Jürgen Machann

Summary

Country: Germany

Publications

  1. pmc Characteristics, changes and influence of body composition during a 4486 km transcontinental ultramarathon: results from the TransEurope FootRace mobile whole body MRI-project
    Uwe H W Schütz
    Department of Diagnostic and Interventional Radiology, University Hospital of Ulm, Albert Einstein Allee 23, 89081 Ulm, Germany
    BMC Med 11:122. 2013
  2. pmc The TransEurope FootRace Project: longitudinal data acquisition in a cluster randomized mobile MRI observational cohort study on 44 endurance runners at a 64-stage 4,486 km transcontinental ultramarathon
    Uwe H W Schütz
    Department of Diagnostic and Interventional Radiology, University Hospital of Ulm, Germany
    BMC Med 10:78. 2012
  3. doi request reprint Diagnostic imaging in obesity
    Jürgen Machann
    Institute for Diabetes Research and Metabolic Diseases IDM of the Helmholtz Center Munich at the University of Tübingen Paul Langerhans Institute Tübingen, Tubingen, Germany
    Best Pract Res Clin Endocrinol Metab 27:261-77. 2013
  4. doi request reprint Fraction of unsaturated fatty acids in visceral adipose tissue (VAT) is lower in subjects with high total VAT volume - a combined 1 H MRS and volumetric MRI study in male subjects
    Jürgen Machann
    Institute for Diabetes Research and Metabolic Diseases IDM of the Helmholtz Centre Munich at the University of Tübingen Paul Langerhans Institute Tübingen, Tubingen, Germany
    NMR Biomed 26:232-6. 2013
  5. ncbi request reprint An interleaved sampling strategy for MR spectroscopy in vivo: applications on human calf musculature
    J Machannab
    Radiologische Klinik, Abteilung für Radiologische Diagnostik, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Magn Reson Imaging 18:189-97. 2000
  6. doi request reprint Morning to evening changes of intramyocellular lipid content in dependence on nutrition and physical activity during one single day: a volume selective 1H-MRS study
    Jürgen Machann
    Department of Diagnostic and Interventional Radiology, Section on Experimental Radiology, Eberhard Karls University Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    MAGMA 24:29-33. 2011
  7. ncbi request reprint Age and gender related effects on adipose tissue compartments of subjects with increased risk for type 2 diabetes: a whole body MRI/MRS study
    J Machann
    Section on Experimental Radiology, Department of Diagnostic Radiology, Eberhard Karls University of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    MAGMA 18:128-37. 2005
  8. ncbi request reprint Hepatic lipid accumulation in healthy subjects: a comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopy
    Jürgen Machann
    Section on Experimental Radiology, Department of Diagnostic Radiology, Eberhard Karls University of Tubingen, Tubingen, Germany
    Magn Reson Med 55:913-7. 2006
  9. doi request reprint (1)H MR spectroscopy of skeletal muscle, liver and bone marrow
    Jürgen Machann
    Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, Eberhard Karls University Tubingen, Tubingen, Germany
    Eur J Radiol 67:275-84. 2008
  10. ncbi request reprint Standardized assessment of whole body adipose tissue topography by MRI
    Jürgen Machann
    Section on Experimental Radiology, University of Tubingen, Tubingen, Germany
    J Magn Reson Imaging 21:455-62. 2005

Detail Information

Publications75

  1. pmc Characteristics, changes and influence of body composition during a 4486 km transcontinental ultramarathon: results from the TransEurope FootRace mobile whole body MRI-project
    Uwe H W Schütz
    Department of Diagnostic and Interventional Radiology, University Hospital of Ulm, Albert Einstein Allee 23, 89081 Ulm, Germany
    BMC Med 11:122. 2013
    ....
  2. pmc The TransEurope FootRace Project: longitudinal data acquisition in a cluster randomized mobile MRI observational cohort study on 44 endurance runners at a 64-stage 4,486 km transcontinental ultramarathon
    Uwe H W Schütz
    Department of Diagnostic and Interventional Radiology, University Hospital of Ulm, Germany
    BMC Med 10:78. 2012
    ..A detailed description of the TEFR project and its implemented measuring methods in relation to the hypotheses are presented...
