fat distribution in humansHarald Staiger
Department of Endocrinology, Metabolism, and Pathobiochemistry, Medical Clinic, Eberhard Karls University, Tubingen, Germany
Obes Res 11:368-72. 2003..We investigated whether serum concentrations of adiponectin are determined by body fat distribution and compared the findings with leptin... - Lipid content in the musculature of the lower leg assessed by fat selective MRI: intra- and interindividual differences and correlation with anthropometric and metabolic dataJürgen Machann
Section on Experimental Radiology, Eberhard Karls University Tubingen, Tubingen, Germany
J Magn Reson Imaging 17:350-7. 2003..To assess the muscular lipid content (LC) in different muscle groups of the lower leg by a magnetic resonance imaging technique working with chemical shift selective excitation, and comparison with anthropometric and metabolic data... - Normal-weight 14-year-old girl with acanthosis nigricans and markedly increased hepatic steatosis: evidence for the important role of ectopic fat deposition in the pathogenesis of insulin resistance in childhood and adolescenceFabian Springer
Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tubingen, Tubingen, Germany
Horm Res Paediatr 74:376-80. 2010..A major factor in the development of insulin resistance is obesity. While the contribution of intrahepatic lipids to insulin resistance is well established in adults, there are only few reports in childhood and adolescence... - Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived 'Browning' Factor Irisin, Determines Insulin SensitivityHarald Staiger
Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tubingen, Germany German Centre for Diabetes Research DZD, Neuherberg, Germany
PLoS ONE 8:e61903. 2013..Our gene expression data point to an unexpected insulin-desensitizing effect of irisin... - Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonanceNina F Schwenzer
Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, Eberhard Karls University, 72076 Tubingen, Germany
J Hepatol 51:433-45. 2009..MR elastography, which can estimate the amount of fibrosis, also appears promising in the differentiation between simple steatosis and steatohepatitis... - The -913 G/A glutamine:fructose-6-phosphate aminotransferase gene polymorphism is associated with measures of obesity and intramyocellular lipid content in nondiabetic subjectsCora Weigert
Department of Internal Medicine, Division of Endocrinology, Metabolism, and Pathobiochemistry, University of Tubingen, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
J Clin Endocrinol Metab 90:1639-43. 2005..In conclusion, we identified two polymorphisms in the 5'-flanking region of GFAT, of which the -913 SNP seems to alter the risk for obesity and IMCL accumulation in male subjects... - Magnetization transfer contrast imaging in bovine and human cortical bone applying an ultrashort echo time sequence at 3 TeslaFabian Springer
Department of Diagnostic and Interventional Radiology, University Hospital Tubingen, Tubingen, Germany
Magn Reson Med 61:1040-8. 2009..21, respectively. In vivo data were obtained from three healthy subjects and showed MTR values of 0.30 +/- 0.08. In vivo studies into MT of cortical bone might have the potential to give new insights in musculoskeletal pathologies... - Quantitative assessment of visceral fat in morbidly obese patients by means of wide-bore MRI and its relation to lower esophageal sphincter pressure and signs of gastroesophageal refluxFabian Springer
Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
Obes Surg 20:749-56. 2010..Furthermore, it was investigated whether gastroesophageal reflux disease (GERD) and lower esophageal sphincter pressure (LESP) are related to the volume of visceral fat masses... - Intrahepatic lipids are predicted by visceral adipose tissue mass in healthy subjectsClaus Thamer
Department of Endocrinology and Metabolism, Eberhard-Karls-University, , Germany
Diabetes Care 27:2726-9. 2004 - The relationships of plasma adiponectin with a favorable lipid profile, decreased inflammation, and less ectopic fat accumulation depend on adiposityKonstantinos Kantartzis
Department of Internal Medicine, Division of Endocrinology, Metabolism, Pathobiochemistry, and Clinical Chemistry, , , Germany
Clin Chem 52:1934-42. 2006..Adiponectin may also have a concentration-related effect on the relationship between visceral adipose tissue and these metabolic characteristics, especially in obese persons... - Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle interventionNorbert Stefan
Department of Internal Medicine, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
J Clin Endocrinol Metab 92:1827-33. 2007..Peroxisome proliferator-activated receptor (PPAR)-delta (gene PPARD) and PPARgamma coactivator 1alpha (gene PPARGC1A) are determinants of mitochondrial function in animals and in vitro... - Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidationRainer Lehmann
Central Laboratory, Division of Clinical Chemistry and Pathobiochemistry, University Hospital Tuebingen, Tuebingen, Germany
PLoS ONE 5:e11519. 2010..We aimed to identify and characterize metabolites, which are components of the regulatory network mediating the beneficial metabolic adaptation to exercise... - 3D proton MR spectroscopic imaging of prostate cancer using a standard spine coil at 1.5 T in clinical routine: a feasibility studyMatthias P Lichy
Section of Experimental Radiology, Department of Radiologic Diagnostics, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany
Eur Radiol 15:653-60. 2005..5 T. It can consequently be applied to patients even with contraindications for endorectal coils. However, spectral quality and signal-to-noise ratio is clearly inferior to 3D MRSI examinations with endorectal coils... - Exercise-induced normalization of decreased BDNF serum concentration in elderly women with remitted major depressionChristoph Laske
Department of Psychiatry and Psychotherapy, University of Tubingen, Germany
Int J Neuropsychopharmacol 13:595-602. 2010..This mechanism may contribute to the beneficial therapeutic and relapse-preventing effects of physical activity on MD... - The Transeurope Footrace Project: longitudinal data acquisition in a cluster randomized mobile MRI observational cohort study on 44 endurance runners at a 64-stage 4,486 km transcontinental ultramarathonUwe H W Schütz
Department of Diagnostic and Interventional Radiology, University Hospital of Ulm, Germany
BMC Med 10:78. 2012..A detailed description of the TEFR project and its implemented measuring methods in relation to the hypotheses are presented... - MRI of muscular fatFritz Schick
Section on Experimental Radiology, University of Tubingen, Tubingen, Germany
Magn Reson Med 47:720-7. 2002..No significant correlation of the muscular fat with the thickness of the subcutaneous fat layer was found. In addition, the body mass index does not appear to determine muscular fat content, except in very obese cases... - Fatty liver is independently associated with alterations in circulating HDL2 and HDL3 subfractionsKonstantinos Kantartzis
Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, , , Germany
Diabetes Care 31:366-8. 2008 - Technical challenges and opportunities of whole-body magnetic resonance imaging at 3TJürgen Machann
Section on Experimental Radiology, Eberhard Karls University Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
Phys Med 24:63-70. 2008..Many problems have to be solved in the near future regarding the variety of MR techniques and applications in all parts of the human body...