Hubert Löwenheim

Summary

Country: Germany

Publications

  1. pmc Stemness of the organ of Corti relates to the epigenetic status of Sox2 enhancers
    Jörg Waldhaus
    Department of Otorhinolaryngology, Head and Neck Surgery, Hearing Research Center Tübingen, University of Tübingen Medical Center, Tubingen, Germany
    PLoS ONE 7:e36066. 2012
  2. ncbi request reprint Determination of hair cell degeneration and hair cell death in neomycin treated cultures of the neonatal rat cochlea
    H Löwenheim
    Department of Otorhinolaryngology, University of Tubingen, Germany
    Hear Res 128:16-26. 1999
  3. doi request reprint [Regenerative medicine. New therapeutic methods in otorhinolaryngology and head and neck surgery]
    H Löwenheim
    Klinik für Hals Nasen Ohren Heilkunde, Universitatsklinikum Tubingen, Elfriede Aulhorn Strasse 5, 72076 Tubingen, Deutschland
    HNO 56:252-7. 2008
  4. ncbi request reprint In vitro expansion of human nasoseptal chondrocytes reveals distinct expression profiles of G1 cell cycle inhibitors for replicative, quiescent, and senescent culture stages
    Hubert Löwenheim
    Department of Otolaryngology Head and Neck Surgery, Hearing Research Center Tübingen, University of Tübingen Medical Center, Tubingen, Germany
    Tissue Eng 11:64-75. 2005
  5. ncbi request reprint [Aquaporine. Discovery, function, and significance for otorhinolaryngology]
    H Löwenheim
    Universitäts Hals Nasen Ohren Klinik Tübingen
    HNO 52:673-8. 2004
  6. ncbi request reprint [Comparative genomic hybridization as cytogenetic tumor diagnosis technique in juvenile angiofibroma]
    H Löwenheim
    Klinik für Hals Nasen Ohren Heilkunde, Universitatsklinikum Tuebingen
    HNO 51:959-61. 2003
  7. ncbi request reprint Regenerative medicine for diseases of the head and neck: principles of in vivo regeneration
    H Löwenheim
    Department of Otolaryngology Head and Neck Surgery, University of Tubingen, Tubingen, Germany
    DNA Cell Biol 22:571-92. 2003
  8. pmc Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti
    H Löwenheim
    Department of Otolaryngology, University of Tubingen, Silcherstrasse 5, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 96:4084-8. 1999
  9. doi request reprint [Regenerative medicine in the treatment of sensorineural hearing loss]
    H Löwenheim
    Klinik für Hals Nasen Ohren Heilkunde, Universitatsklinikum Tubingen, Elfriede Aulhorn Strasse 5, 72076 Tubingen, Deutschland
    HNO 56:288-300. 2008
  10. ncbi request reprint [Basic principles of in vivo regeneration in the area of the head and neck]
    H Löwenheim
    Universitäts Hals Nasen Ohren Klinik, Tubingen
    Laryngorhinootologie 81:S1-23. 2002