  3. doi request reprint Diagnostic imaging in obesity
    Jürgen Machann
    Institute for Diabetes Research and Metabolic Diseases IDM of the Helmholtz Center Munich at the University of Tübingen Paul Langerhans Institute Tübingen, Tubingen, Germany
    Best Pract Res Clin Endocrinol Metab 27:261-77. 2013
    ..Nuclear medicine and in particular Positron Emission Tomography (PET) methods are used to explore central pathophysiology, brown adipose tissue activity and alterations in homeostatic feedback and gut-brain communication...
  4. doi request reprint Fraction of unsaturated fatty acids in visceral adipose tissue (VAT) is lower in subjects with high total VAT volume - a combined 1 H MRS and volumetric MRI study in male subjects
    Jürgen Machann
    Institute for Diabetes Research and Metabolic Diseases IDM of the Helmholtz Centre Munich at the University of Tübingen Paul Langerhans Institute Tübingen, Tubingen, Germany
    NMR Biomed 26:232-6. 2013
    ..Furthermore, changes in VAT composition during weight loss or different forms of diet have yet to be examined...
  5. ncbi request reprint An interleaved sampling strategy for MR spectroscopy in vivo: applications on human calf musculature
    J Machannab
    Radiologische Klinik, Abteilung für Radiologische Diagnostik, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Magn Reson Imaging 18:189-97. 2000
    ..59 +/- 0.19 x 10(-3) mm(2)/s versus 1.20 +/- 0.08 x 10(-3) mm(2)/s in m. tib. ant.). Magnetization transfer experiments with various RF preparation pulse amplitudes led to very similar results for m. tib. ant. and m. soleus...
  6. doi request reprint Morning to evening changes of intramyocellular lipid content in dependence on nutrition and physical activity during one single day: a volume selective 1H-MRS study
    Jürgen Machann
    Department of Diagnostic and Interventional Radiology, Section on Experimental Radiology, Eberhard Karls University Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    MAGMA 24:29-33. 2011
    ....
  7. ncbi request reprint Age and gender related effects on adipose tissue compartments of subjects with increased risk for type 2 diabetes: a whole body MRI/MRS study
    J Machann
    Section on Experimental Radiology, Department of Diagnostic Radiology, Eberhard Karls University of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    MAGMA 18:128-37. 2005
    ....
  8. ncbi request reprint Hepatic lipid accumulation in healthy subjects: a comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopy
    Jürgen Machann
    Section on Experimental Radiology, Department of Diagnostic Radiology, Eberhard Karls University of Tubingen, Tubingen, Germany
    Magn Reson Med 55:913-7. 2006
    ..Fat-selective images provide more spatial information about fat distribution, which makes this technique suitable for clinical imaging of patients with liver disease...
  9. doi request reprint (1)H MR spectroscopy of skeletal muscle, liver and bone marrow
    Jürgen Machann
    Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, Eberhard Karls University Tubingen, Tubingen, Germany
    Eur J Radiol 67:275-84. 2008
    ..Adapted (1)H spectroscopic techniques allow a semi-quantitative analysis of bone marrow composition...
  10. ncbi request reprint Standardized assessment of whole body adipose tissue topography by MRI
    Jürgen Machann
    Section on Experimental Radiology, University of Tubingen, Tubingen, Germany
    J Magn Reson Imaging 21:455-62. 2005
    ....
  11. doi request reprint Follow-up whole-body assessment of adipose tissue compartments during a lifestyle intervention in a large cohort at increased risk for type 2 diabetes
    Jürgen Machann
    Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Radiology 257:353-63. 2010
    ....
  12. ncbi request reprint Magnetic resonance osteodensitometry in human heel bones: correlation with quantitative computed tomography using different measuring parameters
    J Machann
    Department of Diagnostic Radiology, Institute of Physics, Eberhard Karls University Tubingen, Germany
    Invest Radiol 35:393-400. 2000
    ....
