Research Topics
Genomes and Genes | A LupasSummaryCountry: Germany Publications
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Publications
Predicting coiled-coil regions in proteinsA Lupas
Max Planck Institut fur Biochemie, Martinsried, Germany
Curr Opin Struct Biol 7:388-93. 1997....
Coiled coils: new structures and new functionsA Lupas
Abteilung für Molekulare Strukturbiologie, Max Planck Institut fur Biochemie, Martinsried, Germany
Trends Biochem Sci 21:375-82. 1996..This has provided many new insights into the structure of coiled coils, their discontinuities, their relationship with other helical bundles and the problems connected with their prediction from protein sequences...
Classification of tyrosine kinases from Dictyostelium discoideum with two distinct, complete or incomplete catalytic domainsK Adler
Max Planck Institut fur Biochemie, Martinsried, Germany
FEBS Lett 395:286-92. 1996..discoideum, a branch of their own, separate from the tyrosine kinase domains in sensu strictu. Domain II in DPYK4 is found on a different branch close to serine/threonine kinases...
The solution structure of VAT-N reveals a 'missing link' in the evolution of complex enzymes from a simple betaalphabetabeta elementM Coles
Institut fur Organische Chemie und Biochemie, Technische Universitat Munchen, Lichtenbergstrasse 4, 85747, Garching, Germany
Curr Biol 9:1158-68. 1999..VAT shows activity in protein folding and unfolding and thus shares the common function of these ATPases in disassembly and/or degradation of protein complexes...
Characterization of ARC, a divergent member of the AAA ATPase family from Rhodococcus erythropolisS Wolf
Max Planck Institut fur Biochemie, Am Klopferspitz 18a, Martinsried, D 82152, Germany
J Mol Biol 277:13-25. 1998..Two-dimensional crystals grown on lipid monolayers yielded images of the ATPase molecules in "end-on" orientation at 1.9 nm resolution...
The Thermoplasma acidophilum rpl15 gene encodes a homologue of eukaryotic ribosomal proteins L15/YL10P Zwickl
Max Planck Institut fur Biochemie, Martinsried, Germany
Biochem Biophys Res Commun 209:684-8. 1995..59. The RPL15 amino acid sequence shows significant similarity (> 35% identity) to the L15/YL10 proteins of various eukaryotes...
Primary structure of the thermosome from Thermoplasma acidophilumT Waldmann
Max Planck Institut fur Biochemie, Martinsried, Germany
Biol Chem Hoppe Seyler 376:119-26. 1995....
Cloning, sequencing and expression of VAT, a CDC48/p97 ATPase homologue from the archaeon Thermoplasma acidophilumV Pamnani
Max Planck Institut fur Biochemie, Martinsried, Germany
FEBS Lett 404:263-8. 1997..Electron microscopy shows the purified protein to form single and double homo-hexameric rings. Although the symmetry is different, the appearance of the complexes formed of two rings resembles the 20S proteasome and Hsp60/GroEL...
Genetic characterization of gram-positive homologs of the XerCD site-specific recombinasesA F Chalker
SmithKline Beecham Pharmaceuticals, Collegeville, PA 19426 0989, USA
J Mol Microbiol Biotechnol 2:225-33. 2000..S. pneumoniae xer1, 2 and 3 null mutants were each found to be attenuated in a murine infection model, suggesting that they may control processes which affect virulence...
Isolation and cloning of Omp alpha, a coiled-coil protein spanning the periplasmic space of the ancestral eubacterium Thermotoga maritimaA M Engel
Max Planck Institut fur Biochemie, Martinsried, Germany
EMBO J 11:4369-78. 1992....
A mouse Ig kappa domain of very unusual framework structure loses function when converted to the consensusL Ge
Biochemisches Institut, Universitat Zurich, Switzerland
J Biol Chem 270:12446-51. 1995..Removal of the insertion to restore the consensus sequence reduced the binding affinity of 93-6 by a factor 3, while insertion of the missing leucine into FR2 completely abolished binding...
The first characterization of a eubacterial proteasome: the 20S complex of RhodococcusT Tamura
Max Planck Institute for Biochemistry, Martinsried, Germany
Curr Biol 5:766-74. 1995....
The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domainA Greco
Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy
Mol Cell Biol 15:6118-27. 1995..Molecular analysis of the NTRK1 rearranged fragments indicated that the chromosomal rearrangement is reciprocal and balanced and involves loss of a few nucleotides of germ line sequences...
Phosphorylation of an N-terminal regulatory domain activates the CheB methylesterase in bacterial chemotaxisA Lupas
Department of Molecular Biology, Princeton University, New Jersey 08544
J Biol Chem 264:17337-42. 1989..The interplay between the methylesterase and phosphatase activities of CheB may provide a crucial link between adaptation and excitation in stimulus-response coupling...
Citrate sensing by the C4-dicarboxylate/citrate sensor kinase DcuS of Escherichia coli: binding site and conversion of DcuS to a C4-dicarboxylate- or citrate-specific sensorJ Kramer
Institut für Mikrobiologie und Weinforschung, Johannes Gutenberg Universitat Mainz, Becherweg 15, 55099 Mainz, Germany
J Bacteriol 189:4290-8. 2007..Sites C2 and C3 are essential for binding of two carboxylic groups of citrate or of C(4)-dicarboxylates; sites C1 and H are required for other essential purposes...