Collaborators

Detail Information

Publications29

  1. pmc Stemness of the organ of Corti relates to the epigenetic status of Sox2 enhancers
    Jörg Waldhaus
    Department of Otorhinolaryngology, Head and Neck Surgery, Hearing Research Center Tübingen, University of Tübingen Medical Center, Tubingen, Germany
    PLoS ONE 7:e36066. 2012
    ..These observations validate the continued exploration of treatment strategies for dedifferentiating or reprogramming of differentiated supporting cells into progenitors to regenerate the damaged organ of Corti...
  2. ncbi request reprint Determination of hair cell degeneration and hair cell death in neomycin treated cultures of the neonatal rat cochlea
    H Löwenheim
    Department of Otorhinolaryngology, University of Tubingen, Germany
    Hear Res 128:16-26. 1999
    ..After 48 h of neomycin treatment, most apical hair cells survived while most basal hair cells died. Calcein labeling provides a sensitive functional assay for measuring hair cell survival...
  3. doi request reprint [Regenerative medicine. New therapeutic methods in otorhinolaryngology and head and neck surgery]
    H Löwenheim
    Klinik für Hals Nasen Ohren Heilkunde, Universitatsklinikum Tubingen, Elfriede Aulhorn Strasse 5, 72076 Tubingen, Deutschland
    HNO 56:252-7. 2008
  4. ncbi request reprint In vitro expansion of human nasoseptal chondrocytes reveals distinct expression profiles of G1 cell cycle inhibitors for replicative, quiescent, and senescent culture stages
    Hubert Löwenheim
    Department of Otolaryngology Head and Neck Surgery, Hearing Research Center Tübingen, University of Tübingen Medical Center, Tubingen, Germany
    Tissue Eng 11:64-75. 2005
    ..Possible methods of modulation include the targeted elimination of specifically identified cell cycle inhibitors by antisense technologies...
  5. ncbi request reprint [Aquaporine. Discovery, function, and significance for otorhinolaryngology]
    H Löwenheim
    Universitäts Hals Nasen Ohren Klinik Tübingen
    HNO 52:673-8. 2004
  6. ncbi request reprint [Comparative genomic hybridization as cytogenetic tumor diagnosis technique in juvenile angiofibroma]
    H Löwenheim
    Klinik für Hals Nasen Ohren Heilkunde, Universitatsklinikum Tuebingen
    HNO 51:959-61. 2003
  7. ncbi request reprint Regenerative medicine for diseases of the head and neck: principles of in vivo regeneration
    H Löwenheim
    Department of Otolaryngology Head and Neck Surgery, University of Tubingen, Tubingen, Germany
    DNA Cell Biol 22:571-92. 2003
    ..Complex tissue lesions of the head and neck as they occur after trauma or tumor resections may be approached on the basis of relevant mechanisms in epimorphic regeneration with blastema formation...
  8. pmc Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti
    H Löwenheim
    Department of Otolaryngology, University of Tubingen, Silcherstrasse 5, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 96:4084-8. 1999
    ..This finding may provide an important pathway for inducing hair-cell regeneration in the mammalian hearing organ...
  9. doi request reprint [Regenerative medicine in the treatment of sensorineural hearing loss]
    H Löwenheim
    Klinik für Hals Nasen Ohren Heilkunde, Universitatsklinikum Tubingen, Elfriede Aulhorn Strasse 5, 72076 Tubingen, Deutschland
    HNO 56:288-300. 2008
    ..Other current methods to induce hair cell regeneration include the gene transfer of Math1 and transplantation of stem cells to the inner ear...
  10. ncbi request reprint [Basic principles of in vivo regeneration in the area of the head and neck]
    H Löwenheim
    Universitäts Hals Nasen Ohren Klinik, Tubingen
    Laryngorhinootologie 81:S1-23. 2002
  11. ncbi request reprint Regenerative medicine/cellular engineering for diseases of the head and neck
    H Löwenheim
    Department of Otolaryngology Head and Neck Surgery, University of Tubingen, Tubingen, Germany
    DNA Cell Biol 22:547-8. 2003
  12. doi request reprint Randomized, double blind, placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemic the
    Stefan K Plontke
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Tubingen, Tubingen, Germany
    Laryngoscope 119:359-69. 2009
    ..To study the safety and efficacy of continuous intratympanic dexamethasone-phosphate (Dex-P) for severe to profound sudden idiopathic sensorineural hearing (ISSHL) or sudden idiopathic anacusis after failure of systemic therapy...
  13. doi request reprint Co-localisation of K(ir)4.1 and AQP4 in rat and human cochleae reveals a gap in water channel expression at the transduction sites of endocochlear K(+) recycling routes
    Andreas Eckhard
    Hearing Research Centre Department of Otorhinolaryngology Head and Neck Surgery, University of Tübingen Medical Center, Elfriede Aulhorn Straße 5, 72076 Tubingen, Germany
    Cell Tissue Res 350:27-43. 2012
    ..1 and AQP4. The subcellular co-localisation of K(ir)4.1 and AQP4 in the SCs of the cochlea described in this study resembles that of the astroglia of the central nervous system and the glial Mueller cells in the retina...
  14. doi request reprint A novel buoyancy technique optimizes simulated microgravity conditions for whole sensory organ culture in rotating bioreactors
    Heinz J P Arnold
    Department of Otorhinolaryngology Head and Neck Surgery, University of Tübingen Medical Center, Tubingen, Germany
    Tissue Eng Part C Methods 16:51-61. 2010
    ..This buoyancy technique may also be useful in tissue engineering of other high-density structures...
  15. doi request reprint Lack of Tff3 peptide results in hearing impairment and accelerated presbyacusis
    Maria Lubka
    Division of Molecular Genetics, University of Tubingen, Germany
    Cell Physiol Biochem 21:437-44. 2008
    ..These findings suggest that Tff3 could play a role in neurosensory signaling. Further studies are needed to clarify this new function in the auditory system...
  16. pmc Deafness in TRbeta mutants is caused by malformation of the tectorial membrane
    Harald Winter