  13. ncbi request reprint Osteodensitometry of human heel bones by MR spin-echo imaging: comparison with MR gradient-echo imaging and quantitative computed tomography
    J Machann
    Department of Diagnostic Radiology, University of Tubingen, Tubingen, Germany
    J Magn Reson Imaging 14:147-55. 2001
    ..The high correlation between FSE imaging and bone mineral density (BMD) allows possible clinical applications of FSE imaging for diagnosis of osteoporosis. Further improvements of the accuracy using reference phantoms might be possible...
  14. pmc Relationships of circulating sex hormone-binding globulin with metabolic traits in humans
    Andreas Peter
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 59:3167-73. 2010
    ..In the present study, we investigated mechanisms by which high SHBG may prevent development to diabetes...
  15. doi request reprint Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study
    Martin Heni
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes Metab Res Rev 26:200-5. 2010
    ..The aim was to thoroughly quantify the fat content of pancreas sections (caput, corpus, and cauda) and to compare the impact of pancreatic, intrahepatic, and visceral fat on insulin secretion in humans...
  16. pmc No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes
    Karsten Müssig
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tubingen, Otfried Müller Str, 10, 72076 Tubingen, Germany
    BMC Med Genet 11:84. 2010
    ....
  17. doi request reprint Impact of variation in the FTO gene on whole body fat distribution, ectopic fat, and weight loss
    Axel Haupt
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University of Tubingen, Tubingen, Germany
    Obesity (Silver Spring) 16:1969-72. 2008
    ..In conclusion, despite an association with BMI and whole body fat distribution, variation in the FTO locus has no effect on the success of a lifestyle intervention program...
  18. pmc Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 58:2616-23. 2009
    ..We investigated whether the SNP determines liver fat independently of visceral adiposity and whether it may even play a role in protecting from insulin resistance...
  19. doi request reprint Identification and characterization of metabolically benign obesity in humans
    Norbert Stefan
    Department of Internal Medicine IV, University of Tubingen, D 72076 Tubingen, Germany
    Arch Intern Med 168:1609-16. 2008
    ..Conversely, even in obesity, a metabolically benign fat distribution phenotype may exist...
  20. doi request reprint Variants in the CD36 gene locus determine whole-body adiposity, but have no independent effect on insulin sensitivity
    Martin Heni
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tubingen, Member of the German Center for Diabetes Research DZD, Tubingen, Germany
    Obesity (Silver Spring) 19:1004-9. 2011
    ..In the long run, genetic variation within the CD36 locus may contribute to metabolic disease via its effect on body adiposity, but not via an independent effect on insulin sensitivity...
  21. pmc SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention--the TULIP Study
    Peter Weyrich
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tubingen, Germany
    BMC Med Genet 9:100. 2008
    ..To investigate the relevance of SIRT1 for human metabolism and caloric restriction, we analyzed SIRT1 genetic variants in respect to the outcome of a controlled lifestyle intervention in Caucasians at risk for type 2 diabetes...
  22. doi request reprint The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, 72076 Tubingen, Germany
    Clin Sci (Lond) 116:531-7. 2009
    ..This finding may be important in the prevention and treatment of insulin resistance and Type 2 diabetes in subjects with fatty liver...
  23. ncbi request reprint Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study
    Axel Haupt
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Obesity (Silver Spring) 18:1212-7. 2010
    ..009, dominant inheritance model). Therefore, our results suggest that these new obesity SNPs, despite their influence on BMI, are neither associated with a metabolically unfavorable nor with a favorable body composition...
  24. doi request reprint Impact of variation near MC4R on whole-body fat distribution, liver fat, and weight loss
    Axel Haupt
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Obesity (Silver Spring) 17:1942-5. 2009
    ..Thus, this candidate SNP for human obesity may preferentially affect the accumulation of subcutaneous adipose tissue. Furthermore, the variation near MC4R has no effect on success of weight loss during lifestyle intervention...
  25. pmc Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes 58:579-89. 2009
    ..Long-chain fatty acids (LCFAs) contribute to metabolic homeostasis in part via gene regulation. This study's objective was to identify novel LCFA target genes in human skeletal muscle cells (myotubes)...
  26. doi request reprint Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus
    Karsten Müssig
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tubingen, 72076 Tubingen, Germany
    Metabolism 58:1809-11. 2009
    ..02, P = .02, P = .05, and P = .03, respectively). Our data suggest that a common genetic variation within the GPBAR1 gene may not play a major role in the development of prediabetic phenotypes in our white population...
  27. pmc Circulating palmitoleate strongly and independently predicts insulin sensitivity in humans
    Norbert Stefan
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes Care 33:405-7. 2010
    ..We investigated whether palmitoleate, which prevents insulin resistance in mice, predicts insulin sensitivity in humans...
  28. doi request reprint Insulin sensitivity and liver fat: role of iron load
    Michael Haap
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 96:E958-61. 2011
    ..However, a considerable individual variability between LF and insulin sensitivity (IS) is observed, and at equal levels of LF, insulin-resistant as well as insulin-sensitive individuals are found...
  29. doi request reprint Genetic variation in NR1H4 encoding the bile acid receptor FXR determines fasting glucose and free fatty acid levels in humans
    Martin Heni
    Department of Internal Medicine, Division of Endocrinology, University Hospital, Eberhard Karls University Tubingen, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 98:E1224-9. 2013
    ..Bile acid signaling via farnesoid X receptor (FXR) regulates glucose and lipid levels, fat mass, and hepatic steatosis in animal models...
  30. ncbi request reprint High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans
    Norbert Stefan
    Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tubingen, D 72076 Tubingen, Germany
    Diabetes Care 30:1173-8. 2007
    ..To determine which fat compartments are associated with elevated RBP4 levels in humans, we measured circulating RBP4 in 75 healthy subjects and used state-of-the-art measurements of body fat distribution...
  31. doi request reprint RARRES2, encoding the novel adipokine chemerin, is a genetic determinant of disproportionate regional body fat distribution: a comparative magnetic resonance imaging study
    Karsten Müssig
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tubingen, 72076 Tubingen, Germany
    Metabolism 58:519-24. 2009
    ..In generalized obesity, this genetic effect may be masked by the close association between whole-body obesity and visceral fat mass...
  32. pmc Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 8:e61903. 2013
    ....
  33. ncbi request reprint Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans
    Norbert Stefan
    Department of Internal Medicine, University of Tubingen, Germany
    Diabetes Care 29:853-7. 2006
    ..Therefore, we hypothesized that the AHSG plasma protein, which is exclusively secreted by the liver in humans, may not only be associated with insulin resistance but also with fat accumulation in the liver...
  34. ncbi request reprint Intrahepatic lipids are predicted by visceral adipose tissue mass in healthy subjects
    Claus Thamer
    Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
    Diabetes Care 27:2726-9. 2004
  35. doi request reprint Quantitative analysis of adipose tissue in single transverse slices for estimation of volumes of relevant fat tissue compartments: a study in a large cohort of subjects at risk for type 2 diabetes by MRI with comparison to anthropometric data
    Nina F Schwenzer
    Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, Eberhard Karls University, Tubingen, Germany
    Invest Radiol 45:788-94. 2010
    ..In addition, validity of easily accessible anthropometric indices (waist-to-hip-ratio [WHR] and body mass index [BMI]) for prediction of volumes of those adipose tissue compartments were validated and compared...
  36. pmc The D299G/T399I Toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM Studies
    Peter Weyrich
    Division of Endocrinology, Diabetology, Vascular Disease, Nephrology, Clinical Chemistry, Department of Internal Medicine, Paul Langerhans Institute Tübingen, University of Tubingen, Tubingen, Germany
    PLoS ONE 5:e13980. 2010
    ....