    Department of Otorhinolaryngology, Tübingen Hearing Research Center, University of Tubingen, 72076 Tubingen, Germany
    J Neurosci 29:2581-7. 2009
    ....
  17. ncbi request reprint Transtympanic endoscopy for drug delivery to the inner ear using a new microendoscope
    Stefan K R Plontke
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Tubingen, Germany
    Adv Otorhinolaryngol 59:149-55. 2002
    ....
  18. doi request reprint Whole organ culture of the postnatal sensory inner ear in simulated microgravity
    Hartmut Hahn
    Department of Otorhinolaryngology Head and Neck Surgery, Hearing Research Center Tübingen, University of Tübingen Medical Center, Elfriede Aulhorn Strasse 5, D 72076 Tubingen, Germany
    J Neurosci Methods 171:60-71. 2008
    ....
  19. ncbi request reprint Technical note on microcatheter implantation for local inner ear drug delivery: surgical technique and safety aspects
    Stefan K Plontke
    Department of Otorhinolaryngology, Head and Neck Surgery and Tübingen Hearing Research Center, University of Tubingen, Germany
    Otol Neurotol 27:912-7. 2006
    ..Despite its invasiveness, the temporary implantation of a microcatheter into the middle ear cavity is an appropriately safe method for providing continuous drug delivery to the inner ear...
  20. ncbi request reprint The impact of petrosal vein preservation on postoperative auditory function in surgery of petrous apex meningiomas
    Alireza Gharabaghi
    Department of Neurosurgery, University Hospital Tuebingen, Tuebingen, Germany
    Neurosurgery 59:ONS68-74; discussion ONS68-74. 2006
    ..However, there is no systematic clinical study available thus far focusing on the postoperative auditory function after petrosal vein obliteration...
  21. ncbi request reprint Management and outcome after internal carotid artery laceration during surgery of the paranasal sinuses
    Assen Koitschev
    Department of Otorhinolaryngology and Head and Neck Surgery, University of Tuebingen, Germany
    Acta Otolaryngol 126:730-8. 2006
    ..Immediate management is critical and requires interdisciplinary cooperation between the otolaryngologist and interventional neuroradiologist...
  22. ncbi request reprint Delayed otogenic hydrocephalus after acute otitis media in pediatric patients: the changing presentation of a serious otologic complication
    Assen Koitschev
    Department of Otorhinolaryngology and Head and Neck Surgery, University of TübingenTübingen, Germany
    Acta Otolaryngol 125:1230-5. 2005
    ..We therefore advocate that the MRI scans of patients with similar symptoms should be carefully studied to facilitate the early diagnosis of a potentially life-threatening complication...
  23. ncbi request reprint Safe and reliable sound threshold measures with direct vibration of the ossicular chain
    Marcus M Maassen
    Department of Otolaryngology, University of Tubingen, Tubingen, Germany
    Laryngoscope 114:2012-20. 2004
    ..The aim of the study was to evaluate the safety and feasibility of piezoelectric malleus vibration audiometer (MVA), which presents micromechanical vibrations to the umbo membranae tympani...
  24. ncbi request reprint Surgical-handling properties of the titanium prosthesis in ossiculoplasty
    Marcus M Maassen
    Department of Otolaryngology Head and Neck Surgery, University of Tubingen, Elfriede Aulhorn Str 5, D 72076 Tubingen, Germany
    Ear Nose Throat J 84:142-4, 147-9. 2005
    ..Based on the results of 383 of the 400 ossiculoplasties, our survey revealed that the titanium implant was significantly superior to the others in all measured respects...
  25. doi request reprint Water channel proteins in the inner ear and their link to hearing impairment and deafness
    Andreas Eckhard
    Department of Otorhinolaryngology Head and Neck Surgery, University of Tubingen, Tubingen, Germany
    Mol Aspects Med 33:612-37. 2012
    ..The pathophysiological implications of these AQP subtypes for inner ear diseases, that appear to involve impaired fluid regulation, such as Menière's disease and Sjögren's syndrome, are discussed...
  26. ncbi request reprint Outcomes research analysis of continuous intratympanic glucocorticoid delivery in patients with acute severe to profound hearing loss: basis for planning randomized controlled trials
    Stefan Plontke
    Department of Otorhinolaryngology Head and Neck Surgery and Tübingen Hearing Research Center, University of Tubingen, Tubingen, Germany
    Acta Otolaryngol 125:830-9. 2005
    ..Comparison of different application protocols and drug delivery systems will allow assessment of the value of continuous versus intermittent intratympanic glucocorticoid drug delivery...
  27. pmc Altered phenotype of the vestibular organ in GLAST-1 null mice
    Sebastian P Schraven
    Department of Otolaryngology, Tübingen Hearing Research Centre THRC, Molecular Physiology of Hearing, University of Tubingen, Elfriede Aulhorn Str 5, 72076 Tubingen, Germany
    J Assoc Res Otolaryngol 13:323-33. 2012
    ..Taken together, GLAST-1 deletion appeared to preferentially affect the maintenance of a normal postsynaptic/neuronal phenotype, evident only with increasing age...
  28. ncbi request reprint Temporal bone changes in patients with Goldenhar syndrome with special emphasis on inner ear abnormalities
    Florian Hennersdorf
    Department of Diagnostic and Interventional Neuroradiology, Hoppe Seyler Straße 3 and Department of Otorhinolaryngology, Elfriede Aulhorn Straße 5, Tubingen, Germany
    Otol Neurotol 35:826-30. 2014
    ..We examined temporal bone changes with special emphasis on inner ear abnormalities in these patients...
  29. ncbi request reprint Differentiating imaging findings in primary and secondary tumors of the jugular foramen
    Hubert Löwenheim
    Department of Otolaryngology Head and Neck Surgery, University of Tuebingen, Tuebingen, Germany
    Neurosurg Rev 29:1-11; discussion 12-13. 2006
    ..The present study describes and discusses the main differentiating imaging features of lesions involving the jugular foramen, whose accurate preoperative radiological evaluation is essential for proper surgical planning...