  37. doi request reprint Intermuscular adipose tissue (IMAT): association with other adipose tissue compartments and insulin sensitivity
    Michael Boettcher
    Department of Diagnostic and Interventional Radiology, Eberhard Karls University Tubingen, Tubingen, Germany
    J Magn Reson Imaging 29:1340-5. 2009
    ..To quantify intermuscular adipose tissue (IMAT) of the lower leg as well as to investigate associations with other adipose tissue (AT) compartments. The relationship between IMAT and insulin sensitivity was also examined...
  38. doi request reprint Adiponectin oligomers and ectopic fat in liver and skeletal muscle in humans
    Konstantinos Kantartzis
    Division of Endocrinology, Nephrology, Vascular Disease and Clinical Chemistry, Department of Internal Medicine, University of Tubingen, Tubingen, Germany
    Obesity (Silver Spring) 17:390-2. 2009
    ..These data indicate that, among circulating forms of adiponectin, HMW is strongly related to ectopic fat, thus possibly representing the form of adiponectin regulating lipid oxidation in liver and skeletal muscle...
  39. doi request reprint Interscapular fat is strongly associated with insulin resistance
    Claus Thamer
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, Eberhard Karls University, Tubingen, Germany
    J Clin Endocrinol Metab 95:4736-42. 2010
    ..Whole-body magnetic resonance imaging and spectroscopy offer a unique approach to quantify fat depots in larger cohorts...
  40. doi request reprint Assessment of relevant hepatic steatosis in obese adolescents by rapid fat-selective GRE imaging with spatial-spectral excitation: a quantitative comparison with spectroscopic findings
    Fabian Springer
    Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Eur Radiol 21:816-22. 2011
    ..To test the feasibility of fat-selective GRE imaging using a spectral-spatial excitation technique for determination of intrahepatic lipid content (IHL) in obese adolescents...
  41. pmc Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo
    Andreas Peter
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 58:1757-65. 2009
    ..Here, we tested the hypothesis that individual differences in the regulation of SCD1 expression by palmitate exist and influence insulin sensitivity and the cellular response to palmitate...
  42. ncbi request reprint The relationships of plasma adiponectin with a favorable lipid profile, decreased inflammation, and less ectopic fat accumulation depend on adiposity
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Metabolism, Pathobiochemistry, and Clinical Chemistry, Eberhard Karls University of Tubingen, Tubingen, Germany
    Clin Chem 52:1934-42. 2006
    ..Adiposity may also affect the relationship of adiponectin concentrations with serum lipid profile; markers of inflammation, atherosclerosis, and endothelial function; and ectopic fat accumulation...
  43. pmc Liver fat content determined by magnetic resonance imaging and spectroscopy
    Fabian Springer
    Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    World J Gastroenterol 16:1560-6. 2010
    ..In this review, the most common, non-invasive MRS/MRI techniques for assessment of intrahepatic lipid content are described with their inherent advantages and limitations...
  44. pmc Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes
    Axel Haupt
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes 59:747-50. 2010
    ..As TCF7L2 is expressed in adipose tissue and involved in Wnt-dependent regulation of adipogenesis, we studied the impact of TCF7L2 variants on body composition and weight loss during lifestyle intervention...
  45. doi request reprint The insulin effect on cerebrocortical theta activity is associated with serum concentrations of saturated nonesterified Fatty acids
    Otto Tschritter
    Department of Internal Medicine IV, University Hospital, University of Tubingen, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 94:4600-7. 2009
    ..We previously demonstrated by magnetoencephalography in lean humans that insulin stimulates activity in beta and theta frequency bands, whereas this effect was abolished in obese individuals...
  46. doi request reprint T2* relaxometry in liver, pancreas, and spleen in a healthy cohort of one hundred twenty-nine subjects-correlation with age, gender, and serum ferritin
    Nina F Schwenzer
    Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, Eberhard Karls University, Tubingen, Germany
    Invest Radiol 43:854-60. 2008
    ..To assess T2* values of liver, pancreas, and spleen in a healthy cohort and to compare the gained values with serum ferritin levels and anthropometric data. In addition, the relationship of T2* between the 3 organs was investigated...
  47. ncbi request reprint Upstream transcription factor 1 gene polymorphisms are associated with high antilipolytic insulin sensitivity and show gene-gene interactions
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Medicine and Clinical Chemistry, University of Tubingen, Otfried Muller Str 10, 72076, Tubingen, Germany
    J Mol Med (Berl) 85:55-61. 2007
    ..01). In conclusion, subjects carrying the T allele of SNP usf1s1 and the A allele of SNP usf1s2 have a higher antilipolytic insulin sensitivity. Moreover, both SNPs may interact with the -514C > T SNP in LIPC to determine liver fat...
  48. ncbi request reprint Multiple symmetric lipomatosis: a paradigm of metabolically innocent obesity?
    Michael Haap
    Department of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Tubingen, Germany
    Diabetes Care 27:794-5. 2004
  49. ncbi request reprint Fatty liver is independently associated with alterations in circulating HDL2 and HDL3 subfractions
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes Care 31:366-8. 2008
  50. doi request reprint Predicting volumes of metabolically important whole-body adipose tissue compartments in overweight and obese adolescents by different MRI approaches and anthropometry
    Fabian Springer
    Section on Experimental Radiology, University Hospital Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Eur J Radiol 81:1488-94. 2012
    ..To evaluate 5-slice stack/single-slice MRI approaches and anthropometric measures as predictors for metabolically relevant whole-body adipose tissue (AT) compartments in overweight/obese adolescents...
  51. doi request reprint Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain
    Anita M Hennige
    University of Tuebingen, Department of Internal Medicine, Tubingen, Germany
    J Cell Mol Med 14:903-13. 2010
    ....
  52. doi request reprint Quantitative assessment of intrahepatic lipids using fat-selective imaging with spectral-spatial excitation and in-/opposed-phase gradient echo imaging techniques within a study population of extremely obese patients: feasibility on a short, wide-bore MR
    Fabian Springer
    Section on Experimental Radiology, University Hospital Tubingen, Germany
    Invest Radiol 45:484-90. 2010
    ..Furthermore, image quality was assessed for both techniques. Differences in regional fat distribution were assessed using parameter maps of voxel-wise calculated IHL...
  53. ncbi request reprint New imaging techniques of fat, muscle and liver within the context of determining insulin sensitivity
    Norbert Stefan
    Department of Internal Medicine, University of Tubingen, Tubingen, Germany
    Horm Res 64:38-44. 2005
    ..This may allow a search for new candidate genes for type 2 diabetes mellitus and identify, at an early stage, individuals at risk for decline in insulin sensitivity...
  54. pmc Common genetic variation in the SERPINF1 locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levels
    Anja Böhm
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 7:e34035. 2012
    ..Therefore, we assessed whether common genetic variation within the SERPINF1 locus contributes to adipose tissue-related prediabetic phenotypes in humans...
  55. pmc Genetic ablation of cGMP-dependent protein kinase type I causes liver inflammation and fasting hyperglycemia
    Stefan Z Lutz
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 60:1566-76. 2011
    ..However, the impact of a dysfunction of this pathway for glucose metabolism in vivo is unknown...
  56. ncbi request reprint Liver fat and insulin resistance are independently associated with the -514C>T polymorphism of the hepatic lipase gene
    Norbert Stefan
    Department of Internal Medicine, Division of Endocrinology, Metabolism, and Pathobiochemistry, University of Tubingen, Germany
    J Clin Endocrinol Metab 90:4238-43. 2005
    ..Liver fat predicts insulin resistance in humans. So far, there is not much information on genetic determinants of liver fat. Hepatic lipase is a liver-specific enzyme that regulates lipid metabolism...
  57. doi request reprint Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes
    Karsten Müssig
    Department of Diagnostic Radiology, Division of Endocrinology, University Hospital of Tü bingen, Tubingen, Germany
    J Clin Endocrinol Metab 94:1353-60. 2009
    ..The transcription factor forkhead box protein (FOX) O1A plays a crucial role in regulation of beta-cell function and metabolic effects of insulin in the liver...
  58. doi request reprint Aging effects on human calf muscle properties assessed by MRI at 3 Tesla
    Nina F Schwenzer
    Department of Diagnostic and Interventional Radiology, Eberhard Karls University, Tubingen, Germany
    J Magn Reson Imaging 29:1346-54. 2009
    ..To determine age-related changes in MR properties as T2 and T2* relaxation times, fat content, and magnetization transfer in the human calf, and comparison of these effects in different muscle groups...
  59. doi request reprint Quantification of pancreatic lipomatosis and liver steatosis by MRI: comparison of in/opposed-phase and spectral-spatial excitation techniques
    Nina F Schwenzer
    Section on Experimental Radiology, Department of Diagnostic Radiology, Eberhard Karls University, Tubingen, Germany
    Invest Radiol 43:330-7. 2008
    ..Results of both approaches were compared, and influences of T1- and T2*-related corrections were assessed. The possibility of a correlation between pancreatic lipomatosis and liver steatosis was investigated...
  60. ncbi request reprint Lipid content in the musculature of the lower leg assessed by fat selective MRI: intra- and interindividual differences and correlation with anthropometric and metabolic data
    Jürgen Machann
    Section on Experimental Radiology, Eberhard Karls University Tubingen, Tubingen, Germany
    J Magn Reson Imaging 17:350-7. 2003
    ..To assess the muscular lipid content (LC) in different muscle groups of the lower leg by a magnetic resonance imaging technique working with chemical shift selective excitation, and comparison with anthropometric and metabolic data...
  61. doi request reprint High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet
    Günther Silbernagel
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, University of Tubingen, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 97:E2288-92. 2012
    ..Desaturation of fatty acids by stearoyl-CoA desaturase 1 (SCD1) can prevent these deleterious effects. Here we investigated whether DNL and SCD1 are activated in parallel by dietary sugar and influence liver fat accumulation...
  62. doi request reprint Topography mapping of whole body adipose tissue using A fully automated and standardized procedure
    Christian Würslin
    Department of Diagnostic and Interventional Radiology, University of Tubingen, Tubingen, Germany
    J Magn Reson Imaging 31:430-9. 2010
    ..To obtain quantitative measures of human body fat compartments from whole body MR datasets for the risk estimation in subjects prone to metabolic diseases without the need of any user interaction or expert knowledge...
  63. ncbi request reprint Intramyocellular lipids and insulin resistance
    Jürgen Machann
    Department of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Tubingen, Germany
    Diabetes Obes Metab 6:239-48. 2004
    ..Molecular mechanisms and potential genetic factors on IMCL regulation are discussed as well as possible mechanisms of current treatment strategies for improving insulin sensitivity...
  64. ncbi request reprint Relationship of serum adiponectin and leptin concentrations with body fat distribution in humans
    Harald Staiger
    Department of Endocrinology, Metabolism, and Pathobiochemistry, Medical Clinic, Eberhard Karls University, Tubingen, Germany
    Obes Res 11:368-72. 2003
    ..We investigated whether serum concentrations of adiponectin are determined by body fat distribution and compared the findings with leptin...
  65. doi request reprint Normal-weight 14-year-old girl with acanthosis nigricans and markedly increased hepatic steatosis: evidence for the important role of ectopic fat deposition in the pathogenesis of insulin resistance in childhood and adolescence
    Fabian Springer
    Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tubingen, Tubingen, Germany
    Horm Res Paediatr 74:376-80. 2010
    ..A major factor in the development of insulin resistance is obesity. While the contribution of intrahepatic lipids to insulin resistance is well established in adults, there are only few reports in childhood and adolescence...
  66. ncbi request reprint The -913 G/A glutamine:fructose-6-phosphate aminotransferase gene polymorphism is associated with measures of obesity and intramyocellular lipid content in nondiabetic subjects
    Cora Weigert
    Department of Internal Medicine, Division of Endocrinology, Metabolism, and Pathobiochemistry, University of Tubingen, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 90:1639-43. 2005
    ..In conclusion, we identified two polymorphisms in the 5'-flanking region of GFAT, of which the -913 SNP seems to alter the risk for obesity and IMCL accumulation in male subjects...
  67. doi request reprint Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance
    Nina F Schwenzer
    Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, Eberhard Karls University, 72076 Tubingen, Germany
    J Hepatol 51:433-45. 2009
    ..MR elastography, which can estimate the amount of fibrosis, also appears promising in the differentiation between simple steatosis and steatohepatitis...
  68. doi request reprint Magnetization transfer contrast imaging in bovine and human cortical bone applying an ultrashort echo time sequence at 3 Tesla
    Fabian Springer
    Department of Diagnostic and Interventional Radiology, University Hospital Tubingen, Tubingen, Germany
    Magn Reson Med 61:1040-8. 2009
    ..21, respectively. In vivo data were obtained from three healthy subjects and showed MTR values of 0.30 +/- 0.08. In vivo studies into MT of cortical bone might have the potential to give new insights in musculoskeletal pathologies...
  69. doi request reprint Quantitative assessment of visceral fat in morbidly obese patients by means of wide-bore MRI and its relation to lower esophageal sphincter pressure and signs of gastroesophageal reflux
    Fabian Springer
    Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Obes Surg 20:749-56. 2010
    ..Furthermore, it was investigated whether gastroesophageal reflux disease (GERD) and lower esophageal sphincter pressure (LESP) are related to the volume of visceral fat masses...
  70. ncbi request reprint Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention
    Norbert Stefan
    Department of Internal Medicine, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 92:1827-33. 2007
    ..Peroxisome proliferator-activated receptor (PPAR)-delta (gene PPARD) and PPARgamma coactivator 1alpha (gene PPARGC1A) are determinants of mitochondrial function in animals and in vitro...
  71. ncbi request reprint 3D proton MR spectroscopic imaging of prostate cancer using a standard spine coil at 1.5 T in clinical routine: a feasibility study
    Matthias P Lichy
    Section of Experimental Radiology, Department of Radiologic Diagnostics, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany
    Eur Radiol 15:653-60. 2005
    ..5 T. It can consequently be applied to patients even with contraindications for endorectal coils. However, spectral quality and signal-to-noise ratio is clearly inferior to 3D MRSI examinations with endorectal coils...
  72. pmc Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidation
    Rainer Lehmann
    Central Laboratory, Division of Clinical Chemistry and Pathobiochemistry, University Hospital Tuebingen, Tuebingen, Germany
    PLoS ONE 5:e11519. 2010
    ..We aimed to identify and characterize metabolites, which are components of the regulatory network mediating the beneficial metabolic adaptation to exercise...
  73. doi request reprint Exercise-induced normalization of decreased BDNF serum concentration in elderly women with remitted major depression
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tubingen, Germany
    Int J Neuropsychopharmacol 13:595-602. 2010
    ..This mechanism may contribute to the beneficial therapeutic and relapse-preventing effects of physical activity on MD...
  74. ncbi request reprint MRI of muscular fat
    Fritz Schick
    Section on Experimental Radiology, University of Tubingen, Tubingen, Germany
    Magn Reson Med 47:720-7. 2002
    ..No significant correlation of the muscular fat with the thickness of the subcutaneous fat layer was found. In addition, the body mass index does not appear to determine muscular fat content, except in very obese cases...
  75. ncbi request reprint Technical challenges and opportunities of whole-body magnetic resonance imaging at 3T
    Jürgen Machann
    Section on Experimental Radiology, Eberhard Karls University Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Phys Med 24:63-70. 2008
    ..Many problems have to be solved in the near future regarding the variety of MR techniques and applications in all parts of the human body